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Melanoma: HELP
Articles by Norman L. Lehman
Based on 1 article published since 2008
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Between 2008 and 2019, Norman L. Lehman wrote the following article about Melanoma.
 
+ Citations + Abstracts
1 Article Radiation necrosis mimicking rapid intracranial progression of melanoma metastasis in two patients treated with vemurafenib. 2014

Liebner, David A / Walston, Steven A / Cavaliere, Robert / Powers, Ciaran J / Sauvageau, Eric / Lehman, Norman L / Wayne Slone, Hasel / Xu-Welliver, Meng / Xia, Fen / Kendra, Kari L. ·aDepartment of Internal Medicine, Division of Medical Oncology Departments of bBiomedical Informatics cRadiation Oncology dNeurology eNeurologic Surgery fPathology, The Ohio State University gDepartment of Radiology, Division of Diagnostic Radiology, The Ohio State University, Columbus, Ohio, USA. ·Melanoma Res · Pubmed #24407165.

ABSTRACT: Optimal treatment of metastases to the central nervous system (CNS) in patients with malignant melanoma remains a clinical challenge. In particular, for patients with BRAF-mutant melanoma and CNS metastases, much remains unknown about the safety and efficacy of the novel BRAF-targeted agents when administered in close sequence with radiation. We report two cases of rapid development of CNS radiation necrosis in patients with metastatic melanoma treated with the BRAF inhibitor, vemurafenib, closely sequenced with stereotactic radiosurgery or fractionated stereotactic radiation therapy. In the absence of prospective safety data from clinical trials, we advise vigilance in monitoring patients with BRAF-mutant melanoma whose treatment plan includes CNS radiation and vemurafenib and caution when assessing treatment response within the CNS in these patients.