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Melanoma: HELP
Articles by Massimiliano Scalvenzi
Based on 19 articles published since 2010
(Why 19 articles?)
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Between 2010 and 2020, M. Scalvenzi wrote the following 19 articles about Melanoma.
 
+ Citations + Abstracts
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1420806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Review Melanoma of the glans penis successfully treated with topical imiquimod: dermoscopy usefulness in clinical monitoring and review of the literature. 2017

Scalvenzi, Massimiliano / Palmisano, Franco / Russo, Daniela / Mascolo, Massimo / Costa, Claudia. ·Department of Dermatology, Federico II University, Naples, Italy - scalvenz@unina.it. · Department of Dermatology, Federico II University, Naples, Italy. · Department of Biomorphological and Functional Sciences, Federico II University, Naples, Italy. ·G Ital Dermatol Venereol · Pubmed #25236319.

ABSTRACT: Melanoma in situ (MIS) of the penis is very rare in dermatologic literature. The standard of care for MIS is surgical removal by excision with a 5-mm margins or Mohs micrographic surgery. Nevertheless, surgery is occasionally not feasible for a number of reasons, such as patient comorbidities, potential aesthetic and functional impairment and patient preference. Recently, topical treatment with an immunomodulator, imiquimod, has been proposed as an alternative treatment for MIS. Dermoscopy, beyond its well established usefulness in the diagnostic evaluation of melanocytic lesions, has also shown to be an important tool in monitoring therapeutic response to various dermatoses. We present a case of a 38-year-old man who presented a MIS of the glans penis, histopathologically diagnosed, treated successfully using imiquimod.

3 Article Non-Melanoma Skin Cancer in Outdoor Workers: A Study on Actinic Keratosis in Italian Navy Personnel. 2020

Vimercati, Luigi / De Maria, Luigi / Caputi, Antonio / Cannone, Enza Sabrina Silvana / Mansi, Francesca / Cavone, Domenica / Romita, Paolo / Argenziano, Giuseppe / Di Stefani, Alessandro / Parodi, Aurora / Peris, Ketty / Scalvenzi, Massimiliano / Girolomoni, Giampiero / Foti, Caterina. ·Interdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University of Bari, 70124 Bari, Italy. · Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, 70124 Bari, Italy. · Dermatology Unit, Department of Mentals and Physical Health and Preventive medicine, University of Campania Luigi Vanvitelli Naples, 80138 Naples, Italy. · Institute of Dermatology, Università Cattolica, 00168 Rome, Italy. · Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy. · Section of Dermatology, Di.S.Sal. Department of Health Science, University of Genoa, San Martino Polyclinic Hospital, 16132 Genoa, Italy. · Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy. · Department of Medicine, Section of Dermatology, University of Verona, 37134 Verona, Italy. ·Int J Environ Res Public Health · Pubmed #32235587.

ABSTRACT: Occupational exposure to ultraviolet radiation is one of the main risk factors for non-melanoma skin cancer (NMSC) development. The most common variants of NMSC are basal cell carcinomas, squamous cell carcinomas, and actinic keratosis (AK). The latter is nowadays considered by most authors as an early squamous cell carcinoma rather than a precancerous lesion. Outdoor workers have a higher risk of developing NMSC because they spend most of the working day outside. The aim of this descriptive study was to assess the prevalence of skin lesions, especially AK, in a professional category of individuals exposed to ultraviolet (UV) radiation: the Italian Navy. From January to June 2016, a questionnaire and a total skin examination of 921 military personnel were administered by medical specialists (dermatologists) in seven different Italian Navy centres. AK was detected in 217 of 921 (23.5%) workers. Older age, outdoor occupation, longer working life, and fair skin seem to promote the development of AK. Of the 217 workers with AK, 187 (86.2%) had lesions in chronically sun-exposed skin areas. Italian Navy personnel have a high AK prevalence. Further studies are needed to investigate occupational hazards and their health effects among outdoor workers to promote protective behaviour and raise awareness of skin cancer.

4 Article Cutaneous melanoma associated with naevi prevalence: A 15-year cross-sectional retrospective study. 2020

Scalvenzi, Massimiliano / Megna, Matteo / Costa, Claudia / Fabbrocini, Gabriella / Villani, Alessia / Greco, Vincenzo. ·Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. ·Australas J Dermatol · Pubmed #31603538.

ABSTRACT: BACKGROUND/OBJECTIVES: Melanoma may develop de novo or naevus associated (NAM). The exact prevalence and features of NAM are not fully elucidated. METHODS: A 15-year cross-sectional retrospective study was performed of all melanoma cases diagnosed and treated at the skin cancer centre of the University of Naples Federico II from September 2003 to August 2018. Data collected included patient's age, gender, melanoma anatomic site, Breslow thickness, and histolopathology including melanoma-associated lesion characteristics. RESULTS: A total of 1986 melanomas were included in the study. Based on histolopathogical examination, NAM represented 8.4% (n = 167) with de novo melanoma representing the great majority of the melanomas (91.6%). NAM was significantly more common in younger age compared to de novo melamoma (mean age 48 ± 14.9 vs 54.3 ± 15.9 years, P < 0.001), and more frequently involved the trunk (62.3% vs 51.8% P = 0.01). Mean Breslow thickness was significantly higher in de novo melanoma  compared to NAM (0.97 ± 1.48 mm vs 0.83 ± 0.95, P < 0.001). However, in situ melanoma was more commonly observed in de novo melanoma (n = 640, 35.2%) rather than NAM (n = 41, 24.5%; P < 0.01) whereas invasive melanoma represented 75.5% (n = 126) of NAM and 64.8% (n = 1179) of de novo melanoma, P < 0.01. CONCLUSIONS: NAM represent a small percentage of melanomas (8.4%) compared to de novo melanoma. NAM appeared to be significantly more common in younger age and more frequently involved the trunk, being associated with an overall better prognosis, due to a lower mean Breslow thickness respect to de novo melanoma.

5 Article Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study. 2019

Costa, Claudia / Megna, Matteo / Cappello, Milena / Napolitano, Maddalena / Monfrecola, Giuseppe / Scalvenzi, Massimiliano. ·Department of Dermatology, University of Naples Federico II, Naples, Italy. · Department of Dermatology, University of Naples Federico II, Naples, Italy - mat24@libero.it. ·G Ital Dermatol Venereol · Pubmed #28528541.

ABSTRACT: BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking. RESULTS: A total of 760 lesions were excised. 690/760 (90.8%), were identified as typical Spitz nevi, whereas 70/760 lesions (9.2%) consisted of malignant melanocytic lesions. Our study showed that almost 9.2% of clinically and dermoscopically symmetric Spitzoid lesions revealed to be malignant melanocytic lesion. For symmetric Spitzoid looking lesions female sex, clinical palpability, the presence of an inverse network at dermoscopic examination and the involvement of lower limbs were observed as the main factors, which were linked to a higher possibility of being malignant lesions. CONCLUSIONS: In order to avoid missing diagnoses for malignant melanocytic lesions, this study remarked the importance of preventive excision for all Spitzoid-looking lesions in patients ≥12 years, even if they show symmetry at both clinical and dermoscopic level.

6 Article Difficult to diagnose small cutaneous melanoma metastases mimicking angiomas: utility of dermoscopy. 2018

Mazzella, Caterina / Costa, Claudia / Cappello, Milena / Scalvenzi, Massimiliano. ·Department of Dermatology, University of Naples Federico II, Naples, Italy. ·Int J Dermatol · Pubmed #30133751.

ABSTRACT: BACKGROUND: Metastases from melanoma can be found in any organ, while the reported incidence of skin metastases varies between 2 and 20%. Cutaneous melanoma metastases (CMM) can be heterogeneous at clinical examination, and they can simulate other benign and malignant lesions, thus generating major diagnostic troubles for the dermatologist. Dermoscopy is a useful tool that may increase the physician's diagnostic accuracy to this purpose. MATERIALS AND METHODS: Herein, we describe the case of two patients having lesions that can easily be confused with other benign or malignant lesions for their clinical and dermoscopic similarities and for the variability of presentation of skin metastases. The description of the dermoscopy patterns of melanoma metastases may be useful to recognize early metastases, when clinically not suspected, facilitating an early removal and histopathological confirmation. RESULTS: Diagnoses of melanoma metastases and angiomas were confirmed by histological examination. Melanoma metastases show at dermoscopic examination the angioma-like pattern. The ability to detect CMM between other lesions was good taking into consideration that, without the patient's history and with just the dermoscopy image, it could be very difficult to distinguish CMM from other benign or malignant skin lesions. CONCLUSIONS: The present study confirms that dermoscopy is a useful tool to increase the physician's diagnostic accuracy for CMM and allow its differentiation from other cutaneous lesions, always taking into account the patient's medical record.

7 Article Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. 2017

Carrera, Cristina / Segura, Sonia / Aguilera, Paula / Takigami, Carol Midori / Gomes, Antonio / Barreiro, Alicia / Scalvenzi, Massimiliano / Longo, Caterina / Cavicchini, Stefano / Thomas, Luc / Malvehy, Josep / Puig, Susana / Zalaudek, Iris. ·Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, IDIBAPS, Barcelona University, Barcelona, Spain. · Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Barcelona, Spain. · Department of Dermatology, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona, Barcelona, Spain. · Department of Dermatology, University of Naples Federico II, Naples, Italy. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. · UO Dermatologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy. · Department of Dermatology, Lyons Cancer Research Center, INSERM U1052, CNRS UMR5286, Centre Hospitalier Lyon-Sud, Lyon 1 University, Lyon, France. · Dermatology Clinic, Hospital Maggiore, University of Trieste, Trieste, Italy. ·Dermatology · Pubmed #29502116.

ABSTRACT: BACKGROUND: Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. OBJECTIVE: To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. METHODS: Clinical and dermoscopic images of histopathologically proven SK-like MMs (n = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study. Each participant classified each lesion as melanoma or benign tumor. The clinical and clinical-dermoscopic diagnostic accuracies were measured separately. RESULTS: Overall, 54 participants with a mean clinical experience of 15.8 years (SD 11.8) evaluated 231 tumors. Almost 40% of SK-like melanomas were clinically misclassified as benign tumor. Dermoscopy improved diagnostic accuracy for all participants, independently of experience, from 60.9 to 68.1% (p < 0.001), mostly due to a significant increase in the sensitivity (clinical 61.9% vs. dermoscopic 74.5%) (p < 0.001). Dermoscopy did not significantly affect specificity among the experienced participants (≥6 years of experience) compared to clinical examination (61.1 vs. 59.6%, respectively); in contrast, dermoscopy was associated with a decrease in specificity compared to clinical diagnosis among novice participants (< 6 years) (45.6 vs. 61.1%, respectively; p = 0.02). CONCLUSION: Melanomas can be clinically indistinguishable from SKs despite being evaluated by expert dermatologists. Dermoscopy, even in nonexpert hands, significantly improves their recognition.

8 Article Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. 2017

Carrera, Cristina / Segura, Sonia / Aguilera, Paula / Scalvenzi, Massimiliano / Longo, Caterina / Barreiro, Alicia / Broganelli, Paolo / Cavicchini, Stefano / Llambrich, Alex / Zaballos, Pedro / Thomas, Luc / Malvehy, Josep / Puig, Susana / Zalaudek, Iris. ·Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain2Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain. · Department of Dermatology, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona, Barcelona, Spain. · Department of Dermatology, University of Naples Federico II, Naples, Italy. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy6Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. · Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. · Città della Salute e della Scienza, Turin, Italy. · Unità Operative (UO) Dermatologia Fondazione IRCCS, Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. · Dermatology, Hospital Son Llatzer, Palma Mallorca, Spain. · Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain. · Department of Dermatology, Centre Hospitalier Lyon Sud, Lyon 1 University, Lyons Cancer Research Center (Pr Puisieux), Lyon, France. · Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. ·JAMA Dermatol · Pubmed #28355453.

ABSTRACT: Importance: Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas. Objective: To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology. Design, Setting, and Participants: This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven melanomas in 134 patients treated in 9 skin cancer centers in Spain, France, Italy, and Austria. Without knowledge that the definite diagnosis for all the lesions was melanoma, 2 dermoscopy-trained observers evaluated the clinical descriptions and 48 dermoscopic features (including all melanocytic and nonmelanocytic criteria) of all 134 images and classified each dermoscopically as SK or not SK. The total dermoscopy score and the 7-point checklist score were assessed. Images of the lesions and patient data were collected from July 15, 2013, through July 31, 2014. Main Outcomes and Measures: Frequencies of specific morphologic patterns of (clinically and dermoscopically) SK-like melanomas, patient demographics, and interobserver agreement of criteria were evaluated. Results: Of the 134 cases collected from 72 men and 61 women, all of whom were white and who had a mean (SD) age of 55.6 (17.5) years, 110 (82.1%) revealed dermoscopic features suggestive of melanoma, including pigment network (74 [55.2%]), blue-white veil (72 [53.7%]), globules and dots (68 [50.7%]), pseudopods or streaks (47 [35.1%]), and blue-black sign (43 [32.3%]). The remaining 24 cases (17.9%) were considered likely SKs, even by dermoscopy. Overall, lesions showed a scaly and hyperkeratotic surface (45 [33.6%]), yellowish keratin (42 [31.3%]), comedo-like openings (41 [30.5%]), and milia-like cysts (30 [22.4%]). The entire sample achieved a mean (SD) total dermoscopy score of 4.7 (1.6) and a 7-point checklist score of 4.4 (2.3), while dermoscopically SK-like melanomas achieved a total dermoscopy score of only 4.2 (1.3) and a 7-point checklist score of 2.0 (1.9), both in the range of benignity. The most helpful criteria in correctly diagnosing SK-like melanomas were the presence of blue-white veil, pseudopods or streaks, and pigment network. Multivariate analysis found only the blue-black sign to be significantly associated with a correct diagnosis, while hyperkeratosis and fissures and ridges were independent risk markers of dermoscopically SK-like melanomas. Conclusions and Relevance: Seborrheic keratosis-like melanomas can be dermoscopically challenging, but the presence of the blue-black sign, pigment network, pseudopods or streaks, and/or blue-white veil, despite the presence of other SK features, allows the correct diagnosis of most of the difficult melanoma cases.

9 Article Psoriasis in melanoma patients: a prospective pilot study. 2017

Megna, Matteo / Napolitano, Maddalena / Balato, Nicola / Scalvenzi, Massimiliano / Ayala, Fabio / DI Costanzo, Luisa / Lembo, Serena / DI Caprio, Roberta / Patruno, Cataldo / Balato, Anna. ·Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. · Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy - maddy.napolitano@gmail.com. ·G Ital Dermatol Venereol · Pubmed #26632958.

ABSTRACT: BACKGROUND: Melanoma is an immunogenic tumor and the presence of T-cell infiltrates within melanoma lesions may correlated with longer patient survival. Psoriasis is a chronic immune-mediated inflammatory disease, in which the role of T-cells is well established. The aim of our prospective pilot study was to investigate the relationship between melanoma and psoriasis examining 3 groups of patients: the melanoma-group (MG), the psoriasis-group (PG) and the control-group (CG). METHODS: Every patient underwent detailed anamnestic and clinical examination. Moreover, gene expression of interleukin-6 (IL-6), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) was analyzed in all groups and in subjects affected by both melanoma and psoriasis (MP). RESULTS: Melanoma patients showed a lower frequency of psoriasis and positive family history (FH) of psoriasis respect to CG. Moreover, psoriatic patients presented fewer MN, and lower frequency of positive FH of melanoma than CG. IL-6 and IFN-γ were significantly increased in PG and reduced in MG. CONCLUSIONS: We propose a provocative hypothesis of a possible protective role of psoriasis for melanoma development.

10 Article Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study. 2015

Moscarella, Elvira / Lallas, Aimilios / Kyrgidis, Athanassios / Ferrara, Gerardo / Longo, Caterina / Scalvenzi, Massimiliano / Staibano, Stefania / Carrera, Cristina / Díaz, M Alba / Broganelli, Paolo / Tomasini, Carlo / Cavicchini, Stefano / Gianotti, Raffaele / Puig, Susana / Malvehy, Josep / Zaballos, Pedro / Pellacani, Giovanni / Argenziano, Giuseppe. ·Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy. · Department of Oncology, Anatomic Pathology Unit, Gaetano Rummo General Hospital, Benevento, Italy. · Department of Dermatology, University of Naples Federico II, Naples, Italy. · Department of Biomedical Advanced Sciences, Pathology Section, School of Medicine, University of Naples Federico II, Naples, Italy. · Melanoma Unit, Dermatology and Pathology Departments, Hospital Clínic Barcelona, Universitat de Barcelona, Barcelona, Spain. · City of Health and Science of Turin, University of Turin, Turin, Italy. · Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. · Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. · Melanoma Unit, Dermatology and Pathology Departments, Hospital Clínic Barcelona, Universitat de Barcelona, Barcelona, Spain; CIBER of Rare Diseases, Instituto de Salud Carlos III, Barcelona, Spain. · Department of Dermatology, Hospital Sant Pau i Santa Tecla, Tarragona, Spain. · Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. · Dermatology Unit, Second University of Naples, Naples, Italy. Electronic address: g.argenziano@gmail.com. ·J Am Acad Dermatol · Pubmed #26475536.

ABSTRACT: BACKGROUND: Few studies have described the clinical and dermoscopic features of atypical Spitz tumors. OBJECTIVE: We sought to describe the clinical and dermoscopic features of a series of atypical Spitz tumors as compared with those of conventional Spitz nevi. METHODS: This was a multicenter, retrospective, case-control study, analyzing the clinical and dermoscopic characteristics of 55 atypical Spitz tumors and 110 Spitz nevi that were excised and diagnosed histopathologically. RESULTS: The majority of atypical Spitz tumors presented clinically as a plaque or nodule, dermoscopically typified by a multicomponent or nonspecific pattern. A proportion of lesions (16.4%) exhibited the typical nonpigmented Spitzoid pattern of dotted vessels and white lines under dermoscopy. Nodularity, ulceration, linear vessels, polymorphic vessels, white lines, and blue-white veil were associated with atypical Spitz tumors by univariate analysis, but only nodularity and white lines remained significant after multivariate analysis. In contrast, a pigmented typical Spitzoid pattern was a potent predictor of Spitz nevi, associated with 6.5-fold increased probability. LIMITATIONS: Differentiation from Spitzoid melanoma and other nonmelanocytic lesions was not investigated. CONCLUSION: Atypical Spitz tumors are polymorphic melanocytic proliferations with a nodular clinical appearance. Dermoscopically they demonstrate a multicomponent and nonspecific pattern. A typical nonpigmented Spitzoid pattern on dermoscopy (with dotted vessels and white lines) does not exclude atypical Spitz tumors.

11 Article Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. 2015

Romano, Simona / D'Angelillo, Anna / Staibano, Stefania / Simeone, Ester / D'Arrigo, Paolo / Ascierto, Paolo Antonio / Scalvenzi, Massimiliano / Mascolo, Massimo / Ilardi, Gennaro / Merolla, Francesco / Jovarauskaite, Egle / Romano, Maria Fiammetta. ·Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy. · Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. · Melanoma Unit, National Cancer Institute 'G. Pascale Foundation', Naples, Italy. · Dermatology Section, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. · Department of Biological Science, University of Portsmouth, Portsmouth, UK. ·Pigment Cell Melanoma Res · Pubmed #25895097.

ABSTRACT: FKBP51 (gene FKBP5) is an immunophilin capable of immunosuppression expressed in melanoma and lymphocytes. We found increased levels of a spliced FKBP5 variant in the PBMCs of 124 patients with melanoma. This variant encodes for an unknown isoform (FKBP51s). We hypothesized that FKBP51s resulted from tumour interaction with immune cells, through PDL-1/PD-1. To address this issue, we performed melanoma/PBMC cocultures. Furthermore, the immunohistochemistry of 76 melanoma specimens served to investigate whether FKBP51s stained tumour infiltrating lymphocytes. Our results showed that PBMCs expressed FKBP51s when cocultured with melanoma. Tumour PDL-1 knockdown or anti-PD-1 reduced FKBP51s expression in cocultured PBMCs. IHC showed a strong FKBP51s signal in tumour infiltrating lymphocytes, and lymphocytes of the invasion front of the tumour, along with melanoma PDL-1 expression. When overexpressed in melanoma, FKBP51s facilitated PDL-1 expression on the cell surface. In conclusion, our study shows that FKBP51s marks the PBMCs of patients with melanoma and is exploited by the tumour to immunomodulate through PDL-1.

12 Article Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. 2015

Mascolo, Massimo / Russo, Daniela / Scalvenzi, Massimiliano / Varricchio, Silvia / Staibano, Stefania. ·Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy. Electronic address: massimo.mascolo@unina.it. · Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy. · Department of Dermatology, University of Naples Federico II, Naples, Italy. ·J Am Acad Dermatol · Pubmed #25500029.

ABSTRACT: -- No abstract --

13 Article Melanoma detection in Italian pigmented lesion clinics. 2014

Argenziano, G / Moscarella, E / Annetta, A / Battarra, V C / Brunetti, B / Buligan, C / Cantisani, C / Capizzi, R / Carbone, A / Carlino, A / Corsetti, V / Damiano, A / De Salvo, V / De Simone, P / Di Caterino, P / Fargnoli, M C / Ferrari, A / Fossati, B / Frascione, P / Ghigliotti, G / González Inchaurraga, M A / Guerriero, C / Landi, C / Mazzoni, L / Mirizzi, S / Palazzo, G / Pedretti, A / Peris, K / Piemonte, P / Rossi, A / Satta, R / Savoia, F / Scalvenzi, M / Stanganelli, I / Stinco, G / Zampieri, P / Zalaudek, I. ·Skin Cancer Unit Arcispedale Santa Maria Nuova IRCCS Reggio Emilia, Italy - g.argenziano@gmail.com. ·G Ital Dermatol Venereol · Pubmed #24819635.

ABSTRACT: AIM: Accuracy in melanoma detection is important to recognize early curable melanomas and to minimize the unnecessary excision of benign lesions. The aim of this paper was to evaluate melanoma screening accuracy of Italian pigmented lesion clinics in terms of number needed to excise (NNE), melanoma thickness, and number of melanomas diagnosed during patient follow-up. METHODS: Information on all skin tumors excised in 2011 were extracted from the databases of the participating centers. Information whether the lesion was excised at the baseline examination or during patient follow-up was recorded, as well as the overall number of patients examined in each center in 2011. RESULTS: After e-mail solicitation, 22 of 40 centers agreed to participate. A total of 8229 excised lesions were collected. The overall number of examined patients was 86.564, thus 9.5% of screened patients had a lesion removed. Of the excised lesions, 866 were diagnosed as melanoma (1% of examined patients) and 5311 (88.9%) were melanocytic nevi. Three NNE were calculated giving values of 7.9 excised lesions to find 1 melanoma, 7.1 melanocytic lesions to find 1 melanoma, and 3.7 lesions to find 1 skin malignancy. The median melanoma thickness was 0.6 mm, with only 15.1% of melanomas ≥ 1 mm of thickness. Melanomas detected over time were 96 (11.1%; mean thickness, 0.3 mm), with 15.6% of lesions excised after short-term follow-up and 84.4% after long-term follow-up. CONCLUSION: The NNE values comparable to those achieved in specialized clinical settings and the high number of early melanomas diagnosed at the baseline examination or during patient follow-up indicate a high level of accuracy in melanoma screening achieved by Italian pigmented lesion clinics.

14 Article The Italian Euromelanoma Day: evaluation of results and implications for future prevention campaigns. 2014

Suppa, Mariano / Altomare, Gianfranco / Cannavò, Serafinella P / Capizzi, Rodolfo / Catricalà, Caterina / Colombo, Enrico / Fargnoli, Maria C / Fossati, Barbara / Frascione, Pasquale / Lisi, Paolo / Santini, Marcello / Scalvenzi, Massimiliano / Peris, Ketty / Anonymous4460744. ·Department of Dermatology, University of L'Aquila, L'Aquila, Italy. ·Int J Dermatol · Pubmed #23230843.

ABSTRACT: BACKGROUND: Melanoma incidence/mortality is increasing worldwide. "Euromelanoma Day" is a pan-European campaign for skin cancer prevention. Results of the 2010 Euromelanoma Day in Italy are reported herein. MATERIALS AND METHODS: A questionnaire was used to collect data on participants' characteristics and suspected skin cancers. RESULT: A total of 1085 participants was screened (64.1% females, median age 44 years). Suspicion rate, detection rate, and positive predictive values for melanoma were 1.3, 0.28 and 21.4%, respectively. Poorly educated, ≥35 years old, pale-skinned males were at higher risk for skin cancer than highly educated, <35 years old, darker-skinned females, although the latter groups reported sun-seeking behaviors. Full skin examination and dermoscopy were performed in 85.5 and 79.2% of participants. CONCLUSIONS: The 2010 Italian Euromelanoma Day produced good results in terms of melanoma detection/suspicion rates, likely due to the extensive use of full clinical and dermoscopic examinations. The campaign failed to attract many high-risk individuals. Targeted communication strategies are needed to this regard.

15 Article FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. 2013

Romano, S / Staibano, S / Greco, A / Brunetti, A / Nappo, G / Ilardi, G / Martinelli, R / Sorrentino, A / Di Pace, A / Mascolo, M / Bisogni, R / Scalvenzi, M / Alfano, B / Romano, M F. ·Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy. ·Cell Death Dis · Pubmed #23559012.

ABSTRACT: Melanoma is the most aggressive skin cancer; there is no cure in advanced stages. Identifying molecular participants in melanoma progression may provide useful diagnostic and therapeutic tools. FK506 binding protein 51 (FKBP51), an immunophilin with a relevant role in developmental stages, is highly expressed in melanoma and correlates with aggressiveness and therapy resistance. We hypothesized a role for FKBP51 in melanoma invasive behaviour. FKBP51 promoted activation of epithelial-to-mesenchymal transition (EMT) genes and improved melanoma cell migration and invasion. In addition, FKBP51 induced some melanoma stem cell (MCSC) genes. Purified MCSCs expressed high EMT genes levels, suggesting that genetic programs of EMT and MCSCs overlap. Immunohistochemistry of samples from patients showed intense FKBP51 nuclear signal and cytoplasmic positivity for the stem cell marker nestin in extravasating melanoma cells and metastatic brains. In addition, FKBP51 targeting by small interfering RNA (siRNA) prevented the massive metastatic substitution of liver and lung in a mouse model of experimental metastasis. The present study provides evidence that the genetic programs of cancer stemness and invasiveness overlap in melanoma, and that FKBP51 plays a pivotal role in sustaining such a program.

16 Article Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients. 2010

Mascolo, Massimo / Vecchione, Maria Luisa / Ilardi, Gennaro / Scalvenzi, Massimiliano / Molea, Guido / Di Benedetto, Maria / Nugnes, Loredana / Siano, Maria / De Rosa, Gaetano / Staibano, Stefania. ·Department of Biomorphological and Functional Sciences, Pathology Section, University of Naples Federico II, School of Medicine, Naples, Italy. ·BMC Cancer · Pubmed #20178651.

ABSTRACT: BACKGROUND: Cutaneous melanoma (CM) is the most lethal form of skin malignancy, which registers a constant increase in incidence worldwide. The identification of molecular alteration(s) involved in its biological aggressiveness represents a major challenge for researchers, considering that existing therapies are ineffective to treat metastasizing cases. The epigenetic control of chromatin dynamics during DNA synthesis, replication, and repair is fundamental for the orderly progression of cell proliferation. The Chromatin Assembly Factor 1 (CAF-1) complex acts as a major regulator of this process; its intermediate (p60) subunit has been recently proposed as a novel proliferation and prognostic marker for several tumors. We aimed to establish if the evaluation of the expression of CAF-1/p60 in primary CM may help define the prevision of outcome of patients. METHODS: Immunohistochemistry with anti-CAF-1/p60 was performed on paraffin-embedded tissue sections of 130 cases of primary CM retrieved from the archive files of the Department of Biomorphological and Functional Sciences, Section of Pathology, University "Federico II" of Naples, Italy. Results were compared with histopathological and follow-up data of patients. RESULTS: CAF-1/p60 was expressed in all CM. A significant statistical association between the overexpression of the protein and the occurrence of skin, node and/or distant metastases (P < 0.05) emerged, independently from histopathological prognostic factors. CONCLUSIONS: CAF-1/p60 looks promising as a new prognostic marker for CM and sheds new light on the molecular events associated with photocancerogenesis and melanoma biology.The screening for CAF-1/p60 might contribute to the molecular sub-classification of CM, with improved translational outcomes.

17 Minor Second primary melanoma: incidence rate and risk factors. 2020

Villani, Alessia / Fabbrocini, Gabriella / Costa, Claudia / Greco, Vincenzo / Scalvenzi, Massimiliano. ·Dermatology Unit, Department of Clinical Medicine and Surgery, University of Federico II, Naples, Italy. ·J Eur Acad Dermatol Venereol · Pubmed #32314450.

ABSTRACT: It is well-known that melanoma patients have an increased risk to develop second primary melanomas (SPMs)

18 Unspecified A solitary reddish nodule on the upper back of a middle-aged woman. 2017

Mascolo, Massimo / Pagliuca, Francesca / Costa, Claudia / Di Lorenzo, Pierpaolo / Scalvenzi, Massimiliano / Staibano, Stefania. ·Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy. · Department of Dermatology, University of Naples Federico II, Naples, Italy. · Department of Advanced Biomedical Sciences, Forensic Medicine Section, University of Naples Federico II, Naples, Italy. ·J Dtsch Dermatol Ges · Pubmed #28640519.

ABSTRACT: -- No abstract --

19 Unspecified Clinical, dermoscopic and histological features of a combined tumor composed of a melanoma in situ, a basal cell carcinoma and an intradermal naevus. 2012

Scalvenzi, Massimiliano / Costa, Claudia / Palmisano, Franco / Fabbrocini, Gabriella / Siano, Mariella / Staibano, Stefania. ·Departments of Dermatology, Federico II University, Naples, Italy. · Departments of Biomorphological and Functional Sciences, Federico II University, Naples, Italy. ·Dermatol Reports · Pubmed #25386311.

ABSTRACT: The combined tumors are neoplasms consisting of 2 or more distinct cell population that are intimately admixed. The presence of more than one neoplasm in the same lesion comprising melanocytes and keratinocytes are rare but well documented. We report a case of a 65-year-old man with a melanoma in situ, a basal cell carcinoma and an intradermal naevus in collision that clinically appeared as a single lesion. Clinical, dermoscopic and histological features are discussed.