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Herpes Zoster: HELP
Articles from Tunisia
Based on 14 articles published since 2009

These are the 14 published articles about Herpes Zoster that originated from Tunisia during 2009-2019.
+ Citations + Abstracts
1 Article [Herpetic facial paralysis]. 2015

Lahiani, Rim / Mahfoudhi, Madiha. ·Service ORL, Hôpital Charles Nicolle, Tunis, Tunisie. · Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie. ·Pan Afr Med J · Pubmed #26955425.

ABSTRACT: -- No abstract --

2 Article [Ramsay Hunt syndrome]. 2015

Mahfoudhi, Madiha / Lahiani, Rim. ·Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie. · Service d'ORL, Hôpital Charles Nicolle, Tunis, Tunisie. ·Pan Afr Med J · Pubmed #26893805.

ABSTRACT: -- No abstract --

3 Article [Auricular zona complicated by an invalidating vestibular syndrome]. 2015

Mahfoudhi, Madiha / Khaled, Khamassi. ·Service de médecine interne A Hôpital Charles Nicolle, Tunis, Tunisie. · Service ORL, Hôpital Charles Nicolle, Tunis, Tunisie. ·Pan Afr Med J · Pubmed #26430476.

ABSTRACT: -- No abstract --

4 Article Pattern of Acute Retinal Necrosis in a Referral Center in Tunisia, North Africa. 2015

Khochtali, Sana / Abroug, Nesrine / Kahloun, Rim / Ksiaa, Imen / Nahdi, Imen / Zaouali, Sonia / Ben Yahia, Salim / Khairallah, Moncef. ·a Department of Ophthalmology , Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir , Monastir , Tunisia. ·Ocul Immunol Inflamm · Pubmed #24945738.

ABSTRACT: PURPOSE: To describe the pattern of acute retinal necrosis (ARN) syndrome in a referral center in Tunisia. METHODS: Retrospective review of the charts of 12 patients (12 eyes). RESULTS: Necrotizing retinitis involved >50% of the retina in 33.3% of eyes. Polymerase chain reaction on aqueous humor sample identified herpes simplex virus-1 in 4 eyes (33.3%) and varicella zoster virus in 3 eyes (25%), and was negative in 5 eyes (41.7%). All patients received intravenous acyclovir, followed by oral antivirals. Follow-up ranged from 6 to 16 months. Retinal detachment (RD) occurred in 3 eyes (25%), but no patient developed bilateral ARN. Final visual acuity was 20/200 or worse in 7 eyes (58.3%). Delay in diagnosis (p = 0.015), macular involvement (p = 0.045), development of RD (p = 0.018), and 25-50% of retinal involvement (p = 0.045) were associated with a worse visual outcome. CONCLUSION: ARN carries poor visual prognosis in Tunisia.

5 Article Ocular involvement and visual outcome of herpes zoster ophthalmicus: review of 45 patients from Tunisia, North Africa. 2014

Kahloun, Rim / Attia, Sonia / Jelliti, Bechir / Attia, Ahmed Zakaria / Khochtali, Sana / Yahia, Salim Ben / Zaouali, Sonia / Khairallah, Moncef. ·Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, 5019, Tunisia. ·J Ophthalmic Inflamm Infect · Pubmed #25246984.

ABSTRACT: BACKGROUND: Ocular complications of herpes zoster ophthalmicus (HZO) may lead to substantial visual impairment. The purpose of this study was to characterize and analyze ocular involvement and visual outcome of HZO in patients from Tunisia, North Africa. This study is a retrospective chart review of 51 eyes of 45 patients with HZO. RESULTS: Mean age was 44.5 years. Thirty patients (66.7%) were aged over 50 years. Twenty-four patients (53.3%) were male and 21 patients were female (46.7%). There was no statistically significant difference in gender distribution. Initial mean best corrected visual acuity (BCVA) was 20/50. Ocular manifestations included adnexal involvement (58.8%), keratitis (31.4%), keratouveitis (31.4%), isolated anterior uveitis (AU) (29.4%), intraocular pressure elevation (23.5%), oculomotor nerve palsy (5.8%), and optic neuritis (1.9%). Isolated AU (p < 0.001), isolated keratitis (p = 0.001), and intraocular pressure elevation (p = 0.013) were more likely to be concomitant to HZO active skin disease, while keratouveitis occurred more likely more than 1 month after HZO eruption (p < 0.001). AU and keratouveitis were more likely to be associated with age ≥ 50 years (p = 0.001 and p = 0.02, respectively). Ocular complications included neurotrophic keratopathy (1.9%), corneal opacity (5.9%), secondary glaucoma (7.8%), optic atrophy (1.9%), and postherpetic neuralgia (13.3%). Mean follow-up was 12 months. Mean final BCVA was 20/32; it was ≥ 20/40 in 78.4% of the eyes. CONCLUSIONS: Our study provided epidemiologic and clinical data of HZO in a Tunisian population. AU and keratitis were the most common ocular complications. Neurotrophic keratopathy was scarce. The overall visual outcome is good, with about three quarters of the treated patients maintaining VA of 20/40 or better.

6 Article [Viral retinitis following intravitreal triamcinolone injection]. 2013

Zghal, I / Malek, I / Amel, C / Soumaya, O / Bouguila, H / Nacef, L. ·Service d'ophtalmologie A, institut « Hédi Raies » d'ophtalmologie, boulevard 9-Avril, Bab Saadoun, 1006 Tunis, Tunisie. ·J Fr Ophtalmol · Pubmed #23648134.

ABSTRACT: Necrotizing viral retinitis is associated with infection by the Herpes family of viruses, especially herpes simplex virus (HSV), varicella zoster virus (VZV) and occasionally cytomegalovirus (CMV). When the diagnosis is suspected clinically, antiviral therapy must be instituted immediately. We report the case of a patient presenting with necrotizing viral retinitis 3 months following intravitreal injection of triamcinolone acetonide for diabetic macular edema. Fluorescein angiography demonstrated a superior temporal occlusive vasculitis. A diagnostic anterior chamber paracentesis was performed to obtain deoxyribo-nucleic acid (DNA) for a polymerase chain reaction (PCR) test for viral retinitis. PCR was positive for CMV. The patient was placed on intravenous ganciclovir. CMV retinitis is exceedingly rare in immunocompetent patients; however, it remains the most common cause of posterior uveitis in immunocompromised patients. The incidence of this entity remains unknown. Local immunosuppression, the dose and the frequency of injections may explain the occurrence of this severe retinitis.

7 Article Ramsay Hunt syndrome. 2012

Zainine, R / Sellami, M / Charfeddine, A / Beltaief, N / Sahtout, S / Besbes, G. ·Service d'ORL et de chirurgie maxillofaciale, hôpital La Rabta, Jabbari, Tunis, Tunisia. rimzainine@yahoo.fr ·Eur Ann Otorhinolaryngol Head Neck Dis · Pubmed #22364868.

ABSTRACT: INTRODUCTION: Ramsay Hunt syndrome is a viral infection that combines facial palsy and pinnal vesicular rash. OBJECTIVES: To detail diagnostic criteria, treatment and prognosis in Ramsay Hunt syndrome. PATIENTS AND METHODS: A retrospective study of 15 patients with Ramsay Hunt syndrome admitted to the ENT department of La Rabta Hospital (Tunis) from 2003 to 2009. RESULTS: The main presenting symptom was facial palsy associated with conchal vesicular rash. House-Brackmann classification of facial nerve function ranged from III to V. All patients were treated with acyclovir and corticosteroids. Mean follow-up was 8 months. Ten patients showed improvement in facial palsy, four had permanent palsy and one moved from grade IV to grade III. CONCLUSION: Ramsay Hunt syndrome involves severe dysfunction, with poorer facial nerve prognosis than in Bell's palsy.

8 Article Chronic lymphocytic leukemia revealed by a branulomatous zosteriform eruption. 2012

Trojjet, Sondes / Hammami, Houda / Zaraa, Inès / Bouzguarrou, Alia / Joens, Meriem / Haouet, Slim / Ben Osman, Amel / Mokni, Mourad. ·Department of Dermatology, La Rabat Hospital, Tunis Tunisia. ·Skinmed · Pubmed #22324180.

ABSTRACT: A 70-year-old woman presented with an atypical erythematopapular zosteriform eruption of 3 weeks' duration. The patient had no history of previous vesicular eruption. She developed a painful burning sensation on the neck. Clinical examination revealed a cluster of small erythematous firm papules and plaques in a zosteriform distribution on the left ear, face, neck, and shoulder (Figure 1A). The lesions were unilateral and did not cross the midline. Multiple cervical and axillary lymph nodes were palpable. Laboratory tests revealed an increase in white blood cells of 25,000/mm3, with 17,910/mm3 lymphocytes and a normal range of hemoglobin, platelets, creatinine, and liver enzymes. Erythrocyte sedimentation rate was 87 mm. Blood smear results showed small, morphologically mature lymphocyte cells. In immune phenotyping, lymphocyte cells co-express CD5 and B-cell-surface antigens CD19 and CD23, as well as a restriction of kappa immunoglobulin light chains. The cells were CD22-, CD79b-, CD38-, CD10-, CD25- and FMC7-. Computed thoracoabominal tomography revealed cervical, mediastinal, abdominal, and pelvic adenopathy confirming the diagnosis of B-cell chronic lymphocytic leukemia (B-CLL) stage B. Histology of a skin biopsy from a papule showed a dense nodular granulomatous infiltrate in the dermis (Figure 2A). The infiltrate contained epithelioid and giant cells surrounded by lymphocytes and plasma cells. Small monomorphic lymphocytes without mitotic figures predominated (Figure 2B). The epidermis was irregularly thickened. Immunohistology revealed a polymorphous infiltrate with a phenotype of reactive T lymphocytes (CD3, CD5 positive) (Figure 2C), B lymphocytes (CD20 positive) (Figure 2D). Epithelioid and giant cells were positive for CD68 (Figure 2E). A latent herpes zoster infection with granulomatous reaction at the site ofzoster lesions was highly suspected as the patient reported a unilateral burning sensation without a history of vesicular zosteriform eruption. She received treatment with intravenous acyclovir 10 mg/kg every 8 hours. The papular lesions resolved markedly (60%) on macular plaques at the end of the treatment. Following topical treatment with corticosteroids, the lesions healed completely within 4 weeks (Figure 1B). Concerning leukemia, our patient was monitored without therapy by the hematologist.

9 Article Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent Tunisian patients with acute neuromeningeal disorder. 2012

Nahdi, Imen / Boukoum, Hanen / Nabil Ben Salem, Abid / Ben Romdane, Fouad / Hammami, Saber / Chebel, Saber / Mahbouba, Frih-Ayed / Guediche, Mohamed Neji / Chakroun, Mohamed / Aouni, Mahjoub / Imbert-Marcille, Berthe-Marie / Bressollette-Bodin, Celine. ·Laboratory of Contagious Diseases and Biologically Active Substances, LR99-ES27, Faculty of Pharmacy, Monastir University, Monastir, Tunisia. amen_nahdi@yahoo.fr ·J Med Virol · Pubmed #22170549.

ABSTRACT: Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourguiba University Hospital (Monastir, Tunisia) between September 2007 and June 2009. At least one viral genome was detected in 58 (46%) out of 126 CSF samples collected. Enterovirus was detected in 31 of the positive samples (53.4%), CMV in 20 (34.5%), HSV-1 in 3 (5.2%), HSV-2 in 6 (10.3%), VZV in 4 (6.9%), HHV-6 in 2 (3.4%). More than one viral genome was detected in seven CSF samples, including CMV DNA in six of the samples. The high frequency of enteroviral infections in aseptic meningitis was confirmed. The detection of CMV DNA only suggests a direct role of this virus in the etiology of acute neuromeningeal disorder.

10 Article Identification of human herpesviruses 1 to 8 in Tunisian multiple sclerosis patients and healthy blood donors. 2012

Ben Fredj, Nadia / Rotola, Antonella / Nefzi, Faten / Chebel, Saber / Rizzo, Roberta / Caselli, Elisabetta / Frih-Ayed, Mahbouba / Di Luca, Dario / Aouni, Mahjoub. ·Laboratory of Transmissible Diseases and Biological Active substances, LR99-ES27, Faculty of Pharmacy, University of Monastir, Avicenne street 5000, Monastir, Tunisia. benfredj_nadia@yahoo.fr ·J Neurovirol · Pubmed #22058062.

ABSTRACT: Members of the human Herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. To verify the possible role of human herpesviruses (HHVs) as triggering or aggravating factors in relapsing-remitting multiple sclerosis clinical outcome, we studied the prevalence of all eight human herpesviruses in whole blood samples collected from 51 MS patients and from 51 healthy controls. The presence of DNA of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7) and human herpesvirus 8 (HHV-8) was searched by specific nested polymerase chain reaction. HHVs were significantly more prevalent in the blood of MS patients than in those of the controls (P < 10(-4)). HSV-1, HSV-2, HCMV and HHV-8 were negative in both MS patients and controls samples. In MS patients, EBV, HHV-7, HHV-6 and VZV were detected in 31.3%, 33.3%, 5.8% and 7.8% of samples, respectively, compared with 3.9%, 9.8%, 1.96% and 1.96%, respectively, of samples from controls. We found a statistically significant difference only for EBV DNA and for HHV-7 DNA prevalence (P < 0.001 and P = 0.03). Although these results indicate lack of apparent association in terms of gender, type of diagnosis, symptoms, disease score and β interferon treatment between EBV or HHV-7 to MS among Tunisian patients, heterogeneity related to genetic polymorphism as well as geographical distribution of the disease and of pathogens may be of significance.

11 Article Post varicella zoster virus myelitis in immunocompetent patients. 2011

Ben-Amor, Sana / Lammouchi, Turkia / Benslamia, Lamia / Benammou, Soufiene. ·Department of Neurology, Sahloul Hospital, 4054 Sousse, Tunisia. kaffelsana@yahoo.fr ·Neurosciences (Riyadh) · Pubmed #21427667.

ABSTRACT: We report 2 immunocompetent patients with myelitis. The first was a 55-year old man who developed myelitis after intercostal herpes zoster. The second was a 19-year-old boy who presented with myelopathy after varicella infection. Varicella-zoster virus (VZV) myelitis was diagnosed based on the close temporal relationship between rash and onset of clinical symptoms, and by the elevated rate of anti-VZV IgG in the CSF without oligoclonal bands in the first case, and presence of VZV DNA in the second. The course was favorable after a 3-day course of corticosteroids and 3 weeks of acyclovir. Varicella-zoster virus myelitis is uncommon; it affects essentially immunodepressed patients. We highlight the importance of considering the possibility of VZV myelitis, even in immunocompetent patients. The combination of corticoids and acyclovir must be instituted, quickly, to improve functional outcome.

12 Article [Seroprevalence of rubella virus, varicella zoster virus, cytomegalovirus and parvovirus B19 among pregnant women in the Sousse region, Tunisia]. 2011

Hannachi, N / Marzouk, M / Harrabi, I / Ferjani, A / Ksouri, Z / Ghannem, H / Khairi, H / Hidar, S / Boukadida, J. ·Laboratoire de Microbiologie-immunologie, Unité de Recherche « Caractérisation Génomique des Agents Infectieux UR 02SP13 », Avenue Ibn-Jazzar, 4000 Sousse, Tunisie. nhannachi@lycos.com ·Bull Soc Pathol Exot · Pubmed #21243459.

ABSTRACT: The aim of the study is to evaluate seroprevalence of rubella virus (RV), cytomegalovirus (CMV), varicella zoster virus (VZV), and parvovirus B19 (PB19) in 404 Tunisian pregnant women, and to determine reliability of maternal past history of eruption. Sociodemographic characteristics, risk factors, and past history of eruption were collected through a questionnaire. Serologic tests were performed using enzyme immunoassays. Risk factors were analyzed using univariate and multivariate logistic regression models. Seroprevalences were 79.7% for rubella, 96.3% for CMV, 80.9% for VZV, and 76.2% for PB19. In multivariate analysis, the number of persons per room (> 2) in the house during childhood was associated with CMV infection (P = 0.004), irregular professional husband's activity was correlated with VZV infection (P = 0.04), and an age of more than 30 years was associated with PB19 infection (P = 0.02). History of rubella, varicella, and PB19 infection was unknown for, respectively, 55.8%, 20%, and 100% of women. False history of rubella and varicella were found for 7.4% and 15% of women, respectively. The positive and negative predictive values (PPV and NPV) of rubella history were, respectively, 92.6% and 17.2%, and were, respectively, 84.9% and 20.9% for varicella history. Susceptibility to RV, VZV, and PB19 infection remains high in pregnancy in our population. Preventive strategies against congenital rubella must be reinforced. Vaccination against VZV should be considered in seronegative women. Systemic CMV screening is not warranted in our country where high immunity is acquired probably in childhood. Since maternal history of eruption is not reliable, we recommend serologic testing to determine immune status of women.

13 Minor [Parsonage-Turner syndrome following varicella-zoster virus infection]. 2015

Chebbi, Wafa / Kessomtini, Wassia / Kacem, Hanène Haj / Laajili, Hanène / Said, Wafa. ·CHU Taher Sfar Mahdia, service de médecine interne, 5100 Mahdia, Tunisie. Electronic address: chebbiwafamedimegh@yahoo.fr. · CHU Taher Sfar Mahdia, service de médecine physique, 5100 Mahdia, Tunisie. · CHU Taher Sfar Mahdia, service de médecine interne, 5100 Mahdia, Tunisie. ·Presse Med · Pubmed #25704804.

ABSTRACT: -- No abstract --

14 Unspecified Herpes zoster ophthalmicus associated with abducens palsy. 2014

Chaker, Nibrass / Bouladi, Mejda / Chebil, Ahmed / Jemmeli, Mehdi / Mghaieth, Fatma / El Matri, Leila. ·Department B of Ophthalmology, Hedi Rais Institute of Ophthalmology, Faculty of Medicine of Tunis, University of El Manar, Tunis, Tunisia. ·J Neurosci Rural Pract · Pubmed #24966563.

ABSTRACT: The extraocular muscle palsies associated with herpes zoster ophthalmicus (HZO) are transient, self-limiting conditions, usually seen in elderly patients. There are different treatment recommendations for paralytic complications, but prognosis has generally reported to be favorable. A 75-year-old male patient presented with diplopia. Clinical history revealed left facial vesicular eruptions and pain treated by oral aciclovir 1 week following symptom onset. On examination, we observed cicatricial lesions with crusts involving left hemiface, a limitation in abduction of the left eye, and a superficial punctuate keratitis (SPK) with decreased visual acuity (4/10). Examination of the right eye was unremarkable. Hess screen test confirmed left six nerve palsy.