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HIV Seropositivity: HELP
Articles by Andrew P. Steenhoff
Based on 2 articles published since 2008
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Between 2008 and 2019, Andrew Steenhoff wrote the following 2 articles about HIV Seropositivity.
 
+ Citations + Abstracts
1 Article Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia. 2015

Kelly, Matthew S / Wirth, Kathleen E / Steenhoff, Andrew P / Cunningham, Coleen K / Arscott-Mills, Tonya / Boiditswe, Sefelani C / Patel, Mohamed Z / Shah, Samir S / Finalle, Rodney / Makone, Ishmael / Feemster, Kristen A. ·Botswana-UPenn Partnership, Gaborone, Botswana Divisions of Global Health Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina. · Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. · Botswana-UPenn Partnership, Gaborone, Botswana Divisions of Global Health Infectious Diseases, The Children's Hospital of Philadelphia, Pennsylvania Perelman School of Medicine, University of Pennsylvania, Philadelphia. · Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina. · Botswana-UPenn Partnership, Gaborone, Botswana Perelman School of Medicine, University of Pennsylvania, Philadelphia. · Botswana-UPenn Partnership, Gaborone, Botswana. · University of Botswana School of Medicine, Gaborone. · Divisions of Hospital Medicine and Infectious Diseases, Cincinnati Children's Hospital Medical Center, Ohio. · Divisions of Global Health Perelman School of Medicine, University of Pennsylvania, Philadelphia. · Ministry of Health, Gaborone, Botswana. · Divisions of Global Health Infectious Diseases, The Children's Hospital of Philadelphia, Pennsylvania Perelman School of Medicine, University of Pennsylvania, Philadelphia. ·J Pediatric Infect Dis Soc · Pubmed #26582879.

ABSTRACT: BACKGROUND: Human immunodeficiency virus (HIV)-exposed, uninfected (HIV-EU) children are at increased risk of infectious illnesses and mortality compared with children of HIV-negative mothers (HIV-unexposed). However, treatment outcomes for lower respiratory tract infections among HIV-EU children remain poorly defined. METHODS: We conducted a hospital-based, prospective cohort study of N = 238 children aged 1-23 months with pneumonia, defined by the World Health Organization. Children were recruited within 6 hours of presentation to a tertiary hospital in Botswana. The primary outcome--treatment failure at 48 hours--was assessed by an investigator blinded to HIV exposure status. RESULTS: Median age was 6.0 months; 55% were male. One hundred fifty-three (64%) children were HIV-unexposed, 64 (27%) were HIV-EU, and 20 (8%) were HIV-infected; the HIV exposure status of 1 child could not be established. Treatment failure at 48 hours occurred in 79 (33%) children, including in 36 (24%) HIV-unexposed, 30 (47%) HIV-EU, and 12 (60%) HIV-infected children. In multivariable analyses, HIV-EU children were more likely to fail treatment at 48 hours (risk ratio [RR]: 1.83, 95% confidence interval [CI]: 1.27-2.64, P = .001) and had higher in-hospital mortality (RR: 4.31, 95% CI: 1.44-12.87, P = .01) than HIV-unexposed children. Differences in outcomes by HIV exposure status were observed only among children under 6 months of age. HIV-EU children more frequently received treatment with a third-generation cephalosporin, but this did not reduce the risk of treatment failure in this group. CONCLUSIONS: HIV-EU children with pneumonia have higher rates of treatment failure and in-hospital mortality than HIV-unexposed children during the first 6 months of life. Treatment with a third-generation cephalosporins did not improve outcomes among HIV-EU children.

2 Article Depression among HIV-positive individuals in Botswana: a behavioral surveillance. 2011

Lawler, Kathy / Mosepele, Mosepele / Seloilwe, Esther / Ratcliffe, Sarah / Steele, Katherine / Nthobatsang, Rudo / Steenhoff, Andrew. ·Center for AIDS Research, University of Pennsylvania, Philadelphia, PA, USA. kathy.lawler@uphs.upenn.edu ·AIDS Behav · Pubmed #19821023.

ABSTRACT: This study examined incidence of depression in HIV-positive individuals in Botswana. One hundred and twenty HIV-positive individuals were administered a measure of daily activities and two measures of depression. Twenty four to 38% were diagnosed with depression, suicidal ideation ranged from 9 to 12%, with a positive correlation between scores on the two depression measures. Depression was associated with greater impairment in activities of daily living, especially the ability to take medication. These instruments can diagnose depression in persons living with HIV in developing countries, which will help to target those at risk for poor adherence, and will enable better allocation of limited resources.