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Melanoma: HELP
Articles by Olivier Malard
Based on 4 articles published since 2008
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Between 2008 and 2019, O. Malard wrote the following 4 articles about Melanoma.
 
+ Citations + Abstracts
1 Guideline Guidelines of the French Society of Otorhinolaryngology (SFORL), short version. Extension assessment and principles of resection in cutaneous head and neck tumors. 2014

Anonymous4420813 / Durbec, M / Couloigner, V / Tronche, S / Albert, S / Kanitakis, J / Ltaief Boudrigua, A / Malard, O / Maubec, E / Mourrain Langlois, E / Navailles, B / Peuvrel, L / Phulpin, B / Thimonier, J-C / Disant, F / Dolivet, G. ·Service d'ORL, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France. Electronic address: mickael.durbec@chu-lyon.fr. · Société française d'ORL & CCF, 26, rue Lalo, 75116 Paris, France. · Service d'ORL, hôpital Bichat, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France. · Service de dermatologie, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France. · Service de radiologie, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France. · Service d'ORL, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. · Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. · Service de radiologie, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. · Service d'ORL, centre hospitalier de Valence, 179, avenue du Maréchal-Juin, 26000 Valence, France. · Service d'onco-dermatologie, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. · Institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France. · Service d'ORL, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France. · Service d'ORL, département de chirurgie oncologique, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France. ·Eur Ann Otorhinolaryngol Head Neck Dis · Pubmed #25456243.

ABSTRACT: Cutaneous head and neck tumors mainly comprise malignant melanoma, squamous cell carcinoma, trichoblastic carcinoma, Merkel cell carcinoma, adnexal carcinoma, dermatofibrosarcoma protuberans, sclerodermiform basalioma and angiosarcoma. Adapted management requires an experienced team with good knowledge of the various parameters relating to health status, histology, location and extension: risk factors for aggression, extension assessment, resection margin requirements, indications for specific procedures, such as lateral temporal bone resection, orbital exenteration, resection of the calvarium and meningeal envelopes, neck dissection and muscle resection.

2 Review [Karapandzic flap for reconstruction of extensive defects of the lower lip]. 2013

Espitalier, F / Dréno, B / Malard, O. · ·Rev Laryngol Otol Rhinol (Bord) · Pubmed #25252574.

ABSTRACT: OBJECTIVE: To discuss advantages and disadvantages of Karapandzic flap for reconstruction of extensive defects of the lower lip. METHODS: Two clinical observations and a review of the literature are presented. RESULTS: The Karapandzic flap requires only one operating time. The tissue used to reconstruct the lower lip is very close to the resected lip. The functional result is satisfactory, the lips being continent, allowing speech and feeding. The main advantage of this technique is the preservation of the labial sphincter, which is vascularized, mobile and sensitive. The aesthetic result is acceptable. This flap keeps the vermilion, but with rounded commissures that corrects spontaneously. The main disadvantage of this flap is the microstomia, requiring only rarely further surgery. CONCLUSION: The Karapandzic flap is a good option for reconstruction of extensive defects of the lower lip. It recreates the labial sphincter, while maintaining its vascularization and innervation. Functionality is maintained, with an aesthetically acceptable result despite the presence of residual microstomia proportional to the defect.

3 Article Sinonasal mucosal melanoma: A 44-case study and literature analysis. 2017

Dréno, M / Georges, M / Espitalier, F / Ferron, C / Charnolé, A / Dréno, B / Malard, O. ·Service d'ORL et de Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire, 1 Place Alexis-Ricordeau, 44093 Nantes Cedex 1, France. · Service d'Anatomopathologie, Centre Hospitalier Universitaire, 1 Place Alexis-Ricordeau, 44093 Nantes Cedex 1, France. · Service de Dermatologie, Centre Hospitalier Universitaire, 1 Place Alexis-Ricordeau, 44093 Nantes Cedex 1, France. · Service d'ORL et de Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire, 1 Place Alexis-Ricordeau, 44093 Nantes Cedex 1, France. Electronic address: omalard@chu-nantes.fr. ·Eur Ann Otorhinolaryngol Head Neck Dis · Pubmed #28442409.

ABSTRACT: OBJECTIVES: Sinonasal mucosal melanoma is a rare disease, representing 4% of nasal cavity and paranasal sinus malignancies. The aim of this study was to assess the clinical characteristics, progression and treatment of this disease and to identify prognostic factors. MATERIAL AND METHODS: This retrospective review presents a cohort of 44 patients treated for a melanoma arising from the nasal cavity and paranasal sinuses, in the ENT Head and Neck Surgery Department of the University Hospital of Nantes (France) between 1988 and 2015. RESULTS: Mean age at diagnosis was 71.2 years. The main signs at diagnosis were epistaxis and unilateral nasal obstruction. 25% of patients were initially classified as T4. Surgical treatment was performed in 42 patients. Postoperative radiotherapy was performed in 19 cases and adjuvant immunotherapy in 14 cases. Mean follow-up was 50 months. Cumulative overall survival was 71.5% at 1 year and 33% at 5 years. Clinically, headache, facial pain and trigeminal V2 nerve anesthesia were significant factors for poor prognosis. Exclusively nasal involvement was a factor for better overall survival than sinus involvement. Adjuvant radiation therapy showed a non-significant trend toward improved local control. CONCLUSIONS: Mucosal melanoma of the sinonasal cavities has poor prognosis due to high metastatic potential. Surgical resection followed by radiation therapy is the main treatment. There is no consensus regarding new systemic adjuvant treatments in this indication, unlike for primary cutaneous melanoma.

4 Article Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study. 2010

Benlyazid, Adil / Thariat, Juliette / Temam, Stephane / Malard, Olivier / Florescu, Carmen / Choussy, Olivier / Makeieff, Marc / Poissonnet, Gilles / Penel, Nicolas / Righini, Christian / Toussaint, Bruno / Lacau St Guily, Jean / Vergez, Sebastien / Filleron, Thomas. ·Department of Head and Neck Surgery, Claudius Regaud Institute, 20-24 rue du pont Saint Pierre, Toulouse 31052, France. adil.benlyazid@gmail.com ·Arch Otolaryngol Head Neck Surg · Pubmed #21173371.

ABSTRACT: OBJECTIVE: to report patterns of failure according to treatment modality, with an emphasis on the role of postoperative radiotherapy in patients with localized head and neck mucosal melanoma (HNMM) treated during a 28-year period in a multi-institutional setting. DESIGN: retrospective review. SETTING: french medical institutions. PATIENTS: a total of 160 patients with nonmetastatic HNMM treated from 1980 through 2008. INTERVENTIONS: treatment modality consisted of surgery alone (hereinafter, S group) (n = 82 patients) or with postoperative radiotherapy (hereinafter, SRT group) (n = 78). Patients and tumor characteristics were similar in the 2 groups. There was a nonsignificant trend (P = .11) for more locally advanced tumor stage (38.9%) in the SRT group compared with the S group (24.5%). RESULTS: patients in the S group had an increased probability of locoregional recurrence as a first event (55.6%) compared with those in the SRT group (29.9%; P < .01). After adjusting for tumor stage (T1/T2 vs T3/T4), the subdistribution hazard ratio of locoregional relapse was 0.31, (95% confidence interval [CI], 0.15-0.61; P < .01).The rate of distant metastasis as a first event was significantly higher in the SRT group (40.6%) compared with the S group (19.9%; P = .01). Regardless of their treatment, patients who had a locoregional relapse during follow-up had an increased risk of subsequent distant metastasis (hazard ratio, 3.07; 95% CI, 1.65-5.67) and death (hazard ratio, 3.01; 95% CI, 1.91-4.78). CONCLUSIONS: this large retrospective study suggests that postoperative radiotherapy improves the locoregional control of HNMM. The higher rate of distant metastasis was due to more advanced disease in the SRT group.