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Melanoma: HELP
Articles by Iris Zalaudek
Based on 131 articles published since 2010
(Why 131 articles?)

Between 2010 and 2020, I. Zalaudek wrote the following 131 articles about Melanoma.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6
1 Guideline Spitz/Reed nevi: proposal of management recommendations by the Dermoscopy Study Group of the Italian Society of Dermatology (SIDeMaST). 2014

Broganelli, P / Titli, S / Lallas, A / Alaibac M Annetta, A / Battarra, V / Brunetti, B / Castagno, I / Cavicchini, S / Ferrari, A / Ghigliotti, G / Landi, C / Manganoni, A / Moscarella, E / Pellacani, G / Pizzichetta, M A / Rosina, P / Rubegni, P / Satta, R / Scalvenzi, M / Stanganelli, I / Stinco, G / Zalaudek, I / Zampieri, P / Argenziano, G / Anonymous1420806. ·Department of Oncology and Hematology, Section of Dermatology, City of Health and Science Hospital of Turin, Turin, Italy - paolobroganelli@inwind.it. ·G Ital Dermatol Venereol · Pubmed #25213387.

ABSTRACT: -- No abstract --

2 Editorial Is histopathological overdiagnosis of melanoma a good insurance for the future? 2015

Ferrara, Gerardo / Zalaudek, Iris. ·Anatomic Pathology Unit, Gaetano Rummo General Hospital, Benevento, Italy. · Department of Dermatology & Venerology, Medical University of Graz, Graz, Austria. ·Melanoma Manag · Pubmed #30190827.

ABSTRACT: -- No abstract --

3 Editorial The user-generated web-based Dermoscopy Image Archive of the International Dermoscopy Society: a contribution to e-learning and exchange of knowledge. 2011

Niederkorn, A / Gabler, G / Argenziano, G / Muir, J / Zalaudek, I / Soyer, H P / Hofmann-Wellenhof, R. · ·Dermatology · Pubmed #21389684.

ABSTRACT: -- No abstract --

4 Review Clinical usefulness of dermoscopy in the management of lentigo maligna melanoma treated with topical imiquimod: A case report. 2019

Hamilko de Barros, Mayara / Conforti, Claudio / Giuffrida, Roberta / Seabra Resende, Fernanda Simões / Di Meo, Nicola / Zalaudek, Iris. ·Instituto de Dermatologia Professor Rubem David Azulay, Hospital Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil. · Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy. · Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy. · Department of Dermatology and Venereology, University of Graz, Graz, Austria. ·Dermatol Ther · Pubmed #31365164.

ABSTRACT: The importance of dermoscopy for diagnosing lentigo maligna melanoma (LMM) is well known. More recently, dermoscopy has been proposed as a useful tool also for the treatment choice and monitoring. Herein, we present an 87-year-old woman, who was successfully treated with imiquimod 5% cream after surgical persistence of residual LMM and for whom dermoscopy was helpful to assist diagnosis and assess tumor persistence after surgery and its response to topical treatment with imiquimod.

5 Review Improving the early diagnosis of early nodular melanoma: can we do better? 2018

Corneli, Paola / Zalaudek, Iris / Magaton Rizzi, Giovanni / di Meo, Nicola. ·a Dermatology Clinic, Maggiore Hospital , University of Trieste , Trieste , Italy. ·Expert Rev Anticancer Ther · Pubmed #30079779.

ABSTRACT: INTRODUCTION: Cutaneous melanoma is the sixth most common malignant cancer in the USA. Among different subtypes of melanoma, nodular melanoma (NM) accounts about 14% of all cases but is responsible for more than 40% of melanoma deaths. Early diagnosis is the best method to improve melanoma prognosis. Unfortunately, early diagnosis of NM is particularly challenging given that patients often lack identifiable risk factors such as many moles or freckles. Moreover, early NM may mimic a range of benign skin lesions that are not routinely excised or biopsied in every day practice. For this reason, specific clinical and skin imaging clues have been proposed to improve early detection of NM. Areas covered: The review discusses about the noninvasive tools to diagnose thin melanoma, particularly NM. Expert commentary: Currently, dermatologists present a wide opportunity of diagnostic tools. Current data suggest that the early diagnosis of NM is a major challenge as the majority of early NM are symmetric, roundish, and lack specific pattern. Another promising strategy is based on recent data suggesting that artificial intelligence based on deep convolutional neural networking is able to outperform average dermatologist. Further research is necessary to validate the performance of this method in the real world and in the clinical setting.

6 Review Abundance of the benign melanocytic universe: Dermoscopic-histopathological correlation in nevi. 2017

Woltsche, Nora / Schmid-Zalaudek, Karin / Deinlein, Teresa / Rammel, Katrin / Hofmann-Wellenhof, Rainer / Zalaudek, Iris. ·Department of Ophthalmology, Medical University of Graz, Graz, Austria. · Department of Physiology, Medical University of Graz, Graz, Austria. · Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. ·J Dermatol · Pubmed #28447347.

ABSTRACT: The broad universe of "melanocytic nevi" includes a variety of different subtypes, which can be classified either due to their morphology, epidemiology, genetic alterations or risk for developing melanoma. Regarding morphology, on the one hand macroscopic/clinical and on the other hand histopathological appearance were used to subdivide in the past, often resulting in confusion and poor interobserver agreement, while nowadays dermoscopy presents the clinician's precious bridge between naked-eye examination and histopathological diagnostics, allowing prediction of the lesions' histopathology, follow up and monitoring over time without need of excision. The non-invasive dermoscopic examination relies on the assessment of colors, patterns and the distribution of both within a cutaneous lesion. Until today, the correspondence of certain dermoscopic colors and patterns to certain histopathological correlates has been reported for a huge amount of different cutaneous lesions. Moreover, the correspondence of certain dermoscopic features to certain body sites, age groups and pigmentary traits, but also to specific genetic alterations in lesions, has been broadly investigated. Dermoscopy has led us to a new understanding of melanocytic nevi's biology and evolution and, last but not least, to a new classification system, which we want to present herein.

7 Review Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. 2017

Lallas, A / Apalla, Z / Ioannides, D / Lazaridou, E / Kyrgidis, A / Broganelli, P / Alfano, R / Zalaudek, I / Argenziano, G / Anonymous3580894. ·First Department of Dermatology, Aristotle University, Thessaloniki, Greece. · Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. · City of Health and Science University, Turin, Italy. · Department of Anaesthesiology, Surgery and Emergency Medicine, Second University of Naples, Naples, Italy. · Department of Dermatology and Venereology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Austria. · Dermatology Unit, Second University of Naples, Naples, Italy. ·Br J Dermatol · Pubmed #28118479.

ABSTRACT: Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biological behaviour and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphological overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid-looking lesions based on a consensus among experts in the field. After a detailed search of the literature for eligible studies, a data synthesis was performed from 15 studies on dermoscopy of Spitz naevi. Dermoscopically, Spitz naevi are typified by three main patterns: starburst pattern (51%), a pattern of regularly distributed dotted vessels (19%) and globular pattern with reticular depigmentation (17%). A consensus-based algorithm for the management of spitzoid lesions is proposed. According to it, dermoscopically asymmetric lesions with spitzoid features (both flat/raised and nodular) should be excised to rule out melanoma. Dermoscopically symmetric spitzoid nodules should also be excised or closely monitored, irrespective of age, to rule out atypical Spitz tumours. Dermoscopically symmetric, flat spitzoid lesions should be managed according to the age of the patient. Finally, the histopathological diagnosis of atypical Spitz tumour should warrant wide excision but not a sentinel lymph-node biopsy.

8 Review Dermoscopy in the era of dermato-oncology: from bed to bench side and retour. 2016

Woltsche, Nora / Schwab, Christoph / Deinlein, Teresa / Hofmann-Wellenhof, Rainer / Zalaudek, Iris. ·a Department of Dermatology , Medical University of Graz , Graz , Austria. · b Department of Opthalmology , Medical University of Graz , Graz , Austria. ·Expert Rev Anticancer Ther · Pubmed #26999650.

ABSTRACT: Today dermoscopy is standard-of-care in the diagnosis and management of patients with benign and malignant skin tumors because it increases the diagnostic accuracy of skin lesions compared to the naked-eye examination up to 25%. Despite its role in the routine dermato-oncology, it increasingly gained interest as a bridge connecting clinical with basic molecular research in dermato-oncology. Here, we correlate dermoscopy patterns of nevi and melanomas with high and low susceptibility genes and somatic mutations, provide an overview on the clinical and dermoscopic patterns of cutaneous melanoma subtypes, and highlight the role of dermoscopy in the diagnosis of skin eruptions during systemic treatments of advanced melanoma including targeted therapies and immunotherapies.

9 Review Standardization of terminology in dermoscopy/dermatoscopy: Results of the third consensus conference of the International Society of Dermoscopy. 2016

Kittler, Harald / Marghoob, Ashfaq A / Argenziano, Giuseppe / Carrera, Cristina / Curiel-Lewandrowski, Clara / Hofmann-Wellenhof, Rainer / Malvehy, Josep / Menzies, Scott / Puig, Susana / Rabinovitz, Harold / Stolz, Wilhelm / Saida, Toshiaki / Soyer, H Peter / Siegel, Eliot / Stoecker, William V / Scope, Alon / Tanaka, Masaru / Thomas, Luc / Tschandl, Philipp / Zalaudek, Iris / Halpern, Allan. ·Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address: harald.kittler@meduniwien.ac.at. · Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy. · Melanoma Unit, Department of Dermatology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER ER), Instituto de Salud Carlos III, Barcelona, Spain. · University of Arizona Cancer Center, Tucson, Arizona. · Department of Dermatology and Venerology, Nonmelanoma Skin Cancer Unit, Medical University of Graz, Graz, Austria. · Sydney Melanoma Diagnostic Center, Sydney Cancer Center, Royal Prince Alfred Hospital, Camperdown, Australia. · Skin and Cancer Associates, Plantation, Florida. · Department of Dermatology, Klinikum München, Munich, Germany. · Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan. · Dermatology Research Center, University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Australia. · University of Maryland Medical Center, Baltimore Department of Veterans Affairs Medical Center, Baltimore, Maryland. · Department of Dermatology, University of Missouri Health Sciences Center, Columbia, Missouri. · Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Dermatology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. · Department of Dermatology, Keio University, Tokyo, Japan. · Service de Dermatologie, Center Hospitalier Universitaire de Lyon, Lyon, France. · Department of Dermatology, Medical University of Vienna, Vienna, Austria. ·J Am Acad Dermatol · Pubmed #26896294.

ABSTRACT: BACKGROUND: Evolving dermoscopic terminology motivated us to initiate a new consensus. OBJECTIVE: We sought to establish a dictionary of standardized terms. METHODS: We reviewed the medical literature, conducted a survey, and convened a discussion among experts. RESULTS: Two competitive terminologies exist, a more metaphoric terminology that includes numerous terms and a descriptive terminology based on 5 basic terms. In a survey among members of the International Society of Dermoscopy (IDS) 23.5% (n = 201) participants preferentially use descriptive terminology, 20.1% (n = 172) use metaphoric terminology, and 484 (56.5%) use both. More participants who had been initially trained by metaphoric terminology prefer using descriptive terminology than vice versa (9.7% vs 2.6%, P < .001). Most new terms that were published since the last consensus conference in 2003 were unknown to the majority of the participants. There was uniform consensus that both terminologies are suitable, that metaphoric terms need definitions, that synonyms should be avoided, and that the creation of new metaphoric terms should be discouraged. The expert panel proposed a dictionary of standardized terms taking account of metaphoric and descriptive terms. LIMITATIONS: A consensus seeks a workable compromise but does not guarantee its implementation. CONCLUSION: The new consensus provides a revised framework of standardized terms to enhance the consistent use of dermoscopic terminology.

10 Review The use of dermatoscopy in diagnosis and therapy of nonmelanocytic skin cancer. 2016

Deinlein, Teresa / Richtig, Georg / Schwab, Christoph / Scarfi, Federica / Arzberger, Edith / Wolf, Ingrid / Hofmann-Wellenhof, Rainer / Zalaudek, Iris. ·Department of Dermatology and Venereology, Medical University Graz, Graz, Austria. · Department of Ophthalmology, Medical University Graz, Graz, Austria. · Department of Translational Medicine and Surgery, University of Florence, Florence, Italy. ·J Dtsch Dermatol Ges · Pubmed #26819109.

ABSTRACT: Today, dermatoscopy is an integral part of every clinical skin examination, as it markedly enhances the early detection of melanocytic and nonmelanocytic skin cancer (NMSC) compared to naked-eye inspection. Besides its diagnostic use, this noninvasive method is increasingly important in the selection of as well as the response assessment to various therapies used for NMSC, including basal cell carcinoma, actinic keratoses, squamous cell carcinoma, and also rare tumors such as Merkel cell carcinoma, angiosarcoma, or dermatofibrosarcoma protuberans. Thus, dermatoscopy is a valid tool for the preoperative assessment of tumor margins in basal cell carcinoma, but also for follow-up of actinic keratoses after topical treatment. The present article presents an overview on the use of dermatoscopy in the diagnosis and therapy of various types of NMSC.

11 Review No one should die of melanoma: a vision or impossible mission? 2014

Zalaudek, Iris / Moscarella, Elvira / Longo, Caterina / Lallas, Aimilios / Argenziano, Giuseppe / Hofmann-Wellenhof, Rainer. ·Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. · Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento, 80, Reggio Emilia Reggio nell'Emilia, Italy. ·Melanoma Manag · Pubmed #30190809.

ABSTRACT: While the incidence of early-stage melanoma has dramatically increased over the past decades, the incidence and mortality rates of thick melanomas have remained relatively stable during the same period. A number of alternative theories have been postulated in order to explain these divergent trends between thin and thick melanomas, among which is the question of whether nodular melanoma may originate in the dermis. This concept has gained support from recent improvements in the understanding of the origin of melanocytes and the morphological and molecular diversity of melanoma. A dermal origin would plausibly explain why efforts at improving the early detection of melanoma largely fail, as it implies an initially intradermal growth that is hidden from our eyes until clinical signs and symptoms become only secondarily apparent. In light of this, at the current stage, the vision that no one should die of melanoma is an impossible mission.

12 Review When all you have is a dermatoscope- start looking at the nails. 2014

Haenssle, Holger A / Blum, Andreas / Hofmann-Wellenhof, Rainer / Kreusch, Juergen / Stolz, Wilhelm / Argenziano, Giuseppe / Zalaudek, Iris / Brehmer, Franziska. ·Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Heidelberg, Heidelberg, Germany. · Private Dermatology Practice, Konstanz, Germany. · Department of Dermatology, Medical University of Graz, Graz, Austria. · Private Dermatology Practice, Luebeck, Luebeck, Germany. · Clinic of Dermatology and Allergology, Hospital Munich-Schwabing, Munich, Germany. · Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova (IRCCS), Reggio Emilia, Italy. · Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany. ·Dermatol Pract Concept · Pubmed #25396079.

ABSTRACT: Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life-threatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, and, therefore, fingernails and toenails physiologically are non-pigmented. The formation of continuous, longitudinal pigmented streaks (longitudinal melanonychia) may either be caused by a benign activation of matrix melanocytes (e.g., as a result of trauma, inflammation, or adverse drug reactions) or by a true melanocytic proliferation (e.g., in a nevus or melanoma). In general, non-continuous nail alterations, affecting only limited parts of the nail apparatus, are most frequently of non-melanocytic origin. Important and common differential diagnoses in these cases are subungual hemorrhage or onychomycosis. In addition, foreign bodies, bacterial infections, traumatic injuries, or artificial discolorations of the nail unit may less frequently cause non-continuous nail alterations. Many systemic diseases that may also show involvement of the nails (e.g., psoriasis, atopic dermatitis, lichen planus, alopecia areata) tend to induce alterations in numerous if not all nails of the hands and feet. A similar extensive and generalized alteration of nails has been reported after treatment with a number of systemic drugs, especially antibiotics and cytostatics. Benign or malignant neoplasms that may also affect the nail unit include glomus tumor, Bowen's disease, squamous cell carcinoma, and rare collision tumors. This review aims to assist clinicians in correctly evaluating and diagnosing nail disorders with the help of dermatoscopy.

13 Review The dermatoscopic universe of basal cell carcinoma. 2014

Lallas, Aimilios / Apalla, Zoe / Argenziano, Giuseppe / Longo, Caterina / Moscarella, Elvira / Specchio, Francesca / Raucci, Margaritha / Zalaudek, Iris. ·Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy. · Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. · Department of Dermatology, Medical University of Graz, Austria. ·Dermatol Pract Concept · Pubmed #25126452.

ABSTRACT: Following the first descriptions of the dermatoscopic pattern of basal cell carcinoma (BCC) that go back to the very early years of dermatoscopy, the list of dermatoscopic criteria associated with BCC has been several times updated and renewed. Up to date, dermatoscopy has been shown to enhance BCC detection, by facilitating its discrimination from other skin tumors and inflammatory skin diseases. Furthermore, upcoming evidence suggests that the method is also useful for the management of the tumor, since it provides valuable information about the histopathologic subtype, the presence of clinically undetectable pigmentation, the expansion of the tumor beyond clinically visible margins and the response to non-ablative treatments. In the current article, we provide a summary of the traditional and latest knowledge on the value of dermatoscopy for the diagnosis and management of BCC.

14 Review [Dermoscopy of nails]. 2014

Haenssle, H A / Brehmer, F / Zalaudek, I / Hofmann-Wellenhof, R / Kreusch, J / Stolz, W / Argenziano, G / Blum, A. ·Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Georg-August Universität, Robert-Koch Str. 40, 37075, Göttingen, Deutschland, h.haenssle@med.uni-goettingen.de. ·Hautarzt · Pubmed #24668319.

ABSTRACT: Pigmented and nonpigmented nail abnormalities often represent a challenge for clinicians because many, and sometimes potentially life-threatening differential diagnoses must be taken into consideration. Although many details of nail diseases can already be assessed with the naked eye, dermoscopy opens up a second microscopic level of inspection, which can be very useful for the diagnostic process. In the last 20 years dermoscopy has made rapid progress in the further development of criteria for the early recognition of melanoma. In addition, the use of dermoscopy has been extended to the examination of cutaneous adnexa, such as hairs (trichoscopy) and nails (onychoscopy). Many, sometimes highly specific criteria for the dermoscopic assessment of nail diseases have been described in a series of recently published articles. This review article provides important diagnostic aids for a well-founded dermoscopic assessment of nail diseases.

15 Review Pink lesions. 2013

Giacomel, Jason / Zalaudek, Iris. ·Skin Spectrum Medical Services, 400 Canning Highway, Como, Perth, Western Australia 6152, Australia. Electronic address: jasongiacomel@gmail.com. ·Dermatol Clin · Pubmed #24075552.

ABSTRACT: Dermoscopy (dermatoscopy or surface microscopy) is an ancillary dermatologic tool that in experienced hands can improve the accuracy of diagnosis of a variety of benign and malignant pigmented skin tumors. The early and more accurate diagnosis of nonpigmented, or pink, tumors can also be assisted by dermoscopy. This review focuses on the dermoscopic diagnosis of pink lesions, with emphasis on blood vessel morphology and pattern. A 3-step algorithm is presented, which facilitates the timely and more accurate diagnosis of pink tumors and subsequently guides the management for such lesions.

16 Review Blue lesions. 2013

Longo, Caterina / Scope, Alon / Lallas, Aimilios / Zalaudek, Iris / Moscarella, Elvira / Gardini, Stefano / Argenziano, Giuseppe / Pellacani, Giovanni. ·Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: longo.caterina@gmail.com. ·Dermatol Clin · Pubmed #24075551.

ABSTRACT: Blue color is found in a wide range of malignant and benign melanocytic and nonmelanocytic lesions and in lesions that result from penetration of exogenous materials, such as radiation or amalgam tattoo or traumatic penetration of particles. Discriminating between different diagnostic entities that display blue color relies on careful patient examination and lesion assessment. Dermoscopically, the extent, distribution, and patterns created by blue color can help diagnose lesions with specificity and differentiate between benign and malignant entities. This article provides an overview of the main diagnoses whereby blue color can be found, providing simple management rules for these lesions.

17 Review Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. 2013

Ferrara, Gerardo / Gianotti, Raffaele / Cavicchini, Stefano / Salviato, Tiziana / Zalaudek, Iris / Argenziano, Giuseppe. ·Anatomic Pathology Unit, Department of Oncology, 'Gaetano Rummo' General Hospital, Via dell'Angelo 1, Benevento I-82100, Italy. Electronic address: gerardo.ferrara@libero.it. ·Dermatol Clin · Pubmed #24075547.

ABSTRACT: Spitz nevus can clinically present either in the classical (reddish pink) or the pigmented (brownish black) variant. Dermoscopy demonstrates that the pigmented variant is much more common than the classical variant; however, none of these show dermoscopic patterns clearly distinguishable from melanoma. Even histopathologically, a clear-cut differentiation between benign and malignant spitzoid neoplasms is often difficult, so that intermediate diagnostic categories (atypical Spitz nevus and Spitz tumor) are admitted. Because of these difficulties in clinical and histopathologic evaluation, surgical excision is recommended for clinically atypical spitzoid lesions of childhood and for all spitzoid lesions of adulthood.

18 Review Problematic lesions in the elderly. 2013

Zalaudek, Iris / Lallas, Aimilios / Longo, Caterina / Moscarella, Elvira / Tiodorovic-Zivkovic, Danica / Ricci, Cinzia / Albertini, Giuseppe / Argenziano, Giuseppe. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy; Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz 8036, Austria. Electronic address: iris.zalaudek@gmail.com. ·Dermatol Clin · Pubmed #24075544.

ABSTRACT: As the population continues to age, clinicians and dermatologists are increasingly faced with geriatric patients presenting with a range of dermatologic manifestations, including benign and malignant skin tumors. Knowledge of epidemiologic and morphologic features, including dermoscopy of common and benign melanocytic and nonmelanocytic skin tumors, provides the basis for a better understanding and management of problematic skin tumors in this age group. This article provides an overview of common and problematic skin lesions in elderly patients and addresses epidemiologic, clinical, and dermoscopic clues that aid the differential diagnosis and management of challenging skin lesions.

19 Review Problematic lesions in children. 2013

Moscarella, Elvira / Piccolo, Vincenzo / Argenziano, Giuseppe / Lallas, Aimilios / Longo, Caterina / Castagnetti, Fabio / Pizzigoni, Stefania / Zalaudek, Iris. ·Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento, 80, Reggio Emilia 42100, Italy. Electronic address: elvira.moscarella@gmail.com. ·Dermatol Clin · Pubmed #24075543.

ABSTRACT: Melanoma in childhood is rare, and appears more commonly either in association with a preexisting (congenital) nevus, or with spitzoid features than de novo. Thus, problematic melanocytic lesions in children are essentially represented by congenital nevi and Spitz nevi that can be regarded as melanoma precursors and melanoma simulators, respectively. As a consequence, clinical and dermoscopic features of melanoma in children differ from those in an adult population. Herein we describe common clinical and dermoscopic features of problematic lesions in children, focusing on congenital and Spitz/Reed nevi, and including other problematic lesions, such as atypical, blue, acral, and scalp nevi.

20 Review A clinico-dermoscopic approach for skin cancer screening: recommendations involving a survey of the International Dermoscopy Society. 2013

Argenziano, Giuseppe / Giacomel, Jason / Zalaudek, Iris / Blum, Andreas / Braun, Ralph P / Cabo, Horacio / Halpern, Allan / Hofmann-Wellenhof, Rainer / Malvehy, Josep / Marghoob, Ashfaq A / Menzies, Scott / Moscarella, Elvira / Pellacani, Giovanni / Puig, Susana / Rabinovitz, Harold / Saida, Toshiaki / Seidenari, Stefania / Soyer, H Peter / Stolz, Wilhelm / Thomas, Luc / Kittler, Harald. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: g.argenziano@gmail.com. ·Dermatol Clin · Pubmed #24075542.

ABSTRACT: Dermoscopy is useful for skin cancer screening, but a detailed approach is required that integrates this tool into a rational clinical work flow. To investigate clinician perceptions and behavior in approaching patients with skin tumors, a survey was launched by electronic mail through the International Dermoscopy Society. After 4 months, the responses were analyzed and significant findings calculated. Considering the current approach of study participants in examining patients for skin cancer, an up-to-date system of triage is presented in this review, which aims to promote an improved diagnostic accuracy and more timely management of skin malignancy.

21 Review Dermoscopy for the pediatric dermatologist part III: dermoscopy of melanocytic lesions. 2013

Haliasos, Elena C / Kerner, Miryam / Jaimes, Natalia / Zalaudek, Iris / Malvehy, Josep / Hofmann-Wellenhof, Rainer / Braun, Ralph P / Marghoob, Ashfaq A. ·Department of Dermatology, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA. ·Pediatr Dermatol · Pubmed #23252411.

ABSTRACT: Melanocytic nevi encompass a variety of lesions, including blue, Spitz, congenital, and acquired nevi. These nevi can occasionally manifest clinical morphologies resembling melanoma, and the presence of such nevi in children can elicit anxiety in patients, parents, and clinicians. Dermoscopy has been shown to increase the diagnostic accuracy for melanoma and to help differentiate melanoma from nevi, ultimately aiding in the decision-making process as to whether to perform a biopsy. Dermoscopy is the perfect instrument to use during the evaluation of pigmented skin lesions in children because it is painless and provides important information for the clinician that can assist in formulating appropriate management decisions. This review highlights the most common benign dermoscopic patterns encountered in nevi and discuss the 10 most common dermoscopic structures seen in melanomas. Lesions manifesting a benign dermoscopic pattern and lacking any melanoma-specific structures do not need to be excised and can safely be monitored. In contrast, melanomas will invariably deviate from the benign nevus patterns and will usually manifest at least 1 of the 10 melanoma-specific structures: atypical network, negative network, streaks, crystalline structures, atypical dots and globules, irregular blotch, blue-white veil, regression structures, peripheral brown structureless areas, and atypical vessels. It is important to be cognizant of the fact that melanomas in childhood usually do not manifest the clinical ABCD features. Instead, they are often symmetric, amelanotic, nodular lesions. Although the clinical appearance may not be alarming, with dermoscopy they will invariably manifest at least one melanoma-specific structure, the most common being atypical vascular structures and crystalline structures.

22 Review Early diagnosis of melanoma: what is the impact of dermoscopy? 2012

Argenziano, Giuseppe / Albertini, Giuseppe / Castagnetti, Fabio / De Pace, Barbara / Di Lernia, Vito / Longo, Caterina / Pellacani, Giovanni / Piana, Simonetta / Ricci, Cinzia / Zalaudek, Iris. ·Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. g.argenziano@gmail.com ·Dermatol Ther · Pubmed #23046019.

ABSTRACT: There are three possible explanations for the improved melanoma recognition when a clinician uses dermoscopy: first, the presence of early dermoscopy signs that become visible in melanoma much before the appearance of the classical clinical features; second, an increased attitude of clinicians to check more closely clinically banal-looking lesions; and third, an improved attitude of clinicians to monitor their patients. In this review, the light and the dark sides of melanoma screening are briefly discussed, including the need to find better strategies to decrease the number of unnecessary excision of benign lesions on one hand, and to finally decrease melanoma mortality rates on the other.

23 Review New directions in dermatopathology: in vivo confocal microscopy in clinical practice. 2012

Longo, Caterina / Zalaudek, Iris / Argenziano, Giuseppe / Pellacani, Giovanni. ·Dermatology and Skin Care Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, 42100 Reggio Emilia, Italy. ·Dermatol Clin · Pubmed #23021059.

ABSTRACT: In vivo confocal microscopy represents a new device that generates a virtual skin biopsy at cytologic resolution. This article describes the most relevant confocal findings and their histopathologic correlates in skin oncology and inflammatory diseases. The light and dark of confocal microscopy are briefly discussed in relation with its clinical applications.

24 Review Improving triage and management of patients with skin cancer: challenges and considerations for the future. 2012

Argenziano, Giuseppe / Giacomel, Jason / Abramavicus, Alexandre / Pellacani, Giovanni / Longo, Caterina / De Pace, Barbara / Albertini, Giuseppe / Cristofolini, Mario / Zalaudek, Iris. ·Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Viale Risorgimento 80, Reggio Emilia, Italy. g.argenziano@gmail.com ·Expert Rev Anticancer Ther · Pubmed #22594896.

ABSTRACT: Skin cancer is the most common malignancy in humans, thus representing a major health concern. Because of the increasing attention to skin cancer prevention, there has been a growing workload for dermatology clinics, with patients referred from primary care requiring assessment of suspicious skin tumors. This places a strain on limited specialist resources and can create a paradoxical situation wherein an early diagnosis becomes increasingly difficult for those patients who actually do suffer from skin cancer. The aim of these recommendations is to propose an updated, rational system of triage, involving improved accuracy of diagnosis and more timely management of skin cancer by both general practitioners and dermatologists.

25 Review Update on melanoma and non-melanoma skin cancer. Annual Skin Cancer Conference 2011, Hamilton Island, Australia, 5–6 August 2011. 2011

Zalaudek, Iris / Whiteman, David / Rosendahl, Cliff / Menzies, Scott W / Green, Adèle C / Hersey, Peter / Argenziano, Giuseppe. ·Department of Dermatology, Medical University of Graz, Graz, Austria. iris.zalaudek@meduni-graz.at ·Expert Rev Anticancer Ther · Pubmed #22117149.

ABSTRACT: In this article, we will summarize some of the highlights of the third annual conference on skin cancer, with special emphasis on the the recent advances regarding melanoma and non-melanoma skin cancer epidemiology, diagnosis and treatment. Topics were particularly addressed to a newly developing medical branch in Australia, namely that of Primary Care Skin Cancer Practitioners, and focused on strategies to improve primary and secondary prevention and early detection of melanoma and non-melanoma skin cancer using dermoscopy. Controversies related to skin cancer screening programs and recent progresses for treating advanced melanoma were additionally discussed. Yet, besides its scientific goals, the conference aimed also to encourage research originating in primary care and relevant to primary care.