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Melanoma: HELP
Articles by Davorin Herceg
Based on 3 articles published since 2008

Between 2008 and 2019, D. Herceg wrote the following 3 articles about Melanoma.
+ Citations + Abstracts
1 Guideline [CANCER PATIENTS FOLLOW-UP – CROATIAN SOCIETY FOR MEDICAL ONCOLOGY CLINICAL GUIDELINES Part V: melanoma, sarcomas, central nerve system tumors, lung cancer]. 2016

Herceg, Davorin / Jakopović, Marko / Plavetić, Natalija Dedić / Samaržija, Miroslav / Čučević, Branka / Mijatović, Davor / Nikolić, Igor / Trivanović, Dragan / Šeparović, Robert / Vrbanec, Damir. · ·Lijec Vjesn · Pubmed #30148587.

ABSTRACT: Treatment of oncological patients must be based upon multidisciplinary approach, and takes place in specialized oncological centers. By the end of a specific oncological treatment further follow-up is being managed mostly by the oncologists, but the role of the general practitioners becomes more important every day and therefore should be precisely defined. Nowadays, most of the existing follow-up guidelines are not being based on prospective studies, yet on the expert’s opinion of a precise oncological center or specialists. The aim of the Croatian Society of Medical Oncology (CSMO) with these recommendations is to standardize and rationalize the diagnostic procedures’ algorithm in follow–up of oncological patients after primary treatment, in patients with melanoma, sarcomas, central nerve system tumors and lung cancer.


Herceg, Davorin / Buzina, Daska Stulhofer / Ceović, Romana / Dotlić, Snjezana / Ilić, Ivana / Orehovec, Sanda Smuđ / Herceg, Gordana Horvatić / Mijatović, Davor / Separović, Robert / Silovski, Tajana / Vrbanec, Damir. · ·Lijec Vjesn · Pubmed #27290810.

ABSTRACT: Melanoma in the Western world has an increasing incidence. One of the most important factor for the increase in incidence is sporadic, uncontrolled exposure to the sun. The basis for the treatment of primary melanoma is surgical treatment. Treatment of metastatic disease of melanoma in recent years experienced significant changes. BRAF and MEK inhibitors, immunotherapy with programmed cell-death immune checkpoint inhibitors (anti-PD-1-antibodies) are new options for the treatment of metastatic disease. A mulitidisiplinary team of Croatian Society for Medical Oncology provides recommendations for diagnosis, treatment and follow-up of melanoma primarily driven to the discovery of new drugs and therapeutic options, that change the prognosis of patients with metastatic melanoma.

3 Article More than 5000 patients with metastatic melanoma in Europe per year do not have access to recommended first-line innovative treatments. 2017

Kandolf Sekulovic, L / Peris, K / Hauschild, A / Stratigos, A / Grob, J-J / Nathan, P / Dummer, R / Forsea, A-M / Hoeller, C / Gogas, H / Demidov, L / Lebbe, C / Blank, C / Olah, J / Bastholt, L / Herceg, D / Neyns, B / Vieira, R / Hansson, J / Rutkowski, P / Krajsova, I / Bylaite-Bucinskiene, M / Zalaudek, I / Maric-Brozic, J / Babovic, N / Banjin, M / Putnik, K / Weinlich, G / Todorovic, V / Kirov, K / Ocvirk, J / Zhukavets, A / Kukushkina, M / De La Cruz Merino, L / Ymeri, A / Risteski, M / Garbe, C. ·Department of Dermatology, Medical Faculty, Military Medical Academy, Belgrade, Serbia. · Institute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Dermatology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, Germany. · National and Kapodistrian University of Athens, Greece. · Service de Dermatologie et Cancérologie Cutanée, Hopital de la Timone, Marseille, France. · Mount Vernon Cancer Centre, Northwood, United Kingdom. · UniversitätsSpital Zürich-Skin Cancer Center, University Hospital, Zürich, Switzerland. · Carol Davila University of Medicine and Pharmacy, Elias University Hospital Bucharest, Romania. · Department of Dermatology, Medical University of Vienna, Vienna, Austria. · NN Blokhin Russian Cancer Research Center, Moscow, Russia. · APHP Hospital Saint Louis, Paris, France. · Netherland Cancer Institute, Amsterdam, Netherlands. · Department of Dermatology and Allergology, University of Szeged, Hungary. · Department of Oncology, Odense University Hospital, Denmark. · Department of Oncology, University Hospital Zagreb, Croatia. · Department of Medical Oncology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. · Department of Dermatology, Medical Faculty, University of Coimbra, Portugal. · Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden. · Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland. · General Teaching Hospital, Prague, Czech Republic. · Department of Dermatology, Vilnius University, Lithuania. · Division of Dermatology and Venerology, Medical University of Graz, Graz, Austria. · University Hospital Center Sestre Milosrdnice, Zagreb, Croatia. · Institute of Oncology and Radiology of Serbia, Belgrade, Serbia. · Department of Oncology, University Hospital Sarajevo, Bosnia and Herzegovina. · North Estonia Medical Centre, Tallinn, Estonia. · Department of Dermatology & Venerology & Allergy, Medical University Innsbruck, Austria. · Clinic for Oncology and Radiotherapy, Podgorica, Montenegro. · Clinic of Oncodermatology, National Cancer Center, Sofia, Bulgaria. · Institute of Oncology Ljubljana, Ljubljana, Slovenia. · N.N. Alexandrov National Cancer Сenter of Belarus (NCCB), Minsk, Belarus. · National Cancer Institute, Kiev, Ukraine. · Department of Clinical Oncology, Hospital Universitario Virgen Macarena, Sevilla, Spain. · University Hospital Mother Theresa, Tirana, Albania. · University Clinic of Radiotherapy and Oncology, Skopje, Former Yugoslav Republic of Macedonia. · Centre for Dermatooncology, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany. ·Eur J Cancer · Pubmed #28264791.

ABSTRACT: BACKGROUND: Despite the efficacy of innovative treatments for metastatic melanoma, their high costs has led to disparities in cancer care among different European countries. We analysed the availability of these innovative therapies in Europe and estimated the number of patients without access to first-line recommended treatment per current guidelines of professional entities such as the European Society for Medical Oncology (ESMO), the European Organisation for Research and Treatment of Cancer (EORTC), the European Association of Dermato-Oncology (EADO), and European Dermatology Forum (EDF). MATERIALS AND METHODS: Web-based online survey was conducted in 30 European countries with questions about the treatment schedules from 1st May 2015 to 1st May 2016: number of metastatic melanoma patients, registration and reimbursement of innovative medicines (updated data, as of 1st October 2016), percentage of patients treated and availability of clinical studies and compassionate-use programmes. RESULTS: The recommended BRAF inhibitor (BRAFi) + MEK inhibitor (MEKi) combination was both registered and fully reimbursed in 9/30 (30%) countries, and in 13/30 (43%) (all from Eastern Europe) not reimbursed. First-line immunotherapy with anti-PD1 antibodies was registered and fully reimbursed in 14/30 (47%) countries, while in 13/30 (43%) (all from Eastern Europe) not reimbursed. It was estimated that in Europe 19,600 patients with metastatic melanoma are treated, and 5238 (27%) do not have access to recommended first-line therapy. Significant correlation was found between human development index (HDI, UNDP report 2015), (r = 0.662; p < 0.001), health expenditure per capita (r = 0.695; p < 0.001) and the Mackenbach score of health policy performance (r = 0.765; p < 0.001) with the percentage of patients treated with innovative medicines and a number of reimbursed medicines. CONCLUSIONS: Great discrepancy exists in metastatic melanoma treatment across Europe. It is crucial to increase the awareness of national and European policymakers, oncological societies, melanoma patients' associations and pharma industry.