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Infertility: HELP
Articles by Enrica Bentivegna
Based on 4 articles published since 2008
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Between 2008 and 2019, E. Bentivegna wrote the following 4 articles about Infertility.
 
+ Citations + Abstracts
1 Guideline [Fertility preservation, contraception and menopause hormone therapy in women treated for rare ovarian tumors: Guidelines from the French national network dedicated to rare gynaecological cancer]. 2018

Rousset-Jablonski, Christine / Selle, Fréderic / Adda-Herzog, Elodie / Planchamp, François / Selleret, Lise / Pomel, Christophe / Chabbert-Buffet, Nathalie / Daraï, Emile / Pautier, Patricia / Trémollières, Florence / Guyon, Frederic / Rouzier, Roman / Laurence, Valérie / Chopin, Nicolas / Faure-Conter, Cécile / Bentivegna, Enrica / Vacher-Lavenu, Marie-Cécile / Lhomme, Catherine / Floquet, Anne / Treilleux, Isabelle / Lecuru, Fabrice / Gouy, Sébastien / Kalbacher, Elsa / Genestie, Catherine / de la Motte Rouge, Thibault / Ferron, Gwenael / Devouassoux-Shisheboran, Mojgan / Kurtz, Jean-Emmanuel / Namer, Moise / Joly, Florence / Pujade-Lauraine, Eric / Grynberg, Michael / Querleu, Denis / Morice, Philippe / Gompel, Anne / Ray-Coquard, Isabelle. ·Centre Léon-Bérard, 28, rue Laënnec, 69008 Lyon, France; Hospices civils de Lyon, centre hospitalier Lyon-Sud, 165, chemin du grand-Revoyet, 69495 Pierre-Bénite cedex, France. Electronic address: christine.rousset-jablonski@lyon.unicancer.fr. · Groupe hospitalier Diaconesses Croix-Saint-Simon, 12-18, rue du Sergent-Bauchat, 75012 Paris, France. · Hôpital Foch, service de gynécologie-obstétrique, 40, rue Worth, 92151 Suresnes, France. · Institut Bergonié, 229, Cours-de-l'Argonne, 33000 Bordeaux, France. · Hôpital Tenon, service de gynécologie-obstétrique et médecine de la reproduction, 4, rue de la Chine, 75020 Paris, France. · Centre Jean-Perrin, 58, rue Montalembert BP, 392, 63011 Clermont-Ferrand cedex 1, France. · Institut Gustave-Roussy, 114, rue Edouard-Vaillant, 94800 Villejuif, France. · Hôpital Paule-de-Viguier, centre de ménopause et de dépistage de l'ostéoporose, 330, avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse cedex 9, France. · Institut Curie, 26, rue d'Ulm, 75005 Paris, France. · Centre Léon-Bérard, 28, rue Laënnec, 69008 Lyon, France. · Hôpital Cochin-Port Royal, 53, avenue de l'Observatoire, 75014 Paris, France. · Hôpital Européen Geroges-Pompidou, 20, rue Leblanc, 75015 Paris, France. · CHU Besançon-Jean-Minjoz, 3, boulevard Alexandre-Fleming, 25030 Besançon cedex, France. · Centre Eugène-Marquis, avenue de la Bataille-Flandres-Dunkerque, 35000 Rennes, France. · CLCC, institut Claudius-Regaud, IUCT Oncopole, 1, avenue Irène-Joliot-Curie, 31100 Toulouse, France. · Hospices civils de Lyon, centre hospitalier Lyon-Sud, 165, chemin du grand-Revoyet, 69495 Pierre-Bénite cedex, France. · CHU de Strasbourg, hôpital de Hautepierre, avenue Molière, 67200 Strasbourg, France. · Recommandations pour la pratique clinique, Nice-Saint-Paul, 06000 Nice, France. · Centre François-Baclesse, 3, avenue du Général-Harris, 14076 Caen cedex 5, France. · CHU Paris Centre, hôpital Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75004 Paris, France. · Hôpital Jean-Verdier, avenue du 14 juillet, 93140 Bondy, France. ·Bull Cancer · Pubmed #29397916.

ABSTRACT: INTRODUCTION: Rare ovarian tumors include complex borderline ovarian tumors, sex-cord tumors, germ cell tumors, and rare epithelial tumors. Indications and modalities of fertility preservation, infertility management and contraindications for hormonal contraception or menopause hormone therapy are frequent issues in clinical practice. A panel of experts from the French national network dedicated to rare gynaecological cancers, and of experts in reproductive medicine and gynaecology have worked on guidelines about fertility preservation, contraception and menopause hormone therapy in women treated for ovarian rare tumors. METHODS: A panel of 39 experts from different specialties contributed to the preparation of the guidelines, following the DELPHI method (formal consensus method). Statements were drafted after a systematic literature review, and then rated through two successive rounds. RESULTS: Thirty-five recommendations were selected, and concerned indications for fertility preservation, contraindications for ovarian stimulation (in the context of fertility preservation or for infertility management), contraceptive options (especially hormonal ones), and menopause hormone therapy for each tumor type. Overall, prudence has been recommended in the case of potentially hormone-sensitive tumors such as sex cord tumors, serous and endometrioid low-grade adenocarcinomas, as well as for high-risk serous borderline ovarian tumors. DISCUSSION: In the context of a scarce literature, a formal consensus method allowed the elaboration of guidelines, which will help clinicians in the management of these patients.

2 Review Gynaecologic cancer surgery and preservation of fertility. 2018

Bentivegna, E / Maulard, A / Miailhe, G / Gouy, S / Morice, P. ·Département de chirurgie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94085 Villejuif cedex, France. Electronic address: enrica.bentivegna@gustaveroussy.fr. · Département de chirurgie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94085 Villejuif cedex, France. ·J Visc Surg · Pubmed #29735328.

ABSTRACT: For gynecological cancers, even at an early stage, the standard treatment is "radical excision" involving hysterectomy (radical or not) with bilateral salpingo-oophorectomy. But for young patients with early stage disease, many recent studies have focused on preservation of subsequent fertility by keeping at least one ovary and the uterus. The main objective of this fertility-sparing surgery is to preserve fertility, if this can be accomplished without increasing the oncological risks. Whether the initial site of the cancer is the cervix, uterine fundus or ovary, the oncologic validation of fertility-sparing treatment requires several evaluation criteria: a rigorous clinical, radiological and surgical staging to verify that the pathology is truly at an early initial stage; expert pathologic interpretation of biopsy specimens to validate the histological criteria of "good prognosis"; provision of complete and understandable patient education verifying the true objectives for this fertility-sparing treatment (whose intent is to retain a potential for subsequent fertility without guaranteeing it) and provision of an explanation of the oncological constraints and implications of fertility-sparing surgery in the event of a possible pregnancy. As always in oncology, this strategy demands teamwork requiring successive discussions with the patient and spouse and thorough discussion of the oncological safety of this fertility-sparing strategy in multidisciplinary consultation meetings before "giving a green light".

3 Review Fertility results and pregnancy outcomes after conservative treatment of cervical cancer: a systematic review of the literature. 2016

Bentivegna, Enrica / Maulard, Amandine / Pautier, Patricia / Chargari, Cyrus / Gouy, Sebastien / Morice, Philippe. ·Department of Gynecologic Surgery, Gustave Roussy, Villejuif, France. · Department of Medical Oncology, Gustave Roussy, Villejuif, France. · Department of Radiation Oncology, Gustave Roussy, Villejuif, France. · Department of Gynecologic Surgery, Gustave Roussy, Villejuif, France; Unit Institut national de la santé et de la recherche médicale, Villejuif, France; University Paris Sud, Le Kremlin Bicetre, France. Electronic address: morice@igr.fr. ·Fertil Steril · Pubmed #27430207.

ABSTRACT: OBJECTIVES: To evaluate the fertility results, obstetric outcomes, and the management of infertility in patients submitted to fertility-sparing surgery (FSS) for invasive cervical cancer. DESIGN: Systematic review. SETTING: Not applicable. PATIENT(S): Patients submitted to FSS for invasive cervical cancer (stage IB). INTERVENTION(S): Five different FSS procedures were studied. MAIN OUTCOMES MEASURE(S): Fertility, pregnancy outcomes, and management of infertility. RESULT(S): A total of 2,777 patients submitted to FSS and 944 ensuing pregnancies were included in this review. Five different surgical procedures were performed and studied. The overall fertility, live birth, and prematurity rates after these procedures were, respectively, 55%, 70%, and 38%. The pregnancy rate was higher in patients submitted to a vaginal or minimally invasive radical trachelectomy compared with a laparotomic radical trachelectomy. The live birth rate was similar, whatever the FSS procedure. The prematurity rate was significantly lower in patients who had undergone a simple trachelectomy/cone resection and neoadjuvant chemotherapy followed by FSS compared with other conservative surgeries. A majority of second trimester fetal losses and premature deliveries were related to premature rupture of membranes. CONCLUSION(S): The choice between the different FSS procedures depends first and foremost on the oncologic characteristics of the tumor. Nevertheless, when several options seem to offer the same oncologic results (for example, stage IB1 disease >2 cm), fertility results should then be taken into consideration to select the best choice acceptable to the patient/couple.

4 Review Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review. 2016

Bentivegna, Enrica / Gouy, Sebastien / Maulard, Amandine / Chargari, Cyrus / Leary, Alexandra / Morice, Philippe. ·Department of Gynaecological Surgery, Institut Gustave Roussy, Villejuif, France. · Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France. · Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France; Unit INSERM U 981, Gustave Roussy, Villejuif, France. · Department of Gynaecological Surgery, Institut Gustave Roussy, Villejuif, France; Unit INSERM U 10-30, Gustave Roussy, Villejuif, France; University Paris-Sud (Paris XI), Le Kremlin Bicêtre, France. Electronic address: philippe.morice@gustaveroussy.fr. ·Lancet Oncol · Pubmed #27299280.

ABSTRACT: Fertility preservation in young patients with cervical cancer is suitable only for patients with good prognostic factors and disease amenable to surgery without adjuvant therapy. Consequently, it is only offered to patients with early-stage disease (stage IB tumours <4 cm), negative nodes, and non-aggressive histological subtypes. To determine whether fertility preservation is suitable, the first step is pelvic-node dissection to establish nodal spread. Tumour size (≤2 cm vs >2 cm) and lymphovascular space invasion status are two main factors to determine the best fertility-sparing surgical technique. In this systematic Review, we assess six different techniques that are available to preserve fertility (Dargent's procedure, simple trachelectomy or cone resection, neoadjuvant chemotherapy with conservative surgery, and laparotomic, laparoscopic and robot-assisted abdominal radical trachelectomy). The choice between the six different fertility preservation techniques should be based on the experience of the team, discussion with the patient or couple, and, above all, objective oncological data to balance the best chance for cure with optimum fertility results for each procedure.