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Melanoma: HELP
Articles by Tatiana H. Beresnev
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Tatiana Beresnev wrote the following 3 articles about Melanoma.
 
+ Citations + Abstracts
1 Clinical Trial Results of a Randomized Controlled Multicenter Phase III Trial of Percutaneous Hepatic Perfusion Compared with Best Available Care for Patients with Melanoma Liver Metastases. 2016

Hughes, Marybeth S / Zager, Jonathan / Faries, Mark / Alexander, H Richard / Royal, Richard E / Wood, Bradford / Choi, Junsung / McCluskey, Kevin / Whitman, Eric / Agarwala, Sanjiv / Siskin, Gary / Nutting, Charles / Toomey, Mary Ann / Webb, Carole / Beresnev, Tatiana / Pingpank, James F. ·Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. · H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. · John Wayne Cancer Institute, Providence St. John's Health Center, Santa Monica, CA, USA. · Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA. · M.D. Anderson Cancer Center, University of Texas, Houston, TX, USA. · Center for Interventional Oncology, National Institutes of Health, Bethesda, MD, USA. · University of Pittsburgh Schools of the Health Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. · Carol G. Simon Cancer Center, Atlantic Health System, Morristown, NJ, USA. · St. Luke's Cancer Center, Bethlehem, PA, USA. · Albany Medical Neurosciences Institute, Albany, NY, USA. · RIA Endovascular, Greenwood Village, CO, USA. · University of Pittsburgh Schools of the Health Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. pingpankjf@upmc.edu. · Division of Hepatobiliary Surgery, Surgical Oncology Services, Hillman Cancer Center, UPMC, Pittsburgh, PA, USA. pingpankjf@upmc.edu. ·Ann Surg Oncol · Pubmed #26597368.

ABSTRACT: PURPOSE: There is no consensus for the treatment of melanoma metastatic to the liver. Percutaneous hepatic perfusion with melphalan (PHP-Mel) is a method of delivering regional chemotherapy selectively to the liver. In this study, we report the results of a multicenter, randomized controlled trial comparing PHP-Mel with best alternative care (BAC) for patients with ocular or cutaneous melanoma metastatic to the liver. PATIENTS AND METHODS: A total of 93 patients were randomized to PHP-Mel (n = 44) or BAC (n = 49). On the PHP-Mel arm, melphalan was delivered via the hepatic artery, and the hepatic effluent captured and filtered extracorporeally prior to return to the systemic circulation via a venovenous bypass circuit. PHP-Mel was repeatable every 4-8 weeks. The primary endpoint was hepatic progression-free survival (hPFS), and secondary endpoints included overall PFS (oPFS), overall survival (OS), hepatic objective response (hOR), and safety. RESULTS: hPFS was 7.0 months for PHP-Mel and 1.6 months for BAC (p < 0.0001), while oPFS was 5.4 months for PHP-Mel and 1.6 months for BAC (p < 0.0001). Median OS was not significantly different (PHP-Mel 10.6 months vs. BAC 10.0 months), likely due to crossover to PHP-Mel treatment (57.1 %) from the BAC arm, and the hOR was 36.4 % for PHP-Mel and 2.0 % for BAC (p < 0.001). The majority of adverse events were related to bone marrow suppression. Four deaths were attributed to PHP-Mel, three in the primary PHP-Mel group, and one post-crossover to PHP-Mel from BAC. CONCLUSION: This randomized, phase III study demonstrated the efficacy of the PHP-Mel procedure. hPFS, oPFS, and hOR were significantly improved with PHP-Mel. PHP with melphalan should provide a new treatment option for unresectable metastatic melanoma in the liver.

2 Article Unknown primary nasopharyngeal melanoma presenting as severe recurrent epistaxis and hearing loss following treatment and remission of metastatic disease: A case report and literature review. 2015

Azoury, Saïd C / Crompton, Joseph G / Straughan, David M / Klemen, Nicholas D / Reardon, Emily S / Beresnev, Tatiana H / Hughes, Marybeth S. ·Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, USA. Electronic address: sazoury1@jhmi.edu. · Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. · Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., USA. ·Int J Surg Case Rep · Pubmed #25898283.

ABSTRACT: INTRODUCTION: Primary nasopharyngeal melanoma is an exceedingly rare pathology with unclear etiology and oftentimes obscure clinical presentation. Despite improved diagnostic capabilities, these lesions are often diagnosed at an advanced stage and associated prognosis is poor, partly due to high rates of recurrences and metastasis. PRESENTATION OF CASE: A 74-year-old woman was diagnosed with metastatic melanoma to the liver, of unknown primary. Just prior to the time of diagnosis, she experienced several episodes of severe epistaxis which she managed conservatively. Her symptoms eventually subsided without further medical evaluation. The patient was initially treated with interleukin-2 (IL-2) for her advanced disease, but her cancer progressed. She was then enrolled in a protocol for percutaneous hepatic perfusion (PHP) with melphalan and had complete radiographic resolution of disease, yet her nosebleeds recurred and persisted despite conservative measures. Six years after her initial diagnosis, a nasopharyngoscopy demonstrated a pigmented lesion in the posterior nasopharynx. Surgical resection was performed (pathology consistent with mucosal melanoma) followed by radiation therapy. She has since had complete resolution of bleeding and shows no evidence of cancer. DISCUSSION: To our knowledge, this is the first report of a diagnosis of primary nasopharyngeal melanoma 6-years following complete remission of metastatic disease. Surgery remains the primary treatment for disease and symptom control in this setting. CONCLUSION: Timely diagnosis of nasopharyngeal melanomas remains challenging. Thorough clinical evaluations should be performed in such patients, and attention should be paid to recurrent and persistent symptoms, such as epistaxis and hearing loss. This may allow for earlier detection of primary disease.

3 Article Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma. 2010

Varghese, Sheelu / Xu, Hui / Bartlett, David / Hughes, Marybeth / Pingpank, James F / Beresnev, Tatiana / Alexander, H Richard. ·Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. ·Ann Surg Oncol · Pubmed #20221901.

ABSTRACT: BACKGROUND: Patients with ocular melanoma liver metastases have a poor prognosis, treatment options are limited, and median survival is less than 1 year. In this study, we characterized the early molecular changes that occur in tumors immediately after vascular isolation perfusion with melphalan with hyperthermia in patients with hepatic metastases from ocular melanoma. METHODS: Patients underwent treatment on a clinical trial using a 60-min hyperthermic isolated hepatic perfusion (IHP) with melphalan. Microarray analysis was performed in 28 tumor samples obtained intraoperatively of which 12 were pre- and 16 were post-IHP. Various statistical analyses were performed to identify differentially expressed genes and gene categories between the groups. RESULTS: Median survival of 17 treated patients was 11.9 months. Unsupervised hierarchical clustering of all tumors resulted in separation of pre and post-IHP samples into two distinct groups. Analysis of genes showed that the Ras GTPase activator, ecotropic viral integration site 5 (EVI5), and several other melanoma-associated genes were overexpressed in pre-IHP tumors. In post-IHP samples the overexpression of a DNA replication associated gene, replication factor C (RFC5), was significantly associated with shortened survival (P < 0.003). Other major gene ontology categories identified in the post-IHP tumor samples were DNA-directed RNA polymerase activity and chromatin remodeling, both important categories involved in DNA replication and repair. CONCLUSIONS: These results demonstrate that acute changes in gene expression patterns occur in tumors immediately after treatment with melphalan administered via hyperthermic IHP. Rapid activation of DNA synthesis and repair pathways may be a mechanism of acquired tumor resistance in patients with ocular melanoma.