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Hepatitis: HELP
Articles by Muralikrishnan Radhakrishnan
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, M. Radhakrishnan wrote the following 3 articles about Hepatitis.
 
+ Citations + Abstracts
1 Review Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance. 2017

Summers, Jennifer A / Radhakrishnan, Muralikrishnan / Morris, Elizabeth / Chalkidou, Anastasia / Rua, Tiago / Patel, Anita / McMillan, Viktoria / Douiri, Abdel / Wang, Yanzhong / Ayis, Salma / Higgins, Joanne / Keevil, Stephen / Lewis, Cornelius / Peacock, Janet. ·King's Technology Evaluation Centre, London, UK. jennifer.a.summers@kcl.ac.uk. · Division of Health and Social Care Research, King's College London, 4th Floor Addison House, Guy's Campus, London, SE1 1UL, UK. jennifer.a.summers@kcl.ac.uk. · King's Technology Evaluation Centre, London, UK. · King's Health Economics, King's College London, Institute of Psychiatry, The David Goldberg Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK. · Division of Imaging Sciences and Biomedical Engineering King's College London, Department of Biomedical Engineering, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK. · Centre for Primary Care and Public Health, Queen Mary University of London, Yvonne Carter Building, 58 Turner Street, London, E1 2AB, UK. · Division of Health and Social Care Research, King's College London, 4th Floor Addison House, Guy's Campus, London, SE1 1UL, UK. · Medical Technology Evaluation Programme, National Institute for Health and Care Excellence, Level 1A, City Tower, Piccadilly Plaza, Manchester, M1 4BT, UK. · Department of Medical Physics, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK. · Department of Medical Engineering and Physics, King's College Hospital, London, SE5 9RS, UK. · NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, 7th Floor Capital House, 42 Weston Street, London, SE1 3QD, UK. ·Appl Health Econ Health Policy · Pubmed #27601240.

ABSTRACT: Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue. The National Institute for Health and Care Excellence (NICE) Medical Technologies Advisory Committee (MTAC) selected VTq for evaluation and invited the company to submit clinical and economic evidence. King's Technology Evaluation Centre, an External Assessment Centre (EAC) commissioned by NICE, independently assessed the evidence submitted. The EAC conducted its own systematic review, meta-analysis and economic analysis to supplement the company's submitted evidence. The meta-analyses comparing VTq and transient elastography (TE) with liver biopsy (LB) provided pooled estimates of liver stiffness and stage of fibrosis for the study populations (hepatitis B, hepatitis C or combined populations). When comparing significant fibrosis (Metavir score F ≥ 2) for both hepatitis B and C, VTq had slightly higher values for both sensitivity and specificity (77 and 81 %) than TE (76 and 71 %). The overall prevalence of cirrhosis (F4, combined populations) was similar with VTq and TE (23 vs. 23 %), and significant fibrosis (F ≥ 2) was lower for VTq than for TE (55 vs. 62 %). The EAC revised the company's de novo cost model, which resulted in a cost saving of £53 (against TE) and £434 (against LB). Following public consultation, taking into account submitted comments, NICE Medical Technology Guidance MTG27 was published in September 2015. This recommended the adoption of the VTq software to diagnose and monitor liver fibrosis in patients with hepatitis B or hepatitis C.

2 Article Association of interleukin-28B rs12979860 and rs8099917 polymorphisms with sustained viral response in hepatitis C virus genotype 1 and 3 infected patients from the Indian subcontinent. 2016

Ranjan, P / Fletcher, G J / Radhakrishnan, M / Sivakumar, J / Premkumar, P S / Goel, A / Zachariah, U G / Abraham, P. ·Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India. · Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India. · Department of Hepatology, Christian Medical College, Vellore, Tamil Nadu, India. ·Indian J Med Microbiol · Pubmed #27514956.

ABSTRACT: BACKGROUND: Polymorphisms of the IL28B gene (rs12979860 and rs8099917) have been shown to impact treatment responses in hepatitis C virus (HCV) infected patients. The association of these polymorphisms with sustained viral response (SVR) has been studied in HCV genotype 3 infected patients in India, but not in genotype 1. OBJECTIVES: This study aimed to determine the association of IL28B gene polymorphisms and other host and viral factors with treatment response in patients with HCV genotype 1 and 3 infection. MATERIALS AND METHODS: DNA from 42 HCV-infected patients on antiviral therapy was analysed for the IL28B polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Bidirectional sequencing was performed on a subset of samples for verification of PCR-RFLP results. Information on age, weight, height, diabetic status, pre-treatment viral load and alanine aminotransferase (ALT) levels was obtained from clinical records. The IL28B genotypes and the other factors were analysed for their association with SVR. RESULTS: The frequency distribution of rs12979860 CC/CT/TT genotypes was found to be 66.7%, 26.2% and 7.1%, respectively. For rs8099917 genotype, the TT/GT/GG distribution was 73.8%, 21.4% and 4.8%, respectively. SVR was seen in 61.9% of cases (55.6% in genotype 1 and 62.5% in genotype 3). CC genotype at rs12979860 and TT genotype at rs8099917 were significantly higher in responders (P = 0.013 and 0.042, respectively). Lower baseline ALT and rapid viral response were also found to be associated with SVR. On logistic regression analysis, CC genotype at rs12979860 emerged as the most powerful predictor of treatment response. CONCLUSION: IL28B polymorphisms are strong predictors of SVR in patients from the Indian subcontinent infected with HCV genotype 3 and genotype 1.

3 Article Mother to child transmission of hepatitis B virus: a cause for concern. 2015

Ismail, A M / Raghavendran, A / Sivakumar, J / Radhakrishnan, M / Rose, W / Abraham, P. ·Department of Clinical Virology, Christian Medical College, Vellore - 632004, Tamil Nadu, India. ·Indian J Med Microbiol · Pubmed #25657134.

ABSTRACT: Mother to child transmission of hepatitis B virus (HBV) is an important public health issue. India introduced HBV vaccine in 10 states as part of its Universal Immunization Program (UIP). Here we show evidence of mother-to-child transmission of HBV in three families from Jharkhand and Bihar states where HBV vaccination is not yet included in the UIP. This report illustrates the need for active screening of HBV in pregnant women and implementation of HBV vaccine across all states in India to reduce the burden of disease.