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Melanoma: HELP
Articles by Paolo Broganelli
Based on 7 articles published since 2009
(Why 7 articles?)

Between 2009 and 2019, P. Broganelli wrote the following 7 articles about Melanoma.
+ Citations + Abstracts
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1410806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Review Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. 2017

Lallas, A / Apalla, Z / Ioannides, D / Lazaridou, E / Kyrgidis, A / Broganelli, P / Alfano, R / Zalaudek, I / Argenziano, G / Anonymous4790894. ·First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · City of Health and Science University, Turin, Italy. · Department of Anaesthesiology, Surgery and Emergency Medicine, Second University of Naples, Naples, Italy. · Department of Dermatology and Venereology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Austria. · Dermatology Unit, Second University of Naples, Naples, Italy. ·Br J Dermatol · Pubmed #28118479.

ABSTRACT: Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biological behaviour and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphological overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid-looking lesions based on a consensus among experts in the field. After a detailed search of the literature for eligible studies, a data synthesis was performed from 15 studies on dermoscopy of Spitz naevi. Dermoscopically, Spitz naevi are typified by three main patterns: starburst pattern (51%), a pattern of regularly distributed dotted vessels (19%) and globular pattern with reticular depigmentation (17%). A consensus-based algorithm for the management of spitzoid lesions is proposed. According to it, dermoscopically asymmetric lesions with spitzoid features (both flat/raised and nodular) should be excised to rule out melanoma. Dermoscopically symmetric spitzoid nodules should also be excised or closely monitored, irrespective of age, to rule out atypical Spitz tumours. Dermoscopically symmetric, flat spitzoid lesions should be managed according to the age of the patient. Finally, the histopathological diagnosis of atypical Spitz tumour should warrant wide excision but not a sentinel lymph-node biopsy.

3 Article Trends in incidence of thick, thin and in situ melanoma in Europe. 2018

Sacchetto, L / Zanetti, R / Comber, H / Bouchardy, C / Brewster, D H / Broganelli, P / Chirlaque, M D / Coza, D / Galceran, J / Gavin, A / Hackl, M / Katalinic, A / Larønningen, S / Louwman, M W J / Morgan, E / Robsahm, T E / Sanchez, M J / Tryggvadóttir, L / Tumino, R / Van Eycken, E / Vernon, S / Zadnik, V / Rosso, S. ·Piedmont Cancer Registry, A.O.U, Città della Salute e della Scienza di Torino, Turin, Italy; Politecnico di Torino, Turin, Italy; Università degli Studi di Torino, Turin, Italy. Electronic address: lidia.sacchetto@cpo.it. · Piedmont Cancer Registry, A.O.U, Città della Salute e della Scienza di Torino, Turin, Italy. · National Cancer Registry Ireland, Ireland. · Geneva Cancer Registry, Geneva, Switzerland. · Scottish Cancer Registry, Edinburgh, UK. · A.O.U, Città della Salute e della Scienza di Torino, Turin, Italy. · Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, CIBERESP, Spain. · Cluj Regional Cancer Registry, Oncology Institute Cluj, Romania. · Tarragona Cancer Registry, Foundation Society for Cancer Research and Prevention, (FUNCA), Pere Virgili Health Research Institute (IISPV), Reus, Spain. · Northern Ireland Cancer Registry, Queens University Belfast, Belfast, UK. · Austrian National Cancer Registry, Wien, Austria. · Institute for Social Medicine and Epidemiology, University Lübeck, Lubeck, Germany. · Cancer Registry of Norway, Institute of Population Based Cancer Research, Oslo, Norway. · Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands. · Escuela Andaluza de Salud Pública, CIBER de Epidemiología y Salud Pública, (CIBERESP), Ibs, Granada, Spain. · Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland. · Cancer Registry and Histopathology Department, "Civic - M.P.Arezzo" Hospital, ASP, Ragusa, Italy. · Belgian Cancer Registry, Brussel, Belgium. · National Cancer Registration Service - Public Health England, Cambridge, UK. · Epidemiology and Cancer Registry, Institute of Oncology Ljubljana, Ljubljana, Slovenia. ·Eur J Cancer · Pubmed #29395684.

ABSTRACT: BACKGROUND: We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995-2012, stratifying for lesion thickness. MATERIAL AND METHODS: Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved from the publicly available World Health Organization database. RESULTS: Our database covered a population of over 117 million inhabitants and included about 415,000 skin lesions, recorded by 18 European CRs (7 of them with national coverage). During the 1995-2012 period, we observed a statistically significant increase in incidence for both invasive (average annual percent change (AAPC) 4.0% men; 3.0% women) and in situ (AAPC 7.7% men; 6.2% women) cases. DISCUSSION: The increase in invasive lesions seemed mainly driven by thin melanomas (AAPC 10% men; 8.3% women). The incidence of thick melanomas also increased, although more slowly in recent years. Correction for lesions of unknown thickness enhanced the differences between thin and thick cases and flattened the trends. Incidence trends varied considerably across registries, but only Netherlands presented a marked increase above the boundaries of a funnel plot that weighted estimates by their precision. Mortality from invasive melanoma has continued to increase in Norway, Iceland (but only for elder people), the Netherlands and Slovenia.

4 Article Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. 2017

Carrera, Cristina / Segura, Sonia / Aguilera, Paula / Scalvenzi, Massimiliano / Longo, Caterina / Barreiro, Alicia / Broganelli, Paolo / Cavicchini, Stefano / Llambrich, Alex / Zaballos, Pedro / Thomas, Luc / Malvehy, Josep / Puig, Susana / Zalaudek, Iris. ·Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain2Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain. · Department of Dermatology, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona, Barcelona, Spain. · Department of Dermatology, University of Naples Federico II, Naples, Italy. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy6Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. · Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. · Città della Salute e della Scienza, Turin, Italy. · Unità Operative (UO) Dermatologia Fondazione IRCCS, Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. · Dermatology, Hospital Son Llatzer, Palma Mallorca, Spain. · Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain. · Department of Dermatology, Centre Hospitalier Lyon Sud, Lyon 1 University, Lyons Cancer Research Center (Pr Puisieux), Lyon, France. · Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. ·JAMA Dermatol · Pubmed #28355453.

ABSTRACT: Importance: Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas. Objective: To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology. Design, Setting, and Participants: This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven melanomas in 134 patients treated in 9 skin cancer centers in Spain, France, Italy, and Austria. Without knowledge that the definite diagnosis for all the lesions was melanoma, 2 dermoscopy-trained observers evaluated the clinical descriptions and 48 dermoscopic features (including all melanocytic and nonmelanocytic criteria) of all 134 images and classified each dermoscopically as SK or not SK. The total dermoscopy score and the 7-point checklist score were assessed. Images of the lesions and patient data were collected from July 15, 2013, through July 31, 2014. Main Outcomes and Measures: Frequencies of specific morphologic patterns of (clinically and dermoscopically) SK-like melanomas, patient demographics, and interobserver agreement of criteria were evaluated. Results: Of the 134 cases collected from 72 men and 61 women, all of whom were white and who had a mean (SD) age of 55.6 (17.5) years, 110 (82.1%) revealed dermoscopic features suggestive of melanoma, including pigment network (74 [55.2%]), blue-white veil (72 [53.7%]), globules and dots (68 [50.7%]), pseudopods or streaks (47 [35.1%]), and blue-black sign (43 [32.3%]). The remaining 24 cases (17.9%) were considered likely SKs, even by dermoscopy. Overall, lesions showed a scaly and hyperkeratotic surface (45 [33.6%]), yellowish keratin (42 [31.3%]), comedo-like openings (41 [30.5%]), and milia-like cysts (30 [22.4%]). The entire sample achieved a mean (SD) total dermoscopy score of 4.7 (1.6) and a 7-point checklist score of 4.4 (2.3), while dermoscopically SK-like melanomas achieved a total dermoscopy score of only 4.2 (1.3) and a 7-point checklist score of 2.0 (1.9), both in the range of benignity. The most helpful criteria in correctly diagnosing SK-like melanomas were the presence of blue-white veil, pseudopods or streaks, and pigment network. Multivariate analysis found only the blue-black sign to be significantly associated with a correct diagnosis, while hyperkeratosis and fissures and ridges were independent risk markers of dermoscopically SK-like melanomas. Conclusions and Relevance: Seborrheic keratosis-like melanomas can be dermoscopically challenging, but the presence of the blue-black sign, pigment network, pseudopods or streaks, and/or blue-white veil, despite the presence of other SK features, allows the correct diagnosis of most of the difficult melanoma cases.

5 Article Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity. 2009

Ferrara, Gerardo / Giorgio, Caterina M / Zalaudek, Iris / Broganelli, Paolo / Pellacani, Giovanni / Tomasini, Carlo / Argenziano, Giuseppe. ·Department of Oncology, Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Benevento, Italy. ·Dermatology · Pubmed #19590167.

ABSTRACT: BACKGROUND: Sclerosing nevi with pseudomelanomatous features or, else, nevi with regression-like fibrosis (NRLF) are histopathologic simulators of regressing melanoma. OBJECTIVE: We aimed at evaluating the clinical features in a series of NRLF. METHODS: Dermoscopic images of NRLF were re-evaluated according to the amount of regression, the presence of white/blue areas and the 7-point checklist. RESULTS: Forty-six lesions from 44 patients (M:F = 3.4:1; mean age: 42 years) were evaluated. Thirty-seven lesions were excised from the back, mostly from the scapular area. All the lesions were dermoscopically atypical, with large amounts of regression (>10% in 43 cases) and with coexistence of white and blue areas (41 cases). According to the 7-point checklist, 25 lesions were labeled as benign, probably because regression obscured other dermoscopic features of atypia. CONCLUSION: NRLF are mostly found in the convex area of the back. A better recognition of their clinicopathologic features can allow a more conservative management.

6 Minor Two novel H-RAS mutations identified in a child with an atypical spitzoid tumor. 2011

Simi, Lisa / Pinzani, Pamela / Salvianti, Francesca / Lorenzoni, Alessandro / Tomasini, Carlo / Broganelli, Paolo / Orlando, Claudio / Pazzagli, Mario / Massi, Daniela. · ·Arch Dermatol · Pubmed #21482913.

ABSTRACT: -- No abstract --

7 Minor Sclerosing nevus with pseudomelanomatous features and regressing melanoma with nevoid features. 2009

Ferrara, Gerardo / Amantea, Ada / Argenziano, Giuseppe / Broganelli, Paolo / Cesinaro, Anna Maria / Donati, Pietro / Pellacani, Giovanni / Zalaudek, Iris / Tomasini, Carlo. · ·J Cutan Pathol · Pubmed #19586505.

ABSTRACT: -- No abstract --