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Hypertension: HELP
Articles by Jie Liu
Based on 38 articles published since 2010
(Why 38 articles?)
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Between 2010 and 2020, Jie Liu wrote the following 38 articles about Hypertension.
 
+ Citations + Abstracts
Pages: 1 · 2
1 Review Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications. 2019

Zhang, Chun-Fang / Zhao, Fang-Yun / Xu, Shuang-Lan / Liu, Jie / Xing, Xi-Qian / Yang, Jiao. ·Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan, Kunming, Yunnan, China. · Department of Pharmacy, Yan'An Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China. · First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. ·J Cell Physiol · Pubmed #30932199.

ABSTRACT: Autophagy is an important mechanism for cellular self-digestion and basal homeostasis. This gene- and modulator-regulated pathway is conserved in cells. Recently, several studies have shown that autophagic dysfunction is associated with pulmonary hypertension (PH). However, the relationship between autophagy and PH remains controversial. In this review, we mainly introduce the effects of autophagy-related genes and some regulatory molecules on PH and the relationship between autophagy and PH under the conditions of hypoxia, monocrotaline injection, thromboembolic stress, oxidative stress, and other drugs and toxins. The effects of other autophagy-related drugs, such as chloroquine, 3-methyladenine, rapamycin, and other potential therapeutic drugs and targets, in PH are also described.

2 Review Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. 2017

Liu, Jie / Khalil, Raouf A. ·Vascular Surgery Research Laboratories, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States. · Vascular Surgery Research Laboratories, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States. Electronic address: raouf_khalil@hms.harvard.edu. ·Prog Mol Biol Transl Sci · Pubmed #28662828.

ABSTRACT: Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of membrane receptors and postreceptor signaling mechanisms and thereby affect cell function. The MMP family includes collagenases, gelatinases, stromelysins, matrilysins, membrane-type MMPs, and other MMPs. Inactive proMMPs are cleaved by other MMPs or proteases into active MMPs, which interact with various protein substrates in ECM and cell surface. MMPs regulate important biological processes such as vascular remodeling and angiogenesis and may be involved in the pathogenesis of cardiovascular disorders such as hypertension, atherosclerosis, and aneurysm. The role of MMPs is often assessed by measuring their mRNA expression, protein levels, and proteolytic activity using gel zymography. MMP inhibitors are also used to assess the role of MMPs in different biological processes and pathological conditions. MMP activity is regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs), and the MMP/TIMP balance could determine the net MMP activity, ECM turnover, and tissue remodeling. Also, several synthetic MMP inhibitors have been developed. Synthetic MMP inhibitors include a large number of zinc-binding globulins (ZBGs), in addition to non-ZBGs and mechanism-based inhibitors. MMP inhibitors have been proposed as potential tools in the management of osteoarthritis, cancer, and cardiovascular disorders. However, most MMP inhibitors have broad-spectrum actions on multiple MMPs and could cause undesirable musculoskeletal side effects. Currently, doxycycline is the only MMP inhibitor approved by the Food and Drug Administration. New generation biological and synthetic MMP inhibitors may show greater MMP specificity and fewer side effects and could be useful in targeting specific MMPs, reducing unrestrained tissue remodeling, and the management of MMP-related pathological disorders.

3 Clinical Trial Impact of waist circumference and body mass index on risk of cardiometabolic disorder and cardiovascular disease in Chinese adults: a national diabetes and metabolic disorders survey. 2013

Hou, Xuhong / Lu, Juming / Weng, Jianping / Ji, Linong / Shan, Zhongyan / Liu, Jie / Tian, Haoming / Ji, Qiuhe / Zhu, Dalong / Ge, Jiapu / Lin, Lixiang / Chen, Li / Guo, Xiaohui / Zhao, Zhigang / Li, Qiang / Zhou, Zhiguang / Shan, Guangliang / Yang, Zhaojun / Yang, Wenying / Jia, Weiping / Anonymous4850753. ·Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. ·PLoS One · Pubmed #23520466.

ABSTRACT: BACKGROUND: We updated the prevalence of obesity and evaluated the clinical utility of separate and combined waist circumference (WC) or body mass index (BMI) category increments in identifying cardiometabolic disorder (CMD) and cardiovascular disease (CVD) risk in Chinese adults. METHODS AND FINDINGS: 46,024 participants aged ≥20 years, a nationally representative sample surveyed in 2007-2008, were included in this analysis. Taking the cutoffs recommended by the Chinese Joint Committee for Developing Chinese Guidelines (JCDCG) and the Working Group on Obesity in China (WGOC) into account, the participants were divided into four WC and four BMI groups in 0.5-SD increments around the mean, and 16 cross-tabulated combination groups of WC and BMI. 27.1%, 31.4%, and 12.2% of Chinese adults are centrally obese, overweight, or obese according to JCDCG and WGOC criteria. After adjustment for confounders, after a 1-SD increment, WC is associated with a 1.7-fold or 2.2-fold greater risk of having DM or DM plus dyslipidemia than BMI, while BMI was associated with a 2.3-fold or 1.7-fold higher hypertension or hypertension plus dyslipidemia risk than WC. The combination of WC and BMI categories had stronger association with CMD risk, i.e., the adjusted ORs (95% CI) of having DM, hypertension, and dyslipidemia for the combined and separate highest WC and BMI categories were 2.19 (1.96-2.44) vs 1.88 (1.67-2.12) and 1.12 (0.99-1.26); 5.70 (5.24-6.19) vs 1.51 (1.39-1.65) and 1.69 (1.57-1.82); and 3.73 (3.42-4.07) vs 2.16 (1.98-2.35) and 1.33 (1.25-1.40), respectively. The combination of WC and BMI categories was more likely to identify individuals with lower WC and lower BMI at CVD risk, even after the effects of CMD were controlled (all P<0.05). CONCLUSION: Central obesity, overweight, and obesity are epidemic in Chinese adults. The combination of WC and BMI measures is superior to the separate indices in identifying CMD and CVD risk.

4 Article Hypertension prevalence alteration in 92 815 nurses based on the new standard by 2017 ACC/AHA hypertension guideline: observational cross-sectional study from China. 2019

Zhao, Bin / Li, Jing / Liu, Jie / Hao, Yuming / Zhen, Yanjie / Feng, Di / Xu, Menghui / Chen, Ximin / Yang, Xiulan / Zuo, Aifang / Jia, Rufu / Zhang, Ruiqin / Fan, Ailing / Wang, Yun / Yuan, Meijin / Tong, Li / Chen, Shuling / Cui, Jing / Zhao, Meizhu / Cui, Wei. ·Nursing Department, Second Hospital of Hebei Medical University, Shijiazhuang, China. · Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, China. · Nursing Department, Second Hospital of Baoding, Baoding, China. · Nursing Department, Tangshan Gongren Hospital, Tangshan, China. · Nursing Department, Handan Central Hospital, Handan, China. · Neurology Hospital, Cangzhou Central Hospital, Cangzhou, China. · Nursing Department, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, China. · Nursing Department, The People's Hospital of Langfang City, Langfang, China. · Nursing Department, The First Hospital of Qinhuangdao, Qinhuangdao, China. · Nursing Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China. · Nursing Department, Harrison International Peace Hospital, Hengshui, China. · Nursing Department, Chengde Central Hospital, Chengde, China. · Nursing Department, Dingzhou Maternal and Child Health Care Hospital, Dingzhou, China. · Nursing Department, The First Hospital of Xinji, Xinji, China. · Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, China cuiwei21c@163.com. ·BMJ Open · Pubmed #31471431.

ABSTRACT: OBJECTIVES: This study aimed to elucidate the status of hypertension and to analyse the hypertension changes in prevalence, awareness, treatment and control rate among the portion of Chinese nursing staff based on the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) High Blood Pressure Guideline and the 2010 Chinese Guideline for the Management of Hypertension. DESIGN: Cross-sectional study. SETTING: 512 medical institutions in 13 cities in Hebei Province. PARTICIPANTS: The candidates of registered nurses from 512 medical institutions in 13 cities in Hebei Province (N=143 772) were invited to participate in the survey, and few of them who refused to participate were excluded from the research group based on the reasons that 93 603 incumbent nurses at the age of 18-65 accepted to the survey and submitted questionnaires online. Undoubtedly, a response rate of 65.11% was achieved. After excluding 788 individuals with incomplete information in the questionnaires, 92 815 participants were included in the final analysis. MAIN OUTCOME MEASURES: The prevalence, awareness, treatment and control rates of hypertension. RESULTS: 92 815 participants were included in the final analysis, among which consisted of 3677 men (3.96%) and 89 138 women (96.04%). The mean age of the participants was 31.65 (SD=7.47) years.We demonstrated that 26 875 nursing staff were diagnosed as having hypertension according to the new standard by the 2017 ACC/AHA guideline, more than 20 551 cases compared with the previous threshold on the 2010 Chinese guideline. The prevalence of hypertension among nursing staff was 28.96% in the context of the 2017 ACC/AHA guideline, 3.25 times higher than that (6.81%) evaluated by the criteria of the 2010 Chinese guideline. However, the awareness, treatment and control rate (13.50%, 10.73% and 0.81%) were 3.25, 3.22 and 17.48 times lower than those (57.37%, 45.30% and 14.97%) based on the 2010 Chinese guideline, respectively. CONCLUSIONS: This research illustrated that it was crucial to improve the awareness rate, drug treatment rate and control rate of hypertension for nurses. Meanwhile, according to the 2017 ACC/AHA guideline, the prevalence of hypertension in China will increase significantly, which poses a more severe challenge to the management of hypertension in China.

5 Article 5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter. 2019

Xing, Xi-Qian / Li, Bo / Xu, Shuang-Lan / Zhang, Chun-Fang / Liu, Jie / Deng, Yi-Shu / Yang, Jiao. ·Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, 650021, Yunnan, China. · College of Pharmacy, Kunming Medical University, Kunming, 650500, Yunnan, China. · Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, 650021, Yunnan, China. Electronic address: 497992328@qq.com. · First Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China. Electronic address: yangjiaokmu@yahoo.com. ·Eur J Pharmacol · Pubmed #31085236.

ABSTRACT: Phosphatase and tensin homolog (PTEN) plays an important role in the pathogenesis of hypoxic pulmonary hypertension (HPH). A decrease in PTEN expression is associated with the hypermethylation of its promoter. However, whether the demethylation of the PTEN gene could attenuate HPH remains unknown. 5-Aza-2'-deoxycytidine (5-Aza-dC) is a DNA methyltransferase (DNMT) inhibitor. The present study was designed to investigate the effects and mechanisms of 5-Aza-dC on HPH. The proliferation, migration and apoptosis of rat pulmonary artery smooth muscle cells (PASMCs) induced by hypoxia and treated with 5-Aza-dC were detected. The expression of PTEN and DNMTs and the PTEN methylation status of PASMCs were detected. SD rats were randomly divided into normal group, hypoxia group and hypoxia + 5-Aza-dC group. The expression of PTEN was decreased, the expression of DNMTs was increased, and the methylation status of PTEN was increased in hypoxia-induced PASMCs. However, 5-Aza-dC can rescue the decreased PTEN, inhibit DNMT levels in a dose-dependent manner and suppress PTEN methylation. Furthermore, the demethylation of PTEN, which was induced by 5-Aza-dC, inhibited the proliferation, migration and promoted apoptosis in PASMCs. In vivo studies further demonstrated that the expression of PTEN, mean pulmonary artery pressure and right ventricular hypertrophy index in HPH rats was attenuated by 5-Aza-dC. 5-Aza-dC also suppressed the expression of DNMTs and PTEN methylation in the lungs of HPH rats. These results indicated that PTEN promoter methylation status is involved in HPH. 5-Aza-dC, as a DNMT inhibitor, has the potential to attenuate HPH via demethylation of the PTEN promoter.

6 Article Effect of ertugliflozin on blood pressure in patients with type 2 diabetes mellitus: a post hoc pooled analysis of randomized controlled trials. 2019

Liu, Jie / Pong, Annpey / Gallo, Silvina / Darekar, Amanda / Terra, Steven G. ·Merck & Co., Inc., Kenilworth, NJ, USA. jie.liu11@merck.com. · Merck & Co., Inc., Kenilworth, NJ, USA. · Pfizer Pharma GmbH, Berlin, Germany. · Pfizer R&D UK Ltd, Walton Oaks, Tadworth, UK. · Pfizer Inc., Andover, MA, USA. ·Cardiovasc Diabetol · Pubmed #31064361.

ABSTRACT: BACKGROUND: The efficacy of ertugliflozin, a sodium-glucose cotransporter 2 inhibitor, for glycemic and blood pressure (BP) control has been demonstrated in phase 3 studies. To further evaluate the effects of ertugliflozin on BP and other hemodynamic parameters, an analysis was conducted on the pooled patient populations from these studies. METHODS: This was a post hoc analysis of data from three phase 3 studies (NCT01958671, NCT02033889, and NCT02036515) of adults with type 2 diabetes mellitus who received placebo, ertugliflozin 5 mg, or ertugliflozin 15 mg. Outcomes at 26 weeks were analyzed for the pooled population and according to relevant baseline factors, including BP. RESULTS: Of the 1544 patients included (placebo, n = 515; ertugliflozin 5 mg, n = 519; ertugliflozin 15 mg, n = 510), most (67.4-69.0%) had hypertension at baseline. Mean baseline BP was similar across treatment groups (placebo, 129.7/78.0 mmHg; ertugliflozin 5 mg, 131.0/78.4 mmHg; ertugliflozin 15 mg, 130.5/78.4 mmHg). At Week 26, placebo-adjusted least squares (LS) mean changes (95% confidence intervals [CI]) from baseline in systolic BP (SBP) were - 3.7 mmHg (- 5.1, - 2.3) for both ertugliflozin doses. Reductions were consistent across all baseline subgroups. At Week 26, more patients with a baseline SBP ≥ 130 mmHg had a SBP < 130 mmHg with ertugliflozin (38.7% both doses) than with placebo (24.0%), and more patients with a baseline SBP ≥ 140 mmHg attained a SBP < 140 mmHg with ertugliflozin (59.5% [5 mg] and 66.7% [15 mg]) than with placebo (43.8%). Placebo-adjusted LS mean changes (95% CI) in diastolic BP (DBP) with ertugliflozin 5 mg and 15 mg were - 1.8 mmHg (- 2.7, - 0.9) and - 1.6 mmHg (- 2.5, -  0.7), respectively, and in pulse rate were - 1.3 beats per minute (bpm) (- 2.2, - 0.3) and - 1.5 bpm (- 2.5, - 0.6), respectively. Greater reductions in pulse pressure, mean arterial pressure, and double product were observed with ertugliflozin than with placebo. Incidence of adverse event-related osmotic diuresis was low, but greater with ertugliflozin (2.9% [5 mg], 2.4% [15 mg]) than placebo (1.0%). CONCLUSION: Ertugliflozin treatment led to reductions in SBP, DBP, and pulse rate relative to placebo. Reductions in SBP were generally consistent across the subgroups evaluated. Trial registration NCT01958671; NCT02033889; NCT02036515.

7 Article Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin. 2019

Wang, Lei / Liu, Jie / Wang, Wang / Qi, Xianmei / Wang, Ying / Tian, Bo / Dai, Huaping / Wang, Jing / Ning, Wen / Yang, Ting / Wang, Chen. ·Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China. · Department of Physiology and Pathophysiology, School of BasicMedical Sciences, Capital Medical University, Beijing, China. · Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. · Department of Thoracic Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. · Department of Physiology and Pathophysiology, School of BasicMedical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. · Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ·Thorax · Pubmed #30777899.

ABSTRACT: BACKGROUND: The role of interleukin 17 (IL-17) in hypoxic pulmonary hypertension (HPH) remains unclear. This study is designed to explore whether IL-17 is a potential target for HPH treatment. METHODS: Clinic samples from the lung tissue and serum were obtained from qualified patients. Western blotting, immunohistochemistry and/or ELISA were used to measure the expression of relevant proteins. HPH models were established in C57BL/6 wild-type (WT) and RESULTS: Expression of IL-17 was increased in lung tissue of both patients with bronchiectasis/COPD-associated PH and HPH mouse model. Compared with WT mice, CONCLUSIONS: IL-17 contributes to the pathogenesis of HPH through upregulation of β-catenin expression. Targeting IL-17 might provide potential benefits for alternative therapeutic strategies for HPH.

8 Article Inositol 1,4,5-Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation. 2019

Lin, Qingsong / Zhao, Lingyun / Jing, Ran / Trexler, Christa / Wang, Hong / Li, Yali / Tang, Huayuan / Huang, Fang / Zhang, Fei / Fang, Xi / Liu, Jie / Jia, Nan / Chen, Ju / Ouyang, Kunfu. ·1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China. · 2 Department of Cardiology The Second Xiangya Hospital Central South University Changsha Hunan China. · 3 Department of Medicine School of Medicine University of California San Diego La Jolla CA. · 4 Department of Pathophysiology School of Medicine Shenzhen University Shenzhen China. · 5 Department of Cardiology The Eighth Affiliated Hospital Sun Yat-sen University Shenzhen China. ·J Am Heart Assoc · Pubmed #30755057.

ABSTRACT: Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca

9 Article Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults. 2019

Tarumi, Takashi / Thomas, Binu P / Wang, Ciwen / Zhang, Li / Liu, Jie / Turner, Marcel / Riley, Jonathan / Tangella, Nikita / Womack, Kyle B / Kerwin, Diana R / Cullum, C Munro / Lu, Hanzhang / Vongpatanasin, Wanpen / Zhu, David C / Zhang, Rong. ·1 Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA. · 2 Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA. · 3 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. · 4 Department of Ultrasound Diagnostics, Fourth Military Medical University, Xi'an, China. · 5 Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. · 6 Texas Alzheimer's and Memory Disorders, Texas Health Presbyterian Hospital, Dallas, TX, USA. · 7 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. · 8 Department of Radiology, Cognitive Imaging Research Center, Michigan State University, Lansing, MI, USA. · 9 Department of Psychology, Cognitive Imaging Research Center, Michigan State University, Lansing, MI, USA. ·J Cereb Blood Flow Metab · Pubmed #29219028.

ABSTRACT: Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.

10 Article IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells. 2018

Liu, Jie / Wang, Wang / Wang, Lei / Chen, Shihao / Tian, Bo / Huang, Kewu / Corrigan, Chris J / Ying, Sun / Wang, Wei / Wang, Chen. ·The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China; The Department of Physiology and Pathological Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. · The Department of Physiology and Pathological Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. · The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. · Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China. · Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China. · Faculty of Life Sciences & Medicine, School of Immunology & Microbial Sciences, Department of Inflammation Biology, Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK. · The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address: wy_robin@ccmu.edu.cn. · The Department of Respirology, Capital Medical University, Beijing, China. ·EBioMedicine · Pubmed #29921553.

ABSTRACT: IL-33 may play a role in the vascular remodelling of hypoxic pulmonary hypertension (PH) but the precise mechanisms are still unclear. We hypothesized that hypoxia promotes expression of IL-33 and its receptor ST2 on vascular endothelial cells, which in turn leads to dysfunction of vascular endothelial cells and smooth muscle cells contributing to PH. Immunohistochemistry showed that immunoreactivity for IL-33 and ST2 was significantly increased in lung tissue of murine model of hypoxia-induced PH (HPH) and of subjects with bronchiectasis-PH. trans-Thoracic echocardiography showed that haemodynamic changes and right ventricular hypertrophy associated with HPH were significantly abrogated in St2

11 Article Right ventricle performances with echocardiography and 2018

Liu, Jie / Fei, Lei / Huang, Guang-Qing / Shang, Xiao-Ke / Liu, Mei / Pei, Zhi-Jun / Zhang, Yong-Xue. ·1 Department of Nuclear Medicine, Tongji Medical College, Huazhong University of Science and Technology, Union Hospital, Wuhan 430022, China. · 2 Hubei Key Laboratory of Molecular Imaging, Tongji Medical College, Huazhong University of Science and Technology, Union Hospital, Wuhan 430022, China. · 3 Department of Ultrasound Diagnosis, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China. · 4 Department of Cardiac Surgery, Tongji Medical College, Huazhong University of Science and Technology, Union Hospital, Wuhan 430022, China. · 5 Department of PET Center, Hubei University of Medicine, Taihe Hospital, Shiyan 442000, China. ·Exp Biol Med (Maywood) · Pubmed #29763366.

ABSTRACT: Right heart catheterization is commonly used to measure right ventricle hemodynamic parameters and is the gold standard for pulmonary arterial hypertension diagnosis; however, it is not suitable for patients' long-term follow-up. Non-invasive echocardiography and nuclear medicine have been applied to measure right ventricle anatomy and function, but the guidelines for the usefulness of clinical parameters remain to be established. The goal of this study is to identify reliable clinical parameters of right ventricle function in pulmonary arterial hypertension patients and analyze the relationship of these clinical parameters with the disease severity of pulmonary arterial hypertension. In this study, 23 normal subjects and 23 pulmonary arterial hypertension patients were recruited from January 2015 to March 2016. Pulmonary arterial hypertension patients were classified into moderate and severe pulmonary arterial hypertension groups according to their mean pulmonary arterial pressure levels. All the subjects were subjected to physical examination, chest X-ray, 12-lead electrocardiogram, right heart catheterization, two-dimensional echocardiography, and technetium 99m (

12 Article Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults. 2017

Liu, Jie / Jia, Xin / Jia, Senhao / Qin, Xianhui / Zhang, Tao / Liu, Lishun / Li, Haibo / Rong, Dan / Zhou, Ziyi / Song, Yuxiang / Zuo, Shangwei / Duan, Chen / Wu, Zhongyin / Wei, Ren / Ge, Yangyang / Wang, Xian / Kong, Wei / Xu, Xiping / Khalil, Raouf A / Huo, Yong / Guo, Wei. ·Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China. · Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. · National Center for Clinical Research in Kidney Disease, Guangdong Institute of Nephrology, Southern Medical University, Guangzhou, China. · Department of Vascular Surgery, Peking University People's Hospital, Beijing, China. · Institute of Biomedicine, Anhui Medical University, Hefei, China. · Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China. · Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. · Department of Cardiology, Peking University First Hospital, Beijing, China. huoyong@263.net.cn. · Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China. pla301dml@vip.sina.com. ·Sci Rep · Pubmed #29109408.

ABSTRACT: Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle-brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29-1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73-1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.

13 Article Uncontrolled Hypertension Increases with Age in an Older Community-Dwelling Chinese Population in Shanghai. 2017

Peng, Sheng / Shen, Ting / Liu, Jie / Tomlinson, Brian / Sun, Huimin / Chen, Xiaoli / Chan, Paul / Kuang, YaShu / Zheng, Liang / Wu, Hong / Ding, Xugang / Qian, Dingguang / Shen, Yixin / Gao, Pingjin / Fan, Huimin / Liu, Zhongmin / Zhang, Yuzhen. ·1Key Laboratory of Arrhythmias, Ministry of Education, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. · 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. · 3Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. · 4Gaohang Community Medical Center, Shanghai, 201208, China. · 5Shanghai Hypertension Institute, Rui Jin Hospital, JiaoTong Univeristy School of Medicine, Shanghai, 200120, China. ·Aging Dis · Pubmed #28966801.

ABSTRACT: We determined the prevalence of hypertension, medication usage and attainment of blood pressure goals in older (≥65 to <80 years and ≥80 years) urban community-dwelling Chinese subjects. Data were obtained in 3950 subjects (mean age 72.0 years, 1745 male) including 609 subjects aged ≥80 years in the Shanghai Elderly Cardiovascular Health Study (SHECHS). Established cardiovascular disease was present in 7.7% of participants. The prevalence of hypertension was 74.8% overall and it was more than 80% in individuals considered to be in moderate and higher cardiovascular disease risk categories. In hypertensive subjects, 67.1% were on treatment and treatment was more frequent in high and very high cardiovascular risk individuals. Attainment of the systolic blood pressure goal <150 mmHg was 62.9% and was greater in the ≥65 to <80 years group than in the ≥80 years group. The most commonly used antihypertensive treatments were calcium channel blockers (54.2%), followed by angiotensin receptor blockers (43.1%). Diuretics were used in 2.6%. Fixed-dose combination antihypertensive tablets were used in some of the ≥65 to <80 years group (12.4%) and more of the ≥80 years group (18.2%) and 70.9% of the ≥65 to <80 years group and 80.2% of the ≥80 years group were on monotherapy. There were high prevalence and high treatment rates of hypertension, but poor attainment of the systolic blood pressure goal of <150 mmHg, especially in the ≥80 years group of community-dwelling Chinese. Considering that more intensive treatment of hypertension in older subjects may be warranted after recent studies, this might be achieved by more frequent use of combinations of effective therapies and diuretics.

14 Article Correlation between the trajectory of systolic blood pressure and new renal damage in a nonhypertensive population. 2017

Wang, Zhi-Jun / Jia, Dao / Tian, Jun / Liu, Jie / Li, Li-Jie / Huang, Yu-Ling / Cao, Xin-Ying / Ning, Chun-Hong / Zhao, Quan-Hui / Yu, Jun-Xing / Zhang, Rui-Ying / Zhang, Ya-Jing / Gao, Jing-Sheng / Wu, Shou-Ling. ·Departments of aCardiovasology bEmergency Medicine, North China University of Science and Technology Affiliated Hospital cKailuan General Hospital of Tangshan, Tangshan, China. ·Blood Press Monit · Pubmed #28763331.

ABSTRACT: OBJECTIVE: This study aims to investigate the correlation between the trajectory of systolic blood pressure (SBP) and new renal damage in a nonhypertensive population. PATIENTS AND METHODS: This prospective cohort study included a total of 14 382 nonhypertensive individuals, employees of Kailuan Group of Companies, who took part in five healthy examinations in 2006-2007, 2008-2009, 2010-2011, 2012-2013, and 2014-2015, and had complete data. These individuals were divided into four groups according to the different trajectories of SBP: low-low, low-stable, middle-high, and high-high groups. The correlation between the trajectory of SBP and new renal damage in a nonhypertensive population was analyzed using a multivariate Cox's proportional hazard regression model. RESULTS: (a) A total of 14 382 individuals had complete data and the average age of these individuals was 44.6±10.8 years. Among these, 10 888 (75.7%) individuals were men and 3494 (24.3%) individuals were women. (b) These individuals were divided into four groups according to different trajectories of blood pressure: low-low group, accounting for 13.15% (blood pressure was <106 mmHg); low-stable group, accounting for 53.91% (blood pressure was between 115 and 116 mmHg); middle-high group, accounting for 28.77% (blood pressure was between 125 and 131 mmHg); and high-high group, accounting for 4.6% (blood pressure was between 126 and 151 mmHg). (c) With the increase in the trajectory of SBP, the detection rate of renal damage increased gradually. From the low-low group to the high-high group, the detection rates of estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m were 2.3, 2.4, 3.6, and 4.3%, respectively; the positive rates of urinary protein were 1.7, 2.9, 3.8, and 5.5%, respectively; and the detection rates of eGFR less than 60 ml/min/1.73 m or positive urinary protein were 4, 5.2, 7.3, and 9.3%, respectively (P<0.05). (d) After adjustment for other confounding factors, multivariate Cox's proportional hazard regression analysis showed that compared with the low-low group, the risk of eGFR less than 60 ml/min/1.73 m increased by nearly 1.5 times in the high-high group and in the low-stable, middle-high, and high-high groups, the risks of positive urinary protein, eGFR less than 60 ml/min/1.73 m, or positive urinary protein increased by 1.48-2.34 and 1.20-1.70 times, respectively. CONCLUSION: In a nonhypertensive population, the high trajectory of SBP is a risk factor for kidney damage.

15 Article Left Ventricular Fibrosis and Systolic Hypertension Persist in a Repaired Aortic Coarctation Model. 2017

Liu, Jie / Drak, Douglas / Krishnan, Anish / Chen, Sing-Young / Canniffe, Carla / Bao, Shisan / Denyer, Gareth / Celermajer, David S. ·Department of Physiology, The University of Sydney, Camperdown, Australia. Electronic address: liujie@physiol.usyd.edu.au. · Department of Physiology, The University of Sydney, Camperdown, Australia; Sydney Medical School, The University of Sydney, Camperdown, Australia. · Department of Physiology, The University of Sydney, Camperdown, Australia. · School of Molecular Bioscience, The University of Sydney, Camperdown, Australia. · Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, Australia. · Department of Pathology, The University of Sydney, Camperdown, Australia. · Sydney Medical School, The University of Sydney, Camperdown, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, Australia. ·Ann Thorac Surg · Pubmed #28554563.

ABSTRACT: BACKGROUND: Despite successful repair in early life, patients with coarctation of the aorta (CoA) are predisposed to several cardiovascular complications in later life related to systemic hypertension or left ventricular (LV) dysfunction, or both, the pathogenesis of which is unclear. METHODS: Three-week-old Sprague-Dawley rats underwent transverse aortic constriction (TAC) or a sham operation, with release of the constriction 3 weeks later. Twenty-five weeks after the repair operation, animals underwent hemodynamic assessment, LV gene profiling, and histologic analysis. RESULTS: Animals with repaired aortic constriction exhibited a significantly elevated central systolic pressure (116 ± 5 mm Hg vs 103 ± 4 mm Hg; p < 0.05) despite the absence of any significant pressure gradient across the former constriction site compared with shams (5 ± 4 mm Hg vs 0 ± 2 mm Hg; p = 0.2). They also had more than a 2-fold increase in LV collagen deposition (4.86% ± 0.24% vs 2.40% ± 0.18%; p < 0.001). However, no significant differences were noted between the groups in maximum LV pressure (116 ± 3 mm Hg vs 107 ± 3 mm Hg; p = 0.1), LV mass indexed to tibial length (p = 0.07), or myocyte size. There was no significant differential expression of hypertrophy or fibrosis-related genes in the left ventricles of the repaired animals compared with shams. CONCLUSIONS: Despite successful early relief of simulated CoA in early life, relative hypertension and LV fibrosis were demonstrable late consequences in this animal model. This abnormal fibrosis persists in the absence of altered LV hemodynamics and gene expression.

16 Article Tongxinluo improves cognition by decreasing β-amyloid in spontaneous hypertensive rats. 2017

Fei, Yu-Lang / Lv, Hong-Jun / Li, Yan-Bo / Liu, Jie / Qian, Yi-Hua / Yang, Wei-Na / Ma, Kai-Ge / Li, Hong-Bao / Qu, Qiu-Min. ·Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: pwzhang@stu.xjtu.edu.cn. · Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: njdxbjdx@163.com. · Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: yanboli@qq.com. · Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: 546416936@qq.com. · Department of Anatomy, Histology & Embryology, Medicine School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: qianyh38@mail.xjtu.edu.cn. · Department of Anatomy, Histology & Embryology, Medicine School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: wn_yang@mail.xjtu.edu.cn. · Department of Anatomy, Histology & Embryology, Medicine School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: 411652457@qq.com. · Department of Physiology and Pathophysiology, Basic Medical Sciences School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: hongbaoli1985@163.com. · Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: quqiumin@medmail.com.cn. ·Brain Res · Pubmed #28274609.

ABSTRACT: β-Amyloid (Aβ) accumulation in the brain is the major pathophysiology of Alzheimer disease (AD). Hypertension is a risk factor for AD by promoting Aβ deposition. Traditional Chinese medicinal compound tongxinluo (TXL) can improve blood circulation and endothelium-dependent vasodilation. This study investigates the effects of TXL on cognition and Aβ using spontaneously hypertensive rats (SHRs). TXL was intragastrically administered to SHRs at low-dose, mid-dose and high-dose for 15, 30 or 60days. Cognition was evaluated with a Morris Water Maze (MWM). Aβ in the brain was detected by western blot, ELISA and Thioflavin-S staining. Western blot and RT-PCR were employed to exam the expression of receptor for advanced glycation end products (RAGE), low-density lipoprotein receptor-related protein-1 (LRP-1) and amyloid precursor protein (APP). After TXL treatment for 60days, compared with the vehicle, the number of crossed platform and the time spent in the target quadrant increased in parallel with the increasing length of treatment in MWM. Moreover, the Aβ in the hippocampus significantly decreased compared to the vehicle group, both in western blot and ELISA. Additionally, TXL reduced RAGE expression in a dose- and time-depended manner, but LRP-1 expression had no difference between TXL groups and vehicle groups. Furthermore, the β-secretase expression was significantly decreased compared to the vehicle group, but APP expression had no difference. In conclusion, TXL improved cognition and decreased Aβ in SHRs in a dose- and time-dependent manner, the underlying mechanism may involved in inhibiting RAGE and β-secretase expression.

17 Article Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45. 2017

Wang, Xin / Gao, Ming / Zhou, Shanshan / Wang, Jinwen / Liu, Fang / Tian, Feng / Jin, Jing / Ma, Qiang / Xue, Xiaodi / Liu, Jie / Liu, Yuqi / Chen, Yundai. ·Department of Health Statistics, School of Public Health, Fourth Military Medical University, Xi'an, Shanxi Province, China. · Center For Disease Control And Prevention Of The PAP, Beijing, China. · Department of Cardiology, PLA General Hospital, Beijing, 100853, China. · ICU of The first phase Beijing Tsinghua Changgeng Hospital, Beijing, 100044, China. · AnZhen Hospital, Capital Medical University, Beijing, 100029, China. · Department of Cardiology of AnZhen Hospital, Beijing, 100029, China. · Department of Cardiology, PLA General Hospital, Beijing, 100853, China. ametuofo980869@163.com. · Department of Cardiology, PLA General Hospital, Beijing, 100853, China. cyundai@vip.163.com. ·BMC Cardiovasc Disord · Pubmed #28061763.

ABSTRACT: BACKGROUND: The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend is an important contemporary public health issure. METHODS: A total of 5288 patients (≤45 years) diagnosed with CHD and hospitalized at the Chinese PLA General Hospital and Anzhen Hospital, both in Beijing, were enrolled after satisfying the inclusion criteria. RESULTS: Young CHD patients increased in number from 2010 to 2014, especially men. Among the studied patients, there was no significant change over those years in blood pressure, but heart rate increased significantly (P < 0.05) and body mass index showed a rising trend (P > 0.05). The incidence of hypertension increased from 40.7 to 47.5%, diabetes from 20.3 to 26.1%, and hyperlipidemia from 27.3 to 35.7% (P < 0.05). However, the incidences of smoking and drinking both trended downward (P < 0.05). The levels of total cholesterol and triglycerides also showed a downward trend (P < 0.05), as did levels of low-density lipoprotein, but not to the point of statistical significance (P > 0.05). Mortality during hospitalization decreased significantly from 2010 to 2014 (P < 0.05), but there was no significant improvement in the incidences of cardiac death and major adverse cardiovascular events (MACE) after 1-year follow-up (P > 0.05). CONCLUSIONS: Over the 5 years studied, the overall incidence of cardiac death and MACE for young CHD patients (≤45 years) has shown little improvement. Secondary prevention of young CHD, and its risk factors, as well as appropriate courses of medical treatment must be further elucidated.

18 Article [Methods from Huangdi Neijing for treatment of hypertension]. 2016

Liu, Jie / Lin, Min / Lyu, Deke. · ·Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Pubmed #29919987.

ABSTRACT: -- No abstract --

19 Article IP 2016

Lin, Qingsong / Zhao, Guiling / Fang, Xi / Peng, Xiaohong / Tang, Huayuan / Wang, Hong / Jing, Ran / Liu, Jie / Lederer, W Jonathan / Chen, Ju / Ouyang, Kunfu. ·Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China. · Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA. · University of California San Diego, School of Medicine, Department of Medicine, La Jolla, California, USA. · Xiangya Hospital, Central South University, Changsha, China. · Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen, China. ·JCI Insight · Pubmed #27777977.

ABSTRACT: Inositol 1, 4, 5-trisphosphate receptor-mediated (IP

20 Article Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats. 2016

Xu, Tao / Zhang, Zhifei / Liu, Ting / Zhang, Wei / Liu, Jie / Wang, Wang / Wang, Jun. ·Department of Physiology and Pathophysiology, Capital Medical University School of Basic Medical Sciences, Beijing, People's Republic of China; Central Laboratory, Jinzhou Medical University, Jinzhou, People's Republic of China. · Department of Physiology and Pathophysiology, Capital Medical University School of Basic Medical Sciences, Beijing, People's Republic of China. Electronic address: zhifeiz@ccmu.edu.cn. · Department of Physiology and Pathophysiology, Capital Medical University School of Basic Medical Sciences, Beijing, People's Republic of China. · Department of Physiology and Pathophysiology, Capital Medical University School of Basic Medical Sciences, Beijing, People's Republic of China. Electronic address: wang_jun@ccmu.edu.cn. ·J Thorac Cardiovasc Surg · Pubmed #27353339.

ABSTRACT: OBJECTIVE: Inflammation is closely linked to pulmonary arterial hypertension (PAH). Salusin-β, a bioactive peptide, has been reported to participate in vascular inflammation. We therefore hypothesized that salusin-β contributes to monocrotaline (MCT)-induced PAH in rats. METHODS: Male Sprague-Dawley rats were treated with MCT (60 mg kg(-1), single intraperitoneal injection). Salusin-β expression in the lungs of the MCT-treated rats was evaluated using immunofluorescence staining, western blot, and real-time PCR. For salusin-β blockade assay, rats injected with MCT were given a chronic infusion of anti-salusin-β immunoglobulin G (IgG) (salusin-β blocker, 1.0 μg kg(-1) h(-1)) or isotype-matched control IgG. Four weeks after MCT+anti-salusin-β treatment, the effects of salusin-β blockade were determined using hemodynamics, western blot, real-time PCR, and immunohistochemical detection. The effect of salusin-β on human pulmonary arterial endothelial cell (HPAEC) function was detected by adhesion and tube formation experiments in vitro. RESULTS: Salusin-β expression was significantly increased in the lungs of the MCT-treated rats, and immunofluorescence results showed that salusin-β was predominantly expressed in pulmonary macrophages and vascular endothelial cells. Salusin-β blockade significantly ameliorated PAH by acting against pulmonary vascular remodeling, decreasing macrophage infiltration, and reducing pro-inflammatory cytokine expression and nuclear factor-kappa B (NF-κB) activity in the lungs of the MCT-treated rats. In addition, salusin-β could induce cell adhesion and accelerate angiogenesis by activating the NF-κB pathway and promoting pro-inflammatory cytokine expression in the cultured HPAECs. This effect was suppressed by addition of the NF-κB inhibitor, N-acetyl-L-cysteine. CONCLUSIONS: Salusin-β plays a crucial role in the development of MCT-induced PAH models.

21 Article Risk factors for and occurrence of postoperative cervical hematoma after thyroid surgery: A single-institution study based on 5156 cases from the past 2 years. 2016

Liu, Jie / Li, Zhengjiang / Liu, Shaoyan / Wang, Xiaolei / Xu, Zhengang / Tang, Pingzhang. ·Department of Head and Neck Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Science (CAMS), Beijing, China. ·Head Neck · Pubmed #25225123.

ABSTRACT: BACKGROUND: The occurrence of and risk factors for postoperative cervical hematoma remain unclear. METHODS: We conducted a retrospective analysis of 5156 patients treated at a single institution. RESULTS: The occurrence of postoperative cervical hematoma was 0.85% (44 of 5156 patients). The multivariate analysis showed that male sex, benign pathology, hypertension, and previous thyroid surgery are individual risk factors with odds ratios of 1.906, 2.004, 7.962, and 4.407, respectively. The majority (88.7%) of hematomas occurred within 12 hours after surgery. Obvious bleeding points were detected in 28 cases (73.6%) during reexploration, surface of the strap muscle, superior thyroid vessel, and end of the recurrent laryngeal nerve were the most frequent bleeding sources. CONCLUSION: Hematoma often occurs within 12 hours after thyroid surgery. Hypertension, previous thyroid surgery, male sex, and benign pathology may increase the risk of hematoma.

22 Article Red cell distribution width is increased in chronic thromboembolic pulmonary hypertension. 2016

Wang, Wang / Liu, Jie / Yang, Yuan-hua / Zhai, Zhen-guo / Wang, Chen / Wang, Jun. ·Department of Physiology, Capital Medical University, Beijing, China. · Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Capital Medical University, Beijing, China. · Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. · Beijing Hospital, Ministry of Health, Beijing, China. ·Clin Respir J · Pubmed #24989160.

ABSTRACT: INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary embolisms, which promotes pulmonary vascular remodeling. There is significant relationship between red cell distribution width (RDW) and pulmonary hypertension; however, the usefulness of RDW as biomarker for the diagnosis of CTEPH remains poorly defined. OBJECTIVE: This study sought to assess the change and the diagnostic value of RDW in CTEPH. METHODS: This retrospective study included 56 CTEPH patients and 56 sex- and age-matched healthy controls treated at Beijing Chao-Yang Hospital. Correlations between RDW and hematological and hemodynamic parameters were assessed. A logistic regression model was applied to test independent parameters in relation to the diagnosis of CTEPH, and receiver operating characteristic curve was plotted to determine the diagnostic value of RDW in CTEPH. RESULTS: RDW values were significantly higher in CTEPH patients (13.82% ± 1.14%) compared with healthy controls (12.75% ± 0.49%) and in World Health Organization (WHO), functional class III-IV cases (14.39% ± 1.24%) compared with class I-II cases (13.32% ± 0.78%) (both P = 0.000). RDW levels in CTEPH patients showed negative correlations with hemoglobin (r = -0.357, P = 0.007) and cardiac index (r = -0.288, P = 0.031), and positive correlations with pulmonary vascular resistance (r = 0.292, P = 0.029) and WHO functional class (r = 0.450, P = 0.001). Moreover, RDW was an independent parameter in the diagnosis of CTEPH (95% confidence interval: 2.866-13.698, P = 0.000); in particular, an RDW level ≥ 13.05% was the most useful cut-off value, with a sensitivity of 82.1% and a specificity of 71.4%. CONCLUSION: Increased RDW level may be an acceptable diagnostic parameter for CTEPH.

23 Article The Expanding Burden of Elevated Blood Pressure in China: Evidence From Jiangxi Province, 2007-2010. 2015

Xu, Gang / Liu, Junxiu / Liu, Shiwei / Zhou, Haiming / Orekoya, Olubunmi / Liu, Jie / Li, Yichong / Tang, Ji / Zhou, Chunlian / Huang, Jiuling. ·From the Department of Preventive Medicine, School of Basic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China (GX, JH) · Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA (JL, OO) · National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China (SL, YL) · Department of Statistics, University of South Carolina, Columbia, South Carolina, USA (HZ) · Division of Chronic Disease Control and Prevention, Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi, China (JL) · Chinese Preventive Medicine Association, Beijing, China (JT) · and Department of Nosocomial Infectious Prevention and Control, Beijing Friendship Hospital, Capital Medical University, Beijing, China (CZ). ·Medicine (Baltimore) · Pubmed #26426647.

ABSTRACT: Elevated blood pressure (BP) as a risk factor accounts for the biggest burden of disease worldwide and in China. This study aimed to estimate attributed mortality and life expectancy (LE) to elevated BP in Jiangxi province between 2007 and 2010. BP and mortality data (2007 and 2010 inclusive) were obtained from the National Chronic Diseases and Risk Factors Surveillance Survey and Disease Surveillance Points system, respectively. Population-attributable fraction used in comparative risk assessment of the Global Burden of Disease study 2010 were followed to quantify the attributed mortality to elevated BP, subsequently life table methods were applied to estimate its effects on LE. Uncertainty analysis was conducted to get 95% uncertainty intervals (95% uncertainty interval [UI]) for each outcome. There are 35,482 (95% UI: 31,389-39,928) and 47,842 (42,323-53,837) deaths in Jiangxi province were caused by elevated BP in 2007 and 2010, respectively. 2.24 (1.87-2.65) years of LE would be gained if all the attributed deaths were eliminated in 2007, and increased to 3.04 (2.52-3.48) in 2010. If the mean value of elevated BP in 2010 was decreased by 5 and 10 mm Hg, 5324 (4710-5991) and 11,422 (10,104-12,853) deaths would be avoided, with 0.41 (0.37-0.48) and 0.85 (0.71-1.09) years of LE gained, respectively. The deaths attributable to elevated BP in Jiangxi province has increased by 35% from 2007 to 2010, with 0.8 years of LE loss, suggesting the necessity to take actions to control BP in Chinese population.

24 Article [Association between urinary microalbumin-to-creatinine ratio and brachial-ankle pulse wave velocity in hypertensive patients]. 2015

Zhu, Hang / Xue, Hao / Wang, Guangyi / Fu, Zhenhong / Liu, Jie / Shi, Yajun. ·Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. · Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Email: xuehao301@hotmail.com. ·Zhonghua Xin Xue Guan Bing Za Zhi · Pubmed #26082361.

ABSTRACT: OBJECTIVE: To explore the association between urinary microalbumin-to-creatinine ratio (ACR) and brachial-ankle pulse wave velocity (baPWV) in hypertensive patients. METHODS: A total of 877 primary hypertension patients were enrolled in this trial from September 2009 to December 2012, and were randomly recruited and patients were divided into normal ACR group (ACR < 30 mg/g, n = 723), micro-albuminuria group (30 mg/g ≤ ACR < 300 mg/g, n = 136) and macro-albuminuria group (ACR ≥ 300 mg/g, n = 18). baPWV was measure by automatic pulse wave velocity measuring system. RESULTS: The baPWV values in patients of micro-albuminuria group and macro-albuminuria group were significantly higher than in the normal ACR group (all P < 0.05). The baPWV value of macro-albuminuria group was significantly higher than in the micro-albuminuria group (P < 0.05). Linear correlation analysis revealed that ACR was positively correlated with baPWV (r = 0.413, P < 0.01). Multiple linear regression analysis showed that ACR independently correlated with baPWV in patients with primary hypertension (β = 0.29, R(2) = 0.112, P < 0.01) after adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, blood glucose, total cholesterol, low density lipoprotein, high density lipoprotein and triglyceride. Using ACR < 30 mg/g and ACR ≥ 30 mg/g as dichotomous variable, binary logistic regression analysis showed that ACR ≥ 30 mg/g was also a risk factor of the ascending baPWV in primary hypertension patients (OR: 1.73, 95% CI: 1.62-2.98) after adjusting the traditional cardiovascular risk factors. CONCLUSION: ACR is positively correlated to baPWV in primary hypertension patients, and the ascending baPWV is a risk factor of early renal dysfunction in primary hypertension patients.

25 Article Wnt5a attenuates hypoxia-induced pulmonary arteriolar remodeling and right ventricular hypertrophy in mice. 2015

Jin, Yuling / Wang, Wang / Chai, Sanbao / Liu, Jie / Yang, Ting / Wang, Jun. ·Department of Physiology, Capital Medical University, Beijing 100069, P.R. China. · Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100016, P.R. China wang_jun@ccmu.edu.cn dryangting@gmail.com. · Department of Physiology, Capital Medical University, Beijing 100069, P.R. China wang_jun@ccmu.edu.cn dryangting@gmail.com. ·Exp Biol Med (Maywood) · Pubmed #25956683.

ABSTRACT: Hypoxic pulmonary hypertension (HPH), which is characterized by pulmonary arteriolar remodeling and right ventricular hypertrophy, is still a life-threatening disease with the current treatment strategies. The underlying molecular mechanisms of HPH remain unclear. Our previously published study showed that Wnt5a, one of the ligands in the Wnt family, was critically involved in the inhibition of hypoxia-induced pulmonary arterial smooth muscle cell proliferation by downregulation of β-catenin/cyclin D1 in vitro. In this study, we investigated the possible functions and mechanisms of Wnt5a in HPH in vivo. Recombinant mouse Wnt5a (rmWnt5a) or phosphate buffered saline (PBS) was administered to male C57/BL6 mice weekly from the first day to the end of the two or four weeks after exposed to hypoxia (10% O2). Hypoxia-induced pulmonary hypertension was associated with a marked increase in β-catenin/cyclin D1 expression in lungs. Right ventricular systolic pressure and right ventricular hypertrophy index were reduced in animals treated with rmWnt5a compared with PBS. Histology showed less pulmonary vascular remodeling and right ventricular hypertrophy in the group treated with rmWnt5a than with PBS. Treatment with rmWnt5a resulted in a concomitant reduction in β-catenin/cyclin D1 levels in lungs. These data demonstrate that Wnt5a exerts its beneficial effects on HPH by regulating pulmonary vascular remodeling and right ventricular hypertrophy in a manner that is associated with reduction in β-catenin/cyclin D1 signaling. A therapy targeting the β-catenin/cyclin D1 signaling pathway might be a potential strategy for HPH treatment.

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