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Hypertension: HELP
Articles by Hong Yang
Based on 10 articles published since 2010
(Why 10 articles?)
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Between 2010 and 2020, Hong Yang wrote the following 10 articles about Hypertension.
 
+ Citations + Abstracts
1 Article Safety and efficacy of applying sufficient analgesia combined with a minimal sedation program as an early antihypertensive treatment for spontaneous intracerebral hemorrhage: a randomized controlled trial. 2018

Dong, Rui / Li, Fen / Xu, Ying / Chen, Pingyan / Maegele, Marc / Yang, Hong / Chen, Wenjin. ·Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical University, No.183 West Zhongshan Ave, Tianhe District, Guangzhou, 510630, Guangdong, China. · Department of Biostatistics, School of Public Health, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. · Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University (Campus Cologne-Merheim), Ostmerheimerstr. 200, 51109, Cologne, Germany. · Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical University, No.183 West Zhongshan Ave, Tianhe District, Guangzhou, 510630, Guangdong, China. yhicu_1103@163.com. · Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China. drchenwenjin@qq.com. ·Trials · Pubmed #30400977.

ABSTRACT: BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a serious threat to human health. Although early blood pressure (BP) elevation is closely associated with a poor prognosis, the optimal antihypertensive regimen for acute-phase ICH remains controversial. In ICH, pain, sleep deprivation, and stress are usually the main causes of dramatic BP increases. While traditional antihypertensive treatment resolves the increased BP, it does not address the root cause of the disease. Remifentanil relieves pain and, when combined with dexmedetomidine's antisympathetic action, can restore elevated BP to normal levels. Here, we seek to validate the efficacy and safety of applying sufficient analgesia in combination with a minimal sedation program versus antihypertensive drug therapy for the early and rapid stabilization of BP in ICH patients. METHODS/DESIGN: We are conducting a multicenter, prospective, randomized controlled, single-blinded, superiority clinical trial across 15 hospitals. We will enroll 354 subjects in mainland China, and all subjects will be randomized into experimental and control groups in which they will be given remifentanil combined with dexmedetomidine or antihypertensive drugs (urapidil, nicardipine, and labetalol). The primary endpoint will be the systolic BP control rate within 1 h of treatment initiation, and the efficacy and safety of the antihypertensive regimens will be compared between the two groups. Secondary endpoints include the incidence rate of early hemorrhage growth, neurological function, duration of intensive care unit (ICU) stay, and staff satisfaction with the treatment process. DISCUSSION: We hypothesize that applying sufficient analgesia in combination with minimal sedation will act as an effective and safe antihypertensive strategy in ICH and that this treatment strategy could, therefore, be widely used as an ICH acute-phase therapy. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03207100 . Registered on 22 July 2017.

2 Article Positive association between metabolic syndrome and serum uric acid in Wuhan. 2017

Fu, Yuan-Qing / Yang, Hong / Zheng, Ju-Sheng / Zeng, Xiao-Yun / Zeng, Wen / Fan, Zhi-Fen / Chen, Min / Wang, Ling / Li, Duo. ·Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. · Department of Maternal and Infant Nutrition, Beingmate Food Research Institute Co., Ltd, Hangzhou, China. · Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China. · Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. Email: duoli@zju.edu.cn. ·Asia Pac J Clin Nutr · Pubmed #28244715.

ABSTRACT: BACKGROUND AND OBJECTIVES: The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan. METHODS AND STUDY DESIGN: 5,628 subjects (2,838 men, 2,790 women) aged 18-80 years were recruited in Wuhan, China. Biochemical parameters of venous blood were measured by standard methods and metabolic syndrome was defined by Chinese Diabetes Society criteria. Association analysis was performed by logistic regression. RESULTS: 8.2% of the included subjects were confirmed as having metabolic syndrome and 14.4% were confirmed as having hyperuricemia. After multivariable adjustment, logistic regression showed the odds ratios of metabolic syndrome for subjects in the highest quartile of serum uric acid concentration was 2.84 (95% CI: 2.09-3.86) compared with those in the lowest quartile and no gender difference was found. For each component of metabolic syndrome, subjects in the highest quartile of serum uric acid concentrations had increased multivariable odds ratios for high BMI (OR: 3.29, 95% CI: 2.71-3.98), for hypertension (OR: 3.54, 95% CI: 2.93-3.86), for dyslipidemia (OR: 2.49, 95% CI: 1.98-3.14), but not for hyperglycemia (OR: 1.21, 95% CI: 0.87-1.67). CONCLUSIONS: Odd ratio of metabolic syndrome was significantly positively associated with serum uric acid concentration among the present sample of 5,628 subjects in Wuhan.

3 Article Positive association between the metabolic syndrome and white blood cell counts in Chinese. 2017

Yang, Hong / Fu, Yuan-Qing / Yang, Bo / Zheng, Ju-Sheng / Zeng, Xiao-Yun / Zeng, Wen / Fan, Zhi-Fen / Chen, Min / Wang, Ling / Li, Duo. ·Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · Department of Maternal and Infant Nutrition, Beingmate Research Institute, Hangzhou, China. · Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. · College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China. Email: wangling@mail.hzau.edu.cn. ·Asia Pac J Clin Nutr · Pubmed #28049273.

ABSTRACT: BACKGROUND AND OBJECTIVES: The aim was to investigate the association between peripheral circulating white blood cell count (WBC) and the metabolic syndrome among populations in central China. METHODS AND STUDY DESIGN: In the present study, 5,278 subjects (2,412 women, 2,866 men) aged 18-75 years were recruited through a health check program in Wuhan, China. Biochemical and haematological parameters were measured by standard methods and the metabolic syndrome diagnosed as defined by the Chinese Diabetes Society criteria for Chinese. RESULTS: Both WBC counts and prevalence of metabolic syndrome were significantly higher in men than in women (p<0.01). Participants in the highest quartile of white blood cell count had significantly higher odds ratio of metabolic syndrome (3.79, 95% CI: 2.64, 5.44), compared with subjects in the lowest quartile. The trend remained significant after adjustment for confounding factors and in further subgroup-analyses. CONCLUSIONS: Metabolic syndrome prevalence was significantly and positively correlated with the total white blood cell count in this Chinese population.

4 Article Relation of Functional Status to Risk of Development of Atrial Fibrillation. 2017

Ramkumar, Satish / Yang, Hong / Wang, Ying / Nolan, Mark / Negishi, Kazuaki / Sanders, Prashanthan / Marwick, Thomas Hugh. ·Baker IDI Heart and Diabetes Institute, Melbourne, Australia; School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia. · Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. · University of Adelaide, Adelaide, Australia. · Baker IDI Heart and Diabetes Institute, Melbourne, Australia; School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: Tom.Marwick@bakeridi.edu.au. ·Am J Cardiol · Pubmed #27956001.

ABSTRACT: Identifying patients at risk is now important as there are demonstrable ways to alter disease progression which could potentially prevent atrial fibrillation (AF) and its complications. We sought whether impaired functional capacity was associated with risk of AF, independent of myocardial dysfunction. In this community-based study, asymptomatic participants aged ≥65 years were recruited if they had ≥1 risk factor (e.g., hypertension, diabetes mellitus, and obesity). Participants underwent baseline echocardiography (including measurement of myocardial mechanics) and six-minute walk test. The CHARGE-AF score was used to calculate 5-year risk of developing AF. Receiver operating characteristic curves were used to assess for independent risk factors for AF. A total of 607 patients (age 71 ± 5 years, men 47%) were studied at baseline and followed for at least 6 months. Patients in the higher AF risk groups were older and had increased rates of hypertension, diabetes mellitus, and ischemic heart disease (p <0.05). Greater AF risk was associated with lower exercise capacity, independent of lower mean global longitudinal strain, global circumferential strain, greater mean E/e' ratio, indexed left atrial volume and LV mass. Multivariate linear regression confirmed association of LV and functional capacity parameters with AF risk. Although functional capacity is impaired in AF, this association precedes the onset of AF. In conclusion, poor functional status is associated with AF risk, independent of LV function.

5 Article Cervical Decompression Surgery for Cervical Spondylotic Myelopathy and Concomitant Hypertension: A Multicenter Prospective Cohort Study. 2017

Yang, Liang / Yang, Cheng / Pang, Xiaodong / Li, Duanming / Chen, Xiongsheng / Shi, Jiangang / Zhou, Xuhui / Wu, Ye / Lu, Xiang / Yang, Hong / Jia, Lianshun / Peng, Baogan. ·*Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China †Department of Orthopeadics, Pingjin Hospital, Logistics College of Armed Police Forces, Tianjin, China ‡Department of Orthopeadics, Changzheng Hospital, Shanghai, China §Department of Spinal Surgery, General Hospital of Armed Police Force, Beijing, China ¶Department of Orthopeadics, 304th Hospital, Beijing, China. ·Spine (Phila Pa 1976) · Pubmed #27792119.

ABSTRACT: STUDY DESIGN: We performed decompression surgery or conservative treatments on 135 cervical spondylotic myelopathy (CSM) patients with concomitant hypertension and did follow-up assessments up to 1 year to examine the change of blood pressure, spinal cord function, and cervical pain. OBJECTIVE: The aim of this study was to determine whether concomitant hypertension is relieved after decompression surgery, and whether it is related to the improvement of spinal cord function or cervical pain. SUMMARY OF BACKGROUND DATA: In clinical practice, we often found that some patients with CSM have concomitant hypertension. Interestingly, after CSM was treated successfully by decompression surgery, some patients' high blood pressure returned to normal range even without oral medications. METHODS: We enrolled 135 CSM patients with hypertension, 103 of whom received decompression surgery, and remaining 32 patients accepted conservative treatments. We did follow-up assessments at 3, 6, and 12 months. The primary endpoints were changes of blood pressure, and secondary endpoints were changes of modified Japanese Orthopedic Association (mJOA) score and cervical pain visual analogue scale (VAS). Spearman correlation coefficients were calculated between changes in systolic blood pressure (SBP) and mJOA scores, VAS scores. RESULTS: In patients with decompression surgery, the significant decrease in both SBP and diastolic blood pressure (DBP) that was seen 3 months and sustained through subsequent visit at 12 months. Paired-samples t test showed that both SBP and DBP were significantly lower than baseline blood pressure at all time points after procedure (P < 0.001). Significant correlation was found between the improvement rates of mJOA score and changes in SBP (r = -0.579, P < 0.001). But the correlation between changes in VAS score and changes in SBP was not significant (r = 0.58, P = 0.571). CONCLUSION: Cervical decompression surgery could reduce concomitant high blood pressure in CSM patients, indicating a significant association between the decrease in blood pressure and the improvement of spinal cord function. LEVEL OF EVIDENCE: 2.

6 Article Echocardiographic screening for non-ischaemic stage B heart failure in the community. 2016

Yang, Hong / Negishi, Kazuaki / Wang, Ying / Nolan, Mark / Saito, Makoto / Marwick, Thomas H. ·Menzies Institute for Medical Research, Hobart, Tasmania, Australia. · Menzies Institute for Medical Research, Hobart, Tasmania, Australia. Tom.Marwick@bakeridi.edu.au. · Baker-IDI Heart and Diabetes Institute, Melbourne, Australia. Tom.Marwick@bakeridi.edu.au. ·Eur J Heart Fail · Pubmed #27813300.

ABSTRACT: AIMS: Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS: Asymptomatic patients ≥65 years old, with ≥1 HF risk factor (hypertension, type 2 diabetes, or obesity) were recruited from the community; patients with valve disease, reduced ejection fraction (EF), and atrial fibrillation (AF) were excluded. Patients underwent standard clinical evaluation including calculation of the Charlson co-morbidity score and a comprehensive echocardiography including global longitudinal strain (GLS). Functional capacity was assessed by 6 min walk test. New HF and cardiovascular death were assessed after a mean follow-up of 14 ± 4 months by three independent cardiologists using Framingham criteria. Of 410 subjects (median age 70 years; 48% men), the prevalence of stage B HF was 13% [by LV hypertrophy (LVH)], 12% (by abnormal E/e'), 33% (by impaired GLS), and 31% [by left atrial enlargement (LAE)]. New HF symptoms developed in 49, and 2 died of cardiovascular causes, giving an event rate of 104/1000 person-years. These patients were older (P = 0.012), had a higher Charlson co-morbidity score (P < 0.001), larger LV mass and left atrium, higher E/e', and lower GLS (P < 0.05). LAE, LVH, abnormal GLS, and E/e' were independent predictors of new HF. In sequential models, LV mass and GLS added incremental information to clinical parameters. GLS significantly reclassified individuals (P = 0.002), but no reclassification improvement was identified using LV mass index, E/e', and left atrial volume index. CONCLUSION: Echocardiographic assessment (especially GLS and LV mass) provides incremental value in predicting incident HF.

7 Article Importance of Calibration Method in Central Blood Pressure for Cardiac Structural Abnormalities. 2016

Negishi, Kazuaki / Yang, Hong / Wang, Ying / Nolan, Mark T / Negishi, Tomoko / Pathan, Faraz / Marwick, Thomas H / Sharman, James E. ·Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Kazuaki.Negishi@utas.edu.au. · Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. ·Am J Hypertens · Pubmed #27085076.

ABSTRACT: BACKGROUND: Central blood pressure (CBP) independently predicts cardiovascular risk, but calibration methods may affect accuracy of central systolic blood pressure (CSBP). Standard central systolic blood pressure (Stan-CSBP) from peripheral waveforms is usually derived with calibration using brachial SBP and diastolic BP (DBP). However, calibration using oscillometric mean arterial pressure (MAP) and DBP (MAP-CSBP) is purported to provide more accurate representation of true invasive CSBP. This study sought to determine which derived CSBP could more accurately discriminate cardiac structural abnormalities. METHODS: A total of 349 community-based patients with risk factors (71±5years, 161 males) had CSBP measured by brachial oscillometry (Mobil-O-Graph, IEM GmbH, Stolberg, Germany) using 2 calibration methods: MAP-CSBP and Stan-CSBP. Left ventricular hypertrophy (LVH) and left atrial dilatation (LAD) were measured based on standard guidelines. RESULTS: MAP-CSBP was higher than Stan-CSBP (149±20 vs. 128±15mm Hg, P < 0.0001). Although they were modestly correlated (rho = 0.74, P < 0.001), the Bland-Altman plot demonstrated a large bias (21mm Hg) and limits of agreement (24mm Hg). In receiver operating characteristic (ROC) curve analyses, MAP-CSBP significantly better discriminated LVH compared with Stan-CSBP (area under the curve (AUC) 0.66 vs. 0.59, P = 0.0063) and brachial SBP (0.62, P = 0.027). Continuous net reclassification improvement (NRI) (P < 0.001) and integrated discrimination improvement (IDI) (P < 0.001) corroborated superior discrimination of LVH by MAP-CSBP. Similarly, MAP-CSBP better distinguished LAD than Stan-CSBP (AUC 0.63 vs. 0.56, P = 0.005) and conventional brachial SBP (0.58, P = 0.006), whereas Stan-CSBP provided no better discrimination than conventional brachial BP (P = 0.09). CONCLUSIONS: CSBP is calibration dependent and when oscillometric MAP and DBP are used, the derived CSBP is a better discriminator for cardiac structural abnormalities.

8 Article Cervical spondylosis and hypertension: a clinical study of 2 cases. 2015

Peng, Baogan / Pang, Xiaodong / Li, Duanming / Yang, Hong. ·From the Department of Spinal Surgery, General Hospital of Armed Police Force, Beijing, China. ·Medicine (Baltimore) · Pubmed #25761188.

ABSTRACT: Cervical spondylosis and hypertension are all common diseases, but the relationship between them has never been studied. Patients with cervical spondylosis are often accompanied with vertigo. Anterior cervical discectomy and fusion is an effective method of treatment for cervical spondylosis with cervical vertigo that is unresponsive to conservative therapy. We report 2 patients of cervical spondylosis with concomitant cervical vertigo and hypertension who were treated successfully with anterior cervical discectomy and fusion. Stimulation of sympathetic nerve fibers in pathologically degenerative disc could produce sympathetic excitation, and induce a sympathetic reflex to cause cervical vertigo and hypertension. In addition, chronic neck pain could contribute to hypertension development through sympathetic arousal and failure of normal homeostatic pain regulatory mechanisms. Cervical spondylosis may be one of the causes of secondary hypertension. Early treatment for resolution of symptoms of cervical spondylosis may have a beneficial impact on cardiovascular disease risk in patients with cervical spondylosis.

9 Article [Clinical efficacy of laparoscopy-assisted radical gastrectomy in elderly patients with gastric cancer]. 2015

Yang, Hong / Cui, Ming / Xing, Jiadi / Yao, Zhendan / Zhang, Chenghai / Zhang, Nan / Su, Xiangqian. ·Department of Minimally Invasive Gastrointestinal Surgery, Beijing Cancer Hospital and Institute, Peking University Cancer Hospital, Peking University School of Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China. suxiangqian@bjmu.edu.cn. ·Zhonghua Wei Chang Wai Ke Za Zhi · Pubmed #25656025.

ABSTRACT: OBJECTIVE: To investigate the clinical efficacy of laparoscopy-assisted radical gastrectomy in elderly patients with gastric cancer. METHODS: Clinical data of 214 patients with gastric cancer were analyzed retrospectively, who underwent laparoscopy-assisted radical gastrectomy in the Department of Minimally Invasive Gastrointestinal Surgery at Beijing Cancer Hospital between May 2009 and December 2012. The patients were divided into two groups, consisting of elderly group(age ≥70 years old, n=53) and non-elderly group(age <70 years old, n=161). The operative procedure and postoperative recovery were compared between the two groups. RESULTS: Elderly group had a worse ASA score as compared to non-elderly group with significant difference(P<0.05). Among the elderly, the incidences of concomitant diseases, such as hypertension and diabetes, were significantly higher. No significant differences were observed in terms of duration of operation, blood loss, blood transfusion rate, conversion to laparotomy, time to first flatus and postoperative hospital stay between the two groups(P>0.05). The mean number of retrieved lymph nodes in elderly group was less than that of non-elderly group (26.4±9.7 vs. 30.0±12.4), but whose difference was not significant(P>0.05). There were no significant differences between two groups with respect to postoperative complications (30.2% vs. 19.9%, P>0.05) and surgery-related complications(18.9% vs. 18.0%, P>0.05), but the incidence of medical complications was higher in elderly group (11.3% vs. 1.9%, P<0.05). Furthermore, the perioperative mortality was 1.9% and 0.6% respectively in elderly and non-elderly groups without significant difference(P>0.05). CONCLUSION: Associated with more concomitant diseases, the elderly had higher risk of medical complications after operation, while laparoscopy-assisted radical gastrectomy does not increase the risk of surgery-related complications in elderly patients.

10 Article CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population. 2014

Yang, Hong / Fu, Zhenyan / Ma, Yitong / Huang, Ding / Zhu, Qing / Erdenbat, Cha / Xie, Xiang / Liu, Fen / Zheng, Yingying. ·Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University , Urumqi , China. ·Clin Exp Hypertens · Pubmed #24164311.

ABSTRACT: BACKGROUND: CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population. METHODS: In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay. RESULTS: For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females. CONCLUSIONS: The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.