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HIV Seropositivity: HELP
Articles from China
Based on 192 articles published since 2008
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These are the 192 published articles about HIV Seropositivity that originated from China during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8
1 Review Retrospective analysis of 15 cases of Penicillium marneffei infection in HIV-positive and HIV-negative patients. 2017

Li, Yinyin / Lin, Zhongyuan / Shi, Xiang / Mo, Lijun / Li, Wenchao / Mo, Wuning / Yang, Zheng. ·Department of Clinical Laboratory, Guangxi Medical University, Nanning, Guangxi 530021, PR China. · Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address: Mown16300@126.com. · Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address: jackyyoung@foxmail.com. ·Microb Pathog · Pubmed #28104384.

ABSTRACT: Penicillium marneffei (P. marneffei) causes systemic opportunistic infections in immunocompromised individuals, particularly in those infected with human immunodeficiency virus (HIV), and more rarely in HIV-negative patients. We retrospectively analyzed the cases of 15 patients infected with P. marneffei. The patients were divided into two groups: HIV-negative (n = 4) and HIV-positive (n = 11). Of the cases studied, three (75%) of the HIV-negative and six (55%) of the HIV-positive group had an accompanying lung infection. The ratio of CD4

2 Review Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis. 2016

Huo, Zhen-Yu / Peng, Li. ·Department of Respiratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Rd, Chongqing, Yuzhong, 400016, China. · Department of Respiratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Rd, Chongqing, Yuzhong, 400016, China. pli1228@163.com. ·BMC Infect Dis · Pubmed #27450543.

ABSTRACT: BACKGROUND: Although the interferon-γ release assay (IGRA) has become a widely accepted means for the diagnosis of latent tuberculosis infection (LTBI), the role of the IGRA in diagnosing active tuberculosis (ATB) among human immunodeficiency virus (HIV)-seropositive individuals remains controversial. Previous analyses did not set up rational inclusive criteria for screening articles with strict control groups and a gold standard for ATB diagnosis. Therefore, we conducted a systematic review of the latest evidence to evaluate the accuracy of IGRA for HIV-seropositive patients. METHODS: Initially, we searched the EMBASE, Cochrane and MEDLINE databases to find research articles published from January 2000 to October 2015 that used the QuantiFERON-TB Gold In-Tube assay (QFT-IT) or the T-SPOT.TB assay (T-SPOT) to diagnose ATB among HIV-seropositive individuals. We separately calculated the pooled sensitivity, specificity, and proportion of indeterminate events and then summarized the results using forest plots to estimate the accuracy of the QFT-IT and T-SPOT assays. RESULTS: A total of 1,743 studies were discovered after searching; 11 studies met our selection standards and were included for meta-analysis. The pooled sensitivity and specificity of the QFT-IT assay were 69 % (95 % CI, 50-84 %, I(2) = 85.22 %) and 76 % (95 % CI, 53-90 %, I(2) = 98.16 %), respectively, and the optimum area under the curve (AUC) was 0.78 (95 % CI, 0.74-0.82). The pooled sensitivity and specificity of the T-SPOT assay were 89 % (95 % CI, 66-97 %, I(2) = 94.48 %) and 87 % (95 % CI, 38-99 %, I(2) = 97.92 %), respectively, and the AUC was 0.93 (95 % CI, 0.90-0.95). The pooled ratios of the indeterminate results of the QFT-IT and T-SPOT assays were 0.07 (95 % CI, 0.06-0.09, I(2) = 74.8 %) and 0.19 (95 % CI, 0.15-0.24, I(2) = 88.3 %), respectively, calculated using the fixed effect model, and 0.08 (95 % CI, 0.06-0.12, I(2) = 74.8 %) and 0.10 (95 % CI, 0.03-0.25, I(2) = 88.3 %), respectively, calculated using the random effects model. CONCLUSIONS: The IGRA does not appear to be optimal for the clinical confirmation of ATB cases in HIV-seropositive patients; however, the T-SPOT assay may have greater accuracy in distinguishing ATB cases among HIV-infected individuals than the QFT-IT assay, while the QFT-IT assay appears to reduce the occurrence of indeterminate results. Furthermore, modification and additional trial designs are required to improve diagnostic effectiveness.

3 Review Epidemiology of sexually transmitted viral hepatitis in human immunodeficiency virus-positive men who have sex with men in Asia. 2015

Lin, Ada W C / Sridhar, Siddharth / Wong, Ka Hing / Lau, Susanna K P / Woo, Patrick C Y. ·Special Preventive Programme, Department of Health, University of Hong Kong, Hong Kong, China. · Department of Microbiology, University of Hong Kong, Hong Kong, China. · Department of Microbiology, University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China. · Department of Microbiology, University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China. Electronic address: pcywoo@hku.hk. ·J Formos Med Assoc · Pubmed #26375778.

ABSTRACT: Both human immunodeficiency virus (HIV) and viral hepatitis constitute major disease burden globally. As with other parts of the world, the HIV epidemic in Asia impacts mainly on men who have sex with men, one of the at-risk populations for sexually transmitted viral hepatitis. With the increasing availability of effective antiretroviral therapy, HIV-related mortality of people living with HIV has markedly reduced. Liver disease has become an important cause of mortality and morbidity in the HIV-infected population. With the improvement of socioeconomic conditions and availability of healthcare in Asian countries in recent years, the epidemiology of sexually transmitted viral hepatitis among HIV-positive men who have sex with men has also evolved. This review updates the epidemiology of different types of sexually transmitted viral hepatitis in this defined population in Asia.

4 Review Early versus Delayed Antiretroviral Therapy for HIV and Tuberculosis Co-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2015

Yan, Shipeng / Chen, Lizhang / Wu, Wenqiong / Fu, Zhongxi / Zhang, Heng / Li, Zhanzhan / Fu, Chenchao / Mou, Jingsong / Xue, Jing / Hu, Yingyun. ·The Affiliated cancer hospital of Xiangya Scholl of Medicine, Central South University, Changsha, 410013 China. · Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, 410078 China. · Centers for Disease Control and Prevention of Hunan Province, Changsha, Hunan Province, 410005 China. · Centers for Disease Control and Prevention of Changsha City, Changsha, Hunan Province, 410013 China. · Xiangya Hospital, Central South University, Changsha, Hunan Province, 41008 China. · Changsha Medical University, Changsha, Hunan Province, 410000 China. ·PLoS One · Pubmed #26000446.

ABSTRACT: OBJECTIVE: To compare important clinical outcomes between early and delayed initiation of antiretroviral therapy (ART) in adults who had a co-infection of human immunodeficiency virus (HIV) and tuberculosis (TB). METHODS: We performed a systematic search for relevant publications on PubMed, EMBASE, and the International Clinical Trials Registry Platform. We included randomized controlled trials (RCTs) that compared early ART initiation (within four weeks after anti-TB treatment starting) and delayed ART initiation (after eight weeks but less than twelve weeks of anti-TB treatment starting) in the course of TB treatment. Pooled estimates with corresponding 95% confidence interval (95%CI) were calculated with random-effects model. Sensitivity analysis was performed to investigate the stability of pooled estimates. RESULTS: A meta-analysis was evaluated from six RCTs with 2272 participants. Compared to delayed ART initiation, early ART initiation significantly reduces all-cause mortality in HIV-positive patients with TB [incidence rate ratio (IRR) 0.75, 95%CI 0.59 to 0.95; I2 = 0.00%; p = 0.67], even though there is an increased risk for IRD [IRR 2.29, 95%CI 1.81 to 2.91; I22 = 0.00%; p = 0.56]. Additionally, early ART initiation was not associated with an increased risk for grade 3-4 drug-related adverse events [IRR 0.99, 95%CI 0.83 to 1.18; I2 = 0.00%; p = 0.56]. CONCLUSIONS: Although limited evidence, our results provide support for early ART initiation in the course of anti-TB treatment. However, more well-designed cohort or intervention studies are required to further confirm our findings.

5 Review Effectiveness of ART and condom use for prevention of sexual HIV transmission in serodiscordant couples: a systematic review and meta-analysis. 2014

Liu, Huixin / Su, Yingying / Zhu, Lin / Xing, Jiannan / Wu, Jing / Wang, Ning. ·National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. ·PLoS One · Pubmed #25369471.

ABSTRACT: BACKGROUND: Consistent and correct condom use and suppressive antiretroviral therapy for the infected partner are two of the primary strategies recommended for prevention of heterosexual HIV transmission in serodiscordant couples today. The applied effectiveness of treatment as a prevention strategy in China is still under investigation, and much less is known about its effects in the presence of other prevention strategies such as consistent condom use. METHODS: We conducted a systematic search in PubMed and three Chinese language databases to identify relevant articles for the estimation of relative effectiveness of a) consistent condom use and b) ART use by index partners for preventing HIV transmission in serodiscordant couples. We also estimated the prevention effectiveness of ART stratified by condom use level and the prevention effectiveness of consistent condom use stratified by ART use level. RESULTS: Pooled results from the eleven eligible studies found a pooled HIV seroconversion incidence of 0.92 cases per 100 person years (PY) among HIV-negative spouses whose index partners were taking ART versus 2.45 cases per 100 PY in untreated couples. The IRR comparing seroconversion in couples where the index-partner was on ART versus not on ART was 0.47 (95%CI: 0.43, 0.52), while stratified by condom use, the IRR was 0.33(0.17,0.64). The IRR comparing incidence in couples reporting "consistent condom use" versus those reporting otherwise was 0.02(95%CI:0.01,0.04), after stratified by ART use level, the IRR was 0.01(95%CI: 0.00, 0.06). CONCLUSIONS: ART use by index partners could reduce HIV transmission in serodiscordant couples, and the effectiveness of this prevention strategy could be further increased with consistent condom use.

6 Review [A report of lung adenocarcinoma with HIV carrier and the literature review]. 2013

Zhao, Jing / Jiang, Da / Liu, Rongfeng / Li, Xin. ·Department of Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China. ·Zhongguo Fei Ai Za Zhi · Pubmed #23425905.

ABSTRACT: -- No abstract --

7 Review Clinical features and outcome of patients with HIV-negative multicentric Castleman's disease treated with combination chemotherapy: a report on 10 patients. 2013

Zhu, Shou-Hui / Yu, Yong-Hua / Zhang, Yong / Sun, Ju-Jie / Han, Da-Li / Li, Jia. ·Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Ji Yan Road, Jinan, China. ·Med Oncol · Pubmed #23400962.

ABSTRACT: To investigate the clinical characteristics and outcome of patients with HIV-negative multicentric Castleman's disease (MCD) treated exclusively with combination chemotherapy, and review literature to improve the diagnosis and management of this disease. A retrospective study was performed on the medical records of 10 patients with HIV-negative MCD treated exclusively with combination chemotherapy at one medical institution from May 2004 to April 2012. And relevant clinical, pathological, radiographic, and laboratory data were examined in order to evaluate treatment responses, with symptom onsets and survival period serving as the endpoints of the assessment. All patients have multifocal lymphadenopathy, and the associated system symptoms are found in 80 % of the cases. All patients were treated with lymphoma-based chemotherapy alone. The duration of follow-up ranged from 5 to 77 months for nine patients. Four patients were treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) alone: One was alive with no evidence of disease, and three were alive with disease. Three patients received cyclophosphamide, vincristine, and prednisone (COP) alone: One remained alive with disease, and two experienced recurrences and passed away. Two had only minimal response to COP and were switched to CHOP, and they were still alive with disease. MCD is a more progressive clinical entity, and long-term follow-up is necessary. CHOP chemotherapy may be an effective treatment option for patients with MCD, whereas when to start chemotherapy, how many cycles of chemotherapy required, and the role of combined radiotherapy remain to be further studied.

8 Review HIV seroconversion and prevalence rates in heterosexual discordant couples in China: a systematic review and meta-analysis. 2012

Wang, Lan / Peng, Zhihang / Li, Liming / Norris, Jessie L / Wang, Lu / Cao, Weihua / Wang, Ning. ·School of Public Health, Peking University, Beijing, PR, China. ·AIDS Care · Pubmed #22452488.

ABSTRACT: This study aims to systematically review published literature on heterosexual transmission among HIV discordant couples in China. We conducted a systematic review and random-effects meta-analysis of 32 published articles in both Chinese and English. The summarized overall HIV seroconversion rate among discordant couples in China is 1.2 per 100 person-years (95% CI 0.9-1.7/100 PY). The overall estimate for HIV prevalence through heterosexual transmission in discordant couples is 11.5% (95% CI 8.2%-15.2%) in China. In a stratified meta-analysis by region, Henan province showed an HIV seroconversion rate of 0.9/100 PY (95% CI 0.6-1.2/100 PY) and an HIV prevalence rate of 3.9% (95% CI 2.5-5.7%). Yunnan province showed an HIV seroconversion rate of 1.7/100 PY (95% CI 1.2-2.3/100 PY) and an HIV prevalence rate of 17.0% (95% CI 13.7-20.6%). Other provinces collectively showed a HIV seroconversion rate of 3.9/100 PY (95% CI 1.0-8.7/100 PY) and an HIV prevalence rate of 21.5% (95% CI 9.6-36.5%). In a stratified meta-analysis by time, the subgroup from 1994 to 2004 had a seroconversion rate of 3.9/100 PY (95% CI 1.0-8.7/100 PY) and the subgroup from 2005 to 2011 had a seroconversion rate of 1.1/100 PY (95% CI 0.8-1.5/100 PY). These data show that China's free national HIV prevention and treatment program has been successful at limiting transmission in discordant couples. Because heterosexual transmission is now the dominant method of HIV transmission in China, it is important to understand seroconversion and prevalence rates in discordant couples to develop more effective prevention and treatment programs.

9 Clinical Trial Anal Human Papillomavirus Genotyping among HIV-Positive Men Who Have Sex with Men in Xi'an, China. 2015

Li, Zhen / Zhang, Haoran / Li, Xiangwei / Yang, Yu / Xin, Henan / Li, Mufei / Feng, Boxuan / Gao, Lei. ·Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Dan San Tiao No. 9, Beijing, 100730, China. · Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, 100191, China. ·PLoS One · Pubmed #25923768.

ABSTRACT: BACKGROUND: Anal human papillomavirus (HPV) infection and its related diseases are relatively common in men who have sex with men (MSM), especially in those HIV positive. In China, molecular epidemiology of anal HPV infection among HIV-positive MSM has been sparsely studied. METHODS: A cross-sectional study was conducted among HIV-positive MSM in Xi'an, China between April and July 2014. Anal swabs were collected for HPV genotyping. RESULTS: A total of 195 HIV-positive MSM were included in this study. HPV genotyping showed that 99.0% (191/193) of participants were positive for at least one of the targeted 37 HPV genotypes. 183 (94.8%) of them were infected with multiple high-risk types and 154 (79.8%) of them with low-risk HPV types. HPV 18 was the most frequently identified high-risk type, followed by HPV 16 and HPV 51. As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe. High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4+ T cell level. CONCLUSION: Almost all HIV-positive MSM were anal HPV infected in our study. It is highly recommended to consider regular active screening and preventive intervention of HPV infection among this high risk population.

10 Article Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency. 2019

Li, Zichong / Wu, Jun / Chavez, Leonard / Hoh, Rebecca / Deeks, Steven G / Pillai, Satish K / Zhou, Qiang. ·Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America. · School of Pharmaceutical Sciences, Xiamen University, Xiamen, China. · Vitalant Research Institute, San Francisco, California, United States of America. · University of California, San Francisco, California, United States of America. ·PLoS Pathog · Pubmed #30645648.

ABSTRACT: The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are essential to activate HIV-1 transcription. Despite efforts to identify effective latency-reversing agents (LRA), avenues for exposing latent HIV-1 remain inadequate, prompting the need to identify novel LRA targets. Here, by conducting a CRISPR interference-based screen to reiteratively enrich loss-of-function genotypes that increase HIV-1 transcription in latently infected CD4+ T cells, we have discovered a key role of the proteasome in maintaining viral latency. Downregulating or inhibiting the proteasome promotes Tat-transactivation in cell line models. Furthermore, the FDA-approved proteasome inhibitors bortezomib and carfilzomib strongly synergize with existing LRAs to reactivate HIV-1 in CD4+ T cells from antiretroviral therapy-suppressed individuals without inducing cell activation or proliferation. Mechanistically, downregulating/inhibiting the proteasome elevates the levels of ELL2 and ELL2-SECs to enable Tat-transactivation, indicating the proteasome-ELL2 axis as a key regulator of HIV-1 latency and promising target for therapeutic intervention.

11 Article Prevalence of and factors associated with major depressive disorder among HIV-positive individuals in Guangdong, China. 2019

Jiang, Hongbo / Chen, Shuyi / Huang, Xingmei / Huang, Ruoyan / Lin, Peng / Cheng, Weibin / Xu, Meizhen / Yang, Fang / Liu, Jun / Li, Yan / Gao, Yanhui / Yang, Yi. ·Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Road, Haizhu District, Guangzhou, China. · The Second People's Hospital of Bao'an District (Group) General Hospital, Shenzhen, China. · Guangzhou Psychiatric Hospital, Guangzhou, China. · Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. · Guangzhou Center for Disease Control and Prevention, Guangzhou, China. · Haizhu District Center for Disease Control and Prevention, Guangzhou, China. · Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Road, Haizhu District, Guangzhou, China. Electronic address: Gao_yanhui@163.com. · Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Road, Haizhu District, Guangzhou, China. Electronic address: yangyigz@163.com. ·J Affect Disord · Pubmed #30599371.

ABSTRACT: BACKGROUND: People living with HIV may suffer from mental disorders. We aimed to explore the prevalence of and factors associated with major depressive disorder (MDD) among HIV-positive individuals in Guangdong, China, about which little is known. METHODS: A cross-sectional study was conducted to recruit HIV-positive individuals from the Centers for Disease Prevention and Control of Guangzhou, Zhongshan, and Yangjiang from September 2007 to September 2008. Data were collected by questionnaires. MDD was diagnosed and assessed by two psychiatrists using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders-Patient Edition (SCID-I/P) based on the DSM-IV criteria. Multiple logistic regression analyses were conducted to explore the factors associated with MDD. RESULTS: The prevalences of lifetime MDD and current MDD among the 339 included participants were 22.71% (95% confidence interval [CI]: 18.25-27.17%) and 12.09% (95%CI: 8.62%-15.57%), respectively. The results of multiple logistic regression showed that patients with AIDS had a higher risk of lifetime MDD (odds ratio [OR] = 2.69, 95%CI: 1.38-5.26) and current MDD (OR = 3.51, 95%CI: 1.59-7.75) than HIV-infected individuals. Participants with more number of negative life events were more likely to have lifetime MDD (OR = 2.33, 95%CI: 1.34-4.06) and current MDD (OR = 3.77, 95%CI: 1.76-8.09) than individuals with fewer negative life events. Individuals with higher score of social support were less likely to have lifetime MDD (OR = 0.45, 95%CI: 0.26-0.80) and current MDD (OR = 0.46, 95%CI: 0.21-0.97) than individuals with less social support. CONCLUSIONS: The prevalence of MDD was high among HIV-positive individuals in China. AIDS diagnosis, decreased social support, and an increased number of negative life events were risk factors for MDD.

12 Article Trends of HIV incidence and prevalence among men who have sex with men in Beijing, China: Nine consecutive cross-sectional surveys, 2008-2016. 2018

Chen, Qiang / Sun, Yanming / Sun, Weidong / Hao, Mingqiang / Li, Guiying / Su, Xueli / Xin, Ruolei / Lu, Hongyan. ·Institute for AIDS/STD Control and Prevention, Beijing Center for Disease Control and Prevention, Beijing Center for Preventive Medical Research, Beijing, China. ·PLoS One · Pubmed #30092072.

ABSTRACT: BACKGROUND: Sexual transmission of HIV among men who have sex with men (MSM) increased markedly in China during the past decade. HIV incidence is a critical indicator in HIV surveillance and we use a HIV-1 BED-capture-enzyme immunoassay (BED-CEIA) to examine the incidence among MSM in Beijing from 2008 to 2016. Risk factors related to recent HIV infection were also assessed. METHODS: Consecutive cross-sectional surveys on MSM were conducted yearly from 2008 through 2016. Demographic and behaviors data were collected. HIV status was determined and HIV positive specimens were tested for recent infection using BED-CEIA. Specimens with ODn values≤0.8 were considered recently infected, HIV incidence rates and prevalence were then calculated. Risk factors associated with recent HIV infection were assessed by univariate and multivariable logistic regression. RESULTS: From 2008 to 2016, the numbers of eligible participants in the nine consecutive years ranged from 472 to 616. All the 261 eligible HIV-positive specimens were subjected to recent HIV infection testing. HIV prevalence ranged from 5.0% (3.3%-6.8%) to 10.2% (7.8%-12.7%), and incidence ranged from 1.57% (0.19%-2.95%) to 6.63% (3.65%-9.61%). MSM who never or sometimes used condoms during anal sex with men in the past 6 months (aOR = 1.515, 95%CI: 1.016-2.257, p = 0.041), or having syphilis infection (aOR = 1.561, 95%CI: 0.946-2.575, p = 0.081) were more likely to be recently infected with HIV. Being a Beijing resident (aOR = 0.409, 95%CI: 0.212-0.790, p = 0.008), or having only one male anal sex partner in the past 6 months (aOR = 0.467, 95%CI: 0.220-0.994, p = 0.048) were associated with a lower risk for recent HIV infection. CONCLUSIONS: The HIV incidence fluctuated among MSM in Beijing. Unprotected anal sex, having multiple sex partners, being a non-registered Beijing resident and having a syphilis infection play important roles in the recent HIV infection. Effective intervention measures for HIV and syphilis control and prevention should be continuously strengthened.

13 Article The relationship of social support, mental health, and health-related quality of life in human immunodeficiency virus-positive men who have sex with men: From the analysis of canonical correlation and structural equation model: A cross-sectional study. 2018

Shao, Bing / Song, Bo / Feng, Shiyan / Lin, Yuanlong / Du, Juan / Shao, Hong / Chi, Zong / Yang, Yanze / Wang, Fuxiang. ·Department of Epidemiology and Health Statistics, Public Health College of Jilin Medical University, Jilin. · Department of Infectious Diseases. · Center of HIV/AIDS Diagnosis and Treatment, Fourth Affiliated Hospital of Harbin Medical University, Harbin. · Basic Chemistry Laboratory, College of Pharmacy of Jilin Medical University. · Jilin Medical University, Jilin. · Department of Infectious Diseases, Third People's Hospital of Shenzhen, Shenzhen, China. ·Medicine (Baltimore) · Pubmed #30045316.

ABSTRACT: The objective of this study was to reveal the relationships of mental health, social support, health-related quality of life (HRQOL) as well as their dimensions in HIV-positive men who have sex with men (MSM).HIV-positive MSM were interviewed by a cross-sectional study design using the world Health Organization quality of life bref scale, social support rating scale, and self-rated anxiety and depression scales. Canonical correlation analysis and structural equation model (SEM) were utilized to analyze to the collected data.Three first pair of canonical variables that was statistically significant (P < .0001) and verified could account for the largest cumulative proportion were computed from canonical correlation analysis. The results showed, among the dimensions, depression and anxiety were negatively correlated with support utilization and physical health, while subjective support and support utilization were positively correlation with social relationship health. Structural equation model results showed that support utilization (0.632, T = 10.44), depression (0.816, T = 20.37), and environmental dimension (0.833, T = 38.47) had the largest standardized factor loading in social support, mental health, and HRQOL. The structural coefficient between social support and mental health was -0.433 (T = -5.88), between mental health and HRQOL was -0.592 (T = -10.33), between social support and HRQOL was 0.290 (T = 4.10), indicated social support not only exerted a direct influence, but also mediated mental health to have an indirect effect on HRQOL for HIV-positive MSM.Environmental dimension is the foremost factor of HRQOL for HIV-positive MSM. Alleviating anxiety symptoms maybe improve physical health, while promoting the support utilization is an effective measure of alleviating depression and improving social relationship health for this special group.

14 Article [Application of Bernoulli Process Model fitting the effect of intervention measures on sexual transmission among HIV sero-discordant couples]. 2018

Tang, H L / Mao, Y R / Wu, Z Y. ·Division of Integration and Evaluation, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. ·Zhonghua Liu Xing Bing Xue Za Zhi · Pubmed #29936742.

ABSTRACT:

15 Article [Transmitted drug resistance among HIV infected men who have sex with men in Tianjin, 2014-2017]. 2018

Zheng, M N / Ning, T L / Zhou, N / Zhao, X / Li, L / Zhu, J J / Cheng, S H. ·Department for AIDS/STD Control and Prevention, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. ·Zhonghua Liu Xing Bing Xue Za Zhi · Pubmed #29860805.

ABSTRACT:

16 Article HBV and HCV test uptake and correlates among men who have sex with men in China: a nationwide cross-sectional online survey. 2018

Fitzpatrick, Thomas / Pan, Stephen W / Tang, Weiming / Guo, Wilson / Tucker, Joseph D. ·School of Medicine, University of Washington, Seattle, Washington, USA. · Department of Public Health, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China. · UNC Project-China, University of North Carolina, Chapel Hill, North Carolina, USA. · Gillings School of Global Public Health-Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina, USA. · Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. ·Sex Transm Infect · Pubmed #29779005.

ABSTRACT: OBJECTIVES: Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause substantial morbidity and mortality in low-income and middle-income countries, including China. WHO guidelines recommend men who have sex with men (MSM) receive HBV and HCV screening. The purpose of this study was to determine the proportion of MSM in China who have HBV and HCV tested and identify correlates of test uptake. METHODS: We conducted an online cross-sectional survey of young MSM in China. Respondents were asked to report previous HBV and HCV testing, sociodemographic information, sexual risk factors for hepatitis infection, other STI testing and primary care physician (PCP) status. Associations were analysed by logistic regression. RESULTS: 503 eligible MSM completed the survey. 41.0% (206/503) of MSM had HCV tested, and 38.2% (60/157) of MSM with no or uncertain HBV vaccination had HBV tested. In multivariate analysis, HCV testing was correlated with HBV testing (adjusted OR (aOR) 22.98, 95% CI 12.11 to 43.60), HIV testing (aOR 3.64, 95% CI 1.92 to 6.91), HIV-positive status (aOR 1.78, 95% CI 1.07 to 2.98) and having a PCP (aOR 2.40, 95% CI 1.44 to 3.98). Among MSM with no or uncertain HBV vaccination, HBV testing was correlated with HCV testing (aOR 80.85, 95% CI 20.80 to 314.33), HIV testing (aOR 5.26, 95% CI 1.81 to 15.28), HIV-positive status (aOR 3.00, 95% CI 1.22 to 7.37) and having a PCP (aOR 2.69, 95% CI 1.00 to 7.26). CONCLUSIONS: Our data suggest many young MSM in China have not received hepatitis testing. HCV testing rates were lower than those recently reported among MSM in Australia and the USA. The strong correlation between HBV and HCV testing suggests bundled testing interventions may be useful for MSM in China. Men with a PCP were more likely to have received hepatitis testing, consistent with literature demonstrating the importance of primary care in expanding access to testing.

17 Article Factors associated with disclosing men who have sex with men (MSM) sexual behaviors and HIV-positive status: A study based on a social network analysis in Nanjing, China. 2018

Chen, Lusi / Lian, Dashuai / Wang, Bei. ·Department of Epidemiology and Health statistics, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, China. ·PLoS One · Pubmed #29672596.

ABSTRACT: OBJECTIVE: We explored the factors associated with disclosure of men who have with sex with men (MSM) behaviors and HIV-positive status among HIV-positive MSM in Nanjing, China. METHODS: Social network analysis and epidemiological methods were combined in this pilot study. Information about participants' (egos') characteristics and behaviors and their social network members (alters) were collected through interview-administered questionnaires. General estimating equation logistic regression analysis was applied in both univariate and multivariate analysis. RESULTS: Eighty-seven HIV-positive MSM participated. Their mean age was 35.9 ±13.81years. They were more likely to disclose their MSM behavior to their friends [adjust Odds Ratio (AOR) = 6.43, 95% confidence interval (CI):3.08-13.42] or to the social network members who were not heterosexual [AOR = 4.40, 95%CI: 2.17-8.91]. Being participants' friends [AOR = 5.16, 95%CI: 2.03-13.10] or family members [AOR = 6.22, 95%CI: 2.52-15.33] was significantly associated with HIV-positive status disclosure. CONCLUSION: HIV-positive MSM tended to disclose their MSM behaviors and HIV positive status to close friends, family members or other individuals who were HIV-positive, engaging in MSM behavior, or both. Consequently, it will be an effective way to implement HIV prevention and intervention strategies in both MSM population and their trusted social networks.

18 Article Peer counselling versus standard-of-care on reducing high-risk behaviours among newly diagnosed HIV-positive men who have sex with men in Beijing, China: a randomized intervention study. 2018

Liu, Yu / Vermund, Sten H / Ruan, Yuhua / Liu, Hongjie / Rivet Amico, K / Simoni, Jane M / Shepherd, Bryan E / Shao, Yiming / Qian, Han-Zhu. ·Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. · School of Public Health, Yale University, New Haven, CT, USA. · State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, China. · Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, MD, USA. · Department of Health Behavior and Health Education, University of Michigan, Ann Arbor, MI, USA. · Department of Psychology, University of Washington Seattle, Seattle, WA, USA. · Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA. ·J Int AIDS Soc · Pubmed #29430845.

ABSTRACT: INTRODUCTION: Reducing high-risk behaviours (i.e. multiple partnership, condomless anal/vaginal sex, alcohol use before sex, illicit drug use) after HIV diagnosis is critical for curtailing HIV transmission. We designed an intervention to explore peer- counselling in reducing high-risk behaviours among newly diagnosed HIV-positive Chinese men who have sex with men (MSM). METHODS: We randomized 367 newly diagnosed HIV-positive men to either standard-of-care (SOC; n = 183) or peer-counselling intervention (n = 184), and followed them for 12 months (visit at 0-, 3-, 6-, 9- and 12-month). SOC participants received counselling on high-risk behaviour reduction by clinic staff. Intervention participants received both SOC and peer counselling. A generalized estimating equation was used to compare pre-post diagnosis high-risk behaviour change; logistic regression was used to assess the likelihood of practicing high-risk behaviours between intervention and SOC participants. Both intent-to-treat and per-protocol (full-dosage) approaches were used for the analyses. RESULTS: For pre- and post-diagnosis comparisons, multiple partnership fell from 50% to 16% (p < 0.001), alcohol use before sex from 23% to 9% (p = 0.001), illicit drug use from 33% to 6% (p < 0.001), condomless anal sex from 47% to 4% (insertive from 23% to 2%; receptive from 36% to 3%; p < 0.001). In the intent-to-treat analysis accounting for repeated measures, peer counselling was more likely to reduce insertive anal sex (AOR = 0.65; 95% CI: 0.45 to 0.94), condomless anal sex (AOR = 0.27; 95% CI: 0.10 to 0.64) and illicit drug use (AOR = 0.32; 95% CI: 0.16 to 0.64). In the per-protocol analysis, peer counselling was associated with a lower likelihood of using illicit drug (OR = 0.23; 95% CI: 0.07 to 0.81) and having condomless vaginal sex with women (OR = 0.12; 95% CI: 0.07 to 0.98). CONCLUSIONS: We observed a 14 to 43% decrease in the prevalence of selected high-risk behaviours after HIV diagnosis. Peer counselling had a greater impact in reducing condomless anal sex with men, illicit drug use and condomless vaginal sex with women over time. Future studies with exclusive peer-counselling arm are necessary to test its efficacy and effectiveness among Chinese MSM. Clinical Trial Number: NCT01904877.

19 Article [Characteristic and dynamic of HIV-1 subtype distribution in men who have sex with men in Guangzhou, 2008-2015]. 2018

Han, Z G / Zhang, Y L / Wu, H / Cheng, W B / Liang, C Y / Zhong, F / Gao, K / Xu, H F. ·Department of Operational Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. · School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. · Department of AIDS Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. ·Zhonghua Liu Xing Bing Xue Za Zhi · Pubmed #29374899.

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20 Article Poppers use and Sexual Partner Concurrency Increase the HIV Incidence of MSM: a 24-month Prospective Cohort Survey in Shenyang, China. 2018

Chu, Zhen-Xing / Xu, Jun-Jie / Zhang, Yong-Hui / Zhang, Jing / Hu, Qing-Hai / Yun, Ke / Wang, Hong-Yi / Jiang, Yong-Jun / Geng, Wen-Qing / Shang, Hong. ·Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, No 155, Nanjingbei Street, Heping District, Shenyang, Liaoning Province, 110001, China. · Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. · Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, No 155, Nanjingbei Street, Heping District, Shenyang, Liaoning Province, 110001, China. hongshang100@hotmail.com. · Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. hongshang100@hotmail.com. ·Sci Rep · Pubmed #29311552.

ABSTRACT: The use of poppers is highly prevalent in MSM, but little is known about the association between their use and HIV incidence in China. A prospective cohort study was conducted from 2011 to 2013 in MSM in Shenyang. 475(79.6%) of eligible HIV-negative MSM participated in this prospective survey and near one fourth MSM (23.4%) ever used poppers. About one-third of the participants had condomless anal intercourse, half had multiple sexual partners and 10.5% were syphilis positive. The HIV incidence densities were15.5 (95% CI:9.4-23.4)/100 PY[person-years]) and 4.6 (95% CI:2.9-7.0)/100 PY in poppers-users and non-poppers-users, respectively. Predictors of HIV seroconversion included poppers-using-behavior, having had more than two male partners, practicing group sex, unprotected anal intercourse(UAI) with male partners, and baseline syphilis positivity (all P < 0.05). In conclusion, the use of poppers, high-risk-sexual behaviors and syphilis infection significantly increase the HIV incidence among Shenyang MSM. It is essential for policy makers to add poppers to the official controlled illicit drug list to reduce HIV transmission among the MSM community. A comprehensive strategy should also be implemented to control both their high-risk-sexual behaviors and risk of syphilis infection, since these may represent novel ways to prevent new HIV infections in these MSM.

21 Article How newly diagnosed HIV-positive men who have sex with men look at HIV/AIDS - validation of the Chinese version of the revised illness perception questionnaire. 2018

Wu, Xiaobing / Lau, Joseph T F / Mak, Winnie W S / Gu, Jing / Mo, Phoenix K H / Wang, Xiaodong. ·Department of STD control, Shenzhen Center for Chronic Disease Control, No.2021, Buxin Road, Luohu District, Shenzhen City, Guangdong Province, People's Republic of China. · Centre for Health Behaviors Research, School of Public Health and Primary Care, The Chinese University of Hong Kong, 5/F, School of Public Health, Prince of Wales Hospital, Shatin, NT, Hong Kong, Special Administrative Region of China. · Centre for Health Behaviors Research, School of Public Health and Primary Care, The Chinese University of Hong Kong, 5/F, School of Public Health, Prince of Wales Hospital, Shatin, NT, Hong Kong, Special Administrative Region of China. jlau@cuhk.edu.hk. · Department of Psychology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, Special Administrative Region of China. · Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou City, Guangdong province, People's Republic of China. · Chengdu Tongle Health Counselling Service Center, Chengdu City, Sichuan Province, People's Republic of China. ·BMC Infect Dis · Pubmed #29291733.

ABSTRACT: BACKGROUND: Newly diagnosed HIV-positive men who have sex with men (MSM) are an important subgroup in HIV intervention. How newly diagnosed HIV-positive MSM look at HIV/AIDS is consequential and is potentially associated with their risk behaviors and mental health problems. Illness representation has been used to define patients' beliefs and expectations on an illness, and the revised Illness Perception Questionnaire (IPQ-R) has been developed to measure illness representations. This study aims to examine the psychometric properties of the IPQ-R among newly diagnosed HIV-positive MSM and to investigate their views towards HIV/AIDS. METHOD: A total of 225 newly diagnosed HIV-positive MSM completed the Chinese version of IPQ-R. Both confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were applied to examine the factor structure of IPQ-R. RESULTS: CFA showed a poor goodness of fit to the original factor structure of IPQ-R. EFA of the IPQ-R revealed 7 factors, including Emotional Response, Treatment Control, Timeline-acute/chronic, Illness Coherence, Consequence, Personal Control and Helplessness. Cronbach's alpha showed acceptable internal consistency for the derived factors, except the Personal Control (0.61) and Helplessness (0.55). Person correlation coefficients demonstrated that the derived factors of IPQ-R had significant associations with the outcome variables (depression and posttraumatic growth). The scores of the Emotional Response, Consequence, Treatment Control, Personal Control, Timeline-acute/chronic and Illness Coherence were above the midpoint, and the score of the Helplessness was below the midpoint. CONCLUSION: Both similarities and differences were found when the IPQ-R is applied to newly diagnosed HIV-positive MSM. The IPQ-R can be used with some refinements in future studies. Newly diagnosed HIV-positive MSM have a relatively high level of negative perceptions towards HIV/AIDS in both cognitive and emotional aspects.

22 Article Development and optimization of a sensitive pseudovirus-based assay for HIV-1 neutralizing antibodies detection using A3R5 cells. 2018

Chen, Qingqing / Nie, Jianhui / Huang, Weijin / Jiao, Yanmei / Li, Lan / Zhang, Tong / Zhao, Juan / Wu, Hao / Wang, Youchun. ·a Division of HIV/AIDS and Sex-transmitted Virus Vaccines , National Institutes for Food and Drug Control (NIFDC) , Beijing , China. · b Beijing You'an Hospital, Capital Medical University , Beijing , China. ·Hum Vaccin Immunother · Pubmed #28933644.

ABSTRACT: Sensitive assays for HIV-1 neutralizing antibody detection are urgently needed for vaccine immunogen optimization and identification of protective immune response levels. In this study, we developed an easy-to-use HIV-1 pseudovirus neutralization assay based on a human CD4

23 Article HIV Incidence and Care Linkage among MSM First-Time-Testers in Shenyang, China 2012-2014. 2018

Zhang, Jing / Xu, Jun-Jie / Song, Wei / Pan, Shi / Chu, Zhen-Xing / Hu, Qing-Hai / Yu, Huan / Mao, Xiang / Jiang, Yong-Jun / Geng, Wen-Qing / Shang, Hong / Wang, Ning. ·Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, No 155, Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China. · Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. · Shenyang Center for Disease Control and Prevention, No. 37, Qishanzhong Street, Heping District, Shenyang, Liaoning, China. · Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, No 155, Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China. hongshang100@hotmail.com. · Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, No 155, Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China. wangnbj@163.com. · National Center for AIDS/STI Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Beijing, China. wangnbj@163.com. ·AIDS Behav · Pubmed #28660379.

ABSTRACT: HIV testing is the first step to the fulfillment of Treat as Prevention (TasP) and reaching the 90-90-90 goal in HIV control. However, there are still a large number of Men who have Sex with Men (MSM) have never been tested for HIV before, and little is known about the HIV incidence and care linkage among this population. A Mixed method was used to recruit MSM who had never tested for HIV before from January 2012 to December 2014 in Shenyang, China. Potential MSM participants were invited to attend the enrollment for HIV and syphilis testing at a general hospital-based voluntary counseling and test (VCT). HIV confirmed positive subjects were further tested by BED HIV-1 capture enzyme immunoassay (BED-CEIA) to determine the HIV incidence. Syphilis was screened by the rapid plasma reagent test (RPR) and confirmed by Treponema pallidum particle assay (TPPA). All the HIV positive subjects were referred to the local Center for Disease Control and Prevention (CDC) and clinics for HIV primary care and follow-ups. In total 646 HIV first-time-testers of MSM (FMSM) attended this study, 73.4% (474/646) were aged under 31-year-old and 57.3% (370/646) and used the Internet as their major cruising avenue for seeking male sexual partners. The average prevalence of HIV and current syphilis infection was 10.8% (70/646) and 11.0% (71/646), respectively. The HIV incidence was 10.3 (95% confidence interval [CI] 6.1-14.5)/100PY. Multivariate logistic analysis showed that factors such as use of the Internet as the major cruising avenue (adjusted OR [AOR] 2.7, 95% CI 0.9-7.6) and having a current syphilis infection (AOR 4.2, 95% CI 1.8-12.2) were independent correlates of a recent HIV infection. Of the 95 HIV screening test positive FMSM, 73.7% (70/95) returned and be confirmed positive, 92.9% (65/70) of confirmed patients were linked to care. Among those retained and underwent CD4+ T cell test, 76.3% (42/55) started HIV antiretroviral therapy. Among the unconfirmed, 84.0% (21/25) were non-local migrants. The HIV incidence of FMSM in Shenyang was high. Future HIV testing program needs to keep on expanding among the MSM who have never been tested for HIV yet. The Internet-based campaigns and syphilis testing and treatment could represent an opportunity to get access to this hard-to-reach population and link them to HIV care. Future linkage to HIV care of this population should underscore the usage of HIV rapid diagnostic tests to prevent lost at early steps of linkage.

24 Article [Effect of laboratory referencing on data analysis of community viral load in HIV positive MSM from 15 cities, China]. 2017

Dou, Z / Jiang, Z / Pan, P L / Song, W L / Xu, J / Wu, Z Y. ·Division of Prevention and Intervention National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. · Reference Laboratory , National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. · National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. ·Zhonghua Liu Xing Bing Xue Za Zhi · Pubmed #29294587.

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25 Article [Incidence rates of HIV-1 epidemics among 4 high risk groups in Sichuan province during 2011-2015]. 2017

Yang, H / Su, L / Ye, L / Xiao, L / Hu, Y / Shen, M G / Wei, D B / Yuan, D / Zhou, G S / Liu, H L / Yu, J / Liang, S. ·Sichuan Center for Disease Control and Prevention, Chengdu 610041, China. · Liangshan Yi Autonomous Prefecture Center for Disease Control and Prevention, Xichang 615000, China. ·Zhonghua Liu Xing Bing Xue Za Zhi · Pubmed #29294581.

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