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Migraine Disorders: HELP
Articles from Austria
Based on 76 articles published since 2008

These are the 76 published articles about Migraine Disorders that originated from Austria during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4
51 Article Migraine in patients with eating disorders: a study using a sister-pair comparison design. 2011

Seidel, Stefan / Karwautz, Andreas / Wagner, Gudrun / Zormann, Arno / Eder, Harald / Huemer, Julia / Nattiashvili, Sofia / Wöber, Chistian / Wöber-Bingöl, Çiçek. ·Headache Unit at the Department of Neurology, Medical University of Vienna, Vienna, Austria. ·Headache · Pubmed #21284607.

ABSTRACT: OBJECTIVE: To evaluate the relationship between migraine and eating disorders by applying a special study design. BACKGROUND: To date, only a few studies have assessed eating disorders and eating behavior in patients with migraine. METHODS: The distinctive feature of this design is the comparison of sister pairs with one sister suffering from an eating disorder according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition and the other being free of such disease. RESULTS: We investigated 120 female patients with a median age of 24 years (interquartile range 20-31) as well as their non-eating-disordered sisters with a median age of 24 (20-31) years. Headache was diagnosed according to the International Classification of Headache Disorders, Second Edition. Thirteen sister pairs were concordant for the presence of migraine, 67 were concordant for the absence of migraine and 40 were discordant. Among the latter, 21 patients and 19 controls had migraine. The prevalence of migraine was virtually identical in patients (28%) and controls (27%). CONCLUSION: This clinic-based controlled study using a sister-pair comparison design showed no evidence of an increased prevalence of migraine among patients with eating disorder.

52 Article Migraine and weather: a prospective diary-based analysis. 2011

Zebenholzer, Karin / Rudel, Ernest / Frantal, Sophie / Brannath, Werner / Schmidt, Karin / Wöber-Bingöl, Ciçek / Wöber, Christian. ·Medical University of Vienna, Austria. ·Cephalalgia · Pubmed #21112983.

ABSTRACT: AIMS: Weather is mentioned as a trigger factor by migraine patients most frequently. We examined the impact of meteorological factors and the impact of their day-to-day change on the risk of occurrence and persistence of headache and migraine and the correlation of subjective weather perception with objective weather data. METHODS: We performed a prospective, diary-based cohort study in 238 patients suffering from migraine with or without aura. Patients had to live within 25 km of the Vienna meteorological station and were required to keep a diary for 90 days. We analysed 11 meteorological parameters and 17 synoptic weather situations. For evaluating the hazard of occurrence and persistence of migraine and headache, we performed a univariate and a stepwise multivariate Cox regression analysis. We calculated correlations between subjective weather perception and meteorological data. RESULTS: In the uni- and multivariate analysis, a ridge of high pressure increased the risk of headache occurrence, lower mean daily wind speed increased the risk of migraine occurrence and a day-to-day change of daily sunshine duration increased the risk of migraine occurrence. A day-to-day change of the daily minimum temperature decreased the risk of migraine persistence. After correction for multiple testing, none of these findings remained statistically significant. Subjective weather perceptions did not correlate with the occurrence or persistence of migraine or headache. Subjective perception of cold and too-cold weather and of too-warm weather correlated with daily minimum, mean and maximum temperature. CONCLUSION: The influence of weather factors on migraine and headache is small and questionable.

53 Article Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions. 2011

Bernecker, C / Pailer, S / Kieslinger, P / Horejsi, R / Möller, R / Lechner, A / Wallner-Blazek, M / Weiss, S / Fazekas, F / Truschnig-Wilders, M / Gruber, H-J. ·Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria. claudia.bernecker@klinikum-graz.at ·Eur J Neurol · Pubmed #20825467.

ABSTRACT: OBJECTIVE: Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are discussed to be involved in the pathophysiology of migraine. Moreover, MMPs may also be involved in migraine-related metabolic alterations like an atherogenic lipid profile and hyperinsulinemia. The aim of this study was to investigate the impact of MMPs and TIMPs on migraine with and without aura and related metabolic dysfunctions. METHODS: MMP activity, six MMPs and three TIMPs, parameters of the insulin and lipid metabolism as well as anthropometric parameters were determined in 124 non-obese subjects. RESULTS: We found highly significant increased MMP activity in migraine patients independent of aura symptoms, which was associated with migraine with an odds ratio of 7.57. Interestingly, none of the determined MMPs and TIMPs showed significant different serum levels between migraine patients and healthy controls. We found significant correlations between MMP activity and parameters of the insulin and lipid metabolism, like Homeostasis Model Assessment index (HOMA index), cholesterol, triglycerides, and oxidized LDL. CONCLUSION: We show here that increased MMP activity is tightly associated with migraine and migraine-related hyperinsulinemia and atherogenic lipid alterations. Our findings represent a new pathophysiological mechanism, which may be of clinical relevance, especially in regard to therapeutic approaches using MMP inhibitors.

54 Article The prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps. 2010

Mairer, Klemens / Wille, Maria / Burtscher, Martin. ·Department of Sport Science, Medical Section, University of Innsbruck, Fürstenweg 185, Innsbruck, Austria. klemens.mairer@gmail.com ·High Alt Med Biol · Pubmed #21190503.

ABSTRACT: Acute mountain sickness (AMS) is the most common condition of high altitude illnesses. Its prevalence varies between 15% and 80% depending on the speed of ascent, absolute altitude reached, and individual susceptibility. Additionally, we assumed that the more experienced mountaineers of the Western Alps are less susceptible to developing AMS than recreational mountaineers of the Eastern Alps or tourist populations. Therefore, the main goals of the present study were the collection of data regarding the AMS prevalence and triggers in both the Eastern and Western Alps using identical methods. A total of 162 mountaineers, 79 in the Eastern Alps (3454 m) and 83 in the Western Alps (3817 m) were studied on the morning after their first night at high altitude. A diagnosis of AMS was based on a Lake Louise Score (LLS) ≥4, the presence of headache, and at least one additional symptom. Thirty of 79 subjects (38.0%) suffered from AMS at 3454 m in the Eastern Alps as did 29 of 83 (34.9%) at 3817 m in the Western Alps. After adjustment for altitude, the prevalence in the Western Alps constituted 24.5%, which differed significantly (p = 0.04) from that found in the Eastern Alps. The lower mountaineering experience of mountaineers in the Eastern Alps turned out to be the only factor for explaining their higher AMS prevalence. Thus, expert advice by mountain guides or experienced colleagues could help to reduce the AMS risk in these subjects.

55 Article GLP-2 and leptin are associated with hyperinsulinemia in non-obese female migraineurs. 2010

Bernecker, Claudia / Pailer, Sabine / Kieslinger, Petra / Horejsi, Renate / Möller, Reinhard / Lechner, Anita / Wallner-Blazek, Mirja / Weiss, Sabine / Fazekas, Franz / Truschnig-Wilders, Martini / Gruber, Hans-Jürgen. ·Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. claudia.bernecker@klinikum-graz.at ·Cephalalgia · Pubmed #20959431.

ABSTRACT: OBJECTIVE: Impaired insulin metabolism has been implicated in migraine. However, to date only some putative effects, especially regarding the involvement of adipocytokines and glucagon-like peptides (GLPs), have been described. The aim of the present study was to investigate adipocytokines and GLPs in non-obese female migraineurs. METHODS: Various parameters of the insulin metabolism and body measurements were determined in 84 non-obese female subjects. RESULTS: We found highly significantly increased insulin levels with an odds ratio of 10.62 for migraine. Leptin and GLP-2 levels were also increased and correlated with insulin. Logistic regression analysis of leptin and GLP-2 revealed odds ratios of 3.79 and 4.26 for migraine, respectively, when comparing the lowest with the highest quartile of the test variable in the complete study cohort. DISCUSSION: We show that non-obese female migraineurs suffer from hyperinsulinemia, which is associated with elevated leptin and GLP-2 levels. Increased leptin and GLP-2 are risk factors for migraine. Our data suggest that migraine is associated with a higher risk for insulin resistance and its clinical consequences.

56 Article Triggers of migraine and tension-type headache. 2010

Wöber, Christian / Wöber-Bingöl, Ciçek. ·Department of Neurology, Medical University of Vienna, Vienna, Austria. christian.woeber@meduniwien.ac.at ·Handb Clin Neurol · Pubmed #20816418.

ABSTRACT: Identification of trigger factors or precipitants is frequently recommended as a basic strategy in the treatment of migraine and tension-type headache (TTH). Trigger factors increase the probability of headache in the short term. Potential trigger factors have been examined most frequently in migraine and less often in TTH. Many of these factors are related to migraine as well as to TTH, but their prevalence may differ in the two headache types. In this chapter, we will review the findings of retrospective as well as of prospective and controlled studies. Taken together, virtually all aspects of life have been suspected to trigger migraine or TTH, but scientific evidence for many of these triggers is poor. Menstruation has a prominent unfavorable role in migraine and possibly in TTH. There is at least some evidence that environmental factors such as weather, lights, noise and odors, stress and other psychological factors, sleeping problems, fatigue and tiredness may play a role. In addition, intake of alcohol, caffeine withdrawal, skipping meals, and possibly dehydration may trigger migraine and TTH in some patients. Scientific evidence is lacking that any other food or food additive plays a relevant role as a trigger factor of headaches.

57 Article Migraine and vertigo--a prospective diary study. 2010

Salhofer, Sabine / Lieba-Samal, Doris / Freydl, Elisabeth / Bartl, Sigrid / Wiest, Gerald / Wöber, Christian. ·Department of Neurology, Medical University of Vienna, Vienna, Austria. ·Cephalalgia · Pubmed #20647173.

ABSTRACT: The objective of the study was to examine migrainous vertigo prospectively by means of a diary. We included 146 patients with at least one migraine attack per month. All patients underwent a semistructured interview, completed questionnaires on depression, anxiety and quality of sleep and kept a diary covering detailed information on headache, vertigo and dizziness over a period of 30 days. A completed diary was returned by 116 patients (79.5%). Based on the diary migrainous vertigo (MV) was diagnosed in 18 patients (15.5%) and non-migrainous vertigo or dizziness (non-MV) in 35 patients (30.2%). MV was present on 65 of 3477 patient days (1.9%) and non-MV on 145 days (4.2%). MV occurred more often on days with headache (P < 0.001). Its median duration was 3 h and it lasted longer on days with headache than on days without headache (P < 0.001). The most prominent specific feature of MV was head motion intolerance. Patients with MV showed anxiety more often (P < 0.001) and tended to have worse quality of sleep and higher depression scores. In conclusion, vertigo and dizziness are frequent symptoms in migraineurs. The 1-month prevalence of MV is 16% and that of non-MV 30% in patients with at least one migraine attack per month. Frequency of MV is higher and duration longer on days with headache. MV is a risk factor for co-morbid anxiety.

58 Article Cognitive functions, emotional behavior, and quality of life in familial hemiplegic migraine. 2010

Karner, Elfriede / Delazer, Margarete / Benke, Thomas / Bösch, Sylvia. ·Clinical Department of Neurology, Innsbruck Medical University, Austria. elfriede.karner@uki.at ·Cogn Behav Neurol · Pubmed #20535059.

ABSTRACT: OBJECTIVES: To describe the cognitive functions, mood, and quality of life in a family with genetically proved familial hemiplegic migraine (FHM), carrying a missense mutation on chromosome 19 (T666M), corresponding to the most frequent FHM subtype. BACKGROUND: FHM is an autosomal dominant subtype of migraine with an aura, characterized by hemiparesis during the aura. Whereas the genetic background of FHM has been studied intensely, less attention has been paid to cognitive functions and mood between attacks. METHOD: Six patients performed neuropsychologic assessment between attacks. Depression, anxiety, and quality of life were evaluated by questionnaires. Cerebral magnetic resonance imaging was performed. RESULTS: Neuropsychologic assessment revealed a distinct pattern of preserved and impaired functions. Whereas linguistic abilities and verbal memory were intact, all patients showed deficits in figural memory, executive functions, in some aspects of attention, and in dexterity. Intelligence of 1 patient was below average. All but 1 patient reported normal quality of life; there were no symptoms of depression or state anxiety. All patients showed cerebellar atrophy and cerebellar ataxia. CONCLUSION: Cognitive abnormalities and cerebellar atrophy were found in all patients. FHM-related cognitive deficits may be associated to a disturbance of cerebrocerebellar circuits.

59 Article A novel locus for familial migraine on Xp22. 2010

Wieser, Thomas / Pascual, Julio / Oterino, Agusto / Soso, Michael / Barmada, Michael / Gardner, Kathy L. ·Department of Neurology, KH Göttlicher Heiland, Vienna, Austria. ·Headache · Pubmed #20412323.

ABSTRACT: INTRODUCTION: Migraine is thought to be genetically complex. There is evidence of an X-linked dominant genetic component. A locus at Xq24-q28 has already been described supporting this hypothesis. METHODS: The X chromosome in 61 migraine families was screened using markers spanning the entire chromosome. Alleles were assigned using the GeneScan Analysis software, analysis for affected relative allele sharing and linkage was performed using Genehunter X and ALLEGRO. For linkage analysis we chose a model based on epidemiological data as well as assumptions drawn on other complex disorders. RESULTS: Linkage analysis of combined families showed a parametric 2-point logarithm of the odds (LOD) of 2.86 at theta 0.1 between markers DXS8051 and DXS1223, as well as excess allele sharing at marker DXS8051 with a non-parametric LOD score of 2.85. CONCLUSION: These results provide suggestive evidence for a susceptibility locus for migraine on Xp22. Families with different types of migraine contributed to this LOD score.

60 Article Lipid profile in normal weight migraineurs - evidence for cardiovascular risk. 2010

Gruber, H-J / Bernecker, C / Pailer, S / Lechner, A / Horejsi, R / Möller, R / Fazekas, F / Truschnig-Wilders, M. ·Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria. hans-juergen.gruber@klinikum-graz.at ·Eur J Neurol · Pubmed #19968707.

ABSTRACT: BACKGROUND: Recent studies suggest that migraine is associated with metabolic disorders. In particular, migraine may be associated with cardiovascular risk; however, an association of migraine with cardiovascular risk factors like hypercholesterolemia has been proposed, but previous studies have yielded in part conflicting results. The aim of the present study is to evaluate the lipid profile in normal weight migraine patients. METHODS: One hundred thirty-six probands participated in this study. The study group was divided into normal weight migraineurs and control groups, including normal weight controls, obese and overweight controls and migraineurs. Various parameters of the lipid metabolism and inflammatory parameters were investigated. RESULTS: We found significant increased cholesterol, low density lipoprotein cholesterol (LDL-C) and oxidized LDL-C in normal weight migraineurs. Increased oxidized LDL-C was associated with a 7.93-fold increased risk for migraine. Alterations in the lipid profile were not accompanied by increased inflammatory parameters. CONCLUSIONS: We show here that normal weight migraineurs exhibit independent of aura symptoms an atherogenic lipid profile, which shares common features with obesity-related lipid alterations. Our data suggest that migraine is associated with a higher risk for cardiovascular disease and its clinical consequences.

61 Article Increased dopamine is associated with the cGMP and homocysteine pathway in female migraineurs. 2010

Gruber, Hans-Jürgen / Bernecker, Claudia / Pailer, Sabine / Lechner, Anita / Horejsi, Renate / Möller, Reinhard / Fazekas, Franz / Truschnig-Wilders, Martie. ·Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria. ·Headache · Pubmed #19804388.

ABSTRACT: BACKGROUND: The group of catecholamines, which include dopamine, adrenaline, and noradrenaline, are neurotransmitters which have been considered to play a role in the pathogenesis of migraine. However, the impact of catecholamines, especially dopamine on migraine as well as the exact mechanisms is not clear to date as previous studies have yielded in part conflicting results. OBJECTIVE: This study aimed to produce a comprehensive examination of dopamine in migraineurs. METHODS: Catecholamines and various parameters of the homocysteine, folate, and iron metabolism as well as cyclic guanosine monophosphate (cGMP) and inflammatory markers were determined in 135 subjects. RESULTS: We found increased dopamine levels in the headache free period in female migraineurs but not in male patients. Increased dopamine is associated with a 3.30-fold higher risk for migraine in women. We found no significant effects of aura symptoms or menstrual cycle phases on dopamine levels. Dopamine is strongly correlated with cGMP and the homocysteine-folate pathway. CONCLUSION: We show here that female migraineurs exhibit increased dopamine levels in the headache free period which are associated with a higher risk for migraine.

62 Article Hyperinsulinaemia in migraineurs is associated with nitric oxide stress. 2010

Gruber, H-J / Bernecker, C / Pailer, S / Fauler, G / Horejsi, R / Möller, R / Lechner, A / Fazekas, F / Truschnig-Wilders, M. ·Chemical Laboratory Diagnostics, Medical University Graz, Clinical Institute of Medical, Graz, Austria. hans-juergen.gruber@klinikum-graz.at ·Cephalalgia · Pubmed #19740122.

ABSTRACT: There is growing evidence that alterations in the insulin and glucose metabolism may be involved in the pathogenesis of migraine. Nitric oxide (NO) stress has been associated with migraine. However, the role of NO on the insulin and glucose metabolism in migraineurs has remained elusive to date. The aim of the present study was to investigate the insulin and glucose metabolism in migraineurs and to determine possible interactions with the NO pathway. One hundred and twenty non-obese probands participated in this study, including 48 migraineurs and 72 healthy volunteers. Various parameters of the NO pathway, glucose metabolism as well as body measurement parameters were determined. We found a highly significantly increased insulin and Homeostasis Model Assessment (HOMA)-index in migraine patients, whereas fasting glucose was decreased. Logistic regression revealed an odds ratio of 5.67 for migraine, when comparing the lowest with the highest quartile of HOMA. Multivariate analysis showed that HOMA, waist-to-length ratio and nitrite as parameters of NO stress were highly significantly correlated. We show here that hyperinsulinaemia is associated with migraine and, furthermore, is correlated with increased NO stress. These findings represent a new pathophysiological mechanism that may be of clinical relevance.

63 Article Increased nitric oxide stress is associated with migraine. 2010

Gruber, H-J / Bernecker, C / Lechner, A / Weiss, S / Wallner-Blazek, M / Meinitzer, A / Höbarth, G / Renner, W / Fauler, G / Horejsi, R / Fazekas, F / Truschnig-Wilders, M. ·Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria. hans-juergen.gruber@klinikum-graz.at ·Cephalalgia · Pubmed #19673897.

ABSTRACT: Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine remains unclear. We here hypothesize that increased NO in the headache-free period is associated with migraine. One hundred and thirty probands participated in this study. Various parameters of the NO pathway, such as nitrate, nitrite, arginine, citrulline, nitrosylated proteins, asymmetric dimethylarginine, symmetrical dimethylarginine, expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase and two polymorphisms of eNOS were investigated. We found significant increased nitrate and decreased nitrite levels in migraineurs in the headache-free period. Nitrate and nitrite levels showed a significant inverse correlation. Logistic regression revealed an odds ratio of 3.6 for migraine. Other parameters of the NO pathway were neither altered in migraineurs nor correlated with nitrate. We show here that migraine patients suffer under sustained increased nitrosative stress in the headache-free period, which is associated with a 3.6-fold higher risk for migraine.

64 Article No influence of 5-HTTLPR gene polymorphism on migraine symptomatology, comorbid depression, and chronification. 2010

Wieser, Thomas / Dresler, Kathrin / Evers, Stefan / Gaul, Charly / König, Dorothea / Hölzl, Daniela / Berger, Klaus / Nyholt, Dale / Deufel, Thomas. ·Neurologie, Krankenhaus Göttlicher Heiland, Vienna, Austria. ·Headache · Pubmed #19438736.

ABSTRACT: BACKGROUND: The serotonergic system is thought to play an important role for mediating susceptibility to migraine and depression, which is frequently found comorbid in migraine. The functional polymorphism in the serotonin transporter gene linked polymorphic region (5-HTTLPR/SLC6A4) was previously associated with attack frequency and, thus, possibly with chronification. OBJECTIVE: We hypothesized that patients with the "s" allele have higher attack frequency and, paralleling results in depression research, higher scores of depression. METHODS: Genetic analysis of the SLC6A4 44 bp insertion/deletion polymorphism (5-HTTLPR) was performed in 293 patients with migraine with and without aura. Self-rating questionnaires were used for assessment of depression. RESULTS: Multinomial logistic regression analysis found no evidence for association of the 5-HTTLPR polymorphism with either depression or migraine attack frequency. CONCLUSION: We were not able to demonstrate any influence of the serotonin transporter 5-HTTLPR polymorphism on migraine phenomenology (attack frequency or comorbid depression), thereby excluding this variant to be a common genetic denominator for chronic migraine and depression.

65 Article Prevalence of acute mountain sickness in the Eastern Alps. 2009

Mairer, Klemens / Wille, Maria / Bucher, Thomas / Burtscher, Martin. ·Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria. ·High Alt Med Biol · Pubmed #19775213.

ABSTRACT: Little information is available on the prevalence of acute mountain sickness (AMS) in the Eastern Alps compared with the Western Alps. Because of differences regarding the populations of mountaineers, we hypothesized that the prevalence differs between the Eastern and Western Alps. Thus, we determined the prevalence and risk factors of AMS at four different altitudes in the Eastern Alps of Austria. Four hundred and thirty-one recreational hikers were studied using questionnaires on the morning of their first night at high altitude. A diagnosis of AMS was based on a Lake Louise Score > or =4, the presence of headache, and at least one additional symptom. Overall 16.2% of the subjects met the criteria for AMS, and the prevalence of AMS increased significantly with altitude (2200 m: 6.9%; 2500 m: 9.1%; 2800 m: 17.4%; 3500 m: 38.0%). Heavy perceived exertion, a history of migraine, the absolute altitude reached, little mountaineering experience, and inadequate water intake (< or =2 L) were independent AMS risk factors. The reported altitude-related AMS prevalence in the Western Alps is 4% to 8% lower compared with that found in this study for the Eastern Alps. In conclusion, the prevalence of AMS is higher in the tourist population of the Eastern Alps compared to the more experienced mountaineers of the Western Alps. Consideration of easily modifiable risk factors such as individual exertion and water intake could markedly reduce AMS and contribute to the enjoyment of mountaineering.

66 Article The course of migraine-a diary study in unselected patients. 2009

Lieba-Samal, D / Bartl, S / Salhofer, S / Prajsnar, A / Massl, R / Freydl, E / Fathinia, P / Wöber-Bingöl, C / Wöber, C. ·Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria. christian.woeber@meduniwien.ac.at ·Cephalalgia · Pubmed #19735533.

ABSTRACT: The course of disease and the predictive value of depression and anxiety in patients with migraine were prospectively examined. We recruited 393 migraineurs through articles in newspapers and performed a follow-up examination 30 months later. At baseline and follow-up, patients underwent a semistructured interview, filled out the Headache Impact Test (HIT-6), Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) and they kept a headache diary for 30 days. One hundred and fifty-one patients (38.6%) were seen at follow-up. The baseline data of patients with and without follow-up were comparable. At follow-up the number of headache days per month had decreased from 9.6 +/- 5.8 to 8.1 +/- 6.3 (P < 0.001) and the proportion of patients with chronic headache (15.4%) and medication overuse (13%) had remained stable. SDS and SAS scores were associated with a high migraine frequency and high initial SDS scores predicted high migraine frequency at follow-up. This longitudinal study in unselected patients with migraine not excluding subjects with chronic headache, medication overuse, depression or anxiety does not point towards migraine as a progressive disease in the vast majority of patients and confirms the importance of psychiatric comorbidity.

67 Article Two different doses of amitriptyline ER in the prophylaxis of migraine: long-term results and predictive factors. 2009

Lampl, C / Huber, G / Adl, J / Luthringshausen, G / Franz, G / Marecek, S / Weber, J / Baumhackl, U / Mueller, T. ·Department of Neurology and Pain Medicine, Konventhospital Barmherzige Brüder Linz, Linz, Austria. christian.lampl@bblinz.at ·Eur J Neurol · Pubmed #19456855.

ABSTRACT: BACKGROUND AND PURPOSE: The rationale for our study was to examine the prophylactic benefit of two doses of amitriptyline over a 6-month observational period in patients with migraine. We aimed at evaluating whether 50 mg of amitryptiline extended release was more effective than 25 mg in reducing the number of migraine days. METHODS: Primary outcome measure was the reduction of migraine days in time course (i.e., 3 and 6 months after patient enrolment). As secondary analyses, predictors of treatment response were evaluated. Treatment response was defined as reduction of > or =30% and > or =50% in migraine headache days in time course. RESULTS: The intent-to-treat population comprised 132 patients (female 96; male 36) with migraine. Median migraine days per month were reduced from 7 days (range: 6-15) at baseline, to 6 days (range: 4-12; P < 0.001) at 3 months, and to 6 days (range: 3-12; P < 0.001) at 6 months, respectively. However, no statistically significant difference in the number of migraine days was seen between the two treatment groups at 3 and 6 months. As a result of secondary analyses, the number of migraine days per month at baseline was the only independent predictor of response to amitriptyline treatment (for both definitions of treatment response, i.e., response rate > or =30% and response rate > or =50%) at 6 months. CONCLUSIONS: The prophylactic effect of amitriptyline seen in our study was rather weak and did not differ between the two treatment groups. The results of this 6-month, prospective, open-label clinical observation are therefore not encouraging.

68 Article Quality of sleep, fatigue and daytime sleepiness in migraine - a controlled study. 2009

Seidel, S / Hartl, T / Weber, M / Matterey, S / Paul, A / Riederer, F / Gharabaghi, M / Wöber-Bingöl, C / Wöber, C / Anonymous5080621. ·Department of Neurology, Währinger Gürtel 18-20, 1090 Vienna, Austria. ·Cephalalgia · Pubmed #19210514.

ABSTRACT: The objective of this study was to evaluate whether the quality of sleep and the degree of fatigue and daytime sleepiness are related to migraine. We investigated 489 subjects comprising 97 patients with eight or more, 77 patients with five to seven and 196 patients with one to four migraine days per month, and 119 migraine-free controls with fewer than six headache days per year. The patients were recruited via articles in newspapers not stressing the subject of the study. All participants underwent a semistructured interview and completed the Pittsburgh Sleep Quality Index (PSQI), the Fatigue Severity Scale (FSS), the Epworth Sleepiness Scale (ESS) and the Self-rating Depression Scale and the Self-rating Anxiety Scale. For statistical analysis we used two way manovas, post hoc univariate two-way anovas and Hochberg's GT2 tests as well as three-way mixed design anovas. The PSQI total score was highest in patients with frequent migraine (5.9 +/- 4.3) and lowest in controls (4.3 +/- 2.5, P = 0.04). Four subscores of the PSQI showed similar statistically significant differences. The FSS and ESS scores did not differ in the four study groups. Analysing depression and anxiety revealed a significant impact on PSQI, FSS and ESS, but did not demonstrate interactions with migraine, thus suggesting that the impact of migraine is similar in patients without and with psychiatric comorbidity. In conclusion, the quality of sleep is decreased in patients with migraine, whereas fatigue and daytime sleepiness do not differ from healthy controls. The decreased quality of sleep in migraineurs is also a consequence of migraine itself and cannot be explained exclusively by comorbidity with depression or anxiety.

69 Article Burden of atherosclerosis and risk of venous thromboembolism in patients with migraine. 2008

Schwaiger, J / Kiechl, S / Stockner, H / Knoflach, M / Werner, P / Rungger, G / Gasperi, A / Willeit, J. ·Department of Neurology, Innsbruck Medical University, Austria. ·Neurology · Pubmed #18794497.

ABSTRACT: BACKGROUND: Previous studies have yielded evidence of an enhanced risk of cardiovascular disease, especially stroke, among patients with migraine. Our understanding of the underlying mechanisms is far from complete. The aims of the present study were to investigate the potential association between migraine and atherosclerosis and to assess the risk of venous thromboembolism as a clinical surrogate for a procoagulant state in patients with migraine. METHODS: The examination was part of the population-based Bruneck Study. During the 2005 evaluation, 574 participants aged 55-94 years underwent neurologic and laboratory examinations involving a standardized headache interview and scanning of the carotid and femoral arteries to evaluate presence, severity, and progression (2000-2005) of atherosclerosis. RESULTS: A large number of well-founded and putative cardiovascular risk factors have emerged as being unrelated to migraine status. Prevalence, severity, and 5-year progression of carotid and femoral atherosclerosis did not differ significantly between migraineurs with and without aura and nonmigraineurs. In fact, there was even a tendency for atherosclerosis to be less pronounced among patients with migraine, and for the intima-media thickness to be lower (p = 0.029). As a novel finding migraineurs faced a significantly enhanced risk of venous thromboembolism (18.9% vs 7.6% in nonmigraineurs, age/sex-adjusted p = 0.031). CONCLUSION: This study is the first to compare the burden of atherosclerosis as quantified by high-resolution duplex ultrasound between migraineurs and nonmigraineurs in the general community, and provides solid evidence against the view that migraine predisposes to atherosclerosis. The higher risk for venous thromboembolism among migraineurs (prothrombotic state) awaits confirmation and elaboration in future research.

70 Article Difference in triptan effect in patients with migraine and early allodynia. 2008

Lampl, C / Huber, G / Haas, S / Rittberger, E / Diener, H C. ·Department of Neurology and Pain Medicine, Konventhospital Barmherzige Brüder, Linz, Austria. christian.lampl@bblinz.at ·Cephalalgia · Pubmed #18624801.

ABSTRACT: The aim of this study was to determine whether in migraine patients with and without aura early treatment with various triptans leads to differences in pain reduction after 1 h and in modulating cutaneous allodynia. Thirty-six patients with early manifestation of a clinically recognizable allodynia of the face and non-responders to earlier treatment with sumatriptan 100 mg were included. Patients were randomized to six triptan treatment groups. Significant pain reduction was seen only in the group receiving zolmitriptan nasal spray 5 mg with a mean visual analogue scale (VAS) score of 3.8 (s.d. 1.2) at baseline and 2.4 (s.d. 1.3; P = 0.015) at 1 h after using the triptan and was thus a predictor of a VAS score 3 within 1 h. The study results indicate that migraine headache intensity can be reduced within 1 h by using zolmitriptan 5 mg nasal spray in spite of the presence of early cutaneous allodynia.

71 Article Aerobic exercise with relaxation: influence on pain and psychological well-being in female migraine patients. 2008

Dittrich, Sara Maria / Günther, Verena / Franz, Gerhard / Burtscher, Martin / Holzner, Bernhard / Kopp, Martin. ·Center of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Innsbruck, Austria. ·Clin J Sport Med · Pubmed #18614890.

ABSTRACT: OBJECTIVE: The objective of this pilot study was to address the influence of an aerobic exercise program combined with relaxation on pain and psychological variables in migraine patients. DESIGN: Controlled, randomised design with half of the group receiving an intervention (aerobic exercise group) in addition to standard medical care received by all patients. SETTING/PATIENTS/OUTCOME MEASUREMENT: Thirty female migraine outpatients completed a range of psychological questionnaires measuring sensational and affective dimensions of pain, body image, depression, and quality of life. INTERVENTION: The aerobic exercise group (n = 15) participated in a 6-week, twice-weekly, indoor exercise program (45 minutes of gymnastics with music and 15 minutes of progressive muscle relaxation). RESULTS/CONCLUSION: The program led to a significant reduction of self-rated migraine pain intensity. Although there was an improvement in depression-related symptoms within the aerobic exercise group, no significant differences in psychological variables between groups were found.

72 Article First Austrian case of hypnic headache: serial polysomnography and blood pressure monitoring in treatment with indomethacin. 2008

Seidel, S / Zeitlhofer, J / Wöber, C. ·Department of Neurology, Medical University of Vienna, Vienna, Austria. stefan.seidel@meduniwien.ac.at ·Cephalalgia · Pubmed #18498399.

ABSTRACT: -- No abstract --

73 Minor Diagnosing allodynia requires the assessment of pain. 2019

Bornemann-Cimenti, Helmar. ·Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria. ·Pain · Pubmed #30889117.

ABSTRACT: -- No abstract --

74 Unspecified Unique Uses of Cooling Strategies. 2017

Rincon, Fred / Bestle, Morten / Brossner, Gregor / Vanderpol, Jitka. ·1 Department of Neurology, Thomas Jefferson University , Philadelphia, Pennsylvania. · 2 Nordsjaellands Hospital, University of Copenhagen , Copenhagen, Denmark . · 3 Neurointensive Care Unit, Department of Neurology, University Hospital , Innsbruck, Austria . · 4 Penrith Hospital , Cumbria Partnership NHS Foundation Trust, Cumbria, United Kingdom . ·Ther Hypothermia Temp Manag · Pubmed #28813633.

ABSTRACT: -- No abstract --

75 Minor Comment on: Martelletti et al. Refractory chronic migraine: a consensus statement on clinical definition from the European Headache Federation. 2014

Wöber, Christian / Wessely, Peter / Anonymous3140812. ·Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. christian.woeber@meduniwien.ac.at. ·J Headache Pain · Pubmed #25418797.

ABSTRACT: In this letter, we present the Austrian proposal for diagnostic criteria of refractory chronic migraine and we discuss the consensensus statement of the European Headache Feaderation. We focus in particular on the definition of adequate prophylactic treatment, the management of medication overuse and the requirement for CSF analyses in patients with refractory chronic migraine. In our proposal, the criteria for adequate treatment and recommendations for dealing with medication overuse are more explicit than in the EHF proposal, whereas the requirements for CSF analyses and measurement of CSF pressure are not as strict.

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