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Melanoma: HELP
Articles by M. E. Mikucki
Based on 1 article published since 2008
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Between 2008 and 2019, M. E. Mikucki wrote the following article about Melanoma.
 
+ Citations + Abstracts
1 Article Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. 2015

Mikucki, M E / Fisher, D T / Matsuzaki, J / Skitzki, J J / Gaulin, N B / Muhitch, J B / Ku, A W / Frelinger, J G / Odunsi, K / Gajewski, T F / Luster, A D / Evans, S S. ·Department of Immunology, Roswell Park Cancer Institute, Elm &Carlton Streets, Buffalo, New York 14263, USA. · Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. · Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. · Department of Microbiology and Immunology, University of Rochester Medical Center and the Wilmot Cancer Center, Rochester, New York 14642, USA. · Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. · Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. · Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA. · Comprehensive Cancer Center and Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA. · Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. ·Nat Commun · Pubmed #26109379.

ABSTRACT: T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity. Chemokines are credited with guiding the multistep recruitment of CD8(+) T cells across tumour vessels. However, the multiplicity of chemokines within tumours has obscured the contributions of individual chemokine receptor/chemokine pairs to this process. Moreover, recent studies have challenged whether T cells require chemokine receptor signalling at effector sites. Here we investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma. These studies reveal a non-redundant role for Gαi-coupled CXCR3 in stabilizing intravascular adhesion and extravasation of adoptively transferred CD8(+) effectors that is indispensable for therapeutic efficacy. In contrast, functional CCR2 and CCR5 on CD8(+) effectors fail to support trafficking despite the presence of intratumoral cognate chemokines. Taken together, these studies identify CXCR3-mediated trafficking at the tumour vascular interface as a critical checkpoint to effective T-cell-based cancer immunotherapy.