Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Melanoma: HELP
Articles by Giuseppe Argenziano
Based on 168 articles published since 2010
(Why 168 articles?)
||||

Between 2010 and 2020, G. Argenziano wrote the following 168 articles about Melanoma.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1420806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Editorial The user-generated web-based Dermoscopy Image Archive of the International Dermoscopy Society: a contribution to e-learning and exchange of knowledge. 2011

Niederkorn, A / Gabler, G / Argenziano, G / Muir, J / Zalaudek, I / Soyer, H P / Hofmann-Wellenhof, R. · ·Dermatology · Pubmed #21389684.

ABSTRACT: -- No abstract --

3 Review Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis. 2019

Puig, Susana / Granger, Corinne / Garre, Aurora / Trullàs, Carles / Sanmartin, Onofre / Argenziano, Giuseppe. ·Dermatology Department, Melanoma Unit, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. spuig@clinic.cat. · Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. spuig@clinic.cat. · Centro de Investigación en Red de Enfermedades Raras (CIBER ER), Instituto de Salud Carlos III, Barcelona, Spain. spuig@clinic.cat. · Innovation and Development, ISDIN, Barcelona, Spain. · Department of Dermatology, Fundación Instituto Valenciano de Oncologia, Universidad Católica de Valencia San Vicente Martir, Valencia, Spain. · Dermatology Unit, Second University of Naples, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy. ·Dermatol Ther (Heidelb) · Pubmed #30968311.

ABSTRACT: Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue to rise. Apart from visible hyperkeratotic, hyperplastic lesions, AK is also associated with the presence of subclinical lesions adjacent to tumor tissue, which has led to the use of the concept "cancerization field". Although lesion- and field-targeting treatments are currently available, many are associated with local side effects and recurrence of new lesions. This review provides information on AK pathophysiology and treatment options and summarizes the available clinical evidence supporting the use of Eryfotona AK-NMSC, a film-forming medical device with SPF 100+ containing the DNA repair enzyme photolyase, for managing AK, based on the analysis of the results of 228 patients treated with the product. FUNDING: ISDIN funded the Article Processing Charges.

4 Review The use of in vivo reflectance confocal microscopy for the diagnosis of melanoma. 2019

Agozzino, Marina / Moscarella, Elvira / Babino, Graziella / Caccavale, Stefano / Piccolo, Vincenzo / Argenziano, Giuseppe. ·a Dermatology Unit , University of Campania Luigi Vanvitelli , Naples , Italy. ·Expert Rev Anticancer Ther · Pubmed #30869538.

ABSTRACT: INTRODUCTION: The use of reflectance confocal microscopy (RCM) for imaging the skin non-invasively raised constantly during the last decade. One of the main field of application is skin cancer diagnosis, and in particular melanoma diagnosis. Several studies have investigated the diagnostic accuracy of RCM as compared to dermoscopic examination, and its value in enhancing early diagnosis of dermoscopic difficult melanomas. Areas covered: The purpose of this paper was to review the principles behind RCM image acquisition as well as to describe and discuss key RCM features of melanoma. Moreover, we conducted a literature search in order to highlight the current available evidence about RCM sensitivity and specificity in the diagnosis of melanoma. Expert commentary: During the last decade, we assisted at the increasing interest in non invasive imaging tools for the diagnosis of skin cancer. RCM is one of the most studied of a series of diagnostic methods that are emerging in the field of melanoma imaging. Most probably in the future, RCM will be more frequently available in tertiary referral centres, thus the knowledge of the pros and contra of the tool and its clinical applicability is of upmost importance in order to allow correct referrals with the final aim of improving diagnostic accuracy.

5 Review It is finally time for adjuvant therapy in melanoma. 2018

Napolitano, S / Brancaccio, G / Argenziano, G / Martinelli, E / Morgillo, F / Ciardiello, F / Troiani, T. ·Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale "F. Magrassi", Università degli Studi della Campania "Luigi Vanvitelli", Via S. Pansini 5, Napoli 80131, Italy. · Dermatologia e Venerologia, Dipartimento di salute mentale e fisica e medicina riabilitativa, Università degli Studi della Campania "Luigi Vanvitelli", Via S. Pansini 5, Napoli 80131, Italy. · Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale "F. Magrassi", Università degli Studi della Campania "Luigi Vanvitelli", Via S. Pansini 5, Napoli 80131, Italy. Electronic address: teresa.troiani@unicampania.it. ·Cancer Treat Rev · Pubmed #29957365.

ABSTRACT: Although melanoma is amenable to early detection, there has been no decline in the mortality rate of this disease and the prognosis of patients with high-risk primary melanoma or with macroscopic nodal involvement remains poor. The best option for patients with higher-risk melanoma is to receive effective adjuvant therapy in order to reduce their chances of recurrence. Multiple systemic therapeutic agents have been tested as adjuvant therapy for melanoma with durable benefits seen only with interferon- to date. More recently ipilimumab at the high dose of 10 mg/kg has shown a significant improvement in terms of Relapse free survival and Overall survival for stage III melanoma patients but at a significant cost in terms of immune-related toxicities. More recently, novel treatment options have emerged. The results from the latest trials with immunotherapy (PD-1 inhibitors) and molecular targeted therapy (BRAF inhibitor + MEK inhibitor) have revolutionized the management of adjuvant treatment for melanoma. As the results from these trials will mature in the next years, a change in the landscape of adjuvant treatment for melanoma is expected, resulting in new challenges in treatment decisions such as optimizing patients' selection through predictive and prognostic biomarkers, and management of treatment related adverse events, in particular immune related toxicities.

6 Review A meta-analysis of nevus-associated melanoma: Prevalence and practical implications. 2017

Pampena, Riccardo / Kyrgidis, Athanassios / Lallas, Aimilios / Moscarella, Elvira / Argenziano, Giuseppe / Longo, Caterina. ·Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy. · First Department of Dermatology, Aristotle University of Thessaloniki, Thessaloniki, Greece. · Dermatology Unit, University of Campania, Naples, Italy. · Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy; Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: longo.caterina@gmail.com. ·J Am Acad Dermatol · Pubmed #28864306.

ABSTRACT: The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I

7 Review Dermoscopy of Malignant Skin Tumours: What's New? 2017

Russo, Teresa / Piccolo, Vincenzo / Lallas, Aimilios / Giacomel, Jason / Moscarella, Elvira / Alfano, Roberto / Argenziano, Giuseppe. ·Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy. ·Dermatology · Pubmed #28486238.

ABSTRACT: Dermoscopy represents a new and effective tool that assists dermatologists in improving the accuracy of clinical diagnosis in onco-dermatology. The aim of this article is to provide an overview of the latest and important dermoscopic progress and observations in this ever-evolving field of dermatology.

8 Review Dermoscopy pathology correlation in melanoma. 2017

Russo, Teresa / Piccolo, Vincenzo / Ferrara, Gerardo / Agozzino, Marina / Alfano, Roberto / Longo, Caterina / Argenziano, Giuseppe. ·Dermatology Unit, Second University of Naples, Naples, Italy. · Department of Oncology, Anatomical Pathology Unit, Gaetano Rummo General Hospital, Benevento, Italy. · Department of Anesthesiology, Surgery and Emergency, Second University of Naples, Naples, Italy. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. ·J Dermatol · Pubmed #28447355.

ABSTRACT: Dermoscopy is a widely used technique whose role in the clinical (and preoperative) diagnosis of melanocytic and non-melanocytic skin lesions has been well established in recent years. The aim of this paper is to clarify the correlations between the "local" dermoscopic findings in melanoma and the underlying histology, in order to help clinicians in routine practice.

9 Review MELTUMP: how to manage these lesions in the clinical routine. 2017

Piccolo, Vincenzo / Moscarella, Elvira / Lallas, Aimilios / Alfano, Roberto / Ferrara, Gerardo / Argenziano, Giuseppe. ·Dermatology Unit, L. Vanvitelli University, Naples, Italy - piccolo.vincenzo@gmail.com. · Dermatology Unit, L. Vanvitelli University, Naples, Italy. · Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova Institute for Research and Care, Reggio Emilia, Italy. · First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Department of Anesthesiology, Surgery and Emergency, L. Vanvitelli University, Naples, Italy. · Anatomic Pathology Unit, General Hospital of Macerata, Macerata, Italy. ·G Ital Dermatol Venereol · Pubmed #28195450.

ABSTRACT: Although most melanocytic lesions can be diagnosed by histopathologists as benign or malignant with high confidence, a subset of morphologically ambiguous lesions does exist and still represents a significant problem for pathologists. These lesions have been defined as MELTUMP, i.e. melanocytic tumors of uncertain malignant potential. MELTUMP could be considered as a large cauldron in which melanocytic lesions with equivocal morphologic features fall into, including most benign lesions and a minority of melanomas, unfortunately recognizable only a posteriori for their unfavorable outcome. As a consequence of the lack of uniformity in the biologic behavior of melanocytic lesions belonging to the heterogeneous subset of MELTUMP, confusion and lack of agreement in the management of these difficult lesions is increasingly growing up. As most MELTUMP have a favorable prognosis we recommend a conservative approach, avoiding over treatment for this group of lesions.

10 Review Melanoma: clinical and dermoscopic diagnosis. 2017

Brancaccio, Gabriella / Russo, Teresa / Lallas, Aimilios / Moscarella, Elvira / Agozzino, Marina / Argenziano, Giuseppe. ·Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy. · Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy - russo.teresa87@gmail.com. · First Department of Dermatology, Aristotle University, Thessaloniki, Greece. ·G Ital Dermatol Venereol · Pubmed #28121084.

ABSTRACT: Missing the diagnosis of a melanoma is the worst dermatologist nightmare, especially when melanomas have a non-alarming clinical appearance and imitate a completely benign lesion. The use of dermoscopy has provided an effective tool to facilitate the differential diagnosis and to increasingly allow an early diagnosis of melanoma. The aim of this article was to summarize the most recent and important clinical and dermoscopic pearls to recognize melanoma at the earliest stages of its development.

11 Review Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. 2017

Lallas, A / Apalla, Z / Ioannides, D / Lazaridou, E / Kyrgidis, A / Broganelli, P / Alfano, R / Zalaudek, I / Argenziano, G / Anonymous3580894. ·First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · City of Health and Science University, Turin, Italy. · Department of Anaesthesiology, Surgery and Emergency Medicine, Second University of Naples, Naples, Italy. · Department of Dermatology and Venereology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Austria. · Dermatology Unit, Second University of Naples, Naples, Italy. ·Br J Dermatol · Pubmed #28118479.

ABSTRACT: Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biological behaviour and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphological overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid-looking lesions based on a consensus among experts in the field. After a detailed search of the literature for eligible studies, a data synthesis was performed from 15 studies on dermoscopy of Spitz naevi. Dermoscopically, Spitz naevi are typified by three main patterns: starburst pattern (51%), a pattern of regularly distributed dotted vessels (19%) and globular pattern with reticular depigmentation (17%). A consensus-based algorithm for the management of spitzoid lesions is proposed. According to it, dermoscopically asymmetric lesions with spitzoid features (both flat/raised and nodular) should be excised to rule out melanoma. Dermoscopically symmetric spitzoid nodules should also be excised or closely monitored, irrespective of age, to rule out atypical Spitz tumours. Dermoscopically symmetric, flat spitzoid lesions should be managed according to the age of the patient. Finally, the histopathological diagnosis of atypical Spitz tumour should warrant wide excision but not a sentinel lymph-node biopsy.

12 Review Regression in cutaneous melanoma: a comprehensive review from diagnosis to prognosis. 2016

Ribero, S / Moscarella, E / Ferrara, G / Piana, S / Argenziano, G / Longo, C. ·Medical Sciences Department, Section of Dermatology, University of Turin, Turin, Italy. · Department off Twin research and Genetic Epidemiology, King's College London, London, UK. · Skin Cancer Unit, Arcispedale ASMN-IRCCS, Reggio Emilia, Italy. · Pathology Unit, Gaetano Rummo Hospital, Benevento, Italy. · Pathology Unit, Arcispedale ASMN-IRCCS, Reggio Emilia, Italy. · Dermatology Unit, Second University of Naples, Naples, Italy. ·J Eur Acad Dermatol Venereol · Pubmed #27401335.

ABSTRACT: Histological regression in primary cutaneous melanoma occurs in 10-35% of cases. Although a large body of literature exists to suggest that histological regression serves very little purpose in predicting biologic behaviour with melanoma, recognizing the presence of regression at clinical and histological ground may still retain some value in grading melanoma aggressiveness. In the current review, a comprehensive overview of the main aspects of regression will be provided. Histologically, many classifications have been reported so far, but all of them only agreed on the presence of an infiltrate of lymphocytes admixed with pigment-laden macrophages underlying an atrophic epidermis with flattened rete ridges. Upon dermoscopy, regression is also named Blue White Scar-like areas and could be variably admixed with granularity or peppering. Almost fully regressed lesions represent a main diagnostic issue in dermoscopy, and thus, confocal microscopy can be of help to identify whether the tumour is melanocytic or not. The clinical utility of regression as a prognostic factor has been challenged recently. Nowadays, evidences showed that it is less likely associated to SLN metastases.

13 Review Contemporary and potential future molecular diagnosis of melanoma. 2016

Gandolfi, G / Dallaglio, K / Longo, C / Moscarella, E / Lallas, A / Alfano, R / Argenziano, G / Ciarrocchi, A. ·a Laboratory of Translational Research , Arcispedale S. Maria Nuova-IRCCS , Reggio Emilia , Italy. · b Skin Cancer Unit , Arcispedale Santa Maria Nuova-IRCCS , Reggio Emilia , Italy. · c Surgery and Emergency Unit , Second University of Naples , Naples , Italy. · d Dermatology Unit , Second University of Naples , Naples , Italy. ·Expert Rev Mol Diagn · Pubmed #27348706.

ABSTRACT: INTRODUCTION: The increasing incidence of cutaneous melanoma and the still limited effective treatments available for this disease represent a major health problem and a great challenge for research. The raise of the "omics" era and the development of new techniques to explore phenotypic heterogeneity are helping to decipher the mechanisms at the basis of melanoma heterogeneity. AREAS COVERED: We reviewed the most recent publications about the biology of cutaneous melanoma, to provide an overview of the most recent insights into the complexity of this tumor and their potential impact in the clinical settings. Expert commentary: Starting from the first attempts to provide a molecular classification of melanoma, it has been evident that this tumor represents a widely heterogeneous disease. This complexity and the multivariate nature of melanoma represent a major obstacle in developing the best management strategies for patients.

14 Review Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma. 2016

Banzi, Maria / De Blasio, Simona / Lallas, Aimilios / Longo, Caterina / Moscarella, Elvira / Alfano, Roberto / Argenziano, Giuseppe. ·Department of Medical Oncology, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Department of Anesthesiology, Surgery and Emergency, Second University of Naples, Naples, Italy. · Dermatology Unit, Second University of Naples, Naples, Italy. ·Onco Targets Ther · Pubmed #27226731.

ABSTRACT: Prior to 2011, the 1-year survival rates for patients suffering from advanced or metastatic melanoma was as low as 33%, with a median overall survival of about 9 months. Several chemotherapeutic regimens have been applied, either as monochemotherapy or as polychemotherapy, overall not resulting in an improvement of progression-free or overall survival. Novel insights into the epidemiology and biology of melanoma allowed the development of newer therapies. The discovery of mutations in BRAF, a part of the mitogen-activated protein kinase, allowed the development of two BRAF inhibitors, vemurafenib and dabrafenib, which significantly improved the outcome of metastatic melanoma treatment. This article reviews the mechanism of action, efficacy, and safety profile of dabrafenib. An in-depth knowledge of this medication will encourage clinicians to select the appropriate therapeutic strategy for each patient, as well as to prevent or adequately manage side effects, optimizing, thus, the drug's applicability.

15 Review Recent advances in dermoscopy. 2016

Russo, Teresa / Piccolo, Vincenzo / Lallas, Aimilios / Argenziano, Giuseppe. ·Dermatology Unit, Second University of Naples, Naples, Italy. · First Department of Dermatology, Aristotle University of Thessaloniki, Thessaloniki, Greece. ·F1000Res · Pubmed #26949523.

ABSTRACT: The use of dermoscopy has offered a new morphological dimension of skin lesions and has provided an effective diagnostic tool to differentiate melanoma from other benign or malignant skin tumors but also to support the clinical diagnosis in general dermatology. The aim of this article is to provide an overview of the most recent and important advances in the rising world of dermoscopy.

16 Review Standardization of terminology in dermoscopy/dermatoscopy: Results of the third consensus conference of the International Society of Dermoscopy. 2016

Kittler, Harald / Marghoob, Ashfaq A / Argenziano, Giuseppe / Carrera, Cristina / Curiel-Lewandrowski, Clara / Hofmann-Wellenhof, Rainer / Malvehy, Josep / Menzies, Scott / Puig, Susana / Rabinovitz, Harold / Stolz, Wilhelm / Saida, Toshiaki / Soyer, H Peter / Siegel, Eliot / Stoecker, William V / Scope, Alon / Tanaka, Masaru / Thomas, Luc / Tschandl, Philipp / Zalaudek, Iris / Halpern, Allan. ·Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address: harald.kittler@meduniwien.ac.at. · Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy. · Melanoma Unit, Department of Dermatology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER ER), Instituto de Salud Carlos III, Barcelona, Spain. · University of Arizona Cancer Center, Tucson, Arizona. · Department of Dermatology and Venerology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Graz, Austria. · Sydney Melanoma Diagnostic Center, Sydney Cancer Center, Royal Prince Alfred Hospital, Camperdown, Australia. · Skin and Cancer Associates, Plantation, Florida. · Department of Dermatology, Klinikum München, Munich, Germany. · Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan. · Dermatology Research Center, University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Australia. · University of Maryland Medical Center, Baltimore Department of Veterans Affairs Medical Center, Baltimore, Maryland. · Department of Dermatology, University of Missouri Health Sciences Center, Columbia, Missouri. · Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Dermatology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. · Department of Dermatology, Keio University, Tokyo, Japan. · Service de Dermatologie, Center Hospitalier Universitaire de Lyon, Lyon, France. · Department of Dermatology, Medical University of Vienna, Vienna, Austria. ·J Am Acad Dermatol · Pubmed #26896294.

ABSTRACT: BACKGROUND: Evolving dermoscopic terminology motivated us to initiate a new consensus. OBJECTIVE: We sought to establish a dictionary of standardized terms. METHODS: We reviewed the medical literature, conducted a survey, and convened a discussion among experts. RESULTS: Two competitive terminologies exist, a more metaphoric terminology that includes numerous terms and a descriptive terminology based on 5 basic terms. In a survey among members of the International Society of Dermoscopy (IDS) 23.5% (n = 201) participants preferentially use descriptive terminology, 20.1% (n = 172) use metaphoric terminology, and 484 (56.5%) use both. More participants who had been initially trained by metaphoric terminology prefer using descriptive terminology than vice versa (9.7% vs 2.6%, P < .001). Most new terms that were published since the last consensus conference in 2003 were unknown to the majority of the participants. There was uniform consensus that both terminologies are suitable, that metaphoric terms need definitions, that synonyms should be avoided, and that the creation of new metaphoric terms should be discouraged. The expert panel proposed a dictionary of standardized terms taking account of metaphoric and descriptive terms. LIMITATIONS: A consensus seeks a workable compromise but does not guarantee its implementation. CONCLUSION: The new consensus provides a revised framework of standardized terms to enhance the consistent use of dermoscopic terminology.

17 Review Dermoscopy of melanoma and non-melanoma skin cancer. 2015

Babino, G / Lallas, A / Longo, C / Moscarella, E / Alfano, R / Argenziano, G. ·Department of Dermatology, University of Rome Tor Vergata, Rome, Italy - g.argenziano@gmail.com. ·G Ital Dermatol Venereol · Pubmed #26184795.

ABSTRACT: Skin cancer is a major health problem because of its high incidence in white populations, as well as its related potential morbidity and mortality. Dermoscopy is a noninvasive tool that allows the identification of specific morphological features in different skin tumors, improving significantly the early diagnosis of melanoma and non-melanoma skin cancer (NMSC). This tool has also gained increased interest in the management of NMSC therapy and in the post-treatment follow-up. In this article, we provide a review of the dermoscopic patterns and criteria for the diagnosis of melanoma and NMSC described until now in the literature.

18 Review Reflectance confocal microscopy in the diagnosis of solitary pink skin tumours: review of diagnostic clues. 2015

Longo, C / Moscarella, E / Argenziano, G / Lallas, A / Raucci, M / Pellacani, G / Scope, A. ·Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Viale Risorgimento 80, 42100, Reggio Emilia, Italy. · Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy. · Department of Dermatology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ·Br J Dermatol · Pubmed #25640416.

ABSTRACT: Reflectance confocal microscopy (RCM) is a noninvasive tool that can be helpful in the diagnosis of nonpigmented skin tumours. As RCM enables visualization of architectural and cytological structures at near-histological resolution, it can improve the diagnostic accuracy of dermoscopically equivocal solitary pink neoplasms. For management decisions, it is important to identify specific morphological clues that allow bedside classification of nonpigmented skin neoplasms into benign vs. malignant and melanocytic vs. nonmelanocytic. More specifically, the presence of a nested melanocytic proliferation at the dermoepidermal junction or dermis level permits the clinician to ascribe a given lesion as melanocytic; the identification of basaloid bright tumour islands is a key RCM feature for the diagnosis of basal cell carcinoma; and the presence of disarrayed epidermis along with small demarcated papillae is suggestive for the diagnosis of squamous cell carcinoma. The present review offers a comprehensive description of the main RCM diagnostic clues for solitary pink neoplasms that direct clinicians to the correct diagnosis and that may serve as groundwork for future prospective studies.

19 Review No one should die of melanoma: a vision or impossible mission? 2014

Zalaudek, Iris / Moscarella, Elvira / Longo, Caterina / Lallas, Aimilios / Argenziano, Giuseppe / Hofmann-Wellenhof, Rainer. ·Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. · Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento, 80, Reggio Emilia Reggio nell'Emilia, Italy. ·Melanoma Manag · Pubmed #30190809.

ABSTRACT: While the incidence of early-stage melanoma has dramatically increased over the past decades, the incidence and mortality rates of thick melanomas have remained relatively stable during the same period. A number of alternative theories have been postulated in order to explain these divergent trends between thin and thick melanomas, among which is the question of whether nodular melanoma may originate in the dermis. This concept has gained support from recent improvements in the understanding of the origin of melanocytes and the morphological and molecular diversity of melanoma. A dermal origin would plausibly explain why efforts at improving the early detection of melanoma largely fail, as it implies an initially intradermal growth that is hidden from our eyes until clinical signs and symptoms become only secondarily apparent. In light of this, at the current stage, the vision that no one should die of melanoma is an impossible mission.

20 Review When all you have is a dermatoscope- start looking at the nails. 2014

Haenssle, Holger A / Blum, Andreas / Hofmann-Wellenhof, Rainer / Kreusch, Juergen / Stolz, Wilhelm / Argenziano, Giuseppe / Zalaudek, Iris / Brehmer, Franziska. ·Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Heidelberg, Heidelberg, Germany. · Private Dermatology Practice, Konstanz, Germany. · Department of Dermatology, Medical University of Graz, Graz, Austria. · Private Dermatology Practice, Luebeck, Luebeck, Germany. · Clinic of Dermatology and Allergology, Hospital Munich-Schwabing, Munich, Germany. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova (IRCCS), Reggio Emilia, Italy. · Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany. ·Dermatol Pract Concept · Pubmed #25396079.

ABSTRACT: Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life-threatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, and, therefore, fingernails and toenails physiologically are non-pigmented. The formation of continuous, longitudinal pigmented streaks (longitudinal melanonychia) may either be caused by a benign activation of matrix melanocytes (e.g., as a result of trauma, inflammation, or adverse drug reactions) or by a true melanocytic proliferation (e.g., in a nevus or melanoma). In general, non-continuous nail alterations, affecting only limited parts of the nail apparatus, are most frequently of non-melanocytic origin. Important and common differential diagnoses in these cases are subungual hemorrhage or onychomycosis. In addition, foreign bodies, bacterial infections, traumatic injuries, or artificial discolorations of the nail unit may less frequently cause non-continuous nail alterations. Many systemic diseases that may also show involvement of the nails (e.g., psoriasis, atopic dermatitis, lichen planus, alopecia areata) tend to induce alterations in numerous if not all nails of the hands and feet. A similar extensive and generalized alteration of nails has been reported after treatment with a number of systemic drugs, especially antibiotics and cytostatics. Benign or malignant neoplasms that may also affect the nail unit include glomus tumor, Bowen's disease, squamous cell carcinoma, and rare collision tumors. This review aims to assist clinicians in correctly evaluating and diagnosing nail disorders with the help of dermatoscopy.

21 Review The dermatoscopic universe of basal cell carcinoma. 2014

Lallas, Aimilios / Apalla, Zoe / Argenziano, Giuseppe / Longo, Caterina / Moscarella, Elvira / Specchio, Francesca / Raucci, Margaritha / Zalaudek, Iris. ·Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy. · Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. · Department of Dermatology, Medical University of Graz, Austria. ·Dermatol Pract Concept · Pubmed #25126452.

ABSTRACT: Following the first descriptions of the dermatoscopic pattern of basal cell carcinoma (BCC) that go back to the very early years of dermatoscopy, the list of dermatoscopic criteria associated with BCC has been several times updated and renewed. Up to date, dermatoscopy has been shown to enhance BCC detection, by facilitating its discrimination from other skin tumors and inflammatory skin diseases. Furthermore, upcoming evidence suggests that the method is also useful for the management of the tumor, since it provides valuable information about the histopathologic subtype, the presence of clinically undetectable pigmentation, the expansion of the tumor beyond clinically visible margins and the response to non-ablative treatments. In the current article, we provide a summary of the traditional and latest knowledge on the value of dermatoscopy for the diagnosis and management of BCC.

22 Review [Dermoscopy of nails]. 2014

Haenssle, H A / Brehmer, F / Zalaudek, I / Hofmann-Wellenhof, R / Kreusch, J / Stolz, W / Argenziano, G / Blum, A. ·Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Georg-August Universität, Robert-Koch Str. 40, 37075, Göttingen, Deutschland, h.haenssle@med.uni-goettingen.de. ·Hautarzt · Pubmed #24668319.

ABSTRACT: Pigmented and nonpigmented nail abnormalities often represent a challenge for clinicians because many, and sometimes potentially life-threatening differential diagnoses must be taken into consideration. Although many details of nail diseases can already be assessed with the naked eye, dermoscopy opens up a second microscopic level of inspection, which can be very useful for the diagnostic process. In the last 20 years dermoscopy has made rapid progress in the further development of criteria for the early recognition of melanoma. In addition, the use of dermoscopy has been extended to the examination of cutaneous adnexa, such as hairs (trichoscopy) and nails (onychoscopy). Many, sometimes highly specific criteria for the dermoscopic assessment of nail diseases have been described in a series of recently published articles. This review article provides important diagnostic aids for a well-founded dermoscopic assessment of nail diseases.

23 Review Blue lesions. 2013

Longo, Caterina / Scope, Alon / Lallas, Aimilios / Zalaudek, Iris / Moscarella, Elvira / Gardini, Stefano / Argenziano, Giuseppe / Pellacani, Giovanni. ·Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: longo.caterina@gmail.com. ·Dermatol Clin · Pubmed #24075551.

ABSTRACT: Blue color is found in a wide range of malignant and benign melanocytic and nonmelanocytic lesions and in lesions that result from penetration of exogenous materials, such as radiation or amalgam tattoo or traumatic penetration of particles. Discriminating between different diagnostic entities that display blue color relies on careful patient examination and lesion assessment. Dermoscopically, the extent, distribution, and patterns created by blue color can help diagnose lesions with specificity and differentiate between benign and malignant entities. This article provides an overview of the main diagnoses whereby blue color can be found, providing simple management rules for these lesions.

24 Review Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. 2013

Ferrara, Gerardo / Gianotti, Raffaele / Cavicchini, Stefano / Salviato, Tiziana / Zalaudek, Iris / Argenziano, Giuseppe. ·Anatomic Pathology Unit, Department of Oncology, 'Gaetano Rummo' General Hospital, Via dell'Angelo 1, Benevento I-82100, Italy. Electronic address: gerardo.ferrara@libero.it. ·Dermatol Clin · Pubmed #24075547.

ABSTRACT: Spitz nevus can clinically present either in the classical (reddish pink) or the pigmented (brownish black) variant. Dermoscopy demonstrates that the pigmented variant is much more common than the classical variant; however, none of these show dermoscopic patterns clearly distinguishable from melanoma. Even histopathologically, a clear-cut differentiation between benign and malignant spitzoid neoplasms is often difficult, so that intermediate diagnostic categories (atypical Spitz nevus and Spitz tumor) are admitted. Because of these difficulties in clinical and histopathologic evaluation, surgical excision is recommended for clinically atypical spitzoid lesions of childhood and for all spitzoid lesions of adulthood.

25 Review Problematic lesions in the elderly. 2013

Zalaudek, Iris / Lallas, Aimilios / Longo, Caterina / Moscarella, Elvira / Tiodorovic-Zivkovic, Danica / Ricci, Cinzia / Albertini, Giuseppe / Argenziano, Giuseppe. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy; Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz 8036, Austria. Electronic address: iris.zalaudek@gmail.com. ·Dermatol Clin · Pubmed #24075544.

ABSTRACT: As the population continues to age, clinicians and dermatologists are increasingly faced with geriatric patients presenting with a range of dermatologic manifestations, including benign and malignant skin tumors. Knowledge of epidemiologic and morphologic features, including dermoscopy of common and benign melanocytic and nonmelanocytic skin tumors, provides the basis for a better understanding and management of problematic skin tumors in this age group. This article provides an overview of common and problematic skin lesions in elderly patients and addresses epidemiologic, clinical, and dermoscopic clues that aid the differential diagnosis and management of challenging skin lesions.

Next