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HIV Seropositivity: HELP
Articles by Jeffrey D. Klausner
Based on 8 articles published since 2008

Between 2008 and 2019, Jeffrey D. Klausner wrote the following 8 articles about HIV Seropositivity.
+ Citations + Abstracts
1 Review HIV Self-Testing: a Review of Current Implementation and Fidelity. 2016

Estem, Kristecia S / Catania, Joseph / Klausner, Jeffrey D. ·New York City Department of Health and Mental Hygiene, Bureau of HIV/AIDS Prevention and Control, 42-09 28th Street, WS 21-64, Queens, NY, 11101, USA. · Social and Behavioral Health Sciences, Oregon State University College of Public Health and Human Sciences, 401 Waldo Hall, Corvallis, OR, 97331, USA. · Department of Medicine, Division of Infectious Diseases, UCLA David Geffen School of Medicine and Department of Epidemiology, Fielding School of Public Health, 10920 Wilshire Blvd, Suite #350, Los Angeles, CA, 90024, USA. JDKlausner@mednet.ucla.edu. ·Curr HIV/AIDS Rep · Pubmed #26879653.

ABSTRACT: Oral HIV self-testing is an innovative and potentially high-impact means to increase HIV-case identification globally. As a screening test, oral HIV self-testing offers the potential for increased adoption through greater convenience and privacy, and the potential to increase the proportion of the population who test regularly. Research on how best to translate the innovation of oral self-testing to high-risk populations is underway. Currently only one oral HIV self-test kit is FDA-approved (OraQuick In-Home HIV Test) and available for retail sale. In the present report we review recent studies on the dissemination, adoption, and implementation of oral HIV testing. Prior work has focused primarily on adoption, but recent studies have begun to identify methods for improving dissemination and problems associated with self-implementation. At present a major barrier to wider adoption is the relatively high retail cost of the oral HIV test kit. Significant but minor barriers are represented by overly complex instructional materials for some population segments, and dissemination programs of unknown efficacy. Theoretical and practical suggestions for conducting research on dissemination, adoption, and implementation of oral HIV testing are discussed.

2 Clinical Trial Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission. 2015

Adachi, Kristina / Klausner, Jeffrey D / Bristow, Claire C / Xu, Jiahong / Ank, Bonnie / Morgado, Mariza G / Watts, D Heather / Weir, Fred / Persing, David / Mofenson, Lynne M / Veloso, Valdilea G / Pilotto, Jose Henrique / Joao, Esau / Nielsen-Saines, Karin / Anonymous5630842. ·From the *David Geffen UCLA School of Medicine, Los Angeles, CA; †Fielding School of Public Health, UCLA, Los Angeles, CA; ‡Westat, Rockville, MD; §Fundacao Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil; ¶Office of the Global AIDS Coordinator, US Department of State, Washington, DC; ∥Cepheid, Sunnyvale, CA; **Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; ††Hospital Geral de Nova Iguaçu, Nova Iguaçu, RJ, Brazil; and ‡‡Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brazil. ·Sex Transm Dis · Pubmed #26372927.

ABSTRACT: BACKGROUND: Sexually transmitted infections (STIs) such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) can lead to adverse pregnancy and neonatal outcomes. The prevalence of STIs and its association with HIV mother-to-child transmission (MTCT) were evaluated in a substudy analysis from a randomized, multicenter clinical trial. METHODOLOGY: Urine samples from HIV-infected pregnant women collected at the time of labor and delivery were tested using polymerase chain reaction testing for the detection of CT and NG (Xpert CT/NG; Cepheid, Sunnyvale, CA). Infant HIV infection was determined by HIV DNA polymerase chain reaction at 3 months. RESULTS: Of the 1373 urine specimens, 249 (18.1%) were positive for CT and 63 (4.6%) for NG; 35 (2.5%) had both CT and NG detected. Among 117 cases of HIV MTCT (8.5% transmission), the lowest transmission rate occurred among infants born to CT- and NG-uninfected mothers (8.1%) as compared with those infected with only CT (10.7%) and both CT and NG (14.3%; P = 0.04). Infants born to CT-infected mothers had almost a 1.5-fold increased risk for HIV acquisition (odds ratio, 1.47; 95% confidence interval, 0.9-2.3; P = 0.09). CONCLUSIONS: This cohort of HIV-infected pregnant women is at high risk for infection with CT and NG. Analysis suggests that STIs may predispose to an increased HIV MTCT risk in this high-risk cohort of HIV-infected women.

3 Article Using Grindr, a Smartphone Social-Networking Application, to Increase HIV Self-Testing Among Black and Latino Men Who Have Sex With Men in Los Angeles, 2014. 2016

Huang, Emily / Marlin, Robert W / Young, Sean D / Medline, Alex / Klausner, Jeffrey D. ·Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California. · Department of Family Medicine, David Geffen School of Medicine at the University of California, Los Angeles. · McGill University, Montréal, Quebec, Canada. ·AIDS Educ Prev · Pubmed #27427928.

ABSTRACT: In Los Angeles County, about 25% of men who have sex with men (MSM) are HIV-positive but unaware of their status. An advertisement publicizing free HIV self-tests was placed on Grindr, a smartphone social-networking application, from April 17 to May 29, 2014. Users were linked to http://freehivselftests.weebly.com/ to choose a self-test delivery method: U.S. mail, a Walgreens voucher, or from a vending machine. Black or Latino MSM ≥ 18 years old were invited to take a testing experiences survey. During the campaign, the website received 11,939 unique visitors (average: 284 per day) and 334 self-test requests. Among 57 survey respondents, 55 (97%) reported that using the self-test was easy; two persons reported testing HIV positive and both sought medical care. Social networking application self-testing promotion resulted in a large number of self-test requests and has high potential to reach untested high-risk populations who will link to care if they test positive.

4 Article Frequency, patterns, and preferences of lubricant use during anal intercourse within male sexual partnerships in Lima, Peru: implications for a rectal microbicide HIV prevention intervention. 2013

Clark, Jesse L / Salvatierra, Hector J / Segura, Eddy R / Salazar, Ximena / Konda, Kelika / Galea, Jerome / Klausner, Jeffrey D / Coates, Thomas J / Caceres, Carlos F. ·David Geffen School of Medicine at UCLA, Department of Medicine, Infectious Diseases/Program in Global Health, Los Angeles, CA, USA. jlclark@mednet.ucla.edu ·AIDS Care · Pubmed #23082796.

ABSTRACT: Understanding current practices of lubricant use during anal intercourse can help to assess the contexts for the introduction of topical rectal microbicides as an HIV prevention tool for men who have sex with men (MSM). We used quantitative and qualitative methods to assess: current patterns of lubricant use; preferred characteristics of commercial lubricant formulations; and social and behavioral contexts of lubricant use within male sexual partnerships in Lima, Peru. Between 2007 and 2008, we conducted a quantitative behavioral survey with 547 MSM followed by qualitative individual and group interviews with 36 MSM from Lima, Peru. Approximately half of all participants in the quantitative survey (50.3%) reported using commercial lubricant during intercourse occasionally or consistently during the preceding two months, with lack of availability at the time of intercourse the most commonly reported reason for non-use. No clear preferences regarding the color, smell, taste, or viscosity of commercial lubricants were identified, and all participants who reported using a commercial lubricant used the same product ("Love-Lub"). In the qualitative analysis, participants characterized lubricant use as a sexual practice consistently controlled by the receptive partner, who typically obtained and applied lubricant independently, with or without the consent of the insertive partner. Quantitative findings supported this differential pattern of lubricant use, with men who reported sexual identities or roles consistent with receptive anal intercourse, including unprotected receptive intercourse, more likely to report lubricant use than MSM who claimed an exclusively insertive sexual role. Given the social, behavioral, and biological factors contributing to increased vulnerability for HIV and STI acquisition by the receptive partner in anal intercourse, delivery of a topical rectal microbicide as a lubricant formulation could provide an important HIV prevention resource for at-risk MSM in Lima, Peru.

5 Article Methamphetamine use, transmission risk behavior and internet use among HIV-infected patients in medical care, San Francisco, 2008. 2012

Clark, Taylor / Marquez, Carina / Hare, C Bradley / John, Malcolm D / Klausner, Jeffrey D. ·School of Medicine, University of California San Francisco, 94117, USA. taylor.clark@ucsf.edu ·AIDS Behav · Pubmed #21190073.

ABSTRACT: Methamphetamine use is associated with adverse health outcomes and HIV incidence. Few studies have assessed methamphetamine use, sexual behavior and Internet use among HIV-infected patients. Surveys were administered to a sample of HIV-infected patients seeking medical care in a San Francisco county hospital and university-based clinic. In 2008, 35% of homosexual participants, 26% of heterosexual participants and 11% of female participants reported methamphetamine use in the past year. Of participants, 29% reported using the Internet to find sex partners; Internet-users versus non-Internet-users reported a higher median number of sex partners in 6 months (4 vs. 1), were more likely to report unprotected sex (32 vs. 10%), and higher rates of methamphetamine use in the past 12 months (48 vs. 24%). Given the association among methamphetamine use, increased sex partners and Internet use, the Internet may present a new and effective medium for interventions to reduce methamphetamine-associated sexual risk behavior.

6 Article Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion. 2010

Bernstein, Kyle T / Marcus, Julia L / Nieri, Giuliano / Philip, Susan S / Klausner, Jeffrey D. ·Epidemiology, Research and Surveillance, STD Prevention and Control Services, San Francisco Department of Public Health, San Francisco, CA 94103, USA. kyle.bernstein@sfdph.org ·J Acquir Immune Defic Syndr · Pubmed #19935075.

ABSTRACT: INTRODUCTION: HIV infection continues to disproportionately affect men who have sex with men (MSM). Identification of modifiable risk factors for HIV infection among MSM is critical for effective prevention. METHODS: We examined the relationship between number of prior rectal Neisseria gonorrhoeae (GC) or Chlamydia trachomatis (CT) infections and HIV seroconversion in a retrospective cohort of HIV-uninfected MSM diagnosed with a rectal infection. Number of rectal CT or GC infections in the prior 2 years was the primary exposure. Univariate and multivariate Cox proportional hazards models were used to estimate the association between prior rectal infections and HIV seroconversion. RESULTS: A total of 541 MSM were observed for a total of 1197.96 person-years. Overall, 27 (4.99%) of the MSM became infected with HIV, for an estimated annual incidence of 2.25% [95% confidence interval (CI): 1.49 to 3.26]. In multivariate analysis, an early syphilis diagnosis in the past 2 years (hazard ratio = 4.04, 95% CI: 1.19 to 13.79) and 2 prior CT or GC rectal infections in the past 2 years (hazard ratio = 8.85, 95% CI: 2.57 to 30.40) were associated with incident HIV. CONCLUSIONS: Among MSM infected with rectal GC or CT, a history of 2 additional prior rectal infections was associated with an 8-fold increased risk of HIV infection. HIV-uninfected MSM with multiple rectal infections represent a population in need of innovative HIV-prevention interventions.

7 Article Using surveillance data to monitor entry into care of newly diagnosed HIV-infected persons: San Francisco, 2006-2007. 2009

Zetola, Nicola M / Bernstein, Kyle / Ahrens, Katherine / Marcus, Julia L / Philip, Susan / Nieri, Giuliano / Jones, Diane / Hare, C Bradley / Hsu, Ling / Scheer, Susan / Klausner, Jeffrey D. ·Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, USA. nzetola@hotmail.com ·BMC Public Health · Pubmed #19144168.

ABSTRACT: BACKGROUND: Linkage to care after HIV diagnosis is associated with both clinical and public health benefits. However, ensuring and monitoring linkage to care by public health departments has proved to be a difficult task. Here, we report the usefulness of routine monitoring of CD4 T cell counts and plasma HIV viral load as measures of entry into care after HIV diagnosis. METHODS: Since July 1, 2006, the San Francisco Department of Public Health (SFDPH) incorporated monitoring initial primary care visit into standard HIV public health investigation for newly diagnosed HIV-infected patients in select clinics. Entry into care was defined as having at least one visit to a primary HIV care provider after the initial diagnosis of HIV infection. Investigators collected reports from patients, medical providers, laboratories and reviewed medical records to determine the date of the initial health care visit after HIV diagnosis. We identified factors associated with increased likelihood of entering care after HIV diagnosis. RESULTS: One -hundred and sixty new HIV-infected cases were diagnosed between July 1, 2006 and June 30, 2007. Routine surveillance methods found that 101 of those cases entered HIV medical care and monitoring of CD4 T cell counts and plasma HIV viral load confirmed entry to care of 25 more cases, representing a 25% increase over routine data collection methods. We found that being interviewed by a public health investigator was associated with higher odds of entry into care after HIV diagnosis (OR 18.86 [1.83-194.80], p = .001) compared to cases not interviewed. Also, HIV diagnosis at the San Francisco county hospital versus diagnosis at the county municipal STD clinic was associated with higher odds of entry into care (OR 101.71 [5.29-1952.05], p < .001). CONCLUSION: The time from HIV diagnosis to initial CD4 T cell count, CD4 T cell value and HIV viral load testing may be appropriate surveillance measures for evaluating entry into care, as well as performance outcomes for local public health departments' HIV testing programs. Case investigation performed by the public health department or case management by clinic staff was associated with increased and shorter time to entry into HIV medical care.

8 Minor Preventing AIDS deaths: cryptococcal antigen screening and treatment. 2012

Klausner, Jeffrey D / Govender, Nelesh / Oladoyinbo, Samuel / Roy, Monika / Chiller, Tom. · ·Lancet Infect Dis · Pubmed #22632183.

ABSTRACT: -- No abstract --