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Melanoma: HELP
Articles by Giuseppe Stinco
Based on 9 articles published since 2010
(Why 9 articles?)
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Between 2010 and 2020, G. Stinco wrote the following 9 articles about Melanoma.
 
+ Citations + Abstracts
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1420806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Review Giant melanoma of the abdomen: case report and revision of the published cases. 2014

di Meo, Nicola / Stinco, Giuseppe / Gatti, Alessandro / Errichetti, Enzo / Bonin, Serena / Albano, Antonio / Trevisini, Sara / Trevisan, Giusto. ·University of Trieste, Italy. ·Dermatol Online J · Pubmed #25046463.

ABSTRACT: Malignant melanoma presenting as a giant cutaneous mass is rarely observed in clinical practice. A few patients with giant melanoma have been reported, Herein, we document our experience with a patient with giant cutaneous melanoma of the abdomen and review the features of previously reported individuals.

3 Article Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma. 2019

Cauci, Sabina / Buligan, Cinzia / Rocchi, Francesco / Salvador, Ilaria / Xodo, Luigi / Stinco, Giuseppe. ·Department of Medicine, University of Udine, I-33100 Udine, Italy. · Department of Dermatology, University-Hospital of Udine, I-33100 Udine, Italy. ·Oncol Lett · Pubmed #31788049.

ABSTRACT: Immunity and cytokines serve crucial roles in cutaneous melanoma. The present study investigated whether a variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor antagonist (IL-1RA) gene (

4 Article BsmI (rs1544410) and FokI (rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy. 2017

Cauci, Sabina / Maione, Vincenzo / Buligan, Cinzia / Linussio, Martina / Serraino, Diego / Stinco, Giuseppe. ·Department of Medicine, University of Udine, Udine 33100, Italy. · Dermatology Clinic University Hospital of Brescia, Brescia 25123, Italy. ·Cancer Biol Med · Pubmed #28884047.

ABSTRACT: OBJECTIVE: : To investigate whether vitamin D receptor gene ( METHODS: : We studied 120 cutaneous melanoma cases [68 stage I and II non-metastatic melanoma (NMetM) patients, plus 52 Stage III and IV metastatic melanoma (MetM) patients], and 120 matching healthy controls from northeast Italy. RESULTS: : CONCLUSIONS: : Risk factors for cutaneous MetM include two

5 Article Immunohistochemical evaluation of vitamin D receptor (VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms. 2017

La Marra, Francesco / Stinco, Giuseppe / Buligan, Cinzia / Chiriacò, Giovanni / Serraino, Diego / Di Loreto, Carla / Cauci, Sabina. ·Department of Medical Area, School of Medicine, University of Udine, Udine 33100, Italy. · Dermatology Clinic, Udine University-Hospital, University of Udine, Udine 33100, Italy. ·Cancer Biol Med · Pubmed #28607807.

ABSTRACT: OBJECTIVE: : Vitamin D receptor (VDR) mediates vitamin D activity. We examined whether VDR expression in excised melanoma tissues is associated with VDR gene ( METHODS: : We evaluated VDR protein expression (by monoclonal antibody immunostaining), melanoma characteristics, and carriage of RESULTS: : Stage I melanomas, Breslow thickness of <1.00 mm, level II Clark invasion, Aa heterozygous genotype, and AaTT combined genotype were more frequent in melanomas with high CONCLUSIONS: : We highlighted that

6 Article CASH algorithm versus 3-point checklist and its modified version in evaluation of melanocytic pigmented skin lesions: The 4-point checklist. 2016

di Meo, Nicola / Stinco, Giuseppe / Bonin, Serena / Gatti, Alessandro / Trevisini, Sara / Damiani, Giovanni / Vichi, Silvia / Trevisan, Giusto. ·Unit of Dermatology, Department of Medical Sciences, University of Trieste, Trieste, Italy. · Department of Clinical and Experimental Pathology and Medicine, DISM, Institute of Dermatology, University of Udine, Udine, Italy. · Unit of Dermatology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Ospedale Maggiore, Trieste, Italy. ·J Dermatol · Pubmed #26589251.

ABSTRACT: Dermoscopy, in expert hands, increases accuracy, sensitivity and specificity in diagnosis of pigmented skin lesions of a single operator, compared with clinical examination. Simplified algorithmic methods have been developed to help less expert dermoscopists in diagnosis of melanocytic lesions. This study included 125 melanocytic skin lesions divided into melanocytic nevi, dysplastic nevi and thin melanomas (<1 mm). We compared the 3-point checklist and CASH algorithm to analyze different pigmented skin lesions. Based on preliminary results, we proposed a new modified algorithm, called the 4-point checklist, whose accuracy is similar to the CASH algorithm and whose simplicity is similar to the 3-point checklist.

7 Article Cutaneous melanoma frequencies and seasonal trend in 20 years of observation of a population characterised by excessive sun exposure. 2015

Bonin, Serena / Albano, Antonio / di Meo, Nicola / Gatti, Alessandro / Stinco, Giuseppe / Zanconati, Fabrizio / Trevisan, Giusto. ·Department of Medical Sciences, Unit of Dermatology, University of Trieste, Trieste, Italy. · Unit of Dermatology; Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste; Ospedale Maggiore, Trieste, Italy. · Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Italy. · Department of Medical Sciences, Unit of Surgical Pathology, University of Trieste, Trieste, Italy. · Department of Medical Sciences, Unit of Dermatology, University of Trieste, Trieste, Italy; Unit of Dermatology; Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste; Ospedale Maggiore, Trieste, Italy. ·Radiol Oncol · Pubmed #26834525.

ABSTRACT: BACKGROUND: Cutaneous melanoma is an aggressive form of skin cancer. It has become an increasingly common neoplasm in the most developed countries, especially among individuals of European origin. PATIENTS AND METHODS: Anonymous data of patients with cutaneous melanoma were collected from the diagnostic database of the University Hospital of Trieste from 1 January 1990 to 10 December 2013. Our study is based on a population which was constant over the period of observation; it was also well-defined and characterised by unrestrained sun exposure. RESULTS: The number of cutaneous melanomas increased during the period of observation with a seasonality trend and gender related differences both for anatomical sites distribution and stage of the disease. Moreover, 6% of our cohort developed multiple melanomas. CONCLUSIONS: In a well-defined population devoted to excessive sun exposure the frequencies of skin melanomas roughly doubled from 1990 to 2013 following a seasonal trend. In that population, prevention efforts according to gender specific risk behaviour, as well as follow-up programmes both for evaluation of metastatic spreading and for early diagnosis of additional skin melanomas, are crucial due to gender specific differences and to the occurrence of multiple melanomas.

8 Article Melanoma detection in Italian pigmented lesion clinics. 2014

Argenziano, G / Moscarella, E / Annetta, A / Battarra, V C / Brunetti, B / Buligan, C / Cantisani, C / Capizzi, R / Carbone, A / Carlino, A / Corsetti, V / Damiano, A / De Salvo, V / De Simone, P / Di Caterino, P / Fargnoli, M C / Ferrari, A / Fossati, B / Frascione, P / Ghigliotti, G / González Inchaurraga, M A / Guerriero, C / Landi, C / Mazzoni, L / Mirizzi, S / Palazzo, G / Pedretti, A / Peris, K / Piemonte, P / Rossi, A / Satta, R / Savoia, F / Scalvenzi, M / Stanganelli, I / Stinco, G / Zampieri, P / Zalaudek, I. ·Skin Cancer Unit Arcispedale Santa Maria Nuova IRCCS Reggio Emilia, Italy - g.argenziano@gmail.com. ·G Ital Dermatol Venereol · Pubmed #24819635.

ABSTRACT: AIM: Accuracy in melanoma detection is important to recognize early curable melanomas and to minimize the unnecessary excision of benign lesions. The aim of this paper was to evaluate melanoma screening accuracy of Italian pigmented lesion clinics in terms of number needed to excise (NNE), melanoma thickness, and number of melanomas diagnosed during patient follow-up. METHODS: Information on all skin tumors excised in 2011 were extracted from the databases of the participating centers. Information whether the lesion was excised at the baseline examination or during patient follow-up was recorded, as well as the overall number of patients examined in each center in 2011. RESULTS: After e-mail solicitation, 22 of 40 centers agreed to participate. A total of 8229 excised lesions were collected. The overall number of examined patients was 86.564, thus 9.5% of screened patients had a lesion removed. Of the excised lesions, 866 were diagnosed as melanoma (1% of examined patients) and 5311 (88.9%) were melanocytic nevi. Three NNE were calculated giving values of 7.9 excised lesions to find 1 melanoma, 7.1 melanocytic lesions to find 1 melanoma, and 3.7 lesions to find 1 skin malignancy. The median melanoma thickness was 0.6 mm, with only 15.1% of melanomas ≥ 1 mm of thickness. Melanomas detected over time were 96 (11.1%; mean thickness, 0.3 mm), with 15.6% of lesions excised after short-term follow-up and 84.4% after long-term follow-up. CONCLUSION: The NNE values comparable to those achieved in specialized clinical settings and the high number of early melanomas diagnosed at the baseline examination or during patient follow-up indicate a high level of accuracy in melanoma screening achieved by Italian pigmented lesion clinics.

9 Article The role of O6-methylguanine-DNA methyltransferase in a long-surviving metastatic melanoma. 2014

Gatti, Alessandro / di Meo, Nicola / Stinco, Giuseppe / Malagoli, Maria / Bonin, Serena / Trevisan, Giusto. · ·J Cutan Med Surg · Pubmed #24377476.

ABSTRACT: BACKGROUND: Brain metastases commonly occur in patients with metastatic melanoma and are associated with a poor prognosis. Only a few chemotherapeutic agents have been shown to be potentially active. Resistance to chemotherapy is one of the main limitations to treatment. A key mechanism of resistance is O6-methylguanine-DNA methyltransferase (MGMT). The methylation of its promotor could inhibit the activity of this enzyme; consequently, it is very important to evaluate the methylation status of all available specimens. CASE REPORT: We report the case of a long-surviving patient in whom combination treatment with an alkylating agent inhibiting MGMT, such as temozolomide, was useful in clinical control of the disease.