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HIV Seropositivity: HELP
Articles from Illinois
Based on 102 articles published since 2008

These are the 102 published articles about HIV Seropositivity that originated from Illinois during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5
1 Review Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies. 2016

Jindal, Sangita K / Rawlins, Richard G / Muller, Charles H / Drobnis, Erma Z. ·Department Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Montefiore's Institute for Reproductive Medicine and Health, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Electronic address: sangita.k.jindal@gmail.com. · Department Obstetrics and Gynecology, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612. · Male Fertility Lab, Department Urology, University of Washington, 4245 Roosevelt Way NE, Seattle, WA 98105. · Reproductive Medicine and Fertility, Department Obstetrics, Gynecology and Women's Health, University of Missouri, 500 N. Keene St, Suite 203, Columbia, MO 65201. ·Reprod Biomed Online · Pubmed #27235103.

ABSTRACT: According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy. In many cases, only one partner is infected. Legal and ethical questions about treatment of infectious patients aside, the question most asked by clinical embryologists and andrologists is: "What are the laboratory protocols for working with gametes and embryos from patients with infectious disease?" The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.

2 Review Coronary Artery Disease in the Human Immunodeficiency Virus Seropositive Population. 2016

Barakat, Michael G / Arora, Rohit R. ·1Chicago Medical School, North Chicago, IL; and 2Department of Medicine, Chicago Medical School, North Chicago, IL. ·Am J Ther · Pubmed #23797758.

ABSTRACT: The development of efficient combined antiretroviral therapies has lengthened the mean life span of the population affected with human immunodeficiency virus (HIV) transforming this terminal infection to a chronic yet manageable disease. Nonetheless, patients with HIV--treatment naive or not--exhibit larger risks for coronary artery disease than the noninfected population. Moreover, coronary atherosclerosis/arteriosclerosis may be the most prevalent condition in the HIV-infected population that is being accentuated by the effects of viral agents and the antiretroviral drugs, especially protease inhibitors. Nonetheless, generalized metabolic dysfunctions and premature senescence are often attributed to the viremia caused by the HIV infection directly and primarily. Therefore, a multifactorial approach is to be considered when attempting to explain the strong correlation between HIV and coronary artery disease, including co-opportunistic viremias and vitamin D insufficiency/deficiency.

3 Review Systematic review of the performance of HIV viral load technologies on plasma samples. 2014

Sollis, Kimberly A / Smit, Pieter W / Fiscus, Susan / Ford, Nathan / Vitoria, Marco / Essajee, Shaffiq / Barnett, David / Cheng, Ben / Crowe, Suzanne M / Denny, Thomas / Landay, Alan / Stevens, Wendy / Habiyambere, Vincent / Perrins, Jos / Peeling, Rosanna W. ·Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom. · Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America. · Department of HIV/AIDS, World Health Organization, Geneva, Switzerland. · HIV, Medicine and Science, Clinton Health Access Initiative, New York, New York, United States of America. · Department of Haematology, United Kingdom National External Quality Assessment Service (UK NEQAS) for Leucocyte Immunophenotyping, Sheffield, United Kingdom. · Department of Technology and Innovation, Pangaea Global AIDS Foundation, San Fransisco, California, United States of America. · Centre for Biomedical Research, Burnet Institute, Melbourne, Australia. · Department of Medicine, Duke Human Vaccine Institute and Center for HIV/AIDS Vaccine Immunology, Durham, North Carolina, United States of America. · Department of Immunology- Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America. · Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa. ·PLoS One · Pubmed #24558359.

ABSTRACT: BACKGROUND: Viral load (VL) monitoring is the standard of care in developing country settings for detecting HIV treatment failure. Since 2010 the World Health Organization has recommended a phase-in approach to VL monitoring in resource-limited settings. We conducted a systematic review of the accuracy and precision of HIV VL technologies for treatment monitoring. METHODS AND FINDINGS: A search of Medline and Embase was conducted for studies evaluating the accuracy or reproducibility of commercially available HIV VL assays. 37 studies were included for review including evaluations of the Amplicor Monitor HIV-1 v1.5 (n = 25), Cobas TaqMan v2.0 (n = 11), Abbott RealTime HIV-1 (n = 23), Versant HIV-1 RNA bDNA 3.0 (n = 15), Versant HIV-1 RNA kPCR 1.0 (n = 2), ExaVir Load v3 (n = 2), and NucliSens EasyQ v2.0 (n = 1). All currently available HIV VL assays are of sufficient sensitivity to detect plasma virus levels at a lower detection limit of 1,000 copies/mL. Bias data comparing the Abbott RealTime HIV-1, TaqMan v2.0 to the Amplicor Monitor v1.5 showed a tendency of the Abbott RealTime HIV-1 to under-estimate results while the TaqMan v2.0 overestimated VL counts. Compared to the Amplicor Monitor v1.5, 2-26% and 9-70% of results from the Versant bDNA 3.0 and Abbott RealTime HIV-1 differed by greater than 0.5log10. The average intra and inter-assay variation of the Abbott RealTime HIV-1 were 2.95% (range 2.0-5.1%) and 5.44% (range 1.17-30.00%) across the range of VL counts (2log10-7log10). CONCLUSIONS: This review found that all currently available HIV VL assays are of sufficient sensitivity to detect plasma VL of 1,000 copies/mL as a threshold to initiate investigations of treatment adherence or possible treatment failure. Sources of variability between VL assays include differences in technology platform, plasma input volume, and ability to detect HIV-1 subtypes. Monitoring of individual patients should be performed on the same technology platform to ensure appropriate interpretation of changes in VL. Prospero registration # CD42013003603.

4 Review Thalidomide-associated thrombosis in the treatment of HIV-associated severe aphthous disease: a case report and review of the literature. 2012

Hodowanec, Aimee C / Han, Alice / Barker, David E / Rubinstein, Paul G / Max, Blake. ·1Division of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. ·J Int Assoc Physicians AIDS Care (Chic) · Pubmed #22930795.

ABSTRACT: Venous thrombosis is a well-described complication of thalidomide therapy in patients with multiple myeloma (MM). However, an association between thalidomide use and thrombosis in HIV-positive patients has not been previously described. We present the case of a 48-year-old HIV-positive man who developed a deep venous thrombosis while on thalidomide for the treatment of severe aphthous ulcers. We review the management of severe aphthous disease and the potential adverse effects of thalidomide therapy. We examine the association between thalidomide and thrombosis in patients with MM and discuss how the same relationship may or may not exist in HIV-positive patients. Although the strength of the association between thalidomide use and thrombosis in HIV-positive patients being treated for aphthous disease remains unclear, HIV providers should be aware of the potential risk of thrombosis in all patients receiving thalidomide.

5 Review Care of the human immunodeficiency virus-infected menopausal woman. 2012

Cejtin, Helen Elizabeth. ·Department of Obstetrics and Gynecology, John H. Stroger Hospital of Cook County, Chicago, IL, USA. hcejtin@gmail.com ·Am J Obstet Gynecol · Pubmed #22284959.

ABSTRACT: More women than ever before are both human immunodeficiency virus infected and menopausal, because of increased survival and more frequent diagnosis in older women. Such a woman has the combined burden of her infection, its treatment, comorbid conditions, and aging. Thus, she is at risk for a variety of problems, such as disorders of bone mineral density and deficiencies in cognitive functioning. In addition to this, she experiences menopause in a unique fashion, with more symptoms and perhaps at an earlier age. The clinician caring for her must take a proactive approach to this multitude of factors that may affect her health and well-being.

6 Review Understanding HIV disclosure: a review and application of the Disclosure Processes Model. 2011

Chaudoir, Stephenie R / Fisher, Jeffrey D / Simoni, Jane M. ·Department of Psychology, Bradley University, 1501 W Bradley Ave, Peoria, IL 61625, USA. schaudoir@bradley.edu ·Soc Sci Med · Pubmed #21514708.

ABSTRACT: HIV disclosure is a critical component of HIV/AIDS prevention and treatment efforts, yet the field lacks a comprehensive theoretical framework with which to study how HIV-positive individuals make decisions about disclosing their serostatus and how these decisions affect them. Recent theorizing in the context of the Disclosure Processes Model has suggested that the disclosure process consists of antecedent goals, the disclosure event itself, mediating processes and outcomes, and a feedback loop. In this paper, we apply this new theoretical framework to HIV disclosure in order to review the current state of the literature, identify gaps in existing research, and highlight the implications of the framework for future work in this area.

7 Clinical Trial Feasibility of interim positron emission tomography (PET)-adapted therapy in HIV-positive patients with advanced Hodgkin lymphoma (HL): a sub-analysis of SWOG S0816 Phase 2 trial. 2017

Danilov, Alexey V / Li, Hongli / Press, Oliver W / Shapira, Ilan / Swinnen, Lode J / Noy, Ariela / Reid, Erin / Smith, Sonali M / Friedberg, Jonathan W. ·a Oregon Health & Science University , Portland , OR , USA. · b SWOG Statistical Center , Seattle , WA , USA. · c Fred Hutchinson Cancer Research Center , Seattle , WA , USA. · d Mount Sinai Beth Israel Medical Center , New York , NY , USA. · e Johns Hopkins Cancer Center , Baltimore , MD , USA. · f Memorial Sloan Kettering Cancer Center and Weill-Cornell Medical College , New York , NY , USA. · g University of California at San Diego Moores Cancer Center , La Jolla , CA , USA. · h University of Chicago , Chicago , IL , USA. · i University of Rochester , Rochester , NY , USA. ·Leuk Lymphoma · Pubmed #27386786.

ABSTRACT: -- No abstract --

8 Clinical Trial HIV Transmission Risk Behavior in a Cohort of HIV-Infected Treatment-Naïve Men and Women in the United States. 2016

Landovitz, Raphael J / Tran, Thuy Tien T / Cohn, Susan E / Ofotokun, Ighovwhera / Godfrey, Catherine / Kuritzkes, Daniel R / Lennox, Jeffrey L / Currier, Judith S / Ribaudo, Heather J. ·Division of Infectious Diseases, UCLA Center for Clinical AIDS Research and Education, University of California, Los Angeles, 11075 Santa Monica Blvd, Suite 100, Los Angeles, CA, 90025, USA. rlandovitz@mednet.ucla.edu. · Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA. · Division of Infectious Diseases, Northwestern University School of Medicine, Chicago, IL, USA. · Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA. · Therapeutics Research Branch, Division of AIDS, National Institutes of Health, Bethesda, MD, USA. · Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. · Division of Infectious Diseases, UCLA Center for Clinical AIDS Research and Education, University of California, Los Angeles, 11075 Santa Monica Blvd, Suite 100, Los Angeles, CA, 90025, USA. ·AIDS Behav · Pubmed #26979419.

ABSTRACT: Antiretroviral therapy (ART) can minimize HIV transmission. Prevention benefits may be compromised by barriers to virologic suppression, and by increased condomless sex among those initiating ART. We evaluated condomless sex in a cohort of HIVinfected US individuals poised to initiate ART in a clinical trial. We assessed partner and sex act type, condom use, and perception of infectiousness. Six percent of participants reported as not infectious; men who have sex with men were more likely to perceive high infectivity. Prevalence of condomless sex was 44 %; 74 % of those also reported homosexual acquisition of HIV. Predictors of increased risk of condomless sex included greater numbers of lifetime partners, recent stimulant drug use and an HIV-positive or unknown serostatus partner. In the context of serodifferent partners, lower perception of infectiousness was also associated with a higher risk of condomless sex. Results highlight opportunities for prevention education for HIV infected individuals at ART initiation.

9 Clinical Trial Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. 2015

Zariffard, M Reza / Anastos, Kathryn / French, Audrey L / Munyazesa, Elisaphane / Cohen, Mardge / Landay, Alan L / Spear, Gregory T. ·Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America. · Departments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America. · Ruth M. Rothstein CORE Center, Stroger Hospital of Cook County, Chicago, Illinois, United States of America. · Rwanda Biomedical Center, National Reference Laboratory Division, Laboratory Quality Assurance Direction, Kigali, Rwanda. ·PLoS One · Pubmed #25611319.

ABSTRACT: OBJECTIVE: Interleukin-8 (IL-8, CXCL8) plays important roles in immune responses at mucosal sites including in the lower genital tract. Since several types of bacteria produce proteases that cleave IL-8 and many types of bacteria can be present in lower genital tract microbiota, we assessed genital fluids for IL-8 cleavage/alteration. STUDY DESIGN: Genital fluids collected by lavage from 200 women (23 HIV-seronegative and 177 HIV-seropositive) were tested for IL-8 cleavage/alteration by ELISA. RESULTS: IL-8 cleaving/altering activity was observed in fluids from both HIV-positive (28%) and HIV-negative women (35%). There was no clear relationship between the activity and the types of bacteria present in the lower genital tract as determined by high-throughput sequencing of the 16S rRNA gene. Protease inhibitors specific for matrix metalloproteinases (MMPs) reduced the activity and a multiplex assay that detects both inactive and active MMPs showed the presence of multiple MMPs, including MMP-1, -3, -7, -8, -9, -10 and -12 in genital secretions from many of the women. The IL-8-cleaving/altering activity significantly correlated with active MMP-9 as well as with cleavage of a substrate that is acted on by several active MMPs. CONCLUSIONS: These studies show that multiple MMPs are present in the genital tract of women and strongly suggest that MMP-9 in genital secretions can cleave IL-8 at this mucosal site. These studies suggest that MMP-mediated cleavage of IL-8 can modulate inflammatory responses in the lower genital tract.

10 Clinical Trial Computational modeling reveals distinct effects of HIV and history of drug use on decision-making processes in women. 2013

Vassileva, Jasmin / Ahn, Woo-Young / Weber, Kathleen M / Busemeyer, Jerome R / Stout, Julie C / Gonzalez, Raul / Cohen, Mardge H. ·Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, United States of America. jvassileva@psych.uic.edu ·PLoS One · Pubmed #23950880.

ABSTRACT: OBJECTIVE: Drug users and HIV-seropositive individuals often show deficits in decision-making; however the nature of these deficits is not well understood. Recent studies have employed computational modeling approaches to disentangle the psychological processes involved in decision-making. Although such approaches have been used successfully with a number of clinical groups including drug users, no study to date has used computational modeling to examine the effects of HIV on decision-making. In this study, we use this approach to investigate the effects of HIV and drug use on decision-making processes in women, who remain a relatively understudied population. METHOD: Fifty-seven women enrolled in the Women's Interagency HIV Study (WIHS) were classified into one of four groups based on their HIV status and history of crack cocaine and/or heroin drug use (DU): HIV+/DU+ (n = 14); HIV+/DU- (n = 17); HIV-/DU+ (n = 14); and HIV-/DU- (n = 12). We measured decision-making with the Iowa Gambling Task (IGT) and examined behavioral performance and model parameters derived from the best-fitting computational model of the IGT. RESULTS: Although groups showed similar behavioral performance, HIV and DU exhibited differential relationship to model parameters. Specifically, DU was associated with compromised learning/memory and reduced loss aversion, whereas HIV was associated with reduced loss aversion, but was not related to other model parameters. CONCLUSIONS: Results reveal that HIV and DU have differential associations with distinct decision-making processes in women. This study contributes to a growing line of literature which shows that different psychological processes may underlie similar behavioral performance in various clinical groups and may be associated with distinct functional outcomes.

11 Clinical Trial Time to complete wound healing in HIV-positive and HIV-negative men following medical male circumcision in Kisumu, Kenya: a prospective cohort study. 2013

Rogers, John H / Odoyo-June, Elijah / Jaoko, Walter / Bailey, Robert C. ·University of Illinois at Chicago, Chicago, Illinois, United States of America. jhrogers@uic.edu ·PLoS One · Pubmed #23613918.

ABSTRACT: BACKGROUND: While voluntary medical male circumcision (VMMC) has been shown to be protective against HIV-acquisition, the procedure may place men and their partners at risk of HIV infection in the period following circumcision if sex is resumed before the wound is healed. This prospective cohort study evaluates post-circumcision wound healing to determine whether the 42-day post-circumcision abstinence period, recommended by the World Health Organization and adopted by VMMC programs, is optimal. METHODS AND FINDINGS: Men were circumcised by forceps-guided method and their post-circumcision wounds examined weekly for seven weeks and at 12 weeks. Time to complete healing was recorded in completed weeks since circumcision, and its associations with baseline covariates were assessed by Kaplan-Meier methods and Cox Proportional Hazard Models. A total of 215 HIV-negative and 108 HIV-positive men aged 18-35 years (median 26, IQR 23-30) were enrolled. 97.1% of scheduled follow-up visits were completed. At week 4, 59.3% of HIV-positive men and 70.4% of age-matched HIV-negative men were healed. At week 6, these percentages rose to 93.4% in HIV-positive men and 92.6% in age-matched HIV-negative men. There was no difference in the hazard of healing between 108 HIV-positive and 108 age-matched HIV-negative men (HR 0.91 95% CI 0.70-1.20). Early post-operative infection was associated with delayed healing in both HIV-positive and HIV-negative men (HR 0.48 95% CI 0.23-1.00). CONCLUSIONS: Our results indicate that the WHO recommendation for 42-days post-circumcision sexual abstinence should be maintained for both HIV-positive and HIV-negative men. It is important to stress condom use upon resumption of sex in all men undergoing circumcision.

12 Article Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study. 2019

Jones, Jacob D / Kuhn, Taylor / Levine, Andrew / Sacktor, Ned / Munro, Cynthia A / Teplin, Linda A / D'Souza, Gypsyamber / Martin, Eileen M / Becker, James T / Miller, Eric N / Hinkin, Charles H. ·Department of Psychology. · University of California. · Johns Hopkins University. · Northwestern University. · Rush University Medical Center. · University of Pittsburgh. ·Neuropsychology · Pubmed #30816783.

ABSTRACT: OBJECTIVES: Despite treatment-related improvements in morbidity and mortality, HIV-1-infected (HIV+) individuals continue to face a wide range of HIV-associated medical and HIV-associated neurocognitive disorders. Little is known about the impact of cognitive impairment on patients' health-related quality of life (HRQoL). To address this, the current study examined the longitudinal relationship between cognitive functioning and HRQoL among HIV+ individuals. METHOD: The sample consisted of 1,306 HIV+ men enrolled in the Multicenter AIDS Cohort Study. Participants received biannual assessments of cognitive functioning (including tests of processing speed, executive functioning, attention/working memory, motor functioning, learning, and memory) and completed questionnaires assessing HRQoL and depression. Multilevel models were used to examine the longitudinal and cross-lagged relationship between HRQoL and cognition, independent of depression and HIV disease severity. RESULTS: There was a significant relationship between HRQoL and cognitive functioning both between and within subjects. Specifically, individuals who reported better HRQoL reported better cognitive functioning, and longitudinal change in cognition was positively related to change in HRQoL. There was a significant unidirectional-lagged relationship; cognition predicted HRQoL at subsequent visits, but HRQoL did not predict cognitive functioning at subsequent visits. Furthermore, analyses of severity of neurocognitive impairment revealed that transition to a more severe stage of cognitive impairment was associated with a decline in HRQoL. CONCLUSIONS: Overall, the current study suggests that changes in HRQoL are partially driven by changes in cognitive functioning. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

13 Article Randomized controlled trial of a positive affect intervention for methamphetamine users. 2018

Carrico, Adam W / Gόmez, Walter / Jain, Jennifer / Shoptaw, Steven / Discepola, Michael V / Olem, David / Lagana-Jackson, Justin / Andrews, Rick / Neilands, Torsten B / Dilworth, Samantha E / Evans, Jennifer L / Woods, William J / Moskowitz, Judith T. ·Department of Public Health Sciences, University of Miami School of Medicine, 1120 NW 14th St., Office 1005, Miami, FL 33136 USA. Electronic address: a.carrico@miami.edu. · Berkeley School of Social Welfare, University of California, 120 Haviland Hall, #7400, Berkeley, CA 94720 USA. · Department of Medicine, Division of Global Public Health, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 902093 USA. · Departments of Family Medicine and Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, 10080 Wilshire Blvd., Los Angeles, CA 900024 USA. · San Francisco AIDS Foundation, 1035 Market Street, Suite 400, San Francisco, CA 94103 USA. · University of California, San Francisco School of Medicine, Box 0886, 550 16th Street, 3469, San Francisco, CA 94158 USA. · Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 633 N. Saint Clair St., 19th Floor, Chicago, IL 60611 USA. ·Drug Alcohol Depend · Pubmed #30195243.

ABSTRACT: BACKGROUND: Contingency management (CM) is an evidence-based intervention providing rewards in exchange for biomarkers that confirm abstinence from stimulants such as methamphetamine. We tested the efficacy of a positive affect intervention designed to boost the effectiveness of CM with HIV-positive, methamphetamine-using sexual minority men. METHODS: This attention-matched, randomized controlled trial of a positive affect intervention delivered during CM was registered on www.clinicaltrials.gov (NCT01926184). In total, 110 HIV-positive sexual minority men with biologically confirmed, recent methamphetamine use were enrolled. Five individual sessions of a positive affect intervention (n = 55) or an attention-control condition (n = 55) were delivered during three months of CM. Secondary outcomes examined over the 3-month intervention period included: 1) psychological processes relevant to affect regulation (i.e., positive affect, negative affect, and mindfulness); 2) methamphetamine craving; 3) self-reported stimulant use (past 3 months); and 4) cumulative number of urine samples that were non-reactive for stimulants (i.e., methamphetamine and cocaine) during CM. RESULTS: Those randomized to the positive affect intervention reported significant increases in positive affect during individual sessions and increases in mindfulness over the 3-month intervention period. Intervention-related improvements in these psychological processes relevant to affect regulation were paralleled by concurrent decreases in methamphetamine craving and self-reported stimulant use over the 3-month intervention period. CONCLUSIONS: Delivering a positive affect intervention may improve affect regulation as well as reduce methamphetamine craving and stimulant use during CM with HIV-positive, methamphetamine-using sexual minority men.

14 Article Patterns of repeated anal cytology results among HIV-positive and HIV-negative men who have sex with men. 2018

Robbins, Hilary A / Wiley, Dorothy J / Ho, Ken / Plankey, Michael / Reddy, Susheel / Joste, Nancy / Darragh, Teresa M / Breen, Elizabeth C / Young, Stephen / D'Souza, Gypsyamber. ·Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room E6132, Baltimore, MD 21205, USA. · School of Nursing, University of California Los Angeles, Los Angeles, CA, USA. · Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. · Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA. · Department of Infectious Disease, Northwestern University, Chicago, IL, USA. · Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM and Tricore Reference Laboratories, Albuquerque, NM, USA. · Department of Pathology, University of California, San Francisco, CA, USA. · Cousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room E6132, Baltimore, MD 21205, USA. Electronic address: gdsouza2@jhu.edu. ·Papillomavirus Res · Pubmed #29626643.

ABSTRACT: BACKGROUND: Men who have sex with men (MSM) are at increased risk for anal cancer. In cervical cancer screening, patterns of repeated cytology results are used to identify low- and high-risk women, but little is known about these patterns for anal cytology among MSM. METHODS: We analyzed Multicenter AIDS Cohort Study (MACS) data for MSM who were offered anal cytology testing annually (HIV-positive) or every 2 years (HIV-negative) for 4 years. RESULTS: Following an initial negative (normal) cytology, the frequency of a second negative cytology was lower among HIV-positive MSM with CD4 ≥ 500 (74%) or CD4 < 500 (68%) than HIV-negative MSM (83%) (p < 0.001). After an initial abnormal cytology, the frequency of a second abnormal cytology was highest among HIV-positive MSM with CD4 < 500 (70%) compared to CD4 ≥ 500 (53%) or HIV-negative MSM (46%) (p = 0.003). Among HIV-positive MSM with at least three results, 37% had 3 consecutive negative results; 3 consecutive abnormal results were more frequent among CD4 < 500 (22%) than CD4 ≥ 500 (10%) (p = 0.008). CONCLUSIONS: More than one-third of HIV-positive MSM have consistently negative anal cytology over three years. Following abnormal anal cytology, a repeated cytology is commonly negative in HIV-negative or immunocompetent HIV-positive men, while persistent cytological abnormality is more likely among HIV-positive men with CD4 < 500.

15 Article Vitamin D deficiency and periodontal clinical attachment loss in HIV-seropositive women: A secondary analysis conducted in the Women's Interagency HIV Study (WIHS). 2018

Dragonas, Panagiotis / Kaste, Linda M / Nunn, Martha / Gajendrareddy, Praveen K / Weber, Kathleen M / Cohen, Mardge / Adeyemi, Oluwatoyin M / French, Audrey L / Sroussi, Herve Y. ·Department of Periodontology, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA. · Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA. · Department of Periodontics, School of Dentistry, Creighton University, Omaha, NE, USA. · The Core Center, Cook County Health and Hospitals System, Chicago, IL, USA. · The Core Center, Cook County Health and Hospital System, Rush University Medical College, Chicago, IL, USA. · Division of Oral Medicine & Dentistry, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: Hsroussi@bwh.harvard.edu. ·Oral Surg Oral Med Oral Pathol Oral Radiol · Pubmed #29550079.

ABSTRACT: OBJECTIVE: The aim of this study was to test a hypothesized positive association between low vitamin D (VitD) serum levels and the severity of periodontal disease in women with HIV infection. STUDY DESIGN: This was a cross-sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss (CAL) measurements were available for 74 women with HIV infection. VitD levels were treated as both continuous and categorical variables in bivariate and multivariate analyses. Mean clinical attachment loss (mCAL) was determined for each subject by obtaining the averages of measurements taken at 4 sites in each measured tooth. RESULTS: Average age of study participants (n = 74) was 39.6 years (standard deviation 7.2), and the majority were African Americans (70.3%) with VitD deficiency (58.1%). VitD deficiency was positively associated with higher mCAL (P = .012). After adjustment for race, age, smoking, and HIV viral load, an association was found between VitD deficiency and mCAL (Beta 0.438; P = .036). CONCLUSIONS: We identified a previously unreported association between VitD deficiency and mCAL in women with HIV infection. Larger and more inclusive, multisite, longitudinal studies are warranted to investigate whether these findings can be generalized to all individuals with HIV infection in the current treatment era and to determine causality.

16 Article A Study of the Longitudinal Patterns of Stimulant and Amyl Nitrite Use and Sexual Behavior Pre- and Post-HIV Seroconversion Among MSM. 2018

Swartz, James A / McCarty-Caplan, David. ·Jane Addams College of Social Work, University of Illinois at Chicago, 1040 W. Harrison Street, (M/C 309), Chicago, IL, 60607, USA. jaswartz@uic.edu. · Department of Social Work, California State University, Northridge, CA, USA. ·AIDS Behav · Pubmed #29248970.

ABSTRACT: The use of stimulant drugs alone or in combination with amyl nitrites (stimulant/nitrites) has been associated with higher rates of risky sexual behavior and predictive of HIV infection among men who have sex with men. However, the temporal pattern of stimulant/nitrite use pre- and post-seroconversion has not been well established. This study assessed changes in stimulant/nitrite use and risky sexual behavior among seroconverting MSM over time. Data were collected in the Baltimore-Washington, DC; Pittsburgh; Chicago; and Los Angeles sites of the Multicenter AIDS Cohort Study (MACS), a longitudinal study of the natural history of HIV infection among MSM. We used propensity scores to select 1044 MSM from 7087 MACS participants composed of 348 seroconverting, 348 seronegative, and 348 seroprevalent participants matched on demographics, recruitment cohort, and study visits. We centered up to four-years of semi-annual data around the seroconversion visit of the seroconverting case within each matched group of participants. Mixed effects regressions estimated the effects of serostatus, recruitment cohort, and time on self-reported stimulant/nitrite use, numbers of male intercourse partners, and numbers of unprotected receptive anal intercourse (URAI) partners. Covariates included demographics, binge drinking, and marijuana use. Seroconverters had the highest odds of stimulant/inhaled nitrite use (AOR 10.3, CI 4.8-22.0), incident rates of intercourse (IRR 1.6, CI 1.3-2.1), and URAI partners (IRR 5.1, CI 3.5-7.3). All participants decreased drug use and sexual risk behavior over time. However, the decreases were largest for seroconverters who nevertheless maintained the highest rates of stimulant/nitrite use and sexual risk. Cohort-related effects were associated with sharp reductions in stimulant/nitrite use and URAI in the early 1990s that rebounded considerably within the first decade of the 2000s. Although all participants decreased risky sexual behavior and stimulant and/or nitrite use over time, seroconverters had the largest decreases. There was no evidence for abrupt or substantial increases in drug use or risky sex post-seroconversion. However, there was substantial variation at the individual level, with the factors underlying this variation not well understood and worth further study. Moreover, stimulant/nitrite use and risky sexual behavior appear to have been strongly influenced by contextual historical and socio-cultural effects. The manner in which contextual factors influence individual behavior is also not well understood and also warrants further study.

17 Article Disclosure and Stigma of a Positive HIV-Serostatus: A Two-Step Cluster Analysis of the HIV Disclosure Scale. 2018

Guy, Arryn A / Niel, Kristin / Franco Durán, R E. ·Clinical Psychology, Department of Psychology, Illinois Institute of Technology, Tech Central 3424 S State St Rm 201, Chicago, IL, 60616, USA. aguy1@hawk.iit.edu. · St. Jude Children's Research Hospital, Memphis, TN, 38103, USA. · California School of Professional Psychology, Alliant International University, Alhambra, CA, 91790, USA. ·AIDS Behav · Pubmed #29170947.

ABSTRACT: Despite national efforts to improve the public's education about an HIV diagnosis, stigma still plays a significant role in how persons living with HIV (PLH) decide to disclose their serostatus to friends, family, or healthcare workers. Disclosure can be related to both positive and negative psychological health outcomes, including rates of depression and perceived social support. Researchers often assess disclosure patterns in PLH due to its association with important health implications; however, to date, there are no empirically validated measures of HIV-serostatus disclosure. The HIV Disclosure Scale (HDS) was created to assess various aspects of the disclosure process and has been utilized in several studies as an adequate measurement of HIV-serostatus disclosure despite no available psychometric data. This study aims to uncover constructs measured by the HDS using exploratory two-step cluster analysis to provide an initial analysis of the psychometric properties of this scale.

18 Article Are HIV Seroconversions Among Young Men Who Have Sex With Men Associated With Social Network Proximity to Recently or Long-Term HIV-Infected Individuals? 2018

Morgan, Ethan / Skaathun, Britt / Duvoisin, Rebeccah / Michaels, Stuart / Schneider, John A. ·Department of Public Health Sciences, University of Chicago, Chicago, IL. · Chicago Center for HIV Elimination, Chicago, IL. · NORC at the University of Chicago, Chicago, IL. · Department of Medicine, University of Chicago, Chicago, IL. ·J Acquir Immune Defic Syndr · Pubmed #29135652.

ABSTRACT: Debate remains as to the relative HIV transmission contributions from individuals who are recently HIV-infected and individuals who have long-term infections. In this study, we examine the relationship between new HIV seroconversions occurring among young black men who have sex with men and network proximity to recently or long-term HIV-infected individuals. A cohort of young black men who have sex with men (N = 618) was generated through respondent-driven sampling across 3 waves. A recent HIV infection was defined as either: (1) a confirmed seroconversion ≤9 months before interview date or (2) a laboratory confirmed acute infection; long-term HIV-infected individuals were defined as a diagnosis date ≥9 months before interview date. Respondent-driven sampling-weighted logistic regression was used to examine network proximity of HIV transmission events to HIV-infected individuals in the network. Within the cohort, 343 (55.5%) participants were identified as HIV seronegative at baseline. Of these, 33 (9.6%) seroconverted during the study period. The odds of seroconversion increased significantly with each additional recent HIV-infected individual in one's network [adjusted odds ratio = 12.96; 95% confidence interval: 5.69 to 29.50], but were not significantly altered by the number of long-term infected individuals in one's network. In addition, for each member of one's network who used pre-exposure prophylaxis, the odds of seroconversion decreased significantly (adjusted odds ratio = 0.44; 95% confidence interval: 0.20 to 0.96). Early diagnosis and treatment is a critical first step in the HIV care continuum and together with pre-exposure prophylaxis awareness and use are critical targets for disrupting the transmission of HIV through most at-risk networks.

19 Article Underutilization of Statins When Indicated in HIV-Seropositive and Seronegative Women. 2017

Todd, Jonathan V / Cole, Stephen R / Wohl, David A / Simpson, Ross J / Jonsson Funk, Michele / Brookhart, M Alan / Cocohoba, Jennifer / Merenstein, Daniel / Sharma, Anjali / Lazar, Jason / Milam, Joel / Cohen, Mardge / Gange, Stephen / Lewis, Tené T / Burkholder, Greer / Adimora, Adaora A. ·1 Institute for Global Health and Infectious Diseases, University of North Carolina , Chapel Hill, North Carolina. · 2 Department of Epidemiology, University of North Carolina , Gillings School of Global Public Health, Chapel Hill, North Carolina. · 3 Division of Cardiology, Department of Medicine, University of North Carolina , Chapel Hill, North Carolina. · 4 Department of Clinical Pharmacy, University of California San Francisco School of Pharmacy , San Francisco, California. · 5 Department of Family Medicine, Georgetown University Medical Center , Washington, District of Columbia. · 6 Department of Medicine, Albert Einstein College of Medicine , Bronx, New York. · 7 Department of Cardiovascular Disease, SUNY Downstate Medical Center , Brooklyn, New York. · 8 Department of Preventive Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California. · 9 Department of Medicine, Cook County Health and Hospital System and Rush University , Chicago, Illinois. · 10 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland. · 11 Department of Epidemiology, Rollins School of Public Health, Emory University , Atlanta, Georgia . · 12 Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama. ·AIDS Patient Care STDS · Pubmed #29087746.

ABSTRACT: Increased life expectancy of persons living with HIV infection receiving antiretroviral therapy heightens the importance of preventing and treating chronic comorbidities such as cardiovascular disease. While guidelines have increasingly advocated more aggressive use of statins for low-density lipoprotein (LDL) cholesterol reduction, it is unclear whether people with HIV, especially women, are receiving statins when indicated, and whether their HIV disease is a factor in access. We assessed the cumulative incidence of statin use after an indication in the Women's Interagency HIV Study (WIHS), from 2000 to 2014. Additionally, we used weighted proportional hazards regression to estimate the effect of HIV serostatus on the time to initiation of a statin after an indication. Cumulative incidence of statin use 5 years after an indication was low: 38% in HIV-seropositive women and 30% in HIV-seronegative women. Compared to HIV-seronegative women, the weighted hazard ratio for initiation of a statin for HIV-seropositive women over 5 years was 0.94 [95% confidence interval (CI) 0.62, 1.43]. Applying the American College of Cardiology and the American Heart Association (ACC/AHA) guidelines increased the proportion of HIV-seropositive women with a statin indication from 16% to 45%. Clinicians treating HIV-seropositive women should consider more aggressive management of the dyslipidemia often found in this population.

20 Article Effects of sex and HIV serostatus on spatial navigational learning and memory among cocaine users. 2017

Fogel, J / Rubin, L H / Maki, P / Keutmann, M K / Gonzalez, R / Vassileva, J / Martin, E M. ·Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA. · Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. · Department of Psychiatry, Rush University Medical Center, 1645 W. Jackson Blvd., Suite 600, Chicago, IL, 60612, USA. · Department of Psychology, Florida International University, Miami, FL, USA. · Institute for Drug and Alcohol Studies, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. · Department of Psychiatry, Rush University Medical Center, 1645 W. Jackson Blvd., Suite 600, Chicago, IL, 60612, USA. eileen_martin@rush.edu. ·J Neurovirol · Pubmed #28849352.

ABSTRACT: Spatial learning and memory are critically dependent on the integrity of hippocampal systems. Functional MRI and neuropathological studies show that hippocampal circuitry is prominently affected among HIV-seropositive individuals, but potential spatial learning and memory deficits have not been studied in detail in this population. We investigated the independent and interactive effects of sex and HIV serostatus on performance of a spatial learning and memory task in a sample of 181 individuals with a history of cocaine dependence. We found that men showed faster times to completion on immediate recall trials compared with women and that delayed recall was significantly poorer among HIV-infected compared with HIV-uninfected participants. Additionally, a sex × serostatus effect was found on the total number of completed learning trials. Specifically, HIV-infected men successfully completed more learning trials compared with HIV-infected women. Results are discussed in the context of recent reports of sex and HIV serostatus effects on episodic memory performance.

21 Article Chorioretinal Lesions and Symptoms of Elevated Intracranial Pressure. 2017

Bakhsh, Saaquib R / Ali, Mohsin H / Bhat, Pooja. ·Illinois Eye and Ear Infirmary, Department Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois. ·JAMA Ophthalmol · Pubmed #28570740.

ABSTRACT: -- No abstract --

22 Article Concordance Between Anal and Oral Human Papillomavirus Infections Among Young Men Who have Sex With Men. 2017

Steinau, Martin / Gorbach, Pamina / Gratzer, Beau / Braxton, Jim / Kerndt, Peter R / Crosby, Richard A / Unger, Elizabeth R / Markowitz, Lauri E / Meites, Elissa. ·Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. · Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, California. · Howard Brown Health Center, Chicago, Ilinois. · Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia. · College of Public Health, University of Kentucky, Lexington. · Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. ·J Infect Dis · Pubmed #28505338.

ABSTRACT: Prevalence of human papillomavirus (HPV) infections was assessed among 1033 young men who have sex with men (MSM) aged 18-26 years. HPV (any type) was detected in 742 (71.8%) anal specimens and 101 (9.8%) oral specimens. Although HPV was detected in specimens from both anatomical sites in 83 (8.0%) participants, type-specific concordance for at least 1 HPV type was found in only 35 (3.4%) participants. HIV and smoking were associated with higher prevalence at both sites and frequency of concordant types. Coinfections of identical HPV types were rare, suggesting independent infection events and/or different modes of clearance.

23 Article Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors. 2017

Muzaale, A D / Althoff, K N / Sperati, C J / Abraham, A G / Kucirka, L M / Massie, A B / Kitahata, M M / Horberg, M A / Justice, A C / Fischer, M J / Silverberg, M J / Butt, A A / Boswell, S L / Rachlis, A R / Mayor, A M / Gill, M J / Eron, J J / Napravnik, S / Drozd, D R / Martin, J N / Bosch, R J / Durand, C M / Locke, J E / Moore, R D / Lucas, G M / Segev, D L. ·Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. · Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD. · Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. · University of Washington Center for AIDS Research, Seattle, WA. · Mid-Atlantic Permanente Institute, Rockville, MD. · Veterans Affairs Connecticut Healthcare System, West Haven, CT. · Jesse Brown VA Medical Center and Hines VA Hospital, Chicago, IL. · Kaiser Permanente Division of Research, Oakland, CA. · Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar. · Weill Cornell Medical College, Doha, Qatar. · Weill Cornell Medical College, New York, NY. · Fenway Health HIV Cohort, Boston, MA. · Infectious Diseases Division, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. · Universidad Central del Caribe, Bayamón, PR. · Southern Alberta HIV Clinic, Sheldon M. Chumir Health Centre, Calgary, Alberta, Canada. · University of North Carolina, HIV Clinic Cohort, Chapel Hill, NC. · The Polyclinic Madison Center, Seattle, WA. · Department of Epidemiology and Biostatistics, University of California, San Francisco, CA. · Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA. · Department of Surgery, University of Alabama, Birmingham, AL. ·Am J Transplant · Pubmed #28497525.

ABSTRACT: New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years. We used risk associations from multivariable Cox proportional hazards regression to derive cumulative incidence estimates for selected HIV-positive scenarios (no history of diabetes, hypertension, AIDS, or hepatitis C virus coinfection) and compared these estimates with those from similarly selected HIV-negative scenarios. For 40-year-old HIV-positive individuals with health characteristics that were similar to those of age-matched kidney donors, viral load <400 copies/mL, and CD4

24 Article Serodiscussion, Perceived Seroconcordance, and Sexual Risk Behaviors Among Dyads of Men Who Have Sex with Men Who Use Geosocial-Networking Smartphone Applications in London. 2017

Goedel, William C / Schneider, John A / Hagen, Daniel / Duncan, Dustin T. ·1 Department of Population Health, School of Medicine, New York University, New York, NY, USA. · 2 College of Global Public Health, New York University, New York, NY, USA. · 3 Department of Medicine, University of Chicago, Chicago, IL, USA. · 4 Department of Public Health Sciences, University of Chicago, IL, USA. ·J Int Assoc Provid AIDS Care · Pubmed #28485706.

ABSTRACT: Serodiscussion-the mutual discussion of HIV statuses between sexual partners-can be viewed as an essential prerequisite for risk-reduction behaviors among men who have sex with men (MSM). The current study aimed to assess the prevalence of serodiscussion with one's most recent sexual partner and its association with sexual behaviors with these partners. Broadcast advertisements were placed on a geosocial-networking smartphone application, encouraging users to complete an online survey. A total of 200 MSM completed the survey. Serodiscussion occurred in 43.5% of dyads, and it was most common in dyads where both partners were reported to be HIV positive, χ

25 Article Awareness and perceived fairness of Option B+ in Malawi: A population-level perspective 2017

Yeatman, Sara / Trinitapoli, Jenny. ·Department of Health and Behavioral Sciences, University of Colorado Denver, Denver, CO, USA. · Department of Sociology, University of Chicago, Chicago, IL, USA. ·J Int AIDS Soc · Pubmed #28362070.

ABSTRACT: INTRODUCTION: Policies for rationing antiretroviral therapy (ART) have been subject to on-going ethical debates. Introduced in Malawi in 2011, Option B+ prioritized HIV-positive pregnant women for lifelong ART regardless of the underlying state of their immune system, shifting the logic of allocation away from medical eligibility. Despite the rapid expansion of this policy, we know little about how it has been understood and interpreted by the people it affects. METHODS: We assessed awareness and perceived fairness of the prioritization system for ART among a population-based sample of young women (n = 1440) and their partners (n = 574) in southern Malawi. We use a card-sort technique to elicit understandings of who gets ART under Option B+ and who should be prioritized, and we compare perceptions to actual ART policy using sequence analysis and optimal matching. We then use ordered logistic regression to identify the factors associated with policy awareness. RESULTS: In 2015, only 30.7% of women and 21.1% of male partners understood how ART was being distributed. There was widespread confusion around whether otherwise healthy HIV-positive pregnant women could access ART under Option B + . Nonetheless, more young adults thought that the fairest policy should prioritize such women than believed the actual policy did. Women who were older, more educated or had recently engaged with the health system through antenatal care or ART had more accurate understandings of Option B + . Among men, policy awareness was lower, and was patterned only by education. CONCLUSION: Although most respondents were unaware that Option B+ afforded ART access to healthy-pregnant women, Malawians support the prioritization of pregnant women. Countries adopting Option B+ or other new ART policies such as universal test-and-treat should communicate the policies and their rationales to the public - such transparency would be more consistent with a fair and ethical process and could additionally serve to clarify confusion and enhance retention.​​.