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Hypertension: HELP
Articles by Ying Wang
Based on 46 articles published since 2010
(Why 46 articles?)
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Between 2010 and 2020, Ying Wang wrote the following 46 articles about Hypertension.
 
+ Citations + Abstracts
Pages: 1 · 2
1 Review Dietary factors associated with hypertension. 2011

Zhao, Dong / Qi, Yue / Zheng, Zheng / Wang, Ying / Zhang, Xiu-Ying / Li, Hong-Juan / Liu, Hai-Hang / Zhang, Xiao-Ting / Du, Jie / Liu, Jing. ·Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, 2 Anzhen Street, Chaoyang District, Beijing, 100029, China. deezhao@vip.sina.com ·Nat Rev Cardiol · Pubmed #21727918.

ABSTRACT: Hypertension is one of the major risk factors for cardiovascular disease, with an impact on global health. Multiple studies have suggested that various dietary factors are associated with blood pressure (BP) and hypertension. The purpose of this Review is to provide up-to-date knowledge on the impact of dietary factors on BP and hypertension, to compare types and recommended intakes of dietary factors in hypertension management and prevention guidelines from different countries and organizations, and to outline global population-based healthy-diet strategies for hypertension control. Of the 27 dietary factors we evaluated on the basis of specified review criteria, 17 have been proposed to have protective effects against hypertension, six were proposed to be risk factors for hypertension, and the association between BP and the remaining factors was considered inconclusive. Excessive sodium intake is a causal risk factor for hypertension, whereas a diet rich in fruit, vegetables, and low-fat dairy products, and low in sodium and saturated fat has been recommended to prevent and reduce hypertension on the basis of strong evidence. Notable differences exist in the recommended types and intakes of dietary factors among available hypertension management and prevention guidelines. Available evidence supports the vigorous implementation of dietary strategies against hypertension through population-based, national action plans.

2 Clinical Trial A Nested Case-Control Study of Association between Metabolome and Hypertension Risk. 2016

Hao, Yongchen / Wang, Ying / Xi, Lu / Li, Guoqi / Zhao, Fan / Qi, Yue / Liu, Jing / Zhao, Dong. ·Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China. ·Biomed Res Int · Pubmed #27119083.

ABSTRACT: We aimed to explore novel small metabolites that associated with hypertension risk in a population-based nested case-control study. Among 460 individuals with optimal blood pressure (<120/80 mmHg) at baseline, 55 progressed to hypertension during 5 years of follow-up. Twenty-nine cases of incident hypertension and 29 controls, matched for age, sex, and baseline systolic blood pressure, were included in this study. Serum metabolites were measured by gas chromatography-tandem mass spectrometry. t-test and logistic regression analysis were applied to investigate the association between metabolites and incident hypertension. Among the 241 metabolites identified in this study, baseline levels of 26 metabolites were significantly different between hypertension and control groups. After adjusting for body mass index, smoking, and drinking, 16 out of the 26 metabolites were still associated with hypertension risk including four amino acids. Amino acids were negatively associated with risk of future hypertension, with odds ratio (OR) ranging from 0.33 to 0.53. Two of these amino acids were essential amino acids including threonine and phenylalanine. Higher level of lyxose, a fermentation product of gut microbes, was associated with higher risk of hypertension. Our study identified multiple metabolites that associated with hypertension risk. These findings implied that low amino acid levels and gut microbiome might play an important role in the pathogenesis of hypertension.

3 Article Blood pressure and heart rate variability and baroreflex sensitivity in white-coat, masked, and sustained hypertension. 2020

Sheng, Chang-Sheng / Li, Fei-Ka / Cheng, Yi-Bang / Wei, Fang-Fei / Huang, Jian-Feng / Guo, Qian-Hui / Zhang, Dong-Yan / Wang, Ying / An, De-Wei / Huang, Qi-Fang / Li, Yan / Wang, Ji-Guang. ·Centre for Epidemiological Studies and Clinical Trials and Centre for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · Centre for Epidemiological Studies and Clinical Trials and Centre for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. jiguangwang@aim.com. ·Hypertens Res · Pubmed #32051566.

ABSTRACT: We investigated blood pressure (BP) and heart rate variability and baroreflex sensitivity (BRS) in white-coat, masked and sustained hypertension in untreated patients (n = 645). Normotension and white-coat, masked, and sustained hypertension were defined according to the clinic (cutoff 140/90 mmHg) and 24-h ambulatory (130/80 mmHg) BPs. The Finometer device recorded beat-to-beat finger BP and electrocardiograms in the supine and standing positions for the computation of frequency-domain power-spectral BP and heart rate variability indexes and BRS. In multivariate analysis, BP variability indexes in the supine position differed significantly (P < 0.0001) for both low-frequency (LF) and high-frequency (HF) components and the LF/HF ratio, with the lowest LF and HF power and highest LF/HF ratio in white-coat hypertension (n = 28), the highest LF and HF power and lowest LF/HF ratio in sustained hypertension (n = 198), and intermediate values in normotension (n = 189) and masked hypertension (n = 230). These differences diminished in the standing position, being significant (P < 0.0001) only for the LF component variability. The LF/HF ratio in BP in the supine position decreased with advancing age in normotension and sustained hypertension (P ≤ 0.03) but not white-coat or masked hypertension (P ≥ 0.12). For heart rate variability, a significant difference was observed only for the LF component in the supine position (P = 0.0005), which was lowest in white-coat hypertension. BRS in masked and sustained hypertension was significantly (P ≤ 0.0001) lower than that in normotension in both supine and standing positions and decreased with advancing age (P ≤ 0.0001). In conclusion, masked, but not white-coat, hypertension showed similar patterns of, but slightly less severe, changes in BP and heart rate variability and BRS to sustained hypertension.

4 Article Sauchinone inhibits angiotensin II-induced proliferation and migration of vascular smooth muscle cells. 2020

Wang, Ying / Li, Xiaoming / Huang, Xuying / Ma, Sirui / Xing, Yue / Geng, Xiaoying / He, Xu. ·Department of Intensive Care Medicine, Xi'an No.4 Hospital, Shaanxi, China. · Department of Emergency, Xi'an No.4 Hospital, Shaanxi, China. · Department of Ultrasound, Xi'an No.4 Hospital, Shaanxi, China. · Department of Cardiology, Yulin No.2 Hospital, Shaanxi, China. ·Clin Exp Pharmacol Physiol · Pubmed #31587339.

ABSTRACT: Hypertension is a common type of cardiovascular disease that remains a major cause of death in the world. Vascular remodelling is an important complication of hypertension, and vascular smooth muscle cells (VSMCs) play a major role in vascular remodelling. Sauchinone is one of the active lignins which has been found to possess vascular protective effects. However, the functional role of sauchinone in hypertension has not been investigated. The aim of this study was to evaluate the role of sauchinone in the angiotensin II (Ang II)-induced vascular remodelling model in VSMCs. The results showed that treatment of sauchinone inhibited Ang II-induced VSMCs proliferation and migration in VSMCs. Sauchinone treatment suppressed the reactive oxygen species (ROS) production and NADPH oxidase (NOX) activity in Ang II-induced VSMCs. The inhibitory effects of Ang II on expressions of VSMCs phenotype markers including α-smooth muscle actin (α-SMA), calponin, osteopontin were mitigated by sauchinone treatment. Furthermore, sauchinone inhibited Ang II-induced over-activation of TGF-β1/Smad3 signalling pathway in VSMCs. Taken together, this study identified sauchinone as a potential agent for preventing vascular remodelling in hypertension.

5 Article Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension. 2019

Miao, Ran / Gong, Juanni / Zhang, Chunyang / Wang, Ying / Guo, Xiaojuan / Li, Jifeng / Yang, Suqiao / Kuang, Tuguang / Zhong, Jiuchang / Feng, Huasong. ·Medical School of Chinese People's Liberation Army, 28 Fuxing Road, Beijing, 100853, China. · Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. · Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. · Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. · Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. · Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, No.8 South Gongti Road, Beijing, 100020, China. jiuchangzhong@aliyun.com. · Medical School of Chinese People's Liberation Army, 28 Fuxing Road, Beijing, 100853, China. fenghs99@163.com. ·J Thromb Thrombolysis · Pubmed #31776848.

ABSTRACT: The present study was performed to screen for potential molecular biomarkers and to assess the underlying mechanisms of chronic thromboembolic pulmonary hypertension (CTEPH) by using sequencing data analysis of microRNAs (miRNAs) and circular RNAs (circRNAs). Total RNA was isolated from peripheral-blood samples from five CTEPH patients and from five normal individuals. Based upon the identification of differentially expressed miRNAs (Affymetrix miRNA chip) and circRNAs (Agilent circRNA chip), target predictions for these differentially expressed miRNAs and functional enrichment analyses of the miRNAs and circRNAs were performed. Subsequently, the miRNA partner predictions of these differentially expressed circRNAs and co-expression analyses of differentially expressed circRNAs and miRNAs were conducted. Based on the results of these analyses, a competing endogenous RNA (ceRNA) network was constructed. Finally, the expression of circRNAs was detected by quantitative real-time PCR (qRT-PCR). Within the miRNA-circRNA regulatory network, hsa_circ_0026480 and hsa_circ_0046159 were predicted to interact with miR-27a-3p and miR-1226-3p, respectively with greater degree. Specially, ATP2A2-that had a ceRNA relationship with hsa_circ_0046159-was predicted as a target of miR-1226-3p. The results of RT-PCR also revealed a significantly increased expression of hsa_circ_0046159 in CTEPH samples than that in normal samples.

6 Article Short-term effects of ambient particulate matter on blood pressure among children and adolescents:A cross-sectional study in a city of Yangtze River delta, China. 2019

Yang, Hai-Bing / Teng, Chen-Gang / Hu, Jia / Zhu, Xiao-Yan / Wang, Ying / Wu, Jing-Zhi / Xiao, Qi / Yang, Wei / Shen, Hui / Liu, Fang. ·Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, 215004, China. · Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, 215004, China. Electronic address: hujia200606@163.com. · Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, 215004, China; Institute of Suzhou Biobank, Suzhou, Jiangsu, 215004, China. · Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, 215004, China; Department of Occupational and Environmental Health and Key Laboratory of Environmental and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. · School of Community Health Sciences, University of Nevada, Reno, NV, 89154, USA. · Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, 215004, China. Electronic address: liufangszCDC@yeah.net. ·Chemosphere · Pubmed #31549641.

ABSTRACT: Several studies have demonstrated associations between short-term exposure to particulate matter (PM) and blood pressure (BP) among various adults groups, but evidence in children and adolescents is still rare. In 2016, a cross-sectional survey was conducted among 194 104 participants aged 6-17 years in Suzhou, China. Daily concentrations of particulate matters with an aerodynamic diameter of ≤10 μg/m

7 Article Use of labor induction with dinoprostone vaginal suppositories in pregnant women with gestational hypertension. 2019

Hu, Ya-Ping / Zhou, Dong / Li, Min / Wang, Ying / Wang, Ling / Sun, Guo-Qiang / Xiao, Mei. ·Department of Obstetric, Hubei Maternity and Child Health Hospital, Wuhan, China. ·J Obstet Gynaecol Res · Pubmed #31456315.

ABSTRACT: AIM: Gestational hypertension is a common disorder of pregnancy. This study aims to evaluate the effect of labor induction with dinoprostone vaginal suppositories (Propess) on pregnancy outcomes in pregnant women with gestational hypertension. METHODS: The retrospective study included 375 patients with gestational hypertension. All patients were included into three groups according to the characteristics at admission. Women who had initiated labor spontaneously at admission were enrolled in Spontaneous labor group. According to Bishop score, other patients underwent labor induction with Propess or oxytocin were enrolled in Propess group or Oxytocin group. Demographic information and perinatal outcome data were collected. RESULTS: The vaginal delivery rate of the women with gestational hypertension was respectively 93.5% (Spontaneous labor group), 77.0% (Propess group), and 52.5% (Oxytocin group) in three groups with significant difference (P < 0.001). The duration of labor was 8.29 ± 3.70 h (Spontaneous labor group), 8.45 ± 5.21 h (Propess group) and 12.37 ± 11.47 h (Oxytocin group) in three groups, respectively. No differences were found in the intrapartum fever (P = 0.588), intrapartum hemorrhage (P = 0.953), intrapartum maximum blood pressure (P = 0.301 and P = 0.535) and post-partum hemorrhage (P = 0.075) among three groups. Neonatal outcomes were similar among three groups (Neonatal hospitalization rate, P = 0.437; 1-min Apgar score, P = 0.304; 5-min Apgar score, P = 0.340; Birth weight, P = 0.089). No poor maternal and neonatal outcomes occurred. CONCLUSION: Pregnant women with gestational hypertension could have favorable pregnancy outcomes. Using Propess as a mode of labor induction in gestational hypertension is safe and effective, without increasing intrapartum blood pressure and inducing poor pregnancy outcomes.

8 Article Comparison Between Home and Ambulatory Morning Blood Pressure and Morning Hypertension in Their Reproducibility and Associations With Vascular Injury. 2019

Guo, Qian-Hui / Cheng, Yi-Bang / Zhang, Dong-Yan / Wang, Ying / Huang, Qi-Fang / Sheng, Chang-Sheng / Xu, Ting-Yan / Li, Yan / Wang, Ji-Guang. ·From the Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China. ·Hypertension · Pubmed #31104566.

ABSTRACT: Morning blood pressure (BP) is recommended to be assessed by either 24-hour ambulatory or home BP monitoring. By which methods morning BP assessed is more reproducible and more closely associated with vascular injury remains unknown. We, therefore, addressed this issue in 1049 referred untreated outpatients (51.9% women; average age, 51 years) who had performed 24-hour ambulatory and 7-day home BP monitoring and vascular evaluations. Irrespective of the assessment methods, morning BPs were all significantly ( P≤0.027) associated with the arterial measures. The partial correlation coefficients of carotid-femoral pulse wave velocity and urinary albumin-to-creatinine ratio with home morning BPs were greater than those with the ambulatory morning pressures among the first 2 hours after awakening (0.21-0.37 versus 0.15-0.24; P<0.05). The associations with home morning systolic BP remained significant ( P≤0.002) after full adjustment for evening BP, whereas those with ambulatory morning BPs became nonsignificant after full adjustment for 24-hour BP except that of the carotid-femoral pulse wave velocity with ambulatory morning (6:00-10:00) systolic BP. Of the 135 subjects who had both home and repeated 24-hour ambulatory BP monitoring within 1 month, the coefficients of variation were ≈11% for ambulatory morning BPs and 5% for home self-measurements. In conclusion, morning BP, irrespective of the assessment methods and definitions, was generally reproducible and significantly associated with vascular indices. Nevertheless, home morning BP might be preferred than ambulatory measurements because of better reproducibility and stronger correlation with vascular indices.

9 Article Personal exposure to PM 2019

Xia, Bin / Zhou, Yuhan / Zhu, Qingyang / Zhao, Yingya / Wang, Ying / Ge, Wenzhen / Yang, Qing / Zhao, Yan / Wang, Pengpeng / Si, Jingyi / Luo, Ranran / Li, Jialin / Shi, Huijing / Zhang, Yunhui. ·Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China (Fudan University), China; Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China. · The Maternal and Child Healthcare Hospital of Songjiang District, Shanghai, China. · Regeneron Pharmaceuticals Inc., New York, NY, USA. · The Maternal and Child Healthcare Institute of Songjiang District, Shanghai, China. · Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. · Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China. · Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China (Fudan University), China; Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China. Electronic address: yhzhang@shmu.edu.cn. ·Environ Pollut · Pubmed #31004887.

ABSTRACT: Ambient fine particulate matter (PM

10 Article Cross-sectional Association Between Blood Pressure Status and Atrial Fibrillation in an Elderly Chinese Population. 2019

Chen, Yi / Huang, Qi-Fang / Sheng, Chang-Sheng / Lei, Lei / Xu, Shao-Kun / Zhang, Wei / Shao, Shuai / Wang, Dian / Cheng, Yi-Bang / Wang, Ying / Guo, Qian-Hui / Zhang, Dong-Yan / Li, Yan / Li, Yong / Freedman, S Ben / Wang, Ji-Guang. ·Department of Hypertension, Center for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. · Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China. · Sydney Medical School, The University of Sydney, Sydney, Australia. · Department of Cardiology, Concord Hospital and Anzac Research Institute, Concord, Australia. ·Am J Hypertens · Pubmed #31004151.

ABSTRACT: OBJECTIVE: Atrial fibrillation (AF) and hypertension are prevalent chronic disease conditions in the elderly population. In the present cross-sectional study, we investigated the association between blood pressure (BP) and AF in an elderly Chinese population. METHOD: Our elderly (≥65 years) subjects were residents recruited from 6 communities in Shanghai from 2006 to 2017. Atrial fibrillation was systematically screened by rest 12-lead electrocardiogram (ECG) or by a handheld single-lead ECG. BP status was defined according to the European hypertension guidelines as optimal, normal, or high-normal BP, and stage 1, 2, or 3 hypertension. RESULT: In the 6,966 participants (women 56.0%, mean age: 72.3 years), the prevalence of AF was 3.3%, and the prevalence of hypertension was 58.7% (83.7% treated). In all participants, the association with prevalent AF was negative for systolic BP (odds ratio [OR] per 10-mm Hg increase 0.79, 95% confidence interval [CI]: 0.71-0.88, P < 0.0001) but positive for diastolic BP (OR per 5-mm Hg increase 1.11, 95% CI: 1.02-1.22, P = 0.02). In untreated participants (n = 3,544), the association with prevalent AF was U-shaped for both systolic and diastolic BP, with the nadir at high-normal BP and a significantly higher risk of prevalent AF in optimal systolic BP (OR: 3.11, 95% CI: 1.65-5.85, P = 0.004) and stage 2 or 3 diastolic hypertension relative to the nadir (OR: 8.04, 95% CI: 2.28-28.3, P = 0.001). CONCLUSION: In the elderly population, BP shows a complicated relationship with prevalent AF, with high-normal BP at the lowest risk and optimal systolic BP and stage 2 or 3 diastolic hypertension at increased risks.

11 Article Multiscale Fine-Grained Heart Rate Variability Analysis for Recognizing the Severity of Hypertension. 2019

Ni, Hongbo / Wang, Ying / Xu, Guoxing / Shao, Ziqiang / Zhang, Wei / Zhou, Xingshe. ·School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China. ·Comput Math Methods Med · Pubmed #30805022.

ABSTRACT: Hypertension is a common and chronic disease and causes severe damage to patients' health. Blood pressure of a human being is controlled by the autonomic nervous system. Heart rate variability (HRV) is an impact of the autonomic nervous system and an indicator of the balance of the cardiac sympathetic nerve and vagus nerve. HRV is a good method to recognize the severity of hypertension due to the specificity for prediction. In this paper, we proposed a novel fine-grained HRV analysis method to enhance the precision of recognition. In order to analyze the HRV of the patient, we segment the overnight electrocardiogram (ECG) into various scales. 18 HRV multidimensional features in the time, frequency, and nonlinear domain are extracted, and then the temporal pyramid pooling method is designed to reduce feature dimensions. Multifactor analysis of variance (MANOVA) is applied to filter the related features and establish the hypertension recognizing model with relevant features to efficiently recognize the patients' severity. In this paper, 139 hypertension patients' real clinical ECG data are applied, and the overall precision is 95.1%. The experimental results validate the effectiveness and reliability of the proposed recognition method in the work.

12 Article Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin. 2019

Wang, Lei / Liu, Jie / Wang, Wang / Qi, Xianmei / Wang, Ying / Tian, Bo / Dai, Huaping / Wang, Jing / Ning, Wen / Yang, Ting / Wang, Chen. ·Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China. · Department of Physiology and Pathophysiology, School of BasicMedical Sciences, Capital Medical University, Beijing, China. · Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. · Department of Thoracic Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. · Department of Physiology and Pathophysiology, School of BasicMedical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. · Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ·Thorax · Pubmed #30777899.

ABSTRACT: BACKGROUND: The role of interleukin 17 (IL-17) in hypoxic pulmonary hypertension (HPH) remains unclear. This study is designed to explore whether IL-17 is a potential target for HPH treatment. METHODS: Clinic samples from the lung tissue and serum were obtained from qualified patients. Western blotting, immunohistochemistry and/or ELISA were used to measure the expression of relevant proteins. HPH models were established in C57BL/6 wild-type (WT) and RESULTS: Expression of IL-17 was increased in lung tissue of both patients with bronchiectasis/COPD-associated PH and HPH mouse model. Compared with WT mice, CONCLUSIONS: IL-17 contributes to the pathogenesis of HPH through upregulation of β-catenin expression. Targeting IL-17 might provide potential benefits for alternative therapeutic strategies for HPH.

13 Article Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension. 2019

Wang, Ying / Wang, Enfeng / Zhang, Yuebo / Madamsetty, Vijay S / Ji, Baoan / Radisky, Derek C / Grande, Joseph P / Misra, Sanjay / Mukhopadhyay, Debabrata. ·Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, Florida, USA. · Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA. · Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA; and. · Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. ·FASEB J · Pubmed #30118322.

ABSTRACT: Dimethylarginine dimethylaminohydrolases (DDAHs) are known to degrade asymmetric dimethylarginine, an endogenous inhibitor of NOS, and maintain vascular homeostasis; however, the regulatory pathways of DDAHs remain unclear. In this study, we aimed to define the role of transmembrane glycoprotein neuropilin-1 (NRP1) in the expression of DDAHs and investigate the potential roles of NRP1 in regulation of blood pressure. Short hairpin RNA-mediated knockdown of NRP1 reduced the level and mRNA stability of DDAH1 but not DDAH2 in HUVECs, whereas overexpression of NRP1 increased the mRNA stability of DDAH1. Meanwhile, mesenteric arteries and lung vascular endothelial cells of tamoxifen-inducible endothelial cell-specific NRP1 knockout mice exhibited decreased expression of DDAH1 and slightly increased expression of DDAH2. Mechanistically, the regulation of NRP1 on DDAH1 expression is mediated by a posttranscriptional mechanism involving miR-219-5p in HUVECs. Although the endothelial cell-specific NRP1 knockout mice did not exhibit any significant change in blood pressure at the basal level, they were more sensitive to low-dose angiotensin II infusion-induced increases in blood pressure. Our results show that NRP1 is required for full expression of DDAH1 in endothelial cells and that NRP1 contributes to protection from low-dose angiotensin II-induced increases in blood pressure.-Wang, Y., Wang, E., Zhang, Y., Madamsetty, V. S., Ji, B., Radisky, D. C., Grande, J. P., Misra, S., Mukhopadhyay, D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension.

14 Article A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux. 2018

Ma, Ying / Huang, Zhenyu / Zhou, Zhaoli / He, Xiaoyan / Wang, Ying / Meng, Chao / Huang, Gang / Fang, Ningyuan. ·Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. · Department of Neurosurgery, Changzheng Hospital of Shanghai, Second Millitary Medical University, Shanghai 200003, China. · Shanghai Key Laboratory for Molecular Imaging, Collaborative Scientific Research Center. Shanghai University of Medicine & Health Science, Shanghai 200093, China; Department of Pharmacology, School of Pharmacy, Shanghai University of Medicine & Health Science, Shanghai 200093, China. · State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. · Shanghai Key Laboratory for Molecular Imaging, Collaborative Scientific Research Center. Shanghai University of Medicine & Health Science, Shanghai 200093, China. · Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: rjfangny@shsmu.edu.cn. ·Free Radic Biol Med · Pubmed #30321700.

ABSTRACT: A bulk of cholesteryl esters accumulation in macrophage foam cells drives the occurrence and development of atherosclerosis. Evidence now shows that autophagy plays key roles in the degradation of intracellular lipid droplets via autolysosome, and also in the release of intracellular lipids via cholesterol efflux. In this study, we identified that a mitochondria-targeted antioxidant, Mito-Tempol, has protective effects against cholesteryl esters accumulation by activating autophagy. Mito-Tempol was shown to ameliorate the lipid burden for atherosclerosis, both in vitro and in vivo. In the established in vitro foam cell formation system using oxidized low-density lipoprotein (ox-LDL)-loaded THP-1 macrophages, Mito-Tempol prevented intracellular oxidative stress and attenuated lipid accumulation. Mito-Tempol rescued ox-LDL-impaired autophagic flux, thereby facilitating autophagy-mediated lipid degradation in THP-1 macrophages. Meanwhile, Mito-Tempol also increased the efflux of cholesterol via autophagy-dependent ABCA1 and ABCG1 up-regulation. The classical autophagy pathway of mTOR may be one of the effector for the autophagy restoration of Mito-Tempol. Our findings give the first insight that cardiovascular system disease may benefits more from the treatment of Mito-Tempol for its impact of reversing atherosclerosis via autophagy.

15 Article Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor. 2018

Li, Yang / Zhang, Xiaoyi / Li, Lu / Wang, Xiang / Chen, Zhidan / Wang, Xingxu / Wang, Ying / Kang, Le / Ye, Yong / Jia, Jianguo / Zhang, Guoping / Yang, Chunjie / Yuan, Jie / Zhou, Jingmin / Ge, Junbo / Gong, Hui / Zou, Yunzeng. ·Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China. · Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China. · Department of Rehabilitation Medicine, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200127, China. · Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China gonghui2005@fudan.edu.cn zou.yunzeng@zs-hospital.sh.cn. ·Clin Sci (Lond) · Pubmed #30072448.

ABSTRACT: By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found that stretch induced a significantly high level of β-2 microglobulin (β2M), a non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed that serum β2M level was increased in patients with hypertension and further increased in patients with chronic heart failure (HF) as compared with control group, and the high level of serum β2M level correlated to cardiac dysfunction in these patients. In pressure overload mice model by transverse aortic constriction (TAC), β2M levels in serum and heart tissue increased progressively in a time-dependent manner. Exogenous β2M showed pro-fibrotic effects in cultured cardiac fibroblasts but few effects in cardiomyocytes. Adeno-associated virus 9 (AAV9)-mediated knockdown of β2M significantly reduced cardiac β2M level and inhibited myocardial fibrosis and cardiac dysfunction but not cardiac hypertrophy at 4 weeks after TAC.

16 Article Perinatal outcomes following labor induction with dinoprostone in pregnancies with borderline amniotic fluid index at term: A clinical observation study. 2018

Yin, Heng / Zhao, Lei / Lin, Ying / Wang, Ying / Hu, Yaping / Sun, Guoqiang / Xiao, Mei. ·Department of Obstetric, Hubei Maternity and Child Health Hospital, Wuhan, China. ·J Obstet Gynaecol Res · Pubmed #29932485.

ABSTRACT: AIM: To compare perinatal outcomes of dinoprostone for induced labor in pregnancies with a borderline versus normal amniotic fluid index (AFI) at term, and to investigate the related factors affecting outcomes of cesarean section. METHODS: The retrospective study was carried out in Hubei Maternal and Child Health Hospital with singleton pregnancies of 37-42 weeks' gestation from January to August 2016. A total of 992 subjects were divided into two groups: borderline AFI group (n =125) with 5 < AFI ≤ 8 and normal AFI group (n = 867) with 8 < AFI ≤ 24. RESULTS: Time to delivery (P =0.004) and use of oxytocin augmentation (P = 0.011) were significantly lower in pregnancies with borderline AFI. There were no significant differences between the two groups in terms of delivery mode, time to onset of labor, fetal distress, Apgar scores, meconium-stained amniotic fluid, birth weight, or incidences of admission to neonatal intensive care unit (NICU). Gestational hypertension and birth weight were the major factors affecting outcomes of cesarean section in the borderline group (odds ratio [OR] = 13.61, 95% confidence interval [CI] 1.96-94.49, P =0.008 and OR = 1.003, 95% CI 1.001-1.005, P =0.001, respectively). Maternal age (OR = 1.12, 95% CI 1.06-1.19, P < 0.001), parity (OR = 7.57, 95% CI 3.05-18.76, P < 0.001), biparietal diameter (OR = 0.55, 95% CI 0.33-0.91, P = 0.021), and meconium-stained amniotic fluid (OR = 1.56, 95% CI 1.12-2.17, P = 0.009) were related factors in the normal group. CONCLUSION: The perinatal outcomes of dinoprostone for induced labor are comparable between the two groups. Gestational hypertension and birth weight are factors related to outcomes of cesarean section in the borderline group.

17 Article Genistein rescues hypoxia-induced pulmonary arterial hypertension through estrogen receptor and β-adrenoceptor signaling. 2018

Zhang, Ming / Wu, Yujun / Wang, Mengmeng / Wang, Ying / Tausif, Raza / Yang, Ying. ·State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, China. · State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, China. Electronic address: cauvet@163.com. ·J Nutr Biochem · Pubmed #29886191.

ABSTRACT: Pulmonary vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which is characterized by thickening of the medial smooth muscle layer. Hypertrophy of pulmonary artery smooth muscle cells (PASMCs) participates in the development of medial thickening. Genistein can attenuate PAH and inhibit medial thickening of pulmonary arteries. Since hypoxia is one of the main causes of pulmonary hypertension, this study aims to investigate the mechanism of genistein in inhibiting hypertrophic responses in PASMCs induced by hypoxia. Cells isolated from the chick embryo were cultured with or without genistein and subjected to hypoxia or not. The increase of cell surface area and α-smooth muscle actin (α-SMA) of PASMCs was significantly suppressed by genistein during hypoxia. This result was confirmed by the incorporation of puromycin into peptide chains and flow cytometry analysis. Constrained mRNA and protein hypoxia-inducible factor (HIF)-1α expression was improved by genistein under hypoxia condition. Genistein restored redox homeostasis by fluorescent probe determination. The effect of genistein on hypertrophic response was blocked by estrogen receptor inhibitor, β1-adrenoceptor agonist and β2-adrenoceptor antagonist. In conclusion, genistein potently attenuates hypoxia-induced hypertrophy of PASMCs, which may enable a novel therapy for PAH.

18 Article Combined antihypertensive and statin therapy for the prevention of cardiovascular events in patients with hypertension without complications: protocol for a systematic review and meta-analysis. 2018

Wang, Ying / Kuang, Ze-Min / Feng, Shu-Jun / Jiang, Long / Chen, Qiu-Xian / Ji, Xiao-Yun / Cheng, Wen-Li / Hu, Hong-Juan. ·Department of Cardiology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China. · Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing, China. · Department of Cardiology, Institute of Cardiovascular Disease, The Second Affiliated Hospital of Nanchang University, Nanchang, China. · Department of Medical Affairs, Hisun Pfizer Pharmaceuticals Co., Ltd, Shanghai, China. · Teaching and Research Section of Community Nursing, School of Nursing, University of South China, Hengyang, Hunan, China. ·BMJ Open · Pubmed #29858408.

ABSTRACT: INTRODUCTION: High blood pressure (BP) affects over 40% of adults over the age of 25 worldwide and is the leading global risk factor for death or disability. Hypertension is also the most important risk factor for endovascular atherosclerosis, which, when combined with other cardiovascular risk factors, leads to atherosclerotic cardiovascular disease (ASCVD). Statins are one of the most widely used drugs for the prevention of ASCVD. The recently announced study of Heart Outcomes Prevention Evaluation-3 suggests that cholesterol-lowering agents combined with antihypertensive therapy can prevent cardiovascular events and reduce the combined endpoint. We plan to conduct a systematic review and meta-analysis to evaluate whether combined antihypertensive and statin therapy is more beneficial than antihypertensive therapy alone in patients with hypertension without complications. METHODS AND ANALYSIS: We will perform a comprehensive search for randomised controlled trials evaluating combined antihypertensive and statin therapy for the treatment of patients with hypertension. The following English electronic databases will be searched: The Cochrane Library, EMBASE and PubMed. Outcomes will be categorised as short-term (≤6 months) or long-term (>6 months). When evaluating the effects of combined antihypertensive and statin therapy, a short-term outcome is usually defined as a change in BP or lipid levels, while a long-term outcome is usually defined as cardiovascular benefits or risks. The data screening and extraction will be conducted by two different reviewers. The quality of the RCTs will be assessed according to the Cochrane handbook risk of bias tool. ETHICS AND DISSEMINATION: This review does not require ethics approval and the results of the meta-analysis will be submitted to a peer-review journal. PROSPERO REGISTRATION NUMBER: CRD42017071935.

19 Article Assessment of Right Atrium Function in Patients With Systemic Lupus Erythematosus With Different Pulmonary Artery Systolic Pressures by 2-Dimensional Speckle-Tracking Echocardiography. 2018

Sun, Lihua / Wang, Ying / Dong, Yu / Song, Shengda / Luo, Runlan / Li, Guangsen. ·Department of Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian, China. ·J Ultrasound Med · Pubmed #29480580.

ABSTRACT: OBJECTIVES: To assess right atrium (RA) function of patients with systemic lupus erythematosus (SLE) and pulmonary artery hypertension (PAH) by 2-dimensional speckle-tracking echocardiography. METHODS: Thirty matched healthy adults were selected as group A. Then, 102 patients with SLE were divided into 3 groups according to the severity of PAH. Group B included 37 patients without PAH (pulmonary artery [PA] systolic pressure ≤ 30 mm Hg); group C included 34 patients with PAH (PA systolic pressure of 30-50 mm Hg); and group D included 31 patients with PAH (PA systolic pressure ≥ 50 mm Hg). Parameters evaluated included RA maximum volume, minimum volume, preatrial contraction volume, passive ejection fraction (EF), and active EF. The global peak longitudinal systolic strain rate and early and late diastolic strain rates of the RA were obtained by 2-dimensional speckle-tracking echocardiography. RESULTS: No significant differences were found in all parameters between groups B and A (P > .05). The RA maximum volume, minimum volume, preatrial contraction volume, active EF, and late diastolic strain rate in groups C and D were significantly increased compared with those in groups A and B, and the parameters in group D were significantly higher than those in group C (P < .05). Although the RA passive EF, early diastolic strain rate, and systolic strain rate in groups C and D were significantly decreased compared with those in groups A and B, those in group D were significantly lower than those in group C (P < .05). CONCLUSIONS: Two-dimensional speckle-tracking echocardiography could effectively assess RA function in patients with SLE who have different severities of PAH.

20 Article DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension. 2018

Wang, Ying / Huang, Xiaoxi / Leng, Dong / Li, Jifeng / Wang, Lei / Liang, Yan / Wang, Jun / Miao, Ran / Jiang, Tao. ·Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China. · Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine , Beijing , People's Republic of China. · Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China. · Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China. · Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University , Beijing , People's Republic of China. · Department of Physiology, Capital Medical University , Beijing , People's Republic of China. · Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University , Beijing , People's Republic of China. · Beijing Neurosurgical Institute, Capital Medical University , Beijing , People's Republic of China. ·Physiol Genomics · Pubmed #29473816.

ABSTRACT: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening disease, which is often underpinned by vascular remodeling. Pulmonary arterial smooth muscle cells (PASMCs) are the main participants in vascular remodeling. However, their biological role in CTEPH is not entirely clear. In the present study, we analyzed the whole epigenome-wide DNA methylation profile of cultured PASMCs from CTEPH and control cell lines with the Illumina Human Methylation 450K BeadChip. A total of 6,829 significantly differentially methylated probes (DMPs) were detected between these two groups. Among these, 4,246 DMPs were hypermethylated, while 2,583 DMPs were hypomethylated. The functional enrichment analysis of 1,743 DMPs in the promoter regions and corresponding genes indicated that DNA hypermethylation and hypomethylation might be involved in the regulation of genes that have multifarious biological roles, including roles in cancer-related diseases, the regulation of the actin cytoskeleton, cell adhesion, and pattern specification processes. The observed methylations were categorized into the most important functions, including those involved in cell proliferation, immunity, and migration. We speculate that these methylations were most likely involved in the possible pathophysiology of CTEPH. Gene interaction analysis pertaining to signal networks confirmed that PIK3CA and PIK3R1 were important mediators in these whole networks. The mRNA levels of PIK3CA, HIC1, and SSH1 were verified by qPCR and corresponded with DNA methylation differences. Understanding epigenetic features associated with CTEPH may provide new insights into the mechanism that underlie this condition.

21 Article Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension. 2018

Zhang, Xin / Chen, Wenjia / Li, Jiawen / Qi, Shuhan / Hong, Siting / Wang, Ying / Gao, Lei / Shi, Zhiyu / Liu, Yue / Liu, Wenxiu / Chi, Yinyu / Liu, Chunnan / Fu, Yu / Yin, Xinhua. ·Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China. · Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China. Electronic address: yinxinhua5063@163.com. ·Biochem Biophys Res Commun · Pubmed #29128361.

ABSTRACT: Hyperproliferation of vascular smooth muscle cells (VSMC) is a major risk factor for cardiovascular diseases. Proper mitochondrial fission and fusion is involved with VSMC function. However, the role and mechanism of mitochondrial morphological changes in VSMC proliferation are not well understood. Here, we found that calcium sensing receptor (CaSR) was increased in the aortas from spontaneous hypertensive rats (SHRs) compared with age-matched Wistar Kyoto (WKY) rats. There was also an increase in mitochondrial fission and VSMC proliferation, which was attenuated by Calhex231. In primary rat VMSC, angiotensin II (Ang II) stimulation induced cytosolic [Ca

22 Article Renin-angiotensin system regulates pulmonary arterial smooth muscle cell migration in chronic thromboembolic pulmonary hypertension. 2018

Zhang, Yun-Xia / Li, Ji-Feng / Yang, Yuan-Hua / Zhai, Zhen-Guo / Gu, Song / Liu, Yan / Miao, Ran / Zhong, Ping-Ping / Wang, Ying / Huang, Xiao-Xi / Wang, Chen. ·Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. · Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China. · Beijing Institute of Respiratory Medicine , Beijing , China. · Department of Respiratory Disease, Capital Medical University , Beijing , China. · China-Japan Friendship Hospital , Beijing , China. · National Clinical Research Center for Respiratory Diseases , Beijing , China. · Department of Cardiac Surgery, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China. · Department of Pathology, Haidian Maternal & Child Health Hospital , Beijing , China. ·Am J Physiol Lung Cell Mol Physiol · Pubmed #29122755.

ABSTRACT: Pulmonary arterial smooth muscle cell (PASMC) migration plays a key role in vascular remodeling, which occurs during development of chronic thromboembolic pulmonary hypertension (CTEPH). Activation of the renin-angiotensin system (RAS) contributes to vascular remodeling observed in many diseases, including idiopathic pulmonary arterial hypertension. However, the role of RAS imbalance in CTEPH has not been characterized. Here, we hypothesize that RAS imbalance regulates vascular remodeling by promoting PASMC migration in CTEPH. Serum renin and angiotensin II levels in patients with CTEPH were quantified by ELISA. The pulmonary endarterectomy tissues were stained and analyzed by immunohistochemistry. PASMCs were isolated and verified by immunofluorescence staining. PASMC migration was determined by Transwell assay. Phosphorylation and protein level were detected by Western blotting. Serum levels of renin and angiotensin II were increased in patients with CTEPH {renin [median (25th percentile, 75th percentile) in pg/ml], 1,199.94 [690.85, 1,656.90] vs. 595.43 [351.48, 936.43], P < 0.001; angiotensin II [in pg/ml], 63.97 [45.97, 345.24] vs. 56.85 [11.20, 90.37], P < 0.05}. The migration of PASMCs isolated from patients with CTEPH was enhanced compared with control. Angiotensin II promoted the migration of PASMCs via activation of angiotensin II receptor 1 and phosphorylation of ERK1/2, whereas angiotensin-(1-7) counteracted this effect through activation of the Mas receptor and ERK1/2. These results demonstrate that the renin-angiotensin system regulates migration of PASMCs from patients with CTEPH via the ERK1/2 pathway. Our findings suggest that angiotensin-(1-7) or reagents targeting the renin-angiotensin system will be beneficial in the development of novel therapies for CTEPH.

23 Article Effectiveness of self-management support in maintenance haemodialysis patients with hypertension: A pilot cluster randomized controlled trial. 2018

Huang, Baoyan / Li, Zheng / Wang, Ying / Xia, Jinghua / Shi, Tao / Jiang, Jingmei / Nolan, Marie T / Li, Xuemei / Nigwekar, Sagar U / Chen, Limeng. ·Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · Department of Epidemiology & Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · School of Nursing, Johns Hopkins University, Baltimore, USA. · Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA. ·Nephrology (Carlton) · Pubmed #28666310.

ABSTRACT: AIM: Uncontrolled hypertension is an independent risk factor for cardiovascular disease and is the leading cause of mortality in haemodialysis patients. The aim of this study was to examine the effectiveness of self-management support (SMS) for blood pressure (BP) control and health behaviours. METHODS: We conducted a cluster randomized controlled trial (RCT) in which 90 adult haemodialysis patients were assigned to either an SMS or common intervention (CI) group. The SMS group received an intervention consisting of self-management education and motivational interviewing. The CI group received standard care and routine health education. The primary outcome was the BP monitored before each haemodialysis. Secondary outcomes included salt intake (measured using a balance formula), home BP monitoring (HBPM) (assessed using two self-administered questions), and medication adherence (measured using the Medication-taking Behavior Scale). Data were collected at baseline and at 1, 3 and 6 months post-intervention. RESULTS: The SMS group showed continuous reductions in systolic BP from baseline: -9.2, -8.7, and -8.4 mmHg at 1, 3 and 6 months after the intervention, respectively (P < 0.01). Compared with the CI group, the SMS group had a greater decrease in systolic BP at 1 month: -5.9 mmHg (P = 0.0388), but no significant difference was found at 3 or 6 months (P > 0.05). SMS patients showed an improvement in health behaviours relative to baseline (less salt intake, more consistent HBPM, and greater medication adherence) (P < 0.05). CONCLUSIONS: Self-management support obtained short-term success in improving salt restriction, regular performance of HBPM and medication adherence, which led to better BP control.

24 Article Ozone therapy induced sinus arrest in a hypertensive patient with chronic kidney disease: A case report. 2017

Tang, Wen-Juan / Jiang, Long / Wang, Ying / Kuang, Ze-Min. ·The General Hospital of FAW, The Fourth Hospital of Jilin University, Changchun, Jilin Province. · Department of Cardiovascular, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province. · Department of Cardiology, the Chenzhou City First People's Hospital Affiliated to University of South China, Chenzhou, Hunan. · Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing, China. ·Medicine (Baltimore) · Pubmed #29390373.

ABSTRACT: RATIONALE: Ozone autohemotherapy as an alternative treatment method has been applied to the treatment of several diseases. Here, we report a patient used ozone autohemotherapy to treat her hypertension and diabetes. Nevertheless, the patient occurred sudden dizziness and black haze due to hyperkalemia. PATIENT CONCERNS: A 54-year-old woman who was admitted to our emergency department complaining of sudden dizziness and black haze for 5 hours. DIAGNOSES: The blood potassium test showed hyperkalemia. Upon further inquiry of her medical history, the patient received ozone autohemotherapy to treat hypertension and diabetes for 9 days prior to admission. INTERVENTIONS: The ozone therapy had been asked to stop. Insulin, sodium bicarbonate, and sodium polystyrene sulfonate were administered to the patient. OUTCOMES: After treatment, blood potassium remained in the normal range. After 3 days of treatment, the 24-hour dynamic electrocardiogram revealed sinus rhythm with an average heart rate of 82 beats/min, occasional ventricular premature beats, occasional ventricular premature beats, and no ST segment depression. LESSONS: Although ozone therapy is widely used in the treatment of several diseases, adverse reactions should be given attention in clinical practice, especially in patients with chronic kidney disease.

25 Article Association Between Plasma Homocysteine and Microalbuminuria in Untreated Patients with Essential Hypertension: a Case-Control Study. 2017

Kuang, Ze-Min / Wang, Ying / Feng, Shu-Jun / Jiang, Long / Cheng, Wen-Li. ·Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Chaoyang District, Beijing, China. · Department of Cardiology, Chenzhou City First People's Hospital Affiliated with University of South China, Chenzhou, China. · Department of Cardiology, Institute of Cardiovascular Disease, the Second Affiliated Hospital of Nanchang University, Donghu District, Nanchang, China. ·Kidney Blood Press Res · Pubmed #29262410.

ABSTRACT: BACKGROUND/AIMS: Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between Hcy and microalbuminuria. METHODS: This is a 1: 2 matched, hospital-based case-control study. At initial visit, out of 1535 outpatients with no prior history of medication, 450 qualified subjects were selected based on inclusion and exclusion criteria. The concentration of Hcy in the serum was evaluated using a cyclic enzyme method. MAU was defined by a urine albumin/creatinine ratio (UACR) between 30 μg/mg and 300 μg/mg. RESULTS: A total of 450 patients were included in this study (150 in the MAU group and 300 in the non-MAU group). The MAU group had higher mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP), heart rate (HR) and plasma Hcy levels than did the non-MAU group. The area under the receiver operating characteristics (ROC) curves was 0.772 (95% CI: 0.724-0.819, P < 0.001) with a cut-off value of 15.0, and the sensitivity and specificity of Hcy in predicting the MAU status in hypertensive patients were 49.3% and 92.3%, respectively. Multiple logistic regression modelling suggested that patients with a higher Hcy level (> 15 µmol/L) were more likely to have MAU (95% CI: 5.650-16.543, P < 0.001). The other predictive factor for MAU was 24-h mean SBP (95% CI: 0.941-0.993, P = 0.015). CONCLUSION: This matched case-control study indicates that Hcy may increase the susceptibility of essential hypertensive subjects to MAU.

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