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Melanoma: HELP
Articles by David Langford
Based on 3 articles published since 2008

Between 2008 and 2019, D. Langford wrote the following 3 articles about Melanoma.
+ Citations + Abstracts
1 Article Dermoscopy of acral melanoma: a multicenter study on behalf of the international dermoscopy society. 2013

Braun, Ralph P / Thomas, L / Dusza, S W / Gaide, O / Menzies, S / Dalle, S / Blum, A / Argenziano, G / Zalaudek, I / Kopf, A / Rabinovitz, H / Oliviero, M / Perrinaud, A / Cabo, H / Pizzichetta, M / Pozo, L / Langford, D / Tanaka, M / Saida, T / Perusquia Ortiz, A M / Kreusch, J / De Giorgi, V / Piccolo, D / Grichnik, J M / Kittler, H / Puig, S / Malvehy, J / Seidenari, S / Stanganelli, I / French, L / Marghoob, A A. ·Department of Dermatology, University Hospital Zürich, Zürich, Switzerland. ·Dermatology · Pubmed #24296632.

ABSTRACT: BACKGROUND: Most studies on dermoscopy of acral lesions were conducted in Asian populations. In this study, we analyzed these features in a predominantly Caucasian population. OBJECTIVE: Estimate the prevalence of dermoscopic features in acral lesions, and assess their level of agreement between observers. METHODS: In this retrospective multicenter study, 167 acral lesions (66 melanomas) were evaluated for 13 dermoscopic patterns by 26 physicians, via a secured Internet platform. RESULTS: Parallel furrow pattern, bizarre pattern, and diffuse pigmentation with variable shades of brown had the highest prevalence. The agreement for lesion patterns between physicians was variable. Agreement was dependent on the level of diagnostic difficulty. CONCLUSION: Lesions with a diameter >1 cm were more likely to be melanoma. We found as well that a benign pattern can be seen in parts of melanomas. For this reason one should evaluate an acral lesion for the presence of malignant patterns first.

2 Article Accuracy in melanoma detection: a 10-year multicenter survey. 2012

Argenziano, Giuseppe / Cerroni, Lorenzo / Zalaudek, Iris / Staibano, Stefania / Hofmann-Wellenhof, Rainer / Arpaia, Nicola / Bakos, Renato Marchiori / Balme, Brigitte / Bandic, Jadran / Bandelloni, Roberto / Brunasso, Alexandra M G / Cabo, Horacio / Calcara, David A / Carlos-Ortega, Blanca / Carvalho, Ana Carolina / Casas, Gabriel / Dong, Huiting / Ferrara, Gerardo / Filotico, Raffaele / Gómez, Guillermo / Halpern, Allan / Ilardi, Gennaro / Ishiko, Akira / Kandiloglu, Gulsen / Kawasaki, Hiroshi / Kobayashi, Ken / Koga, Hiroshi / Kovalyshyn, Ivanka / Langford, David / Liu, Xin / Marghoob, Ashfaq A / Mascolo, Massimo / Massone, Cesare / Mazzoni, Laura / Menzies, Scott / Minagawa, Akane / Nugnes, Loredana / Ozdemir, Fezal / Pellacani, Giovanni / Seidenari, Stefania / Siamas, Katherine / Stanganelli, Ignazio / Stoecker, William V / Tanaka, Masaru / Thomas, Luc / Tschandl, Philipp / Kittler, Harald. ·Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Viale Risorgimento 80 - 42100 Reggio Emilia, Italy. g.argenziano@gmail.com ·J Am Acad Dermatol · Pubmed #21982636.

ABSTRACT: BACKGROUND: Early excision is the only strategy to reduce melanoma mortality, but unnecessary excision of benign lesions increases morbidity and healthcare costs. OBJECTIVE: To assess accuracy in melanoma detection based on number-needed-to-excise (NNE) values over a 10-year period. METHODS: Information was retrieved on all histopathologically confirmed cutaneous melanomas or melanocytic nevi that were excised between 1998 and 2007 at participating clinics. NNE values were calculated by dividing the total number of excised lesions by the number of melanomas. Analyses included changes in NNE over time, differences in NNE between specialized clinical settings (SCS) versus non-specialized clinical settings (NSCS), and patient factors influencing NNE. RESULTS: The participating clinics contributed a total of 300,215 cases, including 17,172 melanomas and 283,043 melanocytic nevi. The overall NNE values achieved in SCS and NSCS in the 10-year period were 8.7 and 29.4, respectively. The NNE improved over time in SCS (from 12.8 to 6.8), but appeared unchanged in NSCS. Most of the effect on NNE in SCS was due to a greater number of excised melanomas. Higher NNE values were observed in patients younger than 40 years and for lesions located on the trunk. LIMITATIONS: No data concerning the use of dermatoscopy and digital monitoring procedures were collected from the participating centers. CONCLUSION: Over the 10-year study period, accuracy in melanoma detection improved only in specialized clinics maybe because of a larger use of new diagnostic techniques such as dermatoscopy.

3 Article Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. 2008

Menzies, Scott W / Kreusch, Juergen / Byth, Karen / Pizzichetta, Maria A / Marghoob, Ashfaq / Braun, Ralph / Malvehy, Josep / Puig, Susana / Argenziano, Giuseppe / Zalaudek, Iris / Rabinovitz, Harold S / Oliviero, Margaret / Cabo, Horacio / Ahlgrimm-Siess, Verena / Avramidis, Michelle / Guitera, Pascale / Soyer, H Peter / Ghigliotti, Giovanni / Tanaka, Masaru / Perusquia, Ana M / Pagnanelli, Gianluca / Bono, Riccardo / Thomas, Luc / Pellacani, Giovanni / Langford, David / Piccolo, Domenico / Terstappen, Karin / Stanganelli, Ignazio / Llambrich, Alex / Johr, Robert. ·Faculty of Medicine, University of Sydney, Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. scott.menzies@email.cs.nsw.gov.au ·Arch Dermatol · Pubmed #18794455.

ABSTRACT: OBJECTIVE: To determine the predictive dermoscopic features of amelanotic and hypomelanotic melanoma. DESIGN: A total of 105 melanomas (median Breslow thickness, 0.76 mm), 170 benign melanocytic lesions, and 222 nonmelanocytic lesions lacking significant pigment (amelanotic, partially pigmented, and light colored) were imaged using glass-plate dermoscopy devices and scored for 99 dermoscopic features. Diagnostic models were derived from and tested on independent randomly selected lesions. SETTING: Predominantly hospital-based clinics from 5 continents. MAIN OUTCOME MEASURES: Sensitivity, specificity, and odds ratios for individual features and models for the diagnosis of melanoma and malignancy. RESULTS: The most significant negative predictors of melanoma were having multiple (>3) milialike cysts (odds ratio, 0.09; 95% confidence interval, 0.01-0.64), comma vessels with a regular distribution (0.10; 0.01-0.70), comma vessels as the predominant vessel type (0.16; 0.05-0.52), symmetrical pigmentation pattern (0.18; 0.09-0.39), irregular blue-gray globules (0.20; 0.05-0.87), and multiple blue-gray globules (0.28; 0.10-0.81). The most significant positive predictors were having a blue-white veil (odds ratio,13; 95% confidence interval, 3.9-40.0), scarlike depigmentation (4.4; 2.4-8.0), multiple blue-gray dots (3.5; 1.9-6.4), irregularly shaped depigmentation (3.3; 2.0-5.3), irregular brown dots/globules (3.2; 1.8-5.6), 5 to 6 colors (3.2; 1.6-6.3), and predominant central vessels (3.1; 1.6-6.0). A simple model distinguishing melanomas from all nonmelanomas had a sensitivity of 70% and a specificity of 56% in the test set. A model distinguishing all malignant lesions from benign lesions had a sensitivity of 96% and a specificity of 37%. Conclusion Although the diagnostic accuracy of dermoscopy for melanoma lacking significant pigment is inferior to that of more pigmented lesions, features distinguishing the former from benign lesions can be visualized on dermoscopic evaluation.