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Melanoma: HELP
Articles by Ausilia Maria Manganoni
Based on 27 articles published since 2010
(Why 27 articles?)

Between 2010 and 2020, A. Manganoni wrote the following 27 articles about Melanoma.
+ Citations + Abstracts
Pages: 1 · 2
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1420806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Review Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features. 2019

Cinotti, E / Galluccio, D / Tognetti, L / Habougit, C / Manganoni, A M / Venturini, M / Perrot, J L / Rubegni, P. ·Dermatology Section, Department of Medical, Surgical and Neurological Science, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy. · Department of Pathology, University Hospital of St-Etienne, Saint-Etienne, France. · Department of Dermatology, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy. · Department of Dermatology, University Hospital of St-Etienne, Saint-Etienne, France. ·J Eur Acad Dermatol Venereol · Pubmed #31166040.

ABSTRACT: The differential diagnosis of nipple and areola complex (NAC) lesions encompasses a large spectrum of conditions from benign tumours to inflammatory diseases that could be challenging to recognize on clinical ground. While melanoma (MM) of the NAC is exceedingly rare, benign lesions are more frequent but could be difficult to distinguish from MM. Besides MM, other malignant tumours can affect this area and in particular Paget's disease (PD). For clinically doubtful lesions, biopsy is required, with possible functional and aesthetic consequences in this sensitive area. Dermoscopy and reflectance confocal microscopy (RCM) are widely used techniques for the diagnosis of many skin lesions, but their use for NAC lesions is not well established. The objective of this study was to evaluate current literature on these imaging techniques for NAC lesions. We searched in Medline, PubMed and Cochrane database all studies up to November 2018 dealing with dermoscopy, RCM and this special site. We found that the most described malignant tumour was PD and that only two primary MMs of the NAC have been reported with these imaging techniques. Although there are few data on diagnostic accuracy of non-invasive imaging techniques for NAC lesions, it seems that dermoscopy and RCM can add relevant information to be integrated with clinical examination for the diagnosis of NAC lesions and in particular for the differential diagnosis of PD and eczema.

3 Review Cutaneous melanoma in patients in treatment with biological therapy: review of the literature and case report. 2011

Manganoni, Ausilia Maria / Zane, Cristina / Pavoni, Laura / Farisoglio, Camillo / Sereni, Elena / Calzavara-Pinton, Piergiacomo. · ·Dermatol Online J · Pubmed #21906492.

ABSTRACT: Herein we report a case of a melanoma arising in a patient receiving adalimumab and methotrexate for rheumatoid arthritis. A limited number of studies reported melanoma growth in patients undergoing treatment with biologics. This case report with a brief review of literature suggests that patients under treatment with biologics should be counseled to identify new pigmented lesions or changes in preexisting nevi. Clinicians' collaboration will facilitate recognition and timely diagnosis of early melanoma. If there is any doubt, excision for histological evaluation should be considered. Pending new studies, careful observation is encouraged.

4 Article Panniculitis and vitiligo occurring during BRAF and MEK inhibitors combination in advanced melanoma patients: Potential predictive role of treatment efficacy. 2019

Consoli, Francesca / Manganoni, Ausilia Maria / Grisanti, Salvatore / Petrelli, Fausto / Venturini, Marina / Rangoni, Giovanni / Guarneri, Francesco / Incardona, Paolo / Vermi, William / Calzavara Pinton, Pier Giacomo / Berruti, Alfredo. ·Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST-Spedali Civili, Brescia, Italy. · Department of Dermatology, University of Brescia at ASST-Spedali Civili, Brescia, Italy. · Oncology Unit, ASST Bergamo Ovest, Treviglio, Italy. · Department of Pharmacy, ASST-Spedali Civili, Brescia, Italy. · Department of Laboratory Medicine, Unit of Pathology, ASST-Spedali Civili, Brescia, Italy. · Department of Molecular and Translational Medicine, Section of Pathology, School of Medicine, University of Brescia at ASST-Spedali Civili, Brescia, Italy. ·PLoS One · Pubmed #30939167.

ABSTRACT: Panniculitis and vitiligo-like lesions have been recently identified as rare cutaneous side effects of the combination of BRAF and MEK inhibitors, a standard of care in metastatic and locally advanced BRAF V600 mutated melanoma. An immune-mediated mechanism has been advocated in the pathogenesis of these skin lesions. Herein we retrospectively reviewed our institutional experience with the aim to explore the association between the occurrence of panniculitis and vitiligo-like lesions during combination therapy with dabrafenib (D) and trametinib (T) and outcome of advanced melanoma patients. Among 52 consecutive BRAF V600 mutated melanoma patients submitted to DT in our center, 12 (23%) developed immune related skin lesions (IRSLs): 8 panniculitis and 4 vitiligo. Patients with IRSLs diagnosis obtained a better disease response (83% versus 25%) (p = 0.001) than their counterpart and had a longer progression free survival and overall survival. The association of IRSLs and lower risk of disease progression (HR 0.19; CI 95% 0.04-0.90; p = 0.043) was confirmed after adjusting for major prognostic factors in multivariate analysis. IRSLs might represent an easy predictive surrogate marker for treatment response and favourable outcome in melanoma patients submitted to DT combination therapy.

5 Article Collapse of the Plasmacytoid Dendritic Cell Compartment in Advanced Cutaneous Melanomas by Components of the Tumor Cell Secretome. 2019

Vescovi, Raffaella / Monti, Matilde / Moratto, Daniele / Paolini, Lucia / Consoli, Francesca / Benerini, Luisa / Melocchi, Laura / Calza, Stefano / Chiudinelli, Mariella / Rossi, Giulio / Bugatti, Mattia / Maio, Michele / Fonsatti, Ester / Farisoglio, Camillo / Simbolo, Michele / Almici, Camillo / Verardi, Rosanna / Scarpa, Aldo / Bergese, Paolo / Manganoni, Ausilia / Facchetti, Fabio / Vermi, William. ·Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. · Laboratory of Genetic Disorders of Childhood, "Angelo Nocivelli" Institute for Molecular Medicine, Spedali Civili, Brescia, Italy. · Oncology Unit, ASST Spedali Civili di Brescia, Italy. · Pathology Unit, Azienda Romagna, Hospital Santa Maria delle Croci, Ravenna, Italy. · Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy. · Dermathology Unit, ASST Spedali Civili di Brescia, Italy. · ARC-Net Research Centre and Department of Diagnostics and Public Health, Section of Pathology, Università degli Studi di Verona, Verona, Italy. · Department of Transfusion Medicine, Laboratory for Stem Cells Manipulation and Cryopreservation, ASST Spedali Civili, Brescia, Italy. · Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. william.vermi@unibs.it. · Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri. ·Cancer Immunol Res · Pubmed #30401679.

ABSTRACT: Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually fail to eradicate the tumor. Plasmacytoid dendritic cells (PDCs) are potent regulators of the adaptive immune response and can eliminate melanoma cells via TLR-mediated effector functions. The PDC compartment is maintained by progressively restricted bone marrow progenitors. Terminally differentiated PDCs exit the bone marrow into the circulation, then home to lymph nodes and inflamed peripheral tissues. Infiltration by PDCs is documented in various cancers. However, their role within the melanoma immune contexture is not completely known. We found that in locoregional primary cutaneous melanoma (PCM), PDC infiltration was heterogeneous, occurred early, and was recurrently localized at the invasive margin, the site where PDCs interact with CD8

6 Article Morphological classification of melanoma metastasis with reflectance confocal microscopy. 2019

Farnetani, F / Manfredini, M / Longhitano, S / Chester, J / Shaniko, K / Cinotti, E / Mazzoni, L / Venturini, M / Manganoni, A / Longo, C / Reggiani-Bonetti, L / Giannetti, L / Rubegni, P / Calzavara-Pinton, P / Stanganelli, I / Perrot, J L / Pellacani, G. ·Division of Dermatology, Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy. · Division of Dermatology, University of Ferrara, Ferrara, Italy. · Department of Medical, Surgical, and Neurological Science, Dermatology Section, University of Siena, S Maria alle Scotte Hospital, Siena, Italy. · Skin Cancer Unit, IstitutoTumori Romagna (IRST), Meldola, Italy. · Division of Dermatology, SpedaliCivili University Hospital, Brescia, Italy. · Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy. · Department of Pathology, University of Modena and Reggio Emilia, Modena, Italy. · Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy. · Division of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy. · Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. ·J Eur Acad Dermatol Venereol · Pubmed #30394598.

ABSTRACT: BACKGROUND: Cutaneous malignant melanoma metastases differential diagnosis is challenging, as clinical and dermoscopic features can simulate primary melanoma or other benign or malignant skin neoplasms, and in-vivo reflectance confocal microscopy could assist. Our aim was to identify specific reflectance confocal microscopy features for cutaneous malignant melanoma metastases, and epidermal and dermal involvement. METHODS: A retrospective, multicentre observational study of lesions with proven cutaneous malignant melanoma metastases diagnosis between January 2005 and December 2016. Lesions were retrospectively assessed according to morphological features observed at reflectance confocal microscopy. Potential homogeneous subgroups of epidermal or dermal involvement were investigated with cluster analysis. RESULTS: Cutaneous malignant melanoma metastases (51 lesions in 29 patients) exhibited different frequencies of features according to metastasis dermoscopy patterns. Lesions classified at dermoscopy with nevus-like globular and non-globular patterns were more likely to be epidermotropic, showing characteristics of epidermal and dermal involvement at reflectance confocal microscopy. Other dermoscopy pattern classifications were more likely to be dermotropic, showing characteristics od dermal involvement at reflectance confocal microscopy. Distinguishing features at reflectance confocal microscopy included irregular (78%) and altered (63%) epidermis, pagetoid infiltration (51%), disarranged junctional architecture (63%), non-edged papillae (76%), dense and sparse, and cerebriform nests in the upper dermis (74%), and vascularity (51%). Cluster analysis identified three groups, which were retrospectively correlated with histopathological diagnoses of dermotropic and epidermotropic diagnoses (P < 0.001). The third cluster represents lesions with deep dermis morphological changes, which were too deep for evaluation with reflectance confocal microscopy. CONCLUSIONS: Specific reflectance confocal microscopy features of cutaneous malignant melanoma metastases for correct diagnosis, and subtype diagnosis, seem achievable in most cases where morphological alterations are located above the deep dermis.

7 Article Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: A hospital-based case-control study. 2018

Magoni, Michele / Apostoli, Pietro / Donato, Francesco / Manganoni, Ausilia / Comba, Pietro / Fazzo, Lucia / Speziani, Fabrizio / Leonardi, Lucia / Orizio, Grazia / Scarcella, Carmelo / Calzavara Pinton, Piergiacomo / Anonymous6480936. ·ATS Brescia (Brescia Health Protection Agency), Brescia, Italy. Electronic address: michele.magoni@ats-brescia.it. · Department of Medical and Surgical Specialties Radiological Sciences and Public Health, Institute of Occupational Health and Industrial Hygiene, University of Brescia, Italy. · Department of Medical and Surgical Specialties Radiological Sciences and Public Health, Unit of Hygiene, Epidemiology, and Public Health, University of Brescia, Italy. · Section of Dermatology, Department of Clinical and Experimental Sciences, University of Brescia, Italy. · Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy. · ATS Brescia (Brescia Health Protection Agency), Brescia, Italy. ·Environ Int · Pubmed #29421403.

ABSTRACT: Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case-control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95% CI: 0.34-1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95% CI: 1.91-4.73), cumulative lifetime UV exposure (OR = 2.56; 95% CI: 1.35-4.85) and high level of education (OR = 1.45; 95% CI: 1.03-2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population.

8 Article Melanoma in the elderly. 2017

Manganoni, Ausilia M / Pizzatti, Laura / Pavoni, Laura / Consoli, Francesca / Damiani, Enrico / Manca, Giorgio / Gualdi, Giulio / Calzavara-Pinton, Piergiacomo. ·Department of Dermatology, ASST Spedali Civili, Brescia, Italy - ausilia.manganoni@asst-spedalicivili.it. · Department of Dermatology, ASST Spedali Civili, Brescia, Italy. · Department of Oncology, ASST Spedali Civili, Brescia, Italy. · Department of General Surgery II, ASST Spedali Civili, Brescia, Italy. · Department of Plastic Surgery, ASST Spedali Civili, Brescia, Italy. ·G Ital Dermatol Venereol · Pubmed #28209051.

ABSTRACT: BACKGROUND: Among older patients, melanoma in general presents biological features related to a more aggressive biology, such as more locally advanced tumor. Management of melanoma in elderly may be difficult, mainly due to comorbidities. We report the experience of the Melanoma Unit of ASST Spedali Civili in Brescia, Italy. METHODS: Study subjects were drawn from 3444 patients with histological confirmed melanoma. Data were extracted from electronic database of the Melanoma Unit of ASST Spedali Civili in Brescia, Italy. Patients who received diagnosis of cutaneous melanoma at age of 65 years or older were retrospectively evaluated. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated. RESULTS: Of the 805 patients described in this study, 444 were males and 361 females. Statistically significant differences were found between patients aged 65-80 years and those aged >80 years considering melanoma prognostic factors, such as Breslow thickness, number of mitoses/mm2 and ulceration. CONCLUSIONS: Older age is recognized as an independent poor prognostic factor in melanoma patients, and melanoma in older patients have a distinct natural history. It was found that management of cancer in old person represents a major challenge to medical practice. We believe that the choice of therapy should be individualized and based upon the individual's overall health and that, particularly in these cases, management often requires interdisciplinary cooperation between dermatologist, surgical specialist, oncologist and geriatrician.

9 Article Genetic counselling and high-penetrance susceptibility gene analysis reveal the novel CDKN2A p.D84V (c.251A>T) mutation in melanoma-prone families from Italy. 2017

Borroni, Riccardo G / Manganoni, Ausilia M / Grassi, Sara / Grasso, Maurizia / Diegoli, Marta / Giorgianni, Carmela / Favalli, Valentina / Pavoni, Laura / Cespa, Maddalena / Arbustini, Eloisa. ·aLaboratori Sperimentali di Ricerca, Area Trapiantologica bDepartment of Dermatology, Fondazione IRCCS Policlinico San Matteo cDepartment of Dermatology dDepartment of Molecular Medicine, University of Pavia, Pavia eDepartment of Dermatology, A.O. Spedali Civili, Brescia, Italy. ·Melanoma Res · Pubmed #28060055.

ABSTRACT: Genetic susceptibility to primary cutaneous melanoma (PCM) may account for up to 12% of PCMs, presenting as the familial atypical mole/multiple melanoma syndrome (FAMMM), an autosomal dominant condition with incomplete penetrance and variable expressivity, characterized by PCM in at least two relatives and/or more than one PCMs in the same patient. To identify individuals at high genetic risk of PCM, from 1 January 2012 to 31 December 2015, we offered genetic counselling and molecular analysis of the two high-penetrance FAMMM susceptibility genes, cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase 4 (CDK4), to 92 consecutive, unrelated patients with FAMMM. Age at diagnosis and number of PCMs were obtained from medical records; the number of PCMs and affected relatives were recorded for each family. The diagnostic work-up consisted of genetic counselling and cascade genetic testing in patients and further extension to relatives of those identified as mutation carriers. All exons and exon/intron boundaries of CDKN2A and CDK4 genes were screened by direct bidirectional sequencing. We identified CDKN2A mutations in 19 of the 92 unrelated patients (20.6%) and in 14 additional, clinically healthy relatives. Eleven of these latter subsequently underwent excision of dysplastic nevi, but none developed PCM during a median follow-up of 37.3 months. In three patients from unrelated families, the novel CDKN2A p.D84V (c.251A>T) mutation was observed, associated with PCM in each pedigree. Genetic screening of FAMMM patients and their relatives can contribute towards specific primary and secondary prevention programmes for individuals at high genetic risk of PCM. The novel CDKN2A p.D84V (c.251A>T) mutation adds to the known mutations associated with FAMMM.

10 Article In-transit melanoma metastases of the scrotum with unusual clinical-dermoscopic features. 2016

Manganoni, Ausilia M / Pavoni, Laura / Gualdi, Giulio / Calzavara-Pinton, Piergiacomo. ·Department of Dermatology, University Hospital Spedali Civili, Brescia, Italy - manganoni@spedalicivili.brescia.it. ·G Ital Dermatol Venereol · Pubmed #27176090.

ABSTRACT: -- No abstract --

11 Article Differences in clinicopathological features and distribution of risk factors in Italian melanoma patients. 2015

Fava, P / Astrua, C / Chiarugi, A / Crocetti, E / Pimpinelli, N / Fargnoli, M C / Maurichi, A / Rubegni, P / Manganoni, A M / Bottoni, U / Catricalà, C / Cavicchini, S / Santinami, M / Alaibac, M / Annetta, A / Borghi, A / Calzavara Pinton, P / Capizzi, R / Clerico, R / Colombo, E / Corradin, M T / De Simone, P / Fantini, F / Ferreli, C / Filosa, G / Girgenti, V / Giulioni, E / Guarneri, C / Lamberti, A / Lisi, P / Nardini, P / Papini, M / Peris, K / Pizzichetta, M A / Salvini, C / Savoia, P / Strippoli, D / Tolomio, E / Tomassini, M A / Vena, G A / Zichichi, L / Patrizi, A / Argenziano, G / Simonacci, M / Quaglino, P. ·Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy. ·Dermatology · Pubmed #25659983.

ABSTRACT: BACKGROUND: No studies are available in the literature on the distribution of different melanoma features and risk factors in the Italian geographical areas. OBJECTIVE: To identify the differences in clinical-pathological features of melanoma, the distribution of risk factors and sun exposure in various Italian macro-areas. METHODS: Multicentric-observational study involving 1,472 melanoma cases (713 north, 345 centre, 414 south) from 26 referral centres belonging to the Italian Multidisciplinary Group for Melanoma. RESULTS: Melanoma patients in northern regions are younger, with thinner melanoma, multiple primaries, lower-intermediate phototype and higher counts of naevi with respect to southern patients; detection of a primary was mostly connected with a physician examination, while relatives were more involved in the south. Northern patients reported a more frequent use of sunbeds and occurrence of sunburns before melanoma despite sunscreen use and a lower sun exposure during the central hours of the day. CONCLUSIONS: The understanding of differences in risk factors distribution could represent the basis for tailored prevention programmes.

12 Article Melanoma density and relationship with the distribution of melanocytic naevi in an Italian population: a GIPMe study--the Italian multidisciplinary group on melanoma. 2015

Chiarugi, Alessandra / Quaglino, Pietro / Crocetti, Emanuele / Nardini, Paolo / De Giorgi, Vincenzo / Borgognoni, Lorenzo / Brandani, Paola / Gerlini, Gianni / Manganoni, Ausilia Maria / Bernengo, Maria Grazia / Pimpinelli, Nicola / Anonymous7050804. ·aSecondary Prevention and Screening Unit bClinical and Descriptive Epidemiology Unit, Institute for Study and Cancer Prevention (ISPO) cDepartment Surgery and Translational Medicine, Dermatology Division, University of Florence Medical School dPlastic Surgery Unit, Regional Melanoma Referral Centre, S. Maria Annunziata Hospital, Florence eSection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Turin, Turin fDepartment of Dermatology, University of Brescia, Brescia, Italy. ·Melanoma Res · Pubmed #25171087.

ABSTRACT: The most frequent site for melanoma is the back in men and the lower limbs in women, where intermittent sun exposure has been reported to be an environmental agent, although studies on age-specific incidence have suggested that melanoma in chronically sun-exposed areas, such as the face, increases with age. To identify the preferential development of melanoma in chronically or intermittently sun-exposed areas and the relationship between body site distribution and parameters such as sex, age, distribution of melanocytic naevi, atypical naevi and actinic keratoses, a prospective epidemiological multicentre study was carried out on all the consecutive melanoma cases diagnosed in a 2-year period from 27 Italian GIPMe centres (GIPMe: the Italian Multidisciplinary Group on Melanoma). Both the relative density of melanoma (RDM), defined as the ratio between observed and expected melanoma for a specific body site, and the average nevi density were identified. The most common melanoma site was the back, a factor that was not affected by either age or sex, even if men had higher density values. Statistically significant higher RDM values were observed in women aged more than 50 years for leg lesions and in the anterior thighs for young women (<50 years), whereas the lowest values were observed in the posterior thighs in women of any age. Facial RDM was statistically significantly higher than expected in both male and female patients more than 50 years of age. Melanoma was associated with a significantly higher atypical naevi density only for the back, chest and thighs. Indeed, facial melanoma was related to the presence of more than four actinic keratoses and not naevi density. To the best of our knowledge, the RDM method was applied for the first time together with naevus density calculation to obtain these data, which strongly substantiate the 'divergent pathway' hypothesis for the development of melanoma, but not find a direct correlation between melanoma and nevi for each anatomical site.

13 Article Patient perspectives of early detection of melanoma: the experience at the Brescia Melanoma Centre, Italy. 2015

Manganoni, A M / Pavoni, L / Calzavara-Pinton, P. ·Department of Dermatology, University Hospital "Spedali Civili", Brescia, Italy - manganoni@spedalicivili.brescia.it. ·G Ital Dermatol Venereol · Pubmed #24825405.

ABSTRACT: AIM: Skin self-examination is usually recommended for early melanoma diagnosis. Given the current lack of a standardized Skin Self-Examination method, we raised the issue about the suitable approach to explain to patients what can be considered a suspicious lesion. Hereinafter, we report the results of a pilot-study carried out at the Melanoma Centre, University Hospital Spedali Civili Brescia, Italy. METHODS: A consecutive sample of 200 melanoma patients entered into the Melanoma Prevention Project. A detailed survey revealed who had the first suspicion of the melanoma lesion. When melanoma was Self- or Relative-detected, we investigated the signs/symptoms that had alerted patients with reference to the ABCDE rule. The study included also socio-demographic variables, family history of melanoma, skin type, number and type of nevi, and melanoma features. RESULTS: Eighty-seven melanoma had been Self-Detected and 44 Relative-Detected. Patients report most commonly signs/symptoms such as dark colour (58%) and changing in size (47%). Seventy-nine percent of these patients have less than ten nevi and 92% have small and regular moles. CONCLUSION: Sometimes the signs of melanoma seem to be easy to identify. Our patients say that they recognized melanoma on the base of the Colour and the Change in size. Therefore, we propose the short "CC" acronym that could facilitate the melanoma self-diagnosis. The aim is to give a short and effective message that leads patients to have the doubt of a suspicious lesion of melanoma so that they seek medical attention.

14 Article Follow-up of cutaneous melanoma patients: a proposal for standardization. 2014

Moscarella, E / Ricci, C / Borgognoni, L / Bottoni, U / Catricalà, C / Dika, E / Fanti, P A / Landi, C / Manganoni, A M / Pellacani, G / Peris, K / Pimpinelli, N / Quaglino, P / Richetta, A / Simonetti, V / Stanganelli, I / Testori, A / Zalaudek, I / Argenziano, G. ·Dermatology and Skin Cancer Unit Arcispedale S. Maria Nuova, IRCCS Reggio Emilia, Italy - g.argenziano@gmail.com. ·G Ital Dermatol Venereol · Pubmed #24938723.

ABSTRACT: -- No abstract --

15 Article Pigmentation of axillary sentinel nodes from extensive skin tattoo mimics metastatic melanoma: case report. 2014

Manganoni, Ausilia Maria / Sereni, Elena / Pata, Giacomo / Ungari, Marco / Pavoni, Laura / Farisoglio, Camillo / Calzavara-Pinton, Pier Giacomo / Farfaglia, Roberto. ·Department of Dermatology, Brescia Civic Hospital, Brescia, Italy. ·Int J Dermatol · Pubmed #24372317.

ABSTRACT: BACKGROUND: The relationship between the occurrence of skin diseases and skin tattoos remains unclear. Dermatologic disorders have been reported to occur in about 2% of cases. In addition, tattoo pigment can migrate to the regional lymph nodes through the lymphatic vessels and subsequently mimic metastatic disease from melanoma. METHODS: A 23-year-old Caucasian man presented with a pigmented lesion on the left scapular region, which had slowly enlarged over time. The patient exhibited an extensive tattoo on the left upper arm, left shoulder, and part of the upper back. His medical history was unremarkable. The pigmented lesion was excised. Histology confirmed malignant melanoma. Ultrasound examination of the abdomen, neck, and inguinal and axillary lymph nodes and a total body computed tomography scan showed no sign of disease. A re-excision with 2-cm margins and sentinel lymph node biopsy (SLNB) were performed. Two grossly enlarged, black sentinel lymph nodes (SLNs) highly suggestive of melanoma metastases were removed. RESULTS: No evidence of melanoma metastasis was found in any of the sampled tissues. Large amounts of pigment were present within the subcapsular space and sinusoid areas of the two clinically suspicious lymph nodes. Immunohistochemical analysis was negative. CONCLUSIONS: Sentinel lymph node biopsy is widely performed in cutaneous melanoma. Histologic confirmation of any enlarged, pigmented SLN is essential prior to radical surgery, especially when pigmented SLNs are found near a tattoo. Tattoo pigments may deposit in the regional lymph nodes and may clinically mimic metastatic disease. A history of tattooing should be considered in all melanoma patients eligible for SLNB. In a finding of darkly pigmented nodes during SLNB, radical lymphadenectomy should be withheld until immunohistologic confirmation of metastasis in the SLN is obtained.

16 Article Recurrent melanocytic nevi and melanomas in dermoscopy: results of a multicenter study of the International Dermoscopy Society. 2014

Blum, Andreas / Hofmann-Wellenhof, Rainer / Marghoob, Ashfaq A / Argenziano, Giuseppe / Cabo, Horacio / Carrera, Cristina / Costa Soares de Sá, Bianca / Ehrsam, Eric / González, Roger / Malvehy, Josep / Manganoni, Ausilia Maria / Puig, Susana / Simionescu, Olga / Tanaka, Masaru / Thomas, Luc / Tromme, Isabelle / Zalaudek, Iris / Kittler, Harald. ·Public, Private, and Teaching Practice of Dermatology, Konstanz, Germany. · Medical University of Graz, Graz, Austria. · Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · Medical Research Institute "A. Lanari," University of Buenos Aires, Buenos Aires, Argentina. · Melanoma Unit, Department of Dermatology, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en red de enfermedades raras (CIBERER) Enfermedades rara, Barcelona, Spain. · Skin Cancer and Dermatology Center, Hospital AC Camargo São Paulo, Brazil. · Public and Private Practice of Dermatology, Lille, France. · Departamento de Introducción a la Clínica, Facultad de Medicina, UANL, Monterrey, México. · Department of Dermatology, University of Brescia, Brescia, Italy. · First Dermatological Clinic, Carol Davila University of Medicine and Pharmacy, Colentina Hospital, Bucharest, Romania. · Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. · Department of Dermatology, Lyon 1 University Centre Hospitalier Lyon Sud, Pierre Bénite, France. · Department of Dermatology, Centre du Cancer, Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium. · Department of Dermatology, Medical University of Vienna, Vienna, Austria. ·JAMA Dermatol · Pubmed #24226788.

ABSTRACT: IMPORTANCE Differentiating recurrent nevi from recurrent melanoma is challenging. OBJECTIVE To determine dermoscopic features to differentiate recurrent nevi from melanomas. DESIGN, SETTING, AND PARTICIPANTS Retrospective observational study of 15 pigmented lesion clinics from 12 countries; 98 recurrent nevi (61.3%) and 62 recurrent melanomas (38.8%) were collected from January to December 2011. MAIN OUTCOMES AND MEASURES Scoring the dermoscopic features, patterns, and colors in correlation with the histopathologic findings. RESULTS In univariate analysis, radial lines, symmetry, and centrifugal growth pattern were significantly more common dermoscopically in recurrent nevi; in contrast, circles, especially if on the head and neck area, eccentric hyperpigmentation at the periphery, a chaotic and noncontinuous growth pattern, and pigmentation beyond the scar's edge were significantly more common in recurrent melanomas. Patients with recurrent melanomas were significantly older than patients with recurrent nevi (mean [SD] age, 63.1 [17.5] years vs 30.2 [12.4] years) (P<.001), and there was a significantly longer time interval between the first procedure and the second treatment (median time interval, 25 vs 8 months) (P<.001). In a multivariate analysis, pigmentation beyond the scar's edge (P=.002), age (P<.001), and anatomic site (P=.002) were significantly and independently associated with the diagnosis of recurrent melanoma in dermoscopy. CONCLUSIONS AND RELEVANCE Dermoscopically, pigmentation beyond the scar's edge is the strongest clue for melanoma. Dermoscopy is helpful in evaluating recurrent lesions, but final interpretation requires taking into account the patient age, anatomic site, time to recurrence, growth pattern, and, if available, the histopathologic findings of the first excision.

17 Article The controversial management of giant congenital melanocytic nevi. When would it be better "to wait and see"? 2013

Manganoni, A M / Belloni Fortina, A / Pavoni, L / Borroni, R G / Bernardini, B / Peserico, A / Calzavara-Pinton, P. ·Department of Dermatology, University Hospital Spedali Civili, Brescia, Italy. manganoni@spedalicivili.brescia.it ·G Ital Dermatol Venereol · Pubmed #23588146.

ABSTRACT: AIM: A giant congenital nevus is a melanocytic nevus present at birth with wide extent on the skin surface. The management of this nevus remains controversial and needs to be personalized for each patient. METHODS: A retrospective multicenter study was carried out in the Dermatological Departments of Brescia, Padua, and Pavia, Italy. The inclusion criterion was the diagnosis of a giant congenital melanocytic nevus on the basis of clinical observation. RESULTS: Nine patients with giant congenital nevus are reported. None developed melanoma, whereas giant congenital nevi have been slowly fading in pigmentation. CONCLUSION: Having regard to the doubts on treatment that persist in the literature, we should consider that decisional management of giant congenital melanocytic nevi can be really complex, because of the size and depth of lesions. Indeed, the ablative surgery or other treatments might cause significant troubles and complete excision of deeper layers of the lesion is almost impossible to achieve. Moreover, the treatment does not reduce the risk of melanoma and might lead to a greater difficulty in clinical and dermoscopic observation due to the scarring occurrence after therapy. In our retrospective study, the pigmentation of giant congenital melanocytic nevi slowly faded on its own and until now none developed melanoma. Therefore, we suggest a close regular follow-up which should be focused on the exclusion of possible complications. Perhaps, it would be better "to wait and see" since other procedures do not decrease the risk of melanoma, but rather might lead the patient to underestimate it.

18 Article Association between multiple cutaneous melanoma and other primary neoplasms. 2012

Manganoni, A M / Pavoni, L / Farisoglio, C / Sereni, E / Chiudinelli, M / Calzavara-Pinton, P. ·Departments of Dermatology Pathology, University Hospital Spedali Civili, Brescia, Italy. manganoni@spedalicivili.brescia.it ·Clin Exp Dermatol · Pubmed #23020153.

ABSTRACT: BACKGROUND: The risk of a subsequent cancer is an important issue for patients with melanoma. The development of a second primary cancer in patients with a solitary melanoma has been discussed in several studies. However, to our knowledge, the incidence of second primary cancer (SPC) in patients with multiple primary melanoma (MPM) has not been thoroughly investigated. AIM: To quantify the incidence of SPC in patients with MPM, with the aim of possibly developing further preventive measures. METHODS: In a retrospective study, 76 patients with MPM were identified from 2155 patients being followed up at our unit. RESULTS: Of the 76 patients, 12 (16%) developed another neoplasm, with 59% of them having nonmelanoma skin cancer (NMSC), and 41% other noncutaneous cancers. By contrast, only 8% of those with single primary melanoma had other neoplasms (21% of whom had NMSC). CONCLUSIONS: Patients with MPM, especially men with skin phototype II, have a significantly increased incidence of developing SPC, particularly NMSC. Thus, careful monitoring is essential not only to detect recurrence of the original cancer or development of another primary melanoma, but also development of new malignancies of different types, particularly NMSC.

19 Article Familial and sporadic melanoma: different clinical and histopathological features in the Italian population - a multicentre epidemiological study - by GIPMe (Italian Multidisciplinary Group on Melanoma). 2012

Chiarugi, A / Nardini, P / Crocetti, E / Carli, P / De Giorgi, V / Borgognoni, L / Brandani, P / Pimpinelli, N / Manganoni, A M / Quaglino, P / Anonymous650690. ·Secondary Screening Unit, Institute for Study and Cancer Prevention, Florence, Italy. a.chiarugi@ispo.toscana.it ·J Eur Acad Dermatol Venereol · Pubmed #21429041.

ABSTRACT: BACKGROUND: Having a familial member affected by cutaneous melanoma is a risk factor for this neoplasm. Only a few epidemiological case-control studies have been carried out to investigate whether familial and sporadic melanomas show different clinical and histopathological features. OBJECTIVE: The aim of this study was to evaluate eventual different features and risk factors in subjects affected by familial and sporadic cutaneous melanoma. METHODS: A case-control multicentre study interesting 1407 familial (n = 92) and sporadic (n = 1315) melanomas in the Italian population. The analysis was made using t-test for continuous variables and chi-squared test for categorized ones. The variables which have shown statistically significant differences in the two groups in the univariate analysis were included in a multivariate model. RESULTS: The results showed some main significantly clinical differences between the two groups investigated: earlier age at diagnosis, a greater proportion of sunburns and a higher number of naevi were observed for the familial cases compared with sporadic ones. Nevertheless, we did not find a diagnostic anticipation in familial melanomas, in fact the invasion level and the thickness of melanomas was similar in the two groups. CONCLUSION: Some relevant clinical differences are observed between the two groups examined. The familial melanoma members, although carriers of constitutional risk factors, are not careful enough to primary and secondary prevention.

20 Minor Surgical excision margins for melanoma in situ: the experience at the Brescia Melanoma Centre, Italy. 2014

Manganoni, A M / Gualdi, G / Pavoni, L / Calzavara-Pinton, P G. ·Department of Dermatology, University Hospital Spedali Civili, Brescia, Italy. Electronic address: manganoni@spedalicivili.brescia.it. · Department of Dermatology, University Hospital Spedali Civili, Brescia, Italy. ·J Plast Reconstr Aesthet Surg · Pubmed #24838276.

ABSTRACT: -- No abstract --

21 Minor Role of occasional evaluation of the skin in early detection of melanoma in elderly patients. 2012

Manganoni, Ausilia Maria / Pavoni, Laura / Sereni, Elena / Farisoglio, Camillo / Calzavara-Pinton, Piergiacomo. · ·Indian J Dermatol Venereol Leprol · Pubmed #22960837.

ABSTRACT: -- No abstract --

22 Minor Melanoma of unknown primary with nodal metastases, presenting with vitiligo-like depigmentation. 2012

Manganoni, A M / Farfaglia, R / Sereni, E / Farisoglio, C / Pavoni, L / Calzavara-Pinton, P G. · ·G Ital Dermatol Venereol · Pubmed #22481586.

ABSTRACT: -- No abstract --

23 Minor Report of 27 cases of naevus spilus in 2134 patients with melanoma: is naevus spilus a risk marker of cutaneous melanoma? 2012

Manganoni, A M / Pavoni, L / Farisoglio, C / Sereni, E / Calzavara-Pinton, P. · ·J Eur Acad Dermatol Venereol · Pubmed #22168780.

ABSTRACT: -- No abstract --

24 Minor Melanoma in a patient in treatment with eculizumab. 2012

Manganoni, Ausilia Maria / Pavoni, Laura / Facchetti, Fabio / Farisoglio, Camillo / Sereni, Elena / Calzavara-Pinton, PierGiacomo. · ·Ann Hematol · Pubmed #21465187.

ABSTRACT: -- No abstract --

25 Minor Letter: Acral-lentiginous melanoma: Report of 15 cases. 2011

Manganoni, A M / Facchetti, F / Gavazzoni, F / Farisoglio, C / Manca, G / Sereni, E / Marocolo, D / Calzavara-Pinton, P G. · ·Dermatol Online J · Pubmed #21272506.

ABSTRACT: -- No abstract --