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Systemic Lupus Erythematosus: HELP
Articles by Daniel S. Smyk
Based on 3 articles published since 2008
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Between 2008 and 2019, D. S. Smyk wrote the following 3 articles about Lupus Erythematosus, Systemic.
 
+ Citations + Abstracts
1 Review Infectomics and autoinfectomics: a tool to study infectious-induced autoimmunity. 2015

Bogdanos, D P / Smyk, D S / Rigopoulou, E I / Sakkas, L I / Shoenfeld, Y. ·Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, UK Department of Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece bogdanos@med.uth.gr. · Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, UK. · Department of Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. · The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Israel. ·Lupus · Pubmed #25801879.

ABSTRACT: The exposome represents all exogenous and endogenous environmental exposures that begin at preconception and carry on throughout life, while the microbiome reflects the microbial component of the exposome. We recently introduced the concept of infectome and autoinfectome as a means of studying the totality of infections throughout life that participate in the induction as well as the progression of autoimmune diseases in an affected individual. The investigation of the autoinfectome could help us understand why some patients develop more than one autoimmune disease, a phenomenon also known as mosaic of autoimmunity. It could also explain the infectious and autoantibody burden of various autoimmune rheumatic diseases. The close interplay between infections and the immune system should be studied over time, long before the onset of autoaggression and autoimmunity. Tracking down each individual's exposure to infectious agents (as defined by the autoinfectome) would be important for the establishment of a causative link between infection and autoimmunity.

2 Review Tracing environmental markers of autoimmunity: introducing the infectome. 2013

Bogdanos, Dimitrios P / Smyk, Daniel S / Invernizzi, Pietro / Rigopoulou, Eirini I / Blank, Miri / Sakkas, Lazaros / Pouria, Shideh / Shoenfeld, Yehuda. ·Division of Transplantation Immunology and Mucosal Biology, Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, Denmark Hill Campus, London, SE5 9RS, UK. dimitrios.bogdanos@kcl.ac.uk ·Immunol Res · Pubmed #23592050.

ABSTRACT: We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burden which leads to the loss of adaptive mechanisms in the body. These studies complement genome-wide association studies, which establish the genetic predisposition to disease. The infectome is a component which spans the whole life and may begin at the earliest stages right up to the time when the first symptoms manifest, and may thus contribute to the understanding of the pathogenesis of autoimmunity at the prodromal/asymptomatic stages. We provide practical examples and research tools as to how we can investigate disease-specific infectomes, using laboratory approaches employed from projects studying the "immunome" and "microbiome". It is envisioned that an understanding of the infectome and the environmental factors that affect it will allow for earlier patient-specific intervention by clinicians, through the possible treatment of infectious agents as well as other compounding factors, and hence slowing or preventing disease development.

3 Review p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: lessons to learn from ANCA vasculitis and pemphigus vulgaris. 2013

Mavropoulos, Athanasios / Orfanidou, Timoklia / Liaskos, Christos / Smyk, Daniel S / Billinis, Charalambos / Blank, Miri / Rigopoulou, Eirini I / Bogdanos, Dimitrios P. ·Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, Denmark Hill Campus, London SE5 9RS, UK. ·Autoimmun Rev · Pubmed #23207287.

ABSTRACT: Evidence is beginning to accumulate that p38 mitogen activated protein kinase (p38 MAPK) signaling pathway plays an important role in the regulation of cellular and humoral autoimmune responses. The exact mechanisms and the degree by which the p38 MAPK pathway participates in the immune-mediated induction of diseases have started to emerge. This review discusses the recent advances in the molecular dissection of the p38 MAPK pathway and the findings generated by reports investigating its role in the pathogenesis of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and autoimmune hepatitis. Application of newly-developed protocols based on sensitive flow cytometric detection has proven to be a useful tool in the investigation of the phosphorylation of p38 MAPK within different peripheral blood mononuclear cell populations and may help us to better understand the enigmatic role of this signaling cascade in the induction of autoimmunity as well as its role in immunosuppressive-induced remission. Special attention is paid to reported data proposing a specific role for autoantibody-induced activation of p38 MAPK-mediated immunopathology in the pathogenesis of autoimmune blistering diseases and anti-neutrophilic antibody-mediated vasculitides.