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Melanoma: HELP
Articles from Taiwan
Based on 329 articles published since 2008
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These are the 329 published articles about Melanoma that originated from Taiwan during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14
1 Editorial Acral melanoma: a unique disease in Asia. 2013

Chang, John Wen-Cheng. ·Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. ·JAMA Dermatol · Pubmed #24068331.

ABSTRACT: -- No abstract --

2 Review Primary Vaginal Melanoma With Rhabdoid Features: A Case Report and Literature Review. 2017

Lee, Chien-Kuan / Lin, Ho / Su, Chi-Feng / Kok, Victor C. ·Departments of Pathology (C.-K.L., H.L.)Obstetrics & Gynecology (C.-F.S.)Division of Medical Oncology (V.C.K.), Kung Tien General Hospital, Shalu, Taichung, Taiwan. ·Int J Gynecol Pathol · Pubmed #28800579.

ABSTRACT: Primary vaginal melanoma is a rare mucosal neoplasm, which is more aggressive than cutaneous melanoma. Information regarding its morphologic patterns is limited. In particular, the rhabdoid phenotype, mostly observed in metastatic or recurrent cutaneous melanomas, has yet to be reported at this anatomic location. Hence, a potential diagnostic difficulty may arise because of the inability to recognize this unusual histologic variant and its immunohistochemical aberrance. In this report, we describe the case of a primary vaginal melanoma in a 62-year-old woman, who exhibited both rhabdoid and small blue round cell morphologies, absence of S100 protein, and aberrant expression of desmin, CD56, and FLI-1. This report can facilitate the task of expanding the morphologic spectrum of vaginal melanoma, and prevent misdiagnosis and inadequate medical treatment.

3 Review Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis. 2017

Chou, Yi-Ping / Lin, Yin-Ku / Chen, Chun-Han / Fang, Jia-You. ·Division of Trauma, Department of Emergency, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. · Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan. · School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan. · Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. · Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan. · Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan. · Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan. · Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan. · Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan. ·Curr Pharm Des · Pubmed #28699537.

ABSTRACT: Melanoma shows a high possibility of mortality after it metastasizes because of its aggressive nature. Although there are several options for anti-melanoma therapy, this skin malignancy is resistant to some therapies. Chemotherapy, biochemotherapy, immunotherapy, and adoptive cell therapy have failed to exhibit a significant amelioration in overall survival. Nanomedicine provides an opportunity to improve the efficiency of the antimelanoma regimen. Nanoparticles for treating melanoma provide the advantages over conventional therapies such as drug solubility increment, drug stability enhancement, epithelium permeability and bioavailability amelioration, half-life prolonging, tumor targeting, and side effect minimization. Polymeric nanocarriers are the most extensively studied platforms for the treatment of a variety of cancers. The polymers' sophisticated material engineering tailors the controllable physicochemical properties of the nanoparticles for melanoma penetration via passive and active delivery. The present study highlights the recent progress on the development of polymeric nanoparticles for melanoma treatment. We describe the concepts and improvement mechanisms of the nanomedical techniques for melanoma treatment. Passive targeting by modifying the structure and physicochemical characters of polymeric nanocarriers is a strategy for efficient drug delivery to the melanoma and its metastasis. On the other hand, active targeting such as peptide or antibody conjugation is another approach delivering the drugs or genes to the nidus site by the nanocarriers. This review offers an overview of the benefits of polymeric nanosystems for treating melanoma.

4 Review Tumor cell vascular mimicry: Novel targeting opportunity in melanoma. 2016

Hendrix, Mary J C / Seftor, Elisabeth A / Seftor, Richard E B / Chao, Jun-Tzu / Chien, Du-Shieng / Chu, Yi-Wen. ·Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60614, United States; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States. Electronic address: m-hendrix@northwestern.edu. · Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60614, United States. · Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60614, United States; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States. · TaiRx, Inc., Taipei, 11560, Taiwan. ·Pharmacol Ther · Pubmed #26808163.

ABSTRACT: In 1999, the American Journal of Pathology published an article, entitled "Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry" by Maniotis and colleagues, which ignited a spirited debate for several years and earned the journal's distinction of a "citation classic" (Maniotis et al., 1999). Tumor cell vasculogenic mimicry (VM), also known as vascular mimicry, describes the plasticity of aggressive cancer cells forming de novo vascular networks and is associated with the malignant phenotype and poor clinical outcome. The tumor cells capable of VM share the commonality of a stem cell-like, transendothelial phenotype, which may be induced by hypoxia. Since its introduction as a novel paradigm for melanoma tumor perfusion, many studies have contributed new findings illuminating the underlying molecular pathways supporting VM in a variety of tumors, including carcinomas, sarcomas, glioblastomas, astrocytomas, and melanomas. Of special significance is the lack of effectiveness of angiogenesis inhibitors on tumor cell VM, suggesting a selective resistance by this phenotype to conventional therapy. Facilitating the functional plasticity of tumor cell VM are key proteins associated with vascular, stem cell, extracellular matrix, and hypoxia-related signaling pathways--each deserving serious consideration as potential therapeutic targets and diagnostic indicators of the aggressive, metastatic phenotype. This review highlights seminal findings pertinent to VM, including the effects of a novel, small molecular compound, CVM-1118, currently under clinical development to target VM, and illuminates important molecular pathways involved in the suppression of this plastic, aggressive phenotype, using melanoma as a model.

5 Review Posterior choroidal leiomyoma: a rare case report and literature review. 2015

Chiang, Wei-Yu / Lin, Jui-Wei / Yang, I-Hui / Kuo, Hsi-Kung. ·Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. · Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. ·APMIS · Pubmed #25907891.

ABSTRACT: We report a literature review and detailed evaluation of a rare case of posterior choroidal leiomyoma to emphasize the importance of differentiating this from other choroidal tumors. A 30-year-old male presented with variable blurred vision in his right eye secondary to a choroidal tumor. Clinical examinations were performed including fundus photography, optical coherence tomography, B scans, fluorescein and indocyanine green angiography, computed tomography, and magnetic resonance imaging. Preoperative examination revealed a suspected choroidal melanoma and enucleation was performed. However, a definitive diagnosis of choroidal leiomyoma was made following postoperative pathological light microscopy and immunohistochemical studies. Published case reports were collected and the common characteristics and distinctive features were compared with the current case. Posterior choroidal leiomyoma was summarized from the literature, and beneficial information for diagnosis and treatment was obtained. In conclusion, posterior choroidal leiomyoma is rare and should be differentiated from amelanotic melanomas. Despite the benign nature, an explanation regarding the rare incidence and difficult diagnosis of posterior choroidal leiomyoma must be provided to patients, prior to enucleation or detrimental treatment.

6 Review What are the potential benefits of using proton therapy in Taiwanese cancer patients? 2015

Kao, Wei-Heng / Shen, Yi-Liang / Hong, Ji-Hong. ·Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine; Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital; Department of Medical Imaging and Radiological Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan. ·Biomed J · Pubmed #25768324.

ABSTRACT: The potential benefits of proton therapy have been established in pediatric cancer, skull base tumor, uveal melanoma, and other types of cancers. Western and Asian countries, however, have differences in the pattern of cancer incidence; this leads to the difference in patient demographics for proton therapy. Furthermore, the advancement of the scanning beam technique in proton therapy greatly expands the capability of proton therapy in disease sites with great complexity. In this review, we focus on the cancers with high incidence in Taiwan, based on the Cancer Registry Annual Report, 2011, Taiwan. The potential case number and clinical benefits from proton therapy are evaluated and discussed. Two endemic cancers, hepatocellular carcinoma and head and neck cancer, are considered to be the major disease types appropriate for proton therapy in Taiwan. Primary lung cancer and left side breast cancer, which are popular in western countries as well as in Taiwan, are included for discussion. The issue of cost-effectiveness for proton therapy is also reviewed. Finally, we point out the clinical trials that should be conducted for proton therapy in Taiwan.

7 Review Primary leptomeningeal melanoma mimicking meningitis: a case report and literature review. 2015

Hsieh, Yao-Yu / Yang, Shun-Tai / Li, Wei-Hua / Hu, Chaur-Jong / Wang, Liang-Shun. ·Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan. · Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan wangls72269@yahoo.com.tw. ·J Clin Oncol · Pubmed #24637995.

ABSTRACT: -- No abstract --

8 Review Primary leptomeningeal melanoma. 2014

Xie, Zhao-Yu / Hsieh, Kevin Li-Chun / Tsang, Yuk-Ming / Cheung, Wing-Keung / Hsieh, Chen-Hsi. ·Department of Radiology, Division of Medical Imaging, Far Eastern Memorial Hospital, Number 21, Section 2, Nanya S. Road, Banqiao District, New Taipei City 220, Taiwan. · Department of Radiology, Division of Medical Imaging, Far Eastern Memorial Hospital, Number 21, Section 2, Nanya S. Road, Banqiao District, New Taipei City 220, Taiwan. Electronic address: kevinh9396@gmail.com. · Division of Radiation Oncology, Department of Radiology, Far-Eastern Memorial Hospital, New Taipei City, Taiwan. ·J Clin Neurosci · Pubmed #24331626.

ABSTRACT: Primary melanoma of the central nervous system is a rare melanocytic tumor typically located in the leptomeninges. We report a 57-year-old woman with an intracranial leptomeningeal melanoma who presented with myoclonic seizures. Brain CT scan and MRI revealed a hemorrhagic intracranial tumor. The tumor was completely removed and leptomeningeal melanoma was proven pathologically. Follow-up imaging studies up to 19 months showed no recurrence of the disease. Here we present radiological, gross, and pathological images of leptomeningeal melanoma, discuss its characteristics, and review the relevant literature.

9 Review Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. 2012

Wang, Hsiao-Chi / Pao, Jung / Lin, Shuw-Yuan / Sheen, Lee-Yan. ·Institute of Food Science and Technology, National Taiwan University, Taipei, ROC. ·Ann N Y Acad Sci · Pubmed #23050963.

ABSTRACT: Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, including the caspase-dependent and -independent pathways. This short review focuses on the molecular mechanisms of garlic-derived allyl sulfides on skin cancer prevention.

10 Review Cutaneous melanoma: Taiwan experience and literature review. 2010

Chang, John Wen-Cheng. ·Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. wen1902@hotmail.com ·Chang Gung Med J · Pubmed #21199605.

ABSTRACT: Malignant melanoma is a rare disease in Taiwan with an incidence rate of 0.65/100,000. Excessive exposure to ultraviolet radiation is not associated with most Taiwanese melanoma cases. Acral lentiginous melanoma comprises 58% of cutaneous melanoma. Advanced disease is seen in 50% of cases. Surgery, including resection of the primary melanoma, sentinel lymph nodes that may harbor microscopic metastasis, clinically abnormal lymph nodes, and selected distant metastases, is the most important treatment. Lymphatic mapping and sentinel lymph node biopsy has changed the clinical stage in 22.2% of our patients. Adjuvant high-dose interferon significantly prolongs progression-free survival. However, its use in Taiwan is limited by its substantial toxicity. The prognosis of metastatic disease remains poor with a median survival of 12 months. In the past, chemotherapy alone was the most common treatment modality for metastatic disease. Recently biochemotherapy has been more commonly utilized to treat patients with metastatic melanoma.

11 Clinical Trial Immunotherapy with dendritic cells pulsed by autologous dactinomycin-induced melanoma apoptotic bodies for patients with malignant melanoma. 2009

Chang, John W C / Hsieh, Jia-Juan / Shen, Yung-Chi / Ho, E / Chuang, Cheng-Keng / Chen, Yu-Ray / Liao, Shuen-Kuei / Chen, Jen-Shi / Leong, Stanley P L / Hou, Ming-Mo / Chang, Nai-Jen / Wang, Cheng-Hsu. ·Division of Hematology-Oncology, Department of Internal Medicine, Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. wen1902@hotmail.com ·Melanoma Res · Pubmed #19750589.

ABSTRACT: The primary goal of this study was to evaluate the efficacy of immunotherapy for patients with metastatic melanoma with autologous melanoma apoptotic bodies (MAB)-pulsed dendritic cells (DCs). Accessible tumors from eligible patients with refractory metastatic melanoma were surgically removed and processed for primary culture. The autologous tumor cells were treated with dactinomycin to obtain MAB. To generate DCs, adherent peripheral blood mononuclear cells were cultured in complete medium containing granulocyte macrophage-colony stimulating factor and interleukin-4. MAB-pulsed DCs were given either intradermally (i.d.) or intravenously. Patients were immunized at monthly intervals and boosted with keyhole limpet hemocyanin (KLH) and MAB 2 weeks post-vaccination, with a maximum of four cycles. Of the 10 patients enrolled in this trial, nine were treated with MAB-pulsed DCs; two were given intravenous vaccinations and the other seven were i.d. injected. Mild tenderness in the draining lymph nodes lasting for less than 48 h and enlargement of the draining lymph nodes were noted in all seven i.d. cases. Treatment-related grade 3-4 toxicity, neutropenia, skin ulceration, tumor growth at the injection site, and sepsis were not observed in any of the patients. Delayed-type hypersensitivity to KLH was observed in all patients, whereas no delayed-type hypersensitivity to autologous tumor antigens was observed. One patient achieved partial response with reduction in lung metastatic tumor mass, and a presence of vesicles in the post-vaccination KLH response. Two patients had stable disease for more than 24 months; one was still alive at the time of submission of this report, the other eventually developed multiple metastases. MAB-pulsed DC immunotherapy is well tolerated in patients with malignant melanoma; however, its efficacy is only modest. Combination with other modalities is required to enhance DC-based immunotherapy.

12 Article Chrysin inhibit human melanoma A375.S2 cell migration and invasion via affecting MAPK signaling and NF-κB signaling pathway in vitro. 2019

Chen, Hsin-Yu / Jiang, Yi-Wen / Kuo, Chao-Lin / Way, Tzong-Der / Chou, Yu-Cheng / Chang, Yuan-Shiun / Chung, Jing-Gung. ·Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. · Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan. · Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan. · Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. · Department of Biotechnology, Asia University, Taichung, Taiwan. ·Environ Toxicol · Pubmed #30578657.

ABSTRACT: Numerous evidences have shown that chrysin induced cytotoxic effects via induced cell cycle arrest and induction of cell apoptosis in human cancer cell lines, however, no information showed that chrysin inhibited skin cancer cell migration and invasion. In this study, we investigated anti-metastasis mechanisms of chrysin in human melanoma cancer A375.S2 cells in vitro. Under sub-lethal concentrations of chrysin (0, 5, 10, and 15 μM) which inhibits cell mobility, migration and invasion of A375.S2 cells that were assayed by wound healing and Transwell filter. That chrysin inhibited MMP-2 activity in A375.S2 cells was investigated by gelatin zymography assay. Western blotting was used to examine protein expression and results indicated that chrysin inhibited the expression of GRB2, SOS-1, PKC, p-AKT (Thr308), NF-κBp65, and NF-κBp50 at 24 and 48 hours treatment, but only at 10-15 μM of chrysin decreased Ras, PI3K, p-c-Jun, and Snail only at 48 hours treatment and only decrease p-AKT(Ser473) at 24 hours treatment. Furthermore, chrysin (5-15 μM) decreased the expression of uPA, N-cadherin and MMP-1 at 24 and 48 hours treatment but only decreased MMP-2 and VEGF at 48 hours treatment at 10-15 μM and 5-15 μM of chrysin, respectively, however, increased E-cadherin at 5-15 μM treatment. Results of confocal laser microscopy systems indicated that chrysin inhibited expression of NF-κBp65 in A375.S2 cells. Based on these observations, we suggest that chrysin can be used in anti-metastasis of human melanoma cells in the future.

13 Article Melanogenesis Inhibitors from the Rhizoma of Ligusticum Sinense in B16-F10 Melanoma Cells In Vitro and Zebrafish In Vivo. 2018

Cheng, Min-Chi / Lee, Tzong-Huei / Chu, Yi-Tzu / Syu, Li-Ling / Hsu, Su-Jung / Cheng, Chia-Hsiung / Wu, Jender / Lee, Ching-Kuo. ·School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. d301100008@tmu.edu.tw. · Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan. thlee1@ntu.edu.tw. · Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 11031, Taiwan. m303098006@tmu.edu.tw. · Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 11031, Taiwan. goat1201@hotmail.com. · Department of Food Science, National Chiayi University, Chiayi 60004, Taiwan. r1101815@yahoo.com.tw. · Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. chcheng@tmu.edu.tw. · School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. cklee@tmu.edu.tw. · School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. jd0332@tmu.edu.tw. · Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 11031, Taiwan. jd0332@tmu.edu.tw. · Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei 11031, Taiwan. jd0332@tmu.edu.tw. ·Int J Mol Sci · Pubmed #30545008.

ABSTRACT: The rhizoma of

14 Article Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction. 2018

Lu, Chun-Te / Leong, Pui-Ying / Hou, Ting-Yi / Huang, Sheng-Jia / Hsiao, Yu-Ping / Ko, Jiunn-Liang. ·Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Plastic and Reconstructive Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan. · Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Rheumatology, Chung Shan Medical University Hospital, Taichung 402, Taiwan. · Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan. · Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan. · Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: missyuping@gmail.com. · Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan. Electronic address: jlko@csmu.edu.tw. ·Phytomedicine · Pubmed #30466626.

ABSTRACT: BACKGROUND: In terms of melanoma, recent advances have been made in target therapies and immune checkpoint inhibitors, but durable remission is rare. Ganoderma immunomodulatory proteins (GMI) induce a cytotoxic effect in cancer cells via autophagy. However, the role of GMI in melanoma is not clear. PURPOSE: The aims of this study are to investigate the inhibiting effects of GMI combined with chidamide on survival and metastases of melanoma cells via integrin-related signaling pathway and to propose strategies for combining GMI and chidamide using animal model. METHODS: Cell viability was measured by cell CCK-8. The activities of apoptosis- and migration-related proteins were detected on Western blot. Flow cytometry was used to analyze cell cycle distribution and sub-G1 fraction in treated melanoma cells. To evaluate the activity of combination GMI and chidamide treatment, an in vivo anti-tumor metastasis study was performed. RESULTS: GMI combined with chidamide additively induced apoptosis. GMI inhibited the expressions of Integrin α5, αV, β1, and β3. The level of p-FAK was inhibited by GMI. Combination treatment of GMI and chidamide decreased survivin and increased cleaved caspase-7 and LC3 II/I. Integrin-αV overexpression activated p-FAK pathways in A375.S2 cells. GMI significantly inhibited cell growth and migration of A375.S2 cells on wound healing assay. In vivo, GMI combined with chidamide suppressed distal tumor metastasis. CONCLUSION: GMI inhibits the migration and growth of melanoma cells via integrin-related signaling pathway. GMI and chidamide induces apoptosis. In vivo, GMI and chidamide additively reduce distant metastases. GMI and chidamide are potential immunotherapeutic adjuvant for metastatic melanoma.

15 Article Distinct MAPK and PI3K pathway mutations in different melanoma types in Taiwanese individuals. 2018

Gao, Hong-Wei / Tsai, Wen-Chiuan / Perng, Cherng-Lih / Wang, Wei-Ming / Chiang, Chien-Ping. ·Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. · Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Graduate Institute of Biotechnology, Collage of Engineering, National Taipei University of Technology, Taipei, Taiwan. · Division of Clinical Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. · Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. · Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan. ·Eur J Dermatol · Pubmed #30325319.

ABSTRACT: BACKGROUND: A number of studies investigating mutations of genes involved in MAPK and PI3K pathways in melanoma patients have been performed, most of which were based on Caucasian populations. OBJECTIVES: We sought to identify BRAF, NRAS, MEK1, PI3K, and PTEN mutations and further determine possible correlations with clinicopathological parameters in Taiwanese patients with acral, non-chronic sun damaged (NCSD), or mucosal melanoma. MATERIALS & METHODS: Forty melanocytic nevi, 24 dysplastic nevi, and 175 melanomas from Taiwanese patients were analysed for mutations in BRAF, NRAS, MEK1, PI3K, and PTEN genes by PCR and direct sequencing. Immunohistochemical analysis of the respective proteins in nevi and melanomas were also performed to determine possible clinicopathological characteristics. RESULTS: In addition to the classic BRAF CONCLUSIONS: Our findings suggest that oncogenic events may differ among melanomas in Asian patients geographically (e.g. between Japanese and Taiwanese patients). Moreover, distinct genetic alterations were noted among acral, NCSD, and mucosal melanoma patients in our study, and the expression of biomarkers correlated with clinical survival rates differentially among the various melanoma groups.

16 Article Mechanism of Lakoochin A Inducing Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS and MAPKs Pathway. 2018

Peng, Kuo-Ti / Chiang, Yao-Chang / Ko, Horng-Huey / Chi, Pei-Ling / Tsai, Chia-Lan / Ko, Ming-I / Lee, Ming-Hsueh / Hsu, Lee-Fen / Lee, Chiang-Wen. ·Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan. mr3497@adm.cgmh.org.tw. · College of Medicine, Chang Gung University, Guishan Dist., Taoyuan City 33303, Taiwan. mr3497@adm.cgmh.org.tw. · Department of Nursing, Division of Basic Medical Sciences, and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan. yaochang.chiang@gmail.com. · Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. hhko@kmu.edu.tw. · Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Zuoying Dist., Kaohsiung City 81362, Taiwan. chi542738@gmail.com. · Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Zuoying Dist., Kaohsiung City 81362, Taiwan. chi542738@gmail.com. · Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Guishan Dist., Taoyuan City 33303, Taiwan. cltsai@mail.cgust.edu.tw. · Department of Nursing, Division of Basic Medical Sciences, and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan. s041055@mail.cgust.edu.tw. · Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan. ma2072@gmail.com. · Department of Respiratory Care, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan. ma2072@gmail.com. · Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan. lfhsu@mail.cgust.edu.tw. · Department of Respiratory Care, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan. lfhsu@mail.cgust.edu.tw. · Department of Nursing, Division of Basic Medical Sciences, and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan. cwlee@mail.cgust.edu.tw. · Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Guishan Dist., Taoyuan City 33303, Taiwan. cwlee@mail.cgust.edu.tw. · Department of Rehabilitation, Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan. cwlee@mail.cgust.edu.tw. ·Int J Mol Sci · Pubmed #30200660.

ABSTRACT: Malignant melanoma is developed from pigment-containing cells, melanocytes, and primarily found on the skin. Malignant melanoma still has a high mortality rate, which may imply a lack of therapeutic agents. Lakoochin A, a compound isolated from

17 Article New diterpenes leojaponins G-L from Leonurus japonicus. 2018

Lai, Kuan-Ying / Hu, Hao-Chun / Chiang, Hsiu-Mei / Liu, Yi-Jung / Yang, Juan-Cheng / Lin, Yen-An / Chen, Chao-Jung / Chang, Yuan-Shiun / Lee, Chia-Lin. ·Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan. · Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. · Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan. · Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan. · Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan; Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan. · Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 40402, Taiwan. · Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan. Electronic address: chlilee@mail.cmu.edu.tw. ·Fitoterapia · Pubmed #30149097.

ABSTRACT: Six new diterpenes, leojaponins G-L (1-6) along with 19 known compounds (7-25) were isolated from Leonurus japonicus. Their structures were elucidated by NMR, MS, IR, UV, and ECD spectroscopic data. Anti-melanogenesis assay indicated that 7 could safely and dose-dependently decrease melanin production in B16F10 melanoma cell with an IC

18 Article Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. 2018

Cha, Jong-Ho / Yang, Wen-Hao / Xia, Weiya / Wei, Yongkun / Chan, Li-Chuan / Lim, Seung-Oe / Li, Chia-Wei / Kim, Taewan / Chang, Shih-Shin / Lee, Heng-Huan / Hsu, Jennifer L / Wang, Hung-Ling / Kuo, Chu-Wei / Chang, Wei-Chao / Hadad, Sirwan / Purdie, Colin A / McCoy, Aaron M / Cai, Shirong / Tu, Yizheng / Litton, Jennifer K / Mittendorf, Elizabeth A / Moulder, Stacy L / Symmans, William F / Thompson, Alastair M / Piwnica-Worms, Helen / Chen, Chung-Hsuan / Khoo, Kay-Hooi / Hung, Mien-Chie. ·Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. · Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. · Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. · Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. · Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan. · Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan. · Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan. · Department of Surgery, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. · Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. · Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. · Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. · Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. · Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. · Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. · Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan. · Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address: mhung@mdanderson.org. ·Mol Cell · Pubmed #30118680.

ABSTRACT: Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL activity by reducing the stability and membrane localization of programmed death ligand-1 (PD-L1). Furthermore, we discover that AMP-activated protein kinase (AMPK) activated by metformin directly phosphorylates S195 of PD-L1. S195 phosphorylation induces abnormal PD-L1 glycosylation, resulting in its ER accumulation and ER-associated protein degradation (ERAD). Consistently, tumor tissues from metformin-treated breast cancer patients exhibit reduced PD-L1 levels with AMPK activation. Blocking the inhibitory signal of PD-L1 by metformin enhances CTL activity against cancer cells. Our findings identify a new regulatory mechanism of PD-L1 expression through the ERAD pathway and suggest that the metformin-CTLA4 blockade combination has the potential to increase the efficacy of immunotherapy.

19 Article Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro. 2018

Liu, Jia-Fang / Lai, Kuang Chi / Peng, Shu-Fen / Maraming, Pornsuda / Huang, Yi-Ping / Huang, An-Cheng / Chueh, Fu-Shin / Huang, Wen-Wen / Chung, Jing-Gung. ·Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan. f9512940@yahoo.com.tw. · Department of Medical Laboratory Science and Biotechnology, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan. kuangchi_lai@hotmail.com. · Department of Surgery, China Medical University Beigang Hospital, Beigang, Yunlin 65152, Taiwan. kuangchi_lai@hotmail.com. · Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan. t20811@mail.cmuh.org.tw. · Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan. t20811@mail.cmuh.org.tw. · Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand. pornsudamaraming@gmail.com. · Department of Physiology, College of Medicine, China Medical University, Taichung 40402, Taiwan. yphuang@mail.cmu.edu.tw. · Department of Nursing, St. Mary's Junior College of Medicine, Nursing and Management, Yilan 26644, Taiwan. haj@smc.edu.tw. · Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan. fushin@asia.edu.tw. · Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan. wwhuang@mail.cmu.edu.tw. · Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan. jgchung@mail.cmu.edu.tw. · Department of Biotechnology, Asia University, Taichung 41354, Taiwan. jgchung@mail.cmu.edu.tw. ·Molecules · Pubmed #30104528.

ABSTRACT: Many studies have demonstrated that berberine inhibited the cell migration and invasion in human cancer cell lines. However, the exact molecular mechanism of berberine inhibiting the cell migration and invasion of human melanoma A375.S2 and A375.S2/PLX (PLX4032 induced resistant A375.S2) skin cancer cells remains unknown. In this study, we investigated the anti-metastasis mechanisms of berberine in human melanoma cancer A375.S2 cells and A375.S2/PLX resistant cells in vitro. Berberine at low concentrations (0, 1, 1.5 and 2 μM) induced cell morphological changes and reduced the viable cell number and inhibited the mobility, migration, and invasion of A375.S2 cells that were assayed by wound healing and transwell filter. The gelatin zymography assay showed that berberine slightly inhibited MMP-9 activity in A375.S2 cells. Results from western blotting indicated that berberine inhibited the expression of MMP-1, MMP-13, E-cadherin, N-cadherin, RhoA, ROCK1, SOS-1, GRB2, Ras, p-ERK1/2, p-c-Jun, p-FAK, p-AKT, NF-κB, and uPA after 24 h of treatment, but increased the PKC and PI3K in A375.S2 cells. PLX4032 is an inhibitor of the BRAFV600E mutation and used for the treatment of cancer cells harboring activated BRAF mutations. Berberine decrease cell number and inhibited the cell mobility in the resistant A375.S2 (A375.S2/PLX, PLX4032 generated resistant A375.S2 cells). Based on these observations, we suggest that the potential of berberine as an anti-metastatic agent in melanoma that deserves to be investigated in more detail, including in vivo studies in future.

20 Article Bornyl 2018

Yang, Tzu-Yen / Wu, Mei-Li / Chang, Chi-I / Liu, Chih-I / Cheng, Te-Chih / Wu, Yu-Jen. ·Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. gini0307@yahoo.com.tw. · Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. mlwu@mail.npust.edu.tw. · Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. changchii@mail.npust.edu.tw. · Department of Nursing, Mei-ho University, Pingtung 91202, Taiwan. x00002177@meiho.edu.tw. · Department of Nursing, Mei-ho University, Pingtung 91202, Taiwan. x00003077@meiho.edu.tw. · Department of Biological Technology, Meiho University, Pingtung 91202, Taiwan. x00002180@meiho.edu.tw. · Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan. x00002180@meiho.edu.tw. ·Int J Mol Sci · Pubmed #30042328.

ABSTRACT: Bornyl

21 Article Antioxidation and Melanogenesis Inhibition of Various 2018

Chan, Chin-Feng / Wu, Chin-Tung / Huang, Wen-Ying / Lin, Wen-Shin / Wu, Han-Wei / Huang, Teng-Kuan / Chang, Min-Yun / Lin, Yung-Sheng. ·Department of Applied Cosmetology, Hung-Kuang University, Taichung 43302, Taiwan. cfchanjames@hotmail.com. · Bachelor Program in Interdisciplinary Studies, College of Future, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan. ctwu5@yuntech.edu.tw. · Department of Applied Cosmetology, Hung-Kuang University, Taichung 43302, Taiwan. beca690420@hk.edu.tw. · Department of Plant Industry, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. wslin@mail.npust.edu.tw. · Ying Li Biotech Co., Ltd., Taichung 40342, Taiwan. pgrace10171@gmail.com. · Department of Chemical Engineering, National United University, Miaoli 36003, Taiwan. qwe1101237@gmail.com. · Department of Chemical Engineering, National United University, Miaoli 36003, Taiwan. mino@nuu.edu.tw. · Department of Chemical Engineering, National United University, Miaoli 36003, Taiwan. linys@nuu.edu.tw. ·Molecules · Pubmed #30037075.

ABSTRACT: This study investigated the polyphenol content, antioxidant activity, and inhibition ability of mushroom tyrosinase and melanogenesis of

22 Article Intake of folate and other nutrients related to one-carbon metabolism and risk of cutaneous melanoma among US women and men. 2018

Dhana, Ashar / Yen, Hsi / Li, Tricia / Holmes, Michelle D / Qureshi, Abrar A / Cho, Eunyoung. ·Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Dermatology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa. · Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. · Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. · Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. · Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence, RI, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. · Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence, RI, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: eunyoung_cho@brown.edu. ·Cancer Epidemiol · Pubmed #29990794.

ABSTRACT: BACKGROUND: Nutrients involved in one-carbon metabolism - folate, vitamins B6 and B12, methionine, choline, and betaine - have been inversely associated with multiple cancer sites and may be related to skin cancer. However, there is a lack of research on the association between intake of these nutrients and cutaneous melanoma risk. The aim of this study was to examine the associations between intake of one-carbon metabolism nutrients and cutaneous melanoma risk in two large prospective cohorts. METHODS: The cohorts included 75,311 white women and 48,523 white men. Nutrient intake was assessed repeatedly by food frequency questionnaires and self-reported supplement use. We used Cox proportional hazards regression to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) and then pooled HRs using a random-effects model. RESULTS: Over 24-26 years of follow-up, we documented 1328 melanoma cases (648 men and 680 women). Higher intake of folate from food only, but not total folate, was associated with increased melanoma risk (pooled HR for top versus bottom quintile: 1.36; 95% CI: 1.13-1.64; P for trend = 0.001). The association was significant in men, but attenuated in women. Higher intake of vitamins B6 and B12, choline, betaine, and methionine were not associated with melanoma risk, although there was modest increasing trend of risk for vitamin B6 from food only (pooled HR for top versus bottom quintile: 1.18; 95% CI: 0.99-1.41; P for trend = 0.03). CONCLUSIONS: We found some evidence that higher intake of folate from food only was associated with a modest increased risk of cutaneous melanoma. However, since other factors related to dietary folate intake may account for the observed association, our findings warrant further investigation.

23 Article Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-α-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice. 2018

Yang, Chung-Chih / Chang, Cheng-Kuei / Chang, Meng-Ting / Shyur, Lie-Fen. ·Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan. · Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan. · Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. · Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan. · Ph.D. Program in Translational Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ·Int J Cancer · Pubmed #29978476.

ABSTRACT: This study demonstrates the bioefficacy and gives mechanistic insights into a plant galactolipid 1,2-di-O-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol (dLGG) against metastatic melanoma using a syngeneic mouse model implanted with B16

24 Article Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma. 2018

Lin, Kun-I / Lin, Chih-Chien / Kuo, Shyh-Ming / Lai, Jui-Chi / Wang, You-Qi / You, Huey-Ling / Hsu, Mei-Ling / Chen, Chang-Han / Shiu, Li-Yen. ·Department of Cosmetic Science, Providence University, Taichung, Taiwan, R.O.C. · Departments of Obstetrics and Gynecology, Chang Bing Show Chwan Memorial Hospital, Lukang Zhen, Changhua County, Taiwan, R.O.C. · Department of Biomedical Engineering, I-Shou University, Taiwan, R.O.C. · Department of Biological Science and Technology, I-SHOU University, Kaohsiung, Taiwan, R.O.C. · Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C. · Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan, R.O.C. · Guangdong Institution of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, China changhan155@hotmail.com her2neu24@gmail.com. · Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, R.O.C changhan155@hotmail.com her2neu24@gmail.com. · Cell Therapy and Research Center, Department of Medical Research, E-Da Cancer Hospital, Kaohsiung, Taiwan, R.O.C. ·Biosci Rep · Pubmed #29789400.

ABSTRACT: Carnosic acid (CA), a major polyphenolic diterpene present in

25 Article The Effect of Bornyl 2018

Yang, Tzu-Yen / Wu, Yu-Jen / Chang, Chi-I / Chiu, Chien-Chih / Wu, Mei-Li. ·Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91202, Taiwan. gini0307@yahoo.com.tw. · Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan. x00002180@meiho.edu.tw. · Department of Biological Science and Technology, Meiho University, Pingtung 91202, Taiwan. x00002180@meiho.edu.tw. · Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. changchii@mail.npust.edu.tw. · Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. woodnettle2002@gmail.com. · Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91202, Taiwan. mlwu@mail.npust.edu.tw. ·Int J Mol Sci · Pubmed #29734677.

ABSTRACT: Bornyl

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