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Melanoma: HELP
Articles by William K. Murray
Based on 3 articles published since 2009
(Why 3 articles?)

Between 2009 and 2019, W. Murray wrote the following 3 articles about Melanoma.
+ Citations + Abstracts
1 Guideline Clinical practice guidelines for the diagnosis and management of melanoma: melanomas that lack classical clinical features. 2017

Mar, Victoria J / Chamberlain, Alex J / Kelly, John W / Murray, William K / Thompson, John F. ·Victorian Melanoma Service, Alfred Health, Melbourne, VIC victoria.mar@monash.edu. · Victorian Melanoma Service, Alfred Health, Melbourne, VIC. · Peter MacCallum Cancer Centre, Melbourne, VIC. ·Med J Aust · Pubmed #29020893.

ABSTRACT: INTRODUCTION: A Cancer Council Australia multidisciplinary working group is currently revising and updating the 2008 evidence-based clinical practice guidelines for the management of cutaneous melanoma. While there have been many recent improvements in treatment options for metastatic melanoma, early diagnosis remains critical to reducing mortality from the disease. Improved awareness of the atypical presentations of this common malignancy is required to achieve this. A chapter of the new guidelines was therefore developed to aid recognition of atypical melanomas. Main recommendations: Because thick, life-threatening melanomas may lack the more classical ABCD (asymmetry, border irregularity, colour variegation, diameter > 6 mm) features of melanoma, a thorough history of the lesion with regard to change in morphology and growth over time is essential. Any lesion that is changing in morphology or growing over a period of more than one month should be excised or referred for prompt expert opinion. Changes in management as a result of the guidelines: These guidelines provide greater emphasis on improved recognition of the atypical presentations of melanoma, in particular nodular, desmoplastic and acral lentiginous subtypes, with particular awareness of hypomelanotic and amelanotic lesions.

2 Article Sweet syndrome associated with ipilimumab in a patient with metastatic melanoma. 2018

Adler, N R / Murray, W K / Brady, B / McCormack, C / Pan, Y. ·Victorian Melanoma Service, Alfred Hospital, Melbourne, VIC, Australia. · School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. · Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. ·Clin Exp Dermatol · Pubmed #29396853.

ABSTRACT: -- No abstract --

3 Article Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. 2010

Handolias, Despina / Salemi, Renato / Murray, William / Tan, Angela / Liu, Wendy / Viros, Amaya / Dobrovic, Alexander / Kelly, John / McArthur, Grant A. ·Research Division Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia. ·Pigment Cell Melanoma Res · Pubmed #20088873.

ABSTRACT: In melanoma, mutations in KIT are most frequent in acral and mucosal subtypes and rarely reported in cutaneous melanomas particularly those associated with intermittent UV exposure. Conversely melanomas arising within chronic sun damaged skin are considered to harbour KIT mutations at higher rates. To characterize the frequency of KIT mutations in a representative melanoma population, 261 patients from two Australian melanoma centres were prospectively screened for mutations in exons 11, 13 and 17 of the KIT gene. A total of 257 patients had cutaneous melanoma arising from non-acral sites and four were acral melanomas. No mucosal or ocular melanomas were analysed. KIT mutations were identified in five tumours (2% of the entire cohort) including two acral melanomas. Two of the three non-acral melanomas with KIT mutations were associated with markers of chronic sun damage as assessed by the degree of skin elastosis. In the remaining cohort, 43% had chronically sun damaged skin. This report confirms that within an Australian population, KIT mutations are infrequent in cutaneous melanomas associated with both intermittent and chronic sun exposed skin.