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HIV Seropositivity: HELP
Articles by Silvia Scarpona
Based on 1 article published since 2008
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Between 2008 and 2019, Silvia Scarpona wrote the following article about HIV Seropositivity.
 
+ Citations + Abstracts
1 Clinical Trial Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients. 2017

d'Ettorre, Gabriella / Rossi, Giacomo / Scagnolari, Carolina / Andreotti, Mauro / Giustini, Noemi / Serafino, Sara / Schietroma, Ivan / Scheri, Giuseppe Corano / Fard, Saeid Najafi / Trinchieri, Vito / Mastromarino, Paola / Selvaggi, Carla / Scarpona, Silvia / Fanello, Gianfranco / Fiocca, Fausto / Ceccarelli, Giancarlo / Antonelli, Guido / Brenchley, Jason M / Vullo, Vincenzo. ·Department of Public Health and Infectious Diseases, Azienda Policlinico Umberto I of Rome, Rome, Italy. · School of Biosciences, Veterinary Medicine University of Camerino, Matelica, Italy. · Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. · Department of Therapeutic Research and Medicines Evaluation, Italian Institute of Health, Rome, Italy. · Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. · Section of Microbiology, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. · Department of Emergency Surgery-Emergency Endoscopic Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. · Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. ·Immun Inflamm Dis · Pubmed #28474815.

ABSTRACT: INTRODUCTION: HIV infection is characterized by a persistent immune activation associated to a compromised gut barrier immunity and alterations in the profile of the fecal flora linked with the progression of inflammatory symptoms. The effects of high concentration multistrain probiotic (Vivomixx®, Viale del Policlinico 155, Rome, Italy in EU; Visbiome®, Dupont, Madison, Wisconsin in USA) on several aspects of intestinal immunity in ART-experienced HIV-1 patients was evaluated. METHODS: A sub-study of a longitudinal pilot study was performed in HIV-1 patients who received the probiotic supplement twice a day for 6 months (T6). T-cell activation and CD4+ and CD8+ T-cell subsets expressing IFNγ (Th1, Tc1) or IL-17A (Th17, Tc17) were stained by cytoflorimetric analysis. Histological and immunohistochemical analyses were performed on intestinal biopsies while enterocytes apoptosis index was determined by TUNEL assay. RESULTS: A reduction in the frequencies of CD4 CONCLUSIONS: These findings highlight the potential beneficial effects of probiotic supplementation for the reconstitution of physical and immunological integrity of the mucosal intestinal barrier in ART-treated HIV-1-positive patients.