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Melanoma: HELP
Articles by Flávia Vasques Bittencourt
Based on 6 articles published since 2008
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Between 2008 and 2019, Flávia Vasques Bittencourt wrote the following 6 articles about Melanoma.
 
+ Citations + Abstracts
1 Guideline Brazilian guidelines for diagnosis, treatment and follow-up of primary cutaneous melanoma - Part II. 2016

Castro, Luiz Guilherme Martins / Bakos, Renato Marchiori / Duprat Neto, João Pedreira / Bittencourt, Flávia Vasques / Di Giacomo, Thais Helena Bello / Serpa, Sérgio Schrader / Messina, Maria Cristina de Lorenzo / Loureiro, Walter Refkalefsky / Macarenco, Ricardo Silvestre e Silva / Stolf, Hamilton Ometto / Gontijo, Gabriel. ·Hospital Israelita Albert Einstein, SP, Brazil. · Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. · Departamento de Câncer de Pele, A. C. Camargo Cancer Center, São Paulo, SP, Brazil. · Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. · Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil. · Universidade Estadual do Pará, Belém, PA, Brazil. · Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil. ·An Bras Dermatol · Pubmed #26982779.

ABSTRACT: The last Brazilian guidelines on melanoma were published in 2002. Development in diagnosis and treatment made updating necessary. The coordinators elaborated ten clinical questions, based on PICO system. A Medline search, according to specific MeSH terms for each of the 10 questions was performed and articles selected were classified from A to D according to level of scientific evidence. Based on the results, recommendations were defined and classified according to scientific strength. The present Guidelines were divided in two parts for editorial and publication reasons. In this second part, the following clinical questions were answered: 1) which patients with primary cutaneous melanoma benefit from sentinel lymph node biopsy? 2) Follow-up with body mapping is indicated for which patients? 3) Is preventive excision of acral nevi beneficious to patients? 4) Is preventive excision of giant congenital nevi beneficious to patients? 5) How should stages 0 and I primary cutaneous melanoma patients be followed?

2 Guideline Guidelines of the Brazilian Dermatology Society for diagnosis, treatment and follow up of primary cutaneous melanoma--Part I. 2015

Castro, Luiz Guilherme Martins / Messina, Maria Cristina / Loureiro, Walter / Macarenco, Ricardo Silvestre / Duprat Neto, João Pedreira / Di Giacomo, Thais Helena Bello / Bittencourt, Flávia Vasques / Bakos, Renato Marchiori / Serpa, Sérgio Schrader / Stolf, Hamilton Ometto / Gontijo, Gabriel. ·Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. · Universidade Estadual do Pará, Belém, SP, Brazil. · Departamento de Câncer de Pele, A. C. Camargo Cancer Center, São Paulo, SP, Brazil. · Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. · Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. · Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil. · Universidade Estadual Paulista, Botucatu, SP, Brazil. ·An Bras Dermatol · Pubmed #26734867.

ABSTRACT: The last Brazilian guidelines on melanoma were published in 2002. Development in diagnosis and treatment made updating necessary. The coordinators elaborated ten clinical questions, based on PICO system. A Medline search, according to specific MeSH terms for each of the 10 questions was performed and articles selected were classified from A to D according to level of scientific evidence. Based on the results, recommendations were defined and classified according to scientific strength. The present Guidelines were divided in two parts for editorial and publication reasons. In the first part, the following clinical questions were answered: 1) The use of dermoscopy for diagnosis of primary cutaneous melanoma brings benefits for patients when compared with clinical examination? 2) Does dermoscopy favor diagnosis of nail apparatus melanoma? 3) Is there a prognostic difference when incisional or excisional biopsies are used? 4) Does revision by a pathologist trained in melanoma contribute to diagnosis and treatment of primary cutaneous melanoma? What margins should be used to treat lentigo maligna melanoma and melanoma in situ?

3 Review Giant congenital melanocytic nevus. 2013

Viana, Ana Carolina Leite / Gontijo, Bernardo / Bittencourt, Flávia Vasques. ·Minas Gerais Federal University, Teaching Hospital, dermatology service, Belo HorizonteMG, Brazil, MD, MSc - Voluntary dermatologist at the dermatology service at Minas Gerais Federal University Teaching Hospital (UFMG) - Belo Horizonte (MG), Brazil. · Minas Gerais Federal University, Medical School, Belo HorizonteMG, Brazil, MD, PhD - Associate Professor of dermatology at Minas Gerais Federal University Medical School (UFMG) - Belo Horizonte (MG), Brazil. · Minas Gerais Federal University, Medical School, Belo HorizonteMG, Brazil, MD, PhD - Adjunct Professor of dermatology at Minas Gerais Federal University Medical School (UFMG) - Belo Horizonte (MG), Brazil. ·An Bras Dermatol · Pubmed #24474093.

ABSTRACT: Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ≥ 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcated borders and hypertrichosis. Congenital melanocytic nevus is primarily a clinical diagnosis. However, congenital nevi are histologically distinguished from acquired nevi mainly by their larger size, the spread of the nevus cells to the deep layers of the skin and by their more varied architecture and morphology. Although giant congenital melanocytic nevus is recognized as a risk factor for the development of melanoma, the precise magnitude of this risk is still controversial. The estimated lifetime risk of developing melanoma varies from 5 to 10%. On account of these uncertainties and the size of the lesions, the management of giant congenital melanocytic nevus needs individualization. Treatment may include surgical and non-surgical procedures, psychological intervention and/or clinical follow-up, with special attention to changes in color, texture or on the surface of the lesion. The only absolute indication for surgery in giant congenital melanocytic nevus is the development of a malignant neoplasm on the lesion.

4 Article Prognostic factors for metastasis in cutaneous melanoma. 2018

Cherobin, Ana Carolina Figueiredo Pereira / Wainstein, Alberto Julius Alves / Colosimo, Enrico Antônio / Goulart, Eugênio Marcos Andrade / Bittencourt, Flávia Vasques. ·Department of Dermatology, Hospital das Clínicas, Universidade Federal de Minas Gerais (HC-UFMG) - Belo Horizonte (MG), Brazil. · Institute of Post-graduation, Faculdade de Ciências Médicas de Minas Gerais (FCM-MG) - Belo Horizonte (MG), Brazil. · Department of Statistics, Institute of Exact Sciences, Universidade Federal de Minas Gerais (ICEx-UFMG) - Belo Horizonte (MG), Brazil. · Department of Pediatrics, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil. ·An Bras Dermatol · Pubmed #29641692.

ABSTRACT: BACKGROUND: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. OBJECTIVE: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutaneous melanoma. METHODS: Our historical cohort comprised patients with invasive primary cutaneous melanoma seen between 1995 and 2012 at a public university hospital and a private oncologic surgery institution in Southeastern Brazil. The following variables were analyzed: gender, age, family history of melanoma, site of the primary tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and the mitotic index. Kaplan-Meier univariate test and multivariate Cox proportional hazard analysis were used to assess factors associated with disease-free survival. RESULTS: Five hundred and fourteen patients were enrolled. The univariate analysis identified the following significant risk factors: gender, age, site of the tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and mitotic index. Multivariate analysis included 244 patients and detected four significant prognostic factors: male gender, nodular clinical and histologic subtype, Breslow thickness > 4mm, and histologic ulceration. The mitotic index was not included in this analysis. STUDY LIMITATIONS: Small number of patients in multivariate analysis. CONCLUSIONS: The following prognostic factors to the development of melanoma metastasis were identified in the study: male gender, nodular histologic subtype, Breslow thickness > 4mm and ulceration.

5 Article A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma. 2017

Viana, Ana Carolina Leite / Goulart, Eugênio Marcos Andrade / Gontijo, Bernardo / Bittencourt, Flávia Vasques. ·Dermatology Unity - Hospital das Clinicas - Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil. · Department of Pediatrics - School of Medicine, Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil. ·An Bras Dermatol · Pubmed #28538879.

ABSTRACT: Background:: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. Objective:: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. Methods:: Our prospective cohort included only patients with congenital nevi ≥20cm. The cumulative risk of developing melanoma and the standardized morbidity ratio were calculated for patients followed up prospectively for at least 1 month. Results:: Sixty-three patients were enrolled in this study. One patient who developed melanoma prior to enrollment was excluded, and five were eliminated because of insufficient follow-up time. Mean follow-up for the remaining 57 patients was 5.5 years (median 5.2 years). Median age of entry into the study was 2.6 years. Most patients (75.4%) underwent only clinical observation. Melanomas occurred in 2 (3.5%) patients. Five-year cumulative risk for melanoma was 4.8% (95% CI: 1.9-11.5%). Standardized morbidity ratio was 1584 (95% CI: 266-5232, p<0.001). Study limitations:: The small sample size reduces the accuracy of risk estimates. Conclusions:: This study analyzed prospectively for the first time data from South America demonstrating that patients with LCMN have a higher risk of developing melanoma than the general population (p<0.001).

6 Article Epidemiological aspects of melanoma at a university hospital dermatology center over a period of 20 years. 2013

Brandão, Flavia Vieira / Pereira, Ana Francisca Junqueira Ribeiro / Gontijo, Bernardo / Bittencourt, Flávia Vasques. ·Brasilia University (UnB), Hospital Universitário de Brasilia, Brasilia, DF, Brazil. flaviavieirabrandao@yahoo.com.br ·An Bras Dermatol · Pubmed #23793193.

ABSTRACT: BACKGROUND: The incidence of melanoma has been steadily rising in past decades. Although it accounts for only 3% of all skin cancers, it is responsible for 75% of deaths. OBJECTIVE: to describe the epidemiological aspects of melanoma in a university hospital setting over a period of 20 years. METHODS: A total of 166 patients were analyzed between January 1990 and January 2010 for clinical and histological variables and correlations between them. A 5% level of significance was adopted. RESULTS: The majority of patients were Caucasians (74%), females (61%), with a mean age at diagnosis of 55. The predominant histological type was lentigo maligna/lentigo maligna melanoma (35.7%) and the head and neck was the most affected site (30.7%). Among non-Caucasians, the acral region was the most affected. Most tumors were in situ (41.1%). Growth of the lesion was the most frequent complaint (58.1%) and bleeding was most frequently associated with melanomas with a depth > 4mm. There were seven deaths (4.2%), with a high risk among men, non-Caucasians and those under 20 years of age, with a Breslow's depth > 2mm, with lentiginous acral melanoma and with a history of growth and bleeding. CONCLUSIONS: Our sample differs from most of the studies in the predominant location (head and neck), histological type (lentigo maligna/ lentigo maligna melanoma) and a major risk of death under the age of 20, which could be with a reflex of regional variation. Broader studies are necessary for validation of the results.