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Melanoma: HELP
Articles by Iris Zalaudek
Based on 117 articles published since 2008

Between 2008 and 2019, I. Zalaudek wrote the following 117 articles about Melanoma.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1410806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Editorial The user-generated web-based Dermoscopy Image Archive of the International Dermoscopy Society: a contribution to e-learning and exchange of knowledge. 2011

Niederkorn, A / Gabler, G / Argenziano, G / Muir, J / Zalaudek, I / Soyer, H P / Hofmann-Wellenhof, R. · ·Dermatology · Pubmed #21389684.

ABSTRACT: -- No abstract --

3 Editorial Remodeling of the dermoepidermal junction in superficial spreading melanoma: insights gained from correlation of dermoscopy, reflectance confocal microscopy, and histopathologic analysis. 2008

Scope, Alon / Zalaudek, Iris / Ferrara, Gerardo / Argenziano, Giuseppe / Braun, Ralph P / Marghoob, Ashfaq A. · ·Arch Dermatol · Pubmed #19075152.

ABSTRACT: -- No abstract --

4 Editorial Three roots of melanoma. 2008

Zalaudek, Iris / Marghoob, Ashfaq A / Scope, Alon / Leinweber, Bernd / Ferrara, Gerardo / Hofmann-Wellenhof, Rainer / Pellacani, Giovanni / Soyer, H Peter / Argenziano, Giuseppe. · ·Arch Dermatol · Pubmed #18936403.

ABSTRACT: -- No abstract --

5 Review Improving the early diagnosis of early nodular melanoma: can we do better? 2018

Corneli, Paola / Zalaudek, Iris / Magaton Rizzi, Giovanni / di Meo, Nicola. ·a Dermatology Clinic, Maggiore Hospital , University of Trieste , Trieste , Italy. ·Expert Rev Anticancer Ther · Pubmed #30079779.

ABSTRACT: INTRODUCTION: Cutaneous melanoma is the sixth most common malignant cancer in the USA. Among different subtypes of melanoma, nodular melanoma (NM) accounts about 14% of all cases but is responsible for more than 40% of melanoma deaths. Early diagnosis is the best method to improve melanoma prognosis. Unfortunately, early diagnosis of NM is particularly challenging given that patients often lack identifiable risk factors such as many moles or freckles. Moreover, early NM may mimic a range of benign skin lesions that are not routinely excised or biopsied in every day practice. For this reason, specific clinical and skin imaging clues have been proposed to improve early detection of NM. Areas covered: The review discusses about the noninvasive tools to diagnose thin melanoma, particularly NM. Expert commentary: Currently, dermatologists present a wide opportunity of diagnostic tools. Current data suggest that the early diagnosis of NM is a major challenge as the majority of early NM are symmetric, roundish, and lack specific pattern. Another promising strategy is based on recent data suggesting that artificial intelligence based on deep convolutional neural networking is able to outperform average dermatologist. Further research is necessary to validate the performance of this method in the real world and in the clinical setting.

6 Review Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. 2017

Lallas, A / Apalla, Z / Ioannides, D / Lazaridou, E / Kyrgidis, A / Broganelli, P / Alfano, R / Zalaudek, I / Argenziano, G / Anonymous4790894. ·First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · City of Health and Science University, Turin, Italy. · Department of Anaesthesiology, Surgery and Emergency Medicine, Second University of Naples, Naples, Italy. · Department of Dermatology and Venereology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Austria. · Dermatology Unit, Second University of Naples, Naples, Italy. ·Br J Dermatol · Pubmed #28118479.

ABSTRACT: Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biological behaviour and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphological overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid-looking lesions based on a consensus among experts in the field. After a detailed search of the literature for eligible studies, a data synthesis was performed from 15 studies on dermoscopy of Spitz naevi. Dermoscopically, Spitz naevi are typified by three main patterns: starburst pattern (51%), a pattern of regularly distributed dotted vessels (19%) and globular pattern with reticular depigmentation (17%). A consensus-based algorithm for the management of spitzoid lesions is proposed. According to it, dermoscopically asymmetric lesions with spitzoid features (both flat/raised and nodular) should be excised to rule out melanoma. Dermoscopically symmetric spitzoid nodules should also be excised or closely monitored, irrespective of age, to rule out atypical Spitz tumours. Dermoscopically symmetric, flat spitzoid lesions should be managed according to the age of the patient. Finally, the histopathological diagnosis of atypical Spitz tumour should warrant wide excision but not a sentinel lymph-node biopsy.

7 Review Dermoscopy in the era of dermato-oncology: from bed to bench side and retour. 2016

Woltsche, Nora / Schwab, Christoph / Deinlein, Teresa / Hofmann-Wellenhof, Rainer / Zalaudek, Iris. ·a Department of Dermatology , Medical University of Graz , Graz , Austria. · b Department of Opthalmology , Medical University of Graz , Graz , Austria. ·Expert Rev Anticancer Ther · Pubmed #26999650.

ABSTRACT: Today dermoscopy is standard-of-care in the diagnosis and management of patients with benign and malignant skin tumors because it increases the diagnostic accuracy of skin lesions compared to the naked-eye examination up to 25%. Despite its role in the routine dermato-oncology, it increasingly gained interest as a bridge connecting clinical with basic molecular research in dermato-oncology. Here, we correlate dermoscopy patterns of nevi and melanomas with high and low susceptibility genes and somatic mutations, provide an overview on the clinical and dermoscopic patterns of cutaneous melanoma subtypes, and highlight the role of dermoscopy in the diagnosis of skin eruptions during systemic treatments of advanced melanoma including targeted therapies and immunotherapies.

8 Review The use of dermatoscopy in diagnosis and therapy of nonmelanocytic skin cancer. 2016

Deinlein, Teresa / Richtig, Georg / Schwab, Christoph / Scarfi, Federica / Arzberger, Edith / Wolf, Ingrid / Hofmann-Wellenhof, Rainer / Zalaudek, Iris. ·Department of Dermatology and Venereology, Medical University Graz, Graz, Austria. · Department of Ophthalmology, Medical University Graz, Graz, Austria. · Department of Translational Medicine and Surgery, University of Florence, Florence, Italy. ·J Dtsch Dermatol Ges · Pubmed #26819109.

ABSTRACT: Today, dermatoscopy is an integral part of every clinical skin examination, as it markedly enhances the early detection of melanocytic and nonmelanocytic skin cancer (NMSC) compared to naked-eye inspection. Besides its diagnostic use, this noninvasive method is increasingly important in the selection of as well as the response assessment to various therapies used for NMSC, including basal cell carcinoma, actinic keratoses, squamous cell carcinoma, and also rare tumors such as Merkel cell carcinoma, angiosarcoma, or dermatofibrosarcoma protuberans. Thus, dermatoscopy is a valid tool for the preoperative assessment of tumor margins in basal cell carcinoma, but also for follow-up of actinic keratoses after topical treatment. The present article presents an overview on the use of dermatoscopy in the diagnosis and therapy of various types of NMSC.

9 Review [Dermoscopy of nails]. 2014

Haenssle, H A / Brehmer, F / Zalaudek, I / Hofmann-Wellenhof, R / Kreusch, J / Stolz, W / Argenziano, G / Blum, A. ·Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Georg-August Universität, Robert-Koch Str. 40, 37075, Göttingen, Deutschland, h.haenssle@med.uni-goettingen.de. ·Hautarzt · Pubmed #24668319.

ABSTRACT: Pigmented and nonpigmented nail abnormalities often represent a challenge for clinicians because many, and sometimes potentially life-threatening differential diagnoses must be taken into consideration. Although many details of nail diseases can already be assessed with the naked eye, dermoscopy opens up a second microscopic level of inspection, which can be very useful for the diagnostic process. In the last 20 years dermoscopy has made rapid progress in the further development of criteria for the early recognition of melanoma. In addition, the use of dermoscopy has been extended to the examination of cutaneous adnexa, such as hairs (trichoscopy) and nails (onychoscopy). Many, sometimes highly specific criteria for the dermoscopic assessment of nail diseases have been described in a series of recently published articles. This review article provides important diagnostic aids for a well-founded dermoscopic assessment of nail diseases.

10 Review Blue lesions. 2013

Longo, Caterina / Scope, Alon / Lallas, Aimilios / Zalaudek, Iris / Moscarella, Elvira / Gardini, Stefano / Argenziano, Giuseppe / Pellacani, Giovanni. ·Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: longo.caterina@gmail.com. ·Dermatol Clin · Pubmed #24075551.

ABSTRACT: Blue color is found in a wide range of malignant and benign melanocytic and nonmelanocytic lesions and in lesions that result from penetration of exogenous materials, such as radiation or amalgam tattoo or traumatic penetration of particles. Discriminating between different diagnostic entities that display blue color relies on careful patient examination and lesion assessment. Dermoscopically, the extent, distribution, and patterns created by blue color can help diagnose lesions with specificity and differentiate between benign and malignant entities. This article provides an overview of the main diagnoses whereby blue color can be found, providing simple management rules for these lesions.

11 Review Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. 2013

Ferrara, Gerardo / Gianotti, Raffaele / Cavicchini, Stefano / Salviato, Tiziana / Zalaudek, Iris / Argenziano, Giuseppe. ·Anatomic Pathology Unit, Department of Oncology, 'Gaetano Rummo' General Hospital, Via dell'Angelo 1, Benevento I-82100, Italy. Electronic address: gerardo.ferrara@libero.it. ·Dermatol Clin · Pubmed #24075547.

ABSTRACT: Spitz nevus can clinically present either in the classical (reddish pink) or the pigmented (brownish black) variant. Dermoscopy demonstrates that the pigmented variant is much more common than the classical variant; however, none of these show dermoscopic patterns clearly distinguishable from melanoma. Even histopathologically, a clear-cut differentiation between benign and malignant spitzoid neoplasms is often difficult, so that intermediate diagnostic categories (atypical Spitz nevus and Spitz tumor) are admitted. Because of these difficulties in clinical and histopathologic evaluation, surgical excision is recommended for clinically atypical spitzoid lesions of childhood and for all spitzoid lesions of adulthood.

12 Review Problematic lesions in the elderly. 2013

Zalaudek, Iris / Lallas, Aimilios / Longo, Caterina / Moscarella, Elvira / Tiodorovic-Zivkovic, Danica / Ricci, Cinzia / Albertini, Giuseppe / Argenziano, Giuseppe. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy; Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz 8036, Austria. Electronic address: iris.zalaudek@gmail.com. ·Dermatol Clin · Pubmed #24075544.

ABSTRACT: As the population continues to age, clinicians and dermatologists are increasingly faced with geriatric patients presenting with a range of dermatologic manifestations, including benign and malignant skin tumors. Knowledge of epidemiologic and morphologic features, including dermoscopy of common and benign melanocytic and nonmelanocytic skin tumors, provides the basis for a better understanding and management of problematic skin tumors in this age group. This article provides an overview of common and problematic skin lesions in elderly patients and addresses epidemiologic, clinical, and dermoscopic clues that aid the differential diagnosis and management of challenging skin lesions.

13 Review Problematic lesions in children. 2013

Moscarella, Elvira / Piccolo, Vincenzo / Argenziano, Giuseppe / Lallas, Aimilios / Longo, Caterina / Castagnetti, Fabio / Pizzigoni, Stefania / Zalaudek, Iris. ·Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento, 80, Reggio Emilia 42100, Italy. Electronic address: elvira.moscarella@gmail.com. ·Dermatol Clin · Pubmed #24075543.

ABSTRACT: Melanoma in childhood is rare, and appears more commonly either in association with a preexisting (congenital) nevus, or with spitzoid features than de novo. Thus, problematic melanocytic lesions in children are essentially represented by congenital nevi and Spitz nevi that can be regarded as melanoma precursors and melanoma simulators, respectively. As a consequence, clinical and dermoscopic features of melanoma in children differ from those in an adult population. Herein we describe common clinical and dermoscopic features of problematic lesions in children, focusing on congenital and Spitz/Reed nevi, and including other problematic lesions, such as atypical, blue, acral, and scalp nevi.

14 Review A clinico-dermoscopic approach for skin cancer screening: recommendations involving a survey of the International Dermoscopy Society. 2013

Argenziano, Giuseppe / Giacomel, Jason / Zalaudek, Iris / Blum, Andreas / Braun, Ralph P / Cabo, Horacio / Halpern, Allan / Hofmann-Wellenhof, Rainer / Malvehy, Josep / Marghoob, Ashfaq A / Menzies, Scott / Moscarella, Elvira / Pellacani, Giovanni / Puig, Susana / Rabinovitz, Harold / Saida, Toshiaki / Seidenari, Stefania / Soyer, H Peter / Stolz, Wilhelm / Thomas, Luc / Kittler, Harald. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: g.argenziano@gmail.com. ·Dermatol Clin · Pubmed #24075542.

ABSTRACT: Dermoscopy is useful for skin cancer screening, but a detailed approach is required that integrates this tool into a rational clinical work flow. To investigate clinician perceptions and behavior in approaching patients with skin tumors, a survey was launched by electronic mail through the International Dermoscopy Society. After 4 months, the responses were analyzed and significant findings calculated. Considering the current approach of study participants in examining patients for skin cancer, an up-to-date system of triage is presented in this review, which aims to promote an improved diagnostic accuracy and more timely management of skin malignancy.

15 Review Dermoscopy for the pediatric dermatologist part III: dermoscopy of melanocytic lesions. 2013

Haliasos, Elena C / Kerner, Miryam / Jaimes, Natalia / Zalaudek, Iris / Malvehy, Josep / Hofmann-Wellenhof, Rainer / Braun, Ralph P / Marghoob, Ashfaq A. ·Department of Dermatology, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA. ·Pediatr Dermatol · Pubmed #23252411.

ABSTRACT: Melanocytic nevi encompass a variety of lesions, including blue, Spitz, congenital, and acquired nevi. These nevi can occasionally manifest clinical morphologies resembling melanoma, and the presence of such nevi in children can elicit anxiety in patients, parents, and clinicians. Dermoscopy has been shown to increase the diagnostic accuracy for melanoma and to help differentiate melanoma from nevi, ultimately aiding in the decision-making process as to whether to perform a biopsy. Dermoscopy is the perfect instrument to use during the evaluation of pigmented skin lesions in children because it is painless and provides important information for the clinician that can assist in formulating appropriate management decisions. This review highlights the most common benign dermoscopic patterns encountered in nevi and discuss the 10 most common dermoscopic structures seen in melanomas. Lesions manifesting a benign dermoscopic pattern and lacking any melanoma-specific structures do not need to be excised and can safely be monitored. In contrast, melanomas will invariably deviate from the benign nevus patterns and will usually manifest at least 1 of the 10 melanoma-specific structures: atypical network, negative network, streaks, crystalline structures, atypical dots and globules, irregular blotch, blue-white veil, regression structures, peripheral brown structureless areas, and atypical vessels. It is important to be cognizant of the fact that melanomas in childhood usually do not manifest the clinical ABCD features. Instead, they are often symmetric, amelanotic, nodular lesions. Although the clinical appearance may not be alarming, with dermoscopy they will invariably manifest at least one melanoma-specific structure, the most common being atypical vascular structures and crystalline structures.

16 Review Early diagnosis of melanoma: what is the impact of dermoscopy? 2012

Argenziano, Giuseppe / Albertini, Giuseppe / Castagnetti, Fabio / De Pace, Barbara / Di Lernia, Vito / Longo, Caterina / Pellacani, Giovanni / Piana, Simonetta / Ricci, Cinzia / Zalaudek, Iris. ·Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. g.argenziano@gmail.com ·Dermatol Ther · Pubmed #23046019.

ABSTRACT: There are three possible explanations for the improved melanoma recognition when a clinician uses dermoscopy: first, the presence of early dermoscopy signs that become visible in melanoma much before the appearance of the classical clinical features; second, an increased attitude of clinicians to check more closely clinically banal-looking lesions; and third, an improved attitude of clinicians to monitor their patients. In this review, the light and the dark sides of melanoma screening are briefly discussed, including the need to find better strategies to decrease the number of unnecessary excision of benign lesions on one hand, and to finally decrease melanoma mortality rates on the other.

17 Review New directions in dermatopathology: in vivo confocal microscopy in clinical practice. 2012

Longo, Caterina / Zalaudek, Iris / Argenziano, Giuseppe / Pellacani, Giovanni. ·Dermatology and Skin Care Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, 42100 Reggio Emilia, Italy. ·Dermatol Clin · Pubmed #23021059.

ABSTRACT: In vivo confocal microscopy represents a new device that generates a virtual skin biopsy at cytologic resolution. This article describes the most relevant confocal findings and their histopathologic correlates in skin oncology and inflammatory diseases. The light and dark of confocal microscopy are briefly discussed in relation with its clinical applications.

18 Review Improving triage and management of patients with skin cancer: challenges and considerations for the future. 2012

Argenziano, Giuseppe / Giacomel, Jason / Abramavicus, Alexandre / Pellacani, Giovanni / Longo, Caterina / De Pace, Barbara / Albertini, Giuseppe / Cristofolini, Mario / Zalaudek, Iris. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Viale Risorgimento 80, Reggio Emilia, Italy. g.argenziano@gmail.com ·Expert Rev Anticancer Ther · Pubmed #22594896.

ABSTRACT: Skin cancer is the most common malignancy in humans, thus representing a major health concern. Because of the increasing attention to skin cancer prevention, there has been a growing workload for dermatology clinics, with patients referred from primary care requiring assessment of suspicious skin tumors. This places a strain on limited specialist resources and can create a paradoxical situation wherein an early diagnosis becomes increasingly difficult for those patients who actually do suffer from skin cancer. The aim of these recommendations is to propose an updated, rational system of triage, involving improved accuracy of diagnosis and more timely management of skin cancer by both general practitioners and dermatologists.

19 Review Update on melanoma and non-melanoma skin cancer. Annual Skin Cancer Conference 2011, Hamilton Island, Australia, 5–6 August 2011. 2011

Zalaudek, Iris / Whiteman, David / Rosendahl, Cliff / Menzies, Scott W / Green, Adèle C / Hersey, Peter / Argenziano, Giuseppe. ·Department of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@meduni-graz.at ·Expert Rev Anticancer Ther · Pubmed #22117149.

ABSTRACT: In this article, we will summarize some of the highlights of the third annual conference on skin cancer, with special emphasis on the the recent advances regarding melanoma and non-melanoma skin cancer epidemiology, diagnosis and treatment. Topics were particularly addressed to a newly developing medical branch in Australia, namely that of Primary Care Skin Cancer Practitioners, and focused on strategies to improve primary and secondary prevention and early detection of melanoma and non-melanoma skin cancer using dermoscopy. Controversies related to skin cancer screening programs and recent progresses for treating advanced melanoma were additionally discussed. Yet, besides its scientific goals, the conference aimed also to encourage research originating in primary care and relevant to primary care.

20 Review Dermoscopy of benign and malignant neoplasms in the pediatric population. 2010

Haliasos, Helen C / Zalaudek, Iris / Malvehy, Josep / Lanschuetzer, Christoph / Hinter, Helmut / Hofmann-Wellenhof, Rainer / Braun, Ralph / Marghoob, Ashfaq A. ·Division of Dermatology, Medical University of Graz, Graz, Austria. ·Semin Cutan Med Surg · Pubmed #21277535.

ABSTRACT: Dermoscopy is a noninvasive technique that enables visualization of subsurface colors and structures within the skin that are imperceptible to the naked eye. The dermatoscope allows the physician to examine both the macroscopic and microscopic primary morphology of skin lesions, identify subtle clinical clues, confirm naked-eye clinical diagnoses, and monitor treatment progress while posing little threat to the young patient. Dermoscopic findings have been formulated into diagnostic criteria that assist experienced clinicians in differentiating benign and malignant neoplasms. In this review, clinical morphology of melanocytic nevi and melanoma in the pediatric population is examined and the relevant dermoscopic findings and histopathologic correlates that aid in the diagnosis and management of these lesions are described.

21 Review How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. 2010

Zalaudek, Iris / Kreusch, Jürgen / Giacomel, Jason / Ferrara, Gerardo / Catricalà, Caterina / Argenziano, Giuseppe. ·Division of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@meduni-graz.at ·J Am Acad Dermatol · Pubmed #20708470.

ABSTRACT: Nonmelanoma skin cancer refers to a broad class of tumors, including actinic keratosis, basal cell carcinoma, and squamous cell carcinoma, and as a group these are the most frequent cancers occurring in light skinned humans. In contrast to the rarity of amelanotic melanoma, nonmelanoma skin cancer commonly lacks pigmentation. Although these tumors rarely cause death related to metastases, they commonly destroy underlying tissues and should be removed at the earliest possible stage. Dermoscopy improves the clinical diagnosis of nonpigmented skin tumors by allowing the visualization of specific vascular structures that are usually not visible to the naked eye. Dermoscopic vascular patterns of several nonmelanocytic nonpigmented skin tumors, such as sebaceous hyperplasia, seborrheic keratosis, clear cell acanthoma, Bowen disease, or nodular cystic basal cell carcinoma are highly specific, allowing a ready diagnosis in most cases. Others, such as actinic keratosis, pyogenic granuloma, or uncommon adnexal tumors, may be difficult to differentiate even with the aid of dermoscopy. For this reason, general guidelines have been established to assist in making the most appropriate management decision. In the second part of this review of dermoscopic vascular structures of nonpigmented skin tumors, the dermoscopic patterns associated with benign and malignant nonmelanocytic skin tumors and recommendations for the management of these tumors will be discussed.

22 Review How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. 2010

Zalaudek, Iris / Kreusch, Jürgen / Giacomel, Jason / Ferrara, Gerardo / Catricalà, Caterina / Argenziano, Giuseppe. ·Division of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@medunigraz.at ·J Am Acad Dermatol · Pubmed #20708469.

ABSTRACT: Dermoscopy is a noninvasive tool that can be helpful in the diagnosis of nonpigmented skin tumors. This is because dermoscopy permits the visualization of key vascular structures that are usually not visible to the naked eye. Much work has concentrated on the identification of specific morphologic types of vessels that allow a classification into melanocytic versus nonmelanocytic and benign versus malignant nonpigmented skin tumors. Among a broad spectrum of different types of vascular patterns, six main morphologies can be identified. These are comma-like, dotted, linear-irregular, hairpin, glomerular, and arborizing vessels. With some exceptions, comma, dotted, and linear irregular vessels are associated with melanocytic tumors, while the latter three vascular types are generally indicative of keratinocytic tumors. Aside from vascular morphology, the architectural arrangement of vessels within the tumor and the presence of additional dermoscopic clues are equally important for the diagnosis. This article provides a general overview of the dermoscopic evaluation of nonpigmented skin tumors and is divided into two parts. Part I discusses the dermoscopic vascular patterns of benign and malignant melanocytic skin tumors. Part II discusses the dermoscopic vascular patterns of benign and malignant nonmelanocytic nonpigmented skin tumors. In each part, additional special management guidelines for melanocytic and nonmelanocytic nonpigmented skin tumors, respectively, will be discussed.

23 Review The morphologic universe of melanocytic nevi. 2009

Zalaudek, Iris / Manzo, Manuela / Savarese, Imma / Docimo, Giovanni / Ferrara, Gerardo / Argenziano, Giuseppe. ·Division of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@meduni-graz.at ·Semin Cutan Med Surg · Pubmed #19782938.

ABSTRACT: Different types of nevi do exist in relation to their epidemiology, morphology, evolution, and associated melanoma risk. The introduction of dermoscopy opened a new dimension of the morphologic universe of nevi and allowed clinicians to observe colors and structures within nevi that are otherwise not visible to the unaided eye. Because most of these colors and structures correspond to well-defined histopathologic correlates, dermoscopy enables clinicians to date to more precisely predict the histopathology diagnosis and thereby improve on their clinical diagnostic accuracy. Besides the diagnostic impact, the in vivo observation of thousands of nevi using dermoscopy and digital dermoscopic follow-up has opened new understanding about the evolution of nevi and factors influencing the nevus pattern. In consequence, a new nevus classification has been proposed, subdividing nevi into 7 categories, which are as follows: (1) globular/cobblestone nevi, (2) reticular nevi, (3) starburst nevi, (4) homogeneous blue nevi, (5) nevi on special body sites, (6) nevi with special features, and (7) and unclassifiable melanocytic proliferations. This article provides an overview on the morphologic classification of nevi and the factors influencing the nevus pattern.

24 Review Melanoma(s) associated with a quadrant or segmental distribution of atypical melanocytic nevi: case report and review of the literature. 2009

Zalaudek, Iris / Nicolino, Rachele / Ferrara, Gerardo / Capoluongo, Patrizio / Roma, Paolo / Sgambato, Anna / Argenziano, Giuseppe. ·Department of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@meduni-graz.at ·Dermatol Surg · Pubmed #19215269.

ABSTRACT: -- No abstract --

25 Review The most common challenges in melanoma diagnosis and how to avoid them. 2009

Marghoob, Ashfaq A / Changchien, Lily / DeFazio, Jennifer / Dessio, Whitney C / Malvehy, Josep / Zalaudek, Iris / Halpern, Allan C / Scope, Alon. ·Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA. marghooa@mskcc.org ·Australas J Dermatol · Pubmed #19178485.

ABSTRACT: Due to its particularly lethal nature and tendency to affect relatively young individuals, the timely diagnosis of melanoma remains of paramount importance for clinicians and their patients. Unfortunately, melanomas can mimic benign lesions that are overwhelmingly more common in the population than are melanomas, and misdiagnosis or delay in diagnosis of melanoma can occur. Misdiagnosis of melanoma serves as one of the most common causes for malpractice litigation brought against medical practitioners. In this review we describe seven clinical scenarios that represent challenges in melanoma diagnosis and discuss potential strategies for avoiding the errors that commonly give rise to those scenarios.