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Hypertension: HELP
Articles by Ming-Wei Lin
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, Ming-Wei Lin wrote the following 5 articles about Hypertension.
 
+ Citations + Abstracts
1 Article Urinary fatty acid and retinol binding protein-4 predict CKD progression in severe NAFLD patients with hypertension: 4-year study with clinical and experimental approaches. 2020

Tsai, Yu-Lien / Liu, Chih-Wei / Huang, Shiang-Fen / Yang, Ying-Ying / Lin, Ming-Wei / Huang, Chia-Chang / Li, Tzu-Hao / Huang, Yi-Hsiang / Hou, Ming-Chih / Lin, Han-Chieh. ·Department of Medicine. · National Yang-Ming University School of Medicine, Taipei. · Division of Allergy and Immunology. · Institute of Clinical Medicine, Taipei Veterans General Hospital. · Division of Infection. · Division of Gastroenterology and Hepatology. · Division of General Medicine. · Division of clinical skills training center, Department of medical education, Taipei, Taiwan. · Division of Preventive Medicine, Institute of public Health. · Chia-Yi Branch of Taichung Veterans General Hospital, Chiayi. ·Medicine (Baltimore) · Pubmed #31914044.

ABSTRACT: Detection of the chronic kidney disease (CKD) progression can begin early intervention to improve the prognosis of severe non-alcoholic fatty liver disease (NAFLD). This bi-directional cross-sectional study evaluates the roles of fatty acid-binding protein (FABP) and retinol binding protein (RBP4), which are produced from inflamed liver, adipose tissue and immune cells, for the prediction of CKD progression in severe NAFLD. Ninety severe NAFLD patients with hypertension and proteinuria (NAFLDHTN) were enrolled and divided into CKD (n = 39) and non-CKD groups (n = 51). Among 39 NAFLDHTN patients, 18 cases were categorized as CKD progression group. In comparison with CKD stable group (n = 21), the positive correlation between fold change values of hepatic fibrotic score (KPa), urinary FABP4 or urinary RBP4 versus severity of albuminuria were noted among CKD progression group. On multivariate analysis, high body mass index (BMI, >25 kg/m), high hepatic fibrosis score (>9.5 KPa), high urinary level of vascular cell adhesion molecule-1 (VCAM-1, >2239 μg/g cr), high urinary level of FABP4 (>115 ng/g cr) and high urinary level of RBP4 (>33.5 mg/g cr) are 5 independent predictors for progressive CKD during 24 months of follow-up. Synergetic effect was noted among these 5 risk factors for the prediction of CKD progression in NAFLDHTN patients. The in vitro experiments revealed that both FABP4 and RBP4 directly enhanced albumin-induced ER stress and apoptosis of human renal tubular epithelial cell line HK-2 cells and human podocytes cell lines. Through clinical and experimental approaches, this study revealed new 5 synergetic predictors including high BMI, hepatic fibrosis score, urinary level of VCAM-1, urinary level of FABP4 and RBP4, for the CKD progression in severe NAFLD patients with hypertension and proteinuria.

2 Article Alterations in regional myocardial deformation assessed by strain imaging in cardiac amyloidosis. 2016

Lo, Queenie / Haluska, Brian / Chia, Ee-May / Lin, Ming-Wei / Richards, David / Marwick, Thomas / Thomas, Liza. ·University of New South Wales, Sydney, NSW, Australia. · Princess Alexandra Hospital, University of Queensland, Brisbane, Qld, Australia. · Westmead Hospital, Sydney, NSW, Australia. · Liverpool Hospital, Sydney, NSW, Australia. · Menzies Institute, Hobart, TAS, Australia. · University of Sydney, Sydney, NSW, Australia. ·Echocardiography · Pubmed #27600102.

ABSTRACT: BACKGROUND: Cardiac amyloidosis results in increased left ventricular (LV) wall thickness and diastolic dysfunction (DD). Strain measurements using velocity vector imaging (VVI) may further characterize myocardial dysfunction. METHODS: A total of 43 AL amyloidosis patients were compared to age-matched normals and hypertensive patients (HT). Subgroup analysis within the amyloid group was performed based on LV wall thickness (≤14 mm, >14 mm) and diastolic dysfunction (DD) (Group 1: normal and impaired relaxation, Group 2: pseudonormal, Group 3: restrictive). LV strain (longitudinal, circumferential, and radial strain (S) and strain rate [Sr]) were measured using velocity vector imaging (VVI). RESULTS: Increased LV wall thickness and DD were observed in the amyloid group. Global longitudinal (-13.9±4.1% vs -16.7±3.8%; P=.002) and radial (27.4±13.4% vs 38.8±15.7%; P<.001) strain were lower in the amyloid group vs normal controls, while circumferential strain was similar. Segmental analysis demonstrated reduced mid- and basal segmental strain with relative sparing of apical segments in the amyloid group. Reduced longitudinal and radial strain, with preserved circumferential strain, were observed in patients with wall thickness >14 mm; however, circumferential strain was also altered when severe DD (restrictive filling) was present. CONCLUSION: Reduction in longitudinal and radial S and Sr was evident using VVI strain analysis in amyloidosis, with segmental heterogeneity in longitudinal S. There was relative preservation of circumferential strain, which was reduced only in patients with severe DD.

3 Article Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study. 2016

Chang, Tien-Jyun / Wang, Wen-Chang / Hsiung, Chao A / He, Chih-Tsueng / Lin, Ming-Wei / Sheu, Wayne Huey-Herng / Chang, Yi-Cheng / Quertermous, Tom / Chen, Ida / Rotter, Jerome / Chuang, Lee-Ming / Anonymous470861. ·From the Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (T-JC, Y-CC, L-MC) · The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan (W-CW) · Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan (W-CW, C-AH) · Department of Endocrinology and Metabolism, Tri-Service General Hospital, Taipei, Taiwan (C-TH) · Institute of Public Health, National Yang-Ming University, Taipei, Taiwan (M-WL) · Department of Medical Research & Education, Taipei Veterans General Hospital, Taipei, Taiwan (M-WL) · Department of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan (WH-HS) · Graduate Institute of Medical Genomics and Proteomics, National Taiwan University Medical College, Taipei, Taiwan (Y-CC) · Division of Cardiovascular Medicine, Falk CVRC, Stanford University School of Medicine, Stanford, CA (TQ) · Los Angles Biomedical Research Institute, Los Angeles, CA (IC, JR) · Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan (L-MC). ·Medicine (Baltimore) · Pubmed #26962801.

ABSTRACT: Essential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association between the T228A polymorphism and insulin resistance, obesity, and type 2 diabetes. It has been hypothesized that a set of genes responsible for insulin resistance may be closely linked with genes susceptible to the development of hypertension. Identification of insulin resistance-related genetic factors may, therefore, enhance our understanding of essential hypertension. This study aimed to examine whether common SORBS1 genetic variations are associated with blood pressure and age at onset of hypertension in an ethnic Chinese cohort.We genotyped 9 common tagged single nucleotide polymorphisms of the SORBS1 gene in 1136 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance family study. Blood pressure was measured upon enrolment. The associations of the SORBS1 single nucleotide polymorphisms with blood pressure and the presence of hypertension were analyzed with a generalized estimating equation model. We used the false-discovery rate measure Q value with a cutoff <0.1 to adjust for multiple comparisons. In the Cox regression analysis for hypertension-free survival, a robust sandwich variance estimator was used to deal with the within-family correlations with age at onset of hypertension. Gender, body mass index, and antihypertension medication were adjustment covariates in the Cox regression analysis.In this study, genetic variants of rs2281939 and rs2274490 were significantly associated with both systolic and diastolic blood pressure. A genetic variant of rs2274490 was also significantly associated with the presence of hypertension. Furthermore, genetic variants of rs2281939 and rs2274490 were associated with age at onset of hypertension after adjustment for gender, body mass index, and antihypertension medication.In conclusion, we provide evidence for an association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension. The biological mechanism of genetic variation associated with blood pressure regulation needs further investigation.

4 Article Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study. 2013

Ho, Low-Tone / Hsu, Yung-Pei / Hsiao, Chin-Fu / Ting, Chih-Tai / Shih, Kuang-Chung / Chuang, Lee-Ming / Masaki, Kamal / Grove, John / Quertermous, Thomas / Juan, Chi-Chung / Lin, Ming-Wei / Chiang, Shu-Chiung / Chen, Yii-Der I. ·Department of Medical Research and Education, Taipei Veterans General Hospital , Taipei , Taiwan ; School of Medicine, National Yang-Ming University , Taipei , Taiwan ; Faculty of Medicine, National Yang-Ming University , Taipei , Taiwan ; Institute of Physiology, National Yang-Ming University , Taipei , Taiwan ; Institute of Clinical Medicine, National Yang-Ming University , Taipei , Taiwan. · Department of Medical Research and Education, Taipei Veterans General Hospital , Taipei , Taiwan. · Division of Biostatistics and Bioinformatics, National Health Research Institutes , Taipei , Taiwan. · Cardiovascular Center, Taichung Veterans General Hospital , Taichung , Taiwan. · Division of Endocrinology and Metabolism, Tri-Service General Hospital , Taipei , Taiwan. · Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan ; Graduate Institute of Clinical Medicine, National Taiwan University , Taipei , Taiwan. · Kuakini Medical Center , Honolulu , Hawaii. · Department of Public Health Sciences and Epidemiology, John A. Burns School of Medicine, University of Hawaii and Pacific Health Research Institute , Honolulu , Hawaii. · Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University , Stanford, CA , USA. · Department of Medical Research and Education, Taipei Veterans General Hospital , Taipei , Taiwan ; Institute of Physiology, National Yang-Ming University , Taipei , Taiwan ; Institute of Clinical Medicine, National Yang-Ming University , Taipei , Taiwan. · Department of Medical Research and Education, Taipei Veterans General Hospital , Taipei , Taiwan ; Faculty of Medicine, National Yang-Ming University , Taipei , Taiwan. · Information Service Center, Taipei Veterans General Hospital , Taipei , Taiwan. · Medical Genetics Institute, Cedars-Sinai Medical Center, University of California at Los Angeles , Los Angeles, CA , USA. ·Front Endocrinol (Lausanne) · Pubmed #24348460.

ABSTRACT: Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we determined whether the T323C polymorphism (rs5333) of endothelin type A (ETA) receptor, a predominant receptor evoking potent vasoconstrictive action of endothelin-1, contributes to susceptibility to IR-associated hypertension in 1694 subjects of Chinese and Japanese origins. Blood pressures (BPs) and biochemistries were measured. Fasting insulin level, insulin-resistance homeostasis model assessment (HOMAIR) score, and area under curve of insulin concentration (AUCINS) were selected for assessing insulin sensitivity. Genotypes were obtained by methods of polymerase chain reaction-restriction fragment length polymorphism. Foremost findings were that minor allele frequency of the T323C polymorphism was noticeable lower in our overall Asian subjects compared to multi-national population reported in gene database; moreover both the genotypic and allelic frequencies of the polymorphism were significantly different between the two ethnic groups we studied. The genotype distributions at TT/TC/CC were 65, 31, 4% in Chinese and 51, 41, 8% in Japanese, respectively (p < 0.0001). Additionally, carriers of the C homozygote revealed characteristics of IR, namely significantly higher levels of fasting insulin, HOMAIR score, and AUCINS at 29.3, 35.3, and 39.3%, respectively, when compared to their counterparts with TT/TC genotypes in Chinese. Meanwhile, the CC genotype was associated with a higher level of high density lipoprotein cholesterol in Japanese. No association of the polymorphism with BP was observed. This study demonstrated for the first time that T323C polymorphism of ETA receptor gene was associated with an adverse insulin response in Chinese and a favorite atherogenic index in Japanese.

5 Article The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. 2012

Hsiao, Chin-Fu / Sheu, Wayne W H / Hung, Yi-Jen / Lin, Ming-Wei / Curb, David / Ranadex, Koustubh / Quertermous, Thomas / Chen, Yue-Ming / Chen, Ida Yi-Der / Wu, Kwan-Dun. ·Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan. ·J Renin Angiotensin Aldosterone Syst · Pubmed #22419662.

ABSTRACT: INTRODUCTION: The hereditability of insulin resistance has been demonstrated in both familial and twin studies. The effects of renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance remain inconclusive. METHODS: This is a sibling-based association study. Polymorphisms of renin-angiotensin-aldosterone system genes were examined in 1113 hypertension and 676 normotension siblings from Chinese and Japanese hypertensive families. The generalized estimation equations method was used to compare the differences in metabolic variables between hypertension and normotensive siblings. RESULTS: For the G-6A polymorphism of AGT, GG siblings had lower 2-h insulin than siblings carrying the A allele (p=0.006). Siblings with different variants of the angiotensin II type 1 receptor A1166C had no difference in metabolic variables. Siblings carrying the D allele of the angiotensin converting enzyme gene had higher levels of fasting glucose, fasting insulin, area under the curve of insulin levels and the homeostasis model assessment of insulin resistance than II siblings (all p<0.05). Lower levels of fasting glucose and 2-h glucose were observed in siblings with the T allele than their CC homozygotes for the C-344T polymorphism of CYP11B2 (p<0.05). Siblings carrying three high-risk genotypes of the angiotensin converting enzyme, angiotensinogen and CYP11B2 had higher fasting glucose level than siblings carrying no high-risk genotypes (p=0.011). CONCLUSION: Our comprehensive analysis of renin-angiotensin-aldosterone system gene polymorphisms demonstrates that the angiotensin converting enzyme and CYP11B2 gene polymorphisms are associated with insulin resistance in hypertensive families.