Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Migraine Disorders: HELP
Articles from Serbia
Based on 27 articles published since 2009
||||

These are the 27 published articles about Migraine Disorders that originated from Serbia during 2009-2019.
 
+ Citations + Abstracts
Pages: 1 · 2
1 Review Comorbidity of Migraine and Epilepsy in Pediatrics: A Review. 2018

Jancic, Jasna / Djuric, Vesna / Hencic, Boris / van den Anker, John N / Samardzic, Janko. ·1 Clinic of Neurology and Psychiatry for Children and Youth, Medical Faculty, University of Belgrade, Serbia. · 2 Medical Faculty, University of Belgrade, Serbia. · 3 Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland. · 4 Division of Pediatric Clinical Pharmacology, Children's National Medical Center, Washington, DC, USA. · 5 Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands. · 6 Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Serbia. ·J Child Neurol · Pubmed #30095015.

ABSTRACT: Migraine and epilepsy are classified as chronic paroxysmal neurologic disorders sharing many clinical features, as well as possible treatment options. This review highlights the similarities between migraine and epilepsy in pediatrics, focusing on epidemiologic, pathophysiological, genetic, clinical, and pharmacologic aspects. Despite the fact that several syndromes share symptoms of both migraine and epilepsy, further research is needed to clarify the pathophysiological and genetic basis of their comorbidity. Drugs used for prophylactic therapy of migraine and epilepsy have similar pharmacologic properties. The role of epileptic pharmacotherapy in the prophylaxis of migraine is assessed, including the use of conventional antiepileptic drugs, calcium channel blockers, and nonpharmacologic methods such as dietary therapy, supplements, and vagal nerve stimulation. Further randomized, controlled clinical trials assessing pharmacologic and nonpharmacologic methods for the treatment of both disorders are essential, in order to initiate new therapeutic approaches.

2 Review Cluster headache as a first manifestation of multiple sclerosis: case report and literature review. 2014

Mijajlović, Milija D / Aleksić, Vuk M / Covičković Šternić, Nadežda M. ·Department for Cerebrovascular Disorders and Headaches, Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia. ·Neuropsychiatr Dis Treat · Pubmed #25473291.

ABSTRACT: Cluster headache (CH) is estimated to be the most common primary trigeminal autonomic headache, although it is a rare disabling medical condition. Dominant symptoms of CH include severe unilateral orbital, supraorbital, and/or temporal pain, lasting from 15 to 180 minutes if untreated, associated with at least one of various autonomic symptoms during the headache, such as conjunctival injection, lacrimation, nasal congestion and rhinorrhea, facial sweating, miosis, ptosis, and eyelid edema. Headache is not frequently a symptom of multiple sclerosis (MS). The most commonly reported primary headaches are migraine without aura and a tension-type headache. Several described cases involved complicated migraine, ophthalmoplegic migraine-like headache, and finally cluster-like headache. We present a case of a 45-year-old male patient who had typical CH attacks as the initial and only clinical manifestation of MS, which was diagnosed after cerebrospinal fluid (CSF) isoelectric focusing and brain magnetic resonance imaging (MRI) investigation. He presented as a typical cluster-like headache patient since in the background of the CH symptoms and signs, were MS demyelinating lesions. In a patient with CH symptoms one should always think about the possibility of cluster-like-headache, which presents the CH patient with different underlying diseases, so we proposed a protocol to evaluate such patients and exclude diseases that could be in the background of CH symptoms.

3 Review Pathophysiology of migraine--from molecular to personalized medicine. 2013

Kojić, Zvezdana / Stojanović, Dobrica. ·Institute of Physiology, School of Medicine, University of Belgrade. zvezdanak@med.bg.ac.rs ·Med Pregl · Pubmed #23534301.

ABSTRACT: INTRODUCTION: Understanding of migraine pathophysiology has substantially improved over the last two decades. As a result, migraine is now mainly considered to be a disorder of the brain, rather than one of the vasculature or the meninges. PATHOPHYSIOLOGY: Although it remains speculative how exactly they relate to each other, the following three processes are important in migraine: 1. Cortical spreading depression is a wave of intense depolarization, it starts in the occipital lobe, propagates through the brain and is followed by a period of suppressed activity. 2. Activation of the trigemonovascular system causes the release of neuropeptides (e.g. calcitonin gene-related peptide, substance P) from the peripheral trigeminal nerve endings. These neuropeptides are thought to play a role in causing and maintaing headache. 3. Sensitization of peripheral and central brain areas, it is thought that pulsating quality of migraine headache is caused by a process of peripheral sensitization. Cutaneous allodynia is a marker of central sensitization. LINK BETWEEN AURA AND HEADACHE: The view that the aura is caused by cortical spreading depression has become generally accepted, and the same is true for the view that activation of the trigemonovascular system underlies migraine headache. However, the relationship between the aura and the activation of the trigemonovascular system and the start of headache remains elusive. GENETICS OF MIGRAINE: One of the most important aspects of the pathophysiology of migraine is the hereditary nature of the disorder. CONCLUSION: Identification of polymorphisms and genetic biomarkers should help us to understand migraine pathophysiology better and thus enable the development of specific, effective "individually-tailored treatment" for each particular migraine patient (personalized medicine).

4 Article Screening general practice patients for migraine without aura: construction and validation of the Balkan Migraine Screening Questionnaire (BMSQ). 2019

Šukalo, Aziz / Merdžanović, Elma / Alic, Alma / Vrabac-Mujčinagić, Muamera / Alibašić, Esad / Janković, Slobodan M. ·Bosnalijek JSC, Sarajevo, Bosnia and Herzegovina. · Health Care Centre of Canton Sarajevo, Hadžići, Bosnia and Herzegovina. · Health Care Centre Zenica, Zenica, Bosnia and Herzegovina. · Health Care Centre Tuzla, Tuzla, Bosnia and Herzegovina. · Health Care Centre, Kalesija, Bosnia and Herzegovina. · University of Kragujevac, School of Medical Sciences, Kragujevac, Serbia. ·Med Glas (Zenica) · Pubmed #31127712.

ABSTRACT: Aim To develop and validate a screening questionnaire for migraine without aura with sufficient diagnostic accuracy to be used in primary care settings. Methods The study was designed as cross-sectional, multicentric, diagnostic accuracy trial of new questionnaire for screening patients who visit general practitioners, with an aim to reveal migraine without aura. The instrument was constructed for the purpose of this study, and validated on the sample of 429 primary care outpatients. The gold standard of diagnosing migraine without aura was clinical estimate by a neurologist based on the International Classification of Headache Disorders 3rd edition (ICHD-III) criteria. Diagnostic accuracy of the instrument was tested through construction of the Receiver Operator Curve. Results The Balkan Migraine Screening Questionnaire (BMSQ) instrument showed good diagnostic accuracy (sensitivity 83.4% and specificity 79.9%) for migraine without aura, with significant screening yield among previously undiagnosed patients of 75.9%. The study also confirmed a high percentage of patients with hidden migraine without aura (MWA) (52.9%) revealed by the BMSQ and the ICHD-III criteria that would otherwise remain undiagnosed. Conclusion The BMSQ is a valid and reliable clinical instrument for revealing migraine without aura, which could be easily selfadministered by patients. It has high screening yield, discovering majority of patients with previously undiagnosed migraine without aura, whose definite diagnosis should later on be confirmed by the attending physicians using the ICHD-III criteria.

5 Article Translation and Transcultural Validation of Migraine Screening Questionnaire (MS-Q). 2018

Delic, Daniela / Ristic, Ana / Grujic, Brankica / Djakovic, Marinela / Lasic, Amra / Hadzic, Ema / Abadzic, Amira / Hajduk, Dzemal / Keric, Snjezana Prcic / Bajramovic, Raifa / Ganic, Sadeta / Ibrahimovic, Azra / Solbic, Zumra / Jasic, Jasminka / Blagojevic, Danijela / Sopta, Edita / Hodzic, Henrieta / Jankovic, Slobodan M. ·Bosnalijek JSC, Sarajevo, Bosnia and Herzegovina. · Health Care Centre Banja Luka, Banja Luka, Bosnia and Herzegovina. · Health Care Centre of Canton Sarajevo, Sarajevo, Sarajevo, Bosnia and Herzegovina. · Health Care Centre Zenica, Zenica, Bosnia and Herzegovina. · Health Care Centre Visoko, Visoko, Bosnia and Herzegovina. · Health Care Centre Tešanj, Tesanj, Bosnia and Herzegovina. · Health Care Centre Kakanj, Kakanj, Bosnia and Herzegovina. · Health Care Centre Srebrenik, Srebrenik, Bosnia and Herzegovina. · Health Care Centre "S+Medico", Bijeljina, Bosnia & Herzegovina. · Health Care Centre Mostar, Mostar, Bosnia and Herzegovina. · Health Care Centre Livno, Livno, Bosnia and Herzegovina. · University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia. ·Med Arch · Pubmed #30814775.

ABSTRACT: Introduction: Between 30 to 59% of patients with migraine without aura are undiagnosed and improperly treated, because primary care physicians are either too busy or unfamiliar with criteria for diagnosing migraine. Aim: The aim of our study was to translate the Migraine Screen Questionnaire (MS-Q) to BHS (Bosnian/Croatian /Serbian) language and to test reliability and validity of the translation on a sample of primary care patients. Material and Methods: The study was designed as cross-sectional, multi centric, diagnostic accuracy trial of an instrument for screening patients who visit general practitioners, with an aim to reveal migraine without aura. The instrument was the MS-Q, originally written in English and validated in Spanish population, and in this study being translated to BHS language. Results: Translation of the MS-Q to BHS language showed good diagnostic accuracy (sensitivity 80.0% and specificity 87.2%) and reliability (Cohen kappa 0.648) for migraine without aura, with significant screening yield among previously undiagnosed patients of 72.7%. The study also confirmed high percentage of patients with hidden MWA (52.9%) revealed by the MS-Q and ICH criteria that would otherwise remain undiagnosed. Conclusion: The MS-Q translation to BHS language could be considered as valid and reliable clinical instrument for revealing migraine without aura, similar by its performance to original questionnaire. It has considerable screening yield, discovering majority of patients with previously undiagnosed migraine without aura, whose definite diagnosis should later on be confirmed by the attending physicians using the ICH criteria.

6 Article Migraine with aura and white matter tract changes. 2018

Petrušić, Igor / Daković, Marko / Kačar, Katarina / Mićić, Olivera / Zidverc-Trajković, Jasna. ·Faculty of Medicine, University of Belgrade, Belgrade, Serbia. ip7med@yahoo.com. · Faculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia. ip7med@yahoo.com. · Faculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia. · Department of Radiology, Special hospital for prevention and Treatment of Cerebrovascular Diseases "Sveti Sava", Belgrade, Serbia. · Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · Center for headaches, Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia. ·Acta Neurol Belg · Pubmed #30006859.

ABSTRACT: We aimed to explore whether a migraine with aura (MA) is associated with structural changes in tracts of a white matter and to compare parameters of diffusivity between subgroups in migraineurs. Forty-three MA and 20 healthy subjects (HS), balanced by sex and age, were selected for this study. Analysis of diffusion tensor parameters was used to identify differences between MA patients and HS, and then between MA subgroups. A diffusion tensor probabilistic tractography analysis showed that there is no difference between MA patients and HS. However, using more-liberal uncorrected statistical threshold, we noted a trend in MA patients toward lower diffusivity indices of selected white matter tracts located in the forceps minor and right anterior thalamic radiation (ATR), superior longitudinal fasciculus (temporal part) (SLFT), cingulum-cingulate tract, and left uncinate fasciculus. Migraineurs who experienced somatosensory and dysphasic aura, besides visual symptoms, had tendency toward lower diffusivity indices, relative to migraineurs who experienced only visual symptoms, in the right inferior longitudinal fasciculus, forceps minor, and right superior longitudinal fasciculus (parietal part), SLFT, and cingulum-angular bundle. Aura frequency were negatively correlated with axial diffusivity and mean diffusivity of the right ATR (partial correlation = - 0.474; p = 0.002; partial correlation = - 0.460; p = 0.002), respectively. There were no significant differences between MA patients and HS, neither between MA subgroups. Migraineurs with abundant symptoms during the aura possibly have more myelinated fibers relative to those who experience only visual symptoms. Lower diffusivity indices of the right ATR are linked to more frequent migraine with aura attacks.

7 Article Migraine with Aura: Surface-Based Analysis of the Cerebral Cortex with Magnetic Resonance Imaging. 2018

Petrusic, Igor / Dakovic, Marko / Kacar, Katarina / Zidverc-Trajkovic, Jasna. ·Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. · Faculty of Physical Chemistry, University of Belgrade, Belgrade 11000, Serbia. · Department of Radiology, Special Hospital for Prevention and Treatment of Cerebrovascular Diseases "Saint Sava", Belgrade 11000, Serbia. · Center for Headaches, Neurology Clinic, Clinical Center of Serbia, Belgrade 11000, Serbia. ·Korean J Radiol · Pubmed #29962883.

ABSTRACT: Objective: Previous migraine studies have reported gray matter alterations in various cortical regions with conflicting results. This study aimed to explore a cortical morphometric difference in migraineurs with aura (MA) compared to healthy subjects (HS) and to delineate a possible difference between the cortical morphological features and different aura phenotypes. Materials and Methods: Forty-eight MA and 30 HS that were balanced by sex, age, and educational level were selected for this study. T2-weighted and three-dimensional T1-weighted magnetic resonance imaging (MRI) of the brain were acquired using a 1.5T MRI scanner. Surface-based morphometry from the MRI data was used to identify differences between the MA and HS group, and then between MA subgroups. The MA group was subdivided into migraineurs who experienced only visual aura (MVA) and migraineurs who had visual, somatosensory and dysphasic symptoms (MVA+). Results: The MVA+ group had significantly reduced cortical surface area of the left rostral middle frontal cortex compared with the MVA group ( Conclusion: Migraineurs with aura demonstrates different morphometric features from HS in multiple cortical regions. MVA+ have different morphometric features in the left frontal and temporal lobe relative to MVA, which could be a source of distinct symptoms and serve as potential biomarkers of different MA subtypes.

8 Article Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe. 2018

Scarpato, Elena / Kolacek, Sanja / Jojkic-Pavkov, Danijela / Konjik, Vlatka / Živković, Nataša / Roman, Enriqueta / Kostovski, Aco / Zdraveska, Nikolina / Altamimi, Eyad / Papadopoulou, Alexandra / Karagiozoglou-Lampoudi, Thomai / Shamir, Raanan / Bar Lev, Michal Rozenfeld / Koleilat, Aziz / Mneimneh, Sirin / Bruzzese, Dario / Leis, Rosaura / Staiano, Annamaria / Anonymous641599. ·Section of Paediatrics, Department of Translational Medical Sciences, University "Federico II," Naples, Italy. · Referral Centre for Paediatric Gastroenterology and Nutrition, "University Children's Hospital," Zagreb, Croatia. · Department of Paediatrics, Institute for Child and Youth Health Care of Vojvodina, Medical Faculty Novi Sad, Novi Sad, Serbia. · Department of Paediatric Gastroenterology, University Hospital Osijek, Osijek, Croatia. · Department of Paediatrics, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. · University Children Hospital, Faculty of Medicine, Skopje, Macedonia. · Pediatric Department, Jordan University of Science and Technology, Irbid, Jordan. · First Department of Paediatrics, University of Athens, Athens Children's Hospital "Agia Sophia," Athens, Greece. · Nutrition and Dietetics Department, School of Food Technology and Nutrition, Technological Education Institute, Thessaloniki, Greece. · Institute of Gastroenterology, Nutrition and Liver Diseases, Sackler Faculty of Medicine, Tel Aviv University, "Schneider Children's Medical Center of Israel," Petach Tikva, Israel. · Makassed University General Hospital, Beirut, Lebanon. · Department of Public Health, University "Federico II," Naples, Italy. · Pediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Clìnico Universitario de Santiago, Santiago de Compostela, Spain. · Section of Paediatrics, Department of Translational Medical Sciences, University "Federico II," Naples, Italy. Electronic address: staiano@unina.it. ·Clin Gastroenterol Hepatol · Pubmed #29129667.

ABSTRACT: BACKGROUND & AIMS: Little is known about the prevalence of functional gastrointestinal disorders (FGIDs) in children from the Mediterranean area of Europe. We aimed to assess the prevalence of FGIDs in children and adolescents in this region. METHODS: We collected data on 13,750 children (4-18 years old) enrolled in the Mediterranean-European Area Project, a school-based health study performed in Croatia, Greece, Israel, Italy, Jordan, Lebanon, Macedonia, Serbia, and Spain. Data were collected from March to June and in September of 2016. We analyzed data from 6602 students 4 to 10 years old (group A; mean age, 7.7 ± 1.9 y), and 7148 subjects 11 to 18 years old (group B; mean age, 13.8 ± 2.1 y). Children with FGIDs were identified based on answers to questionnaires on pediatric gastrointestinal symptoms, selected based on Rome III criteria. RESULTS: In group A, the prevalence of FGIDs was 20.7%. The most frequent disorders were functional constipation (11.7%), irritable bowel syndrome (IBS, 4%), aerophagia (3.5%), and abdominal migraine (3.1%). The prevalence of abdominal migraine was significantly higher in girls than in boys (P = .007). In group B, the overall prevalence of FGIDs was 26.6%. The most frequent disorders were functional constipation (13.1%), abdominal migraine (7.8%), aerophagia (6.3%), and IBS (5.6%). In group B, FGIDs had a higher prevalence among girls than boys (P < .001). In both groups, we found significant differences in the prevalence of specific disorders among specific countries. CONCLUSIONS: In an analysis of data on children 4 to 18 years old from the Mediterranean-European Area Project, we found FGIDs to be more frequent in girls. Functional constipation, aerophagia, abdominal migraine, and IBS are the most common disorders. However, the prevalence of FGIDs varies significantly among countries.

9 Article A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis. 2017

Kovacevic, Gordana / Stevanovic, Dejan / Bogicevic, Dragana / Nikolic, Dimitrije / Ostojic, Slavica / Tadic, Biljana Vucetic / Nikolic, Blažo / Bosiocic, Ivana / Ivancevic, Nikola / Jovanovic, Kristina / Samardzic, Janko / Jancic, Jasna. ·Mother and Child Health Institute of Serbia, R. Dakica St. 6-8, 11070, Belgrade, Serbia. · Clinic for Neurology and Psychiatry for Children and Youth Dr Subotica 6a, 11000 Belgrade, Serbia. · University Children's Hospital, Tirsova 10, 11000 Belgrade, Serbia, Faculty of Medicine, University in Belgrade, Dr Subotica 2, 11000 Belgrade, Serbia. · University Children's Hospital, Tirsova 10, 11000 Belgrade, Serbia. · Faculty of Medicine, University in Belgrade, Dr Subotica 2, 11000 Belgrade, Serbia, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Dr Subotica 1/3, 11000 Belgrade, Serbia. · Clinic for Neurology and Psychiatry for Children and Youth Dr Subotica 6a, 11000 Belgrade, Serbia, Faculty of Medicine, University in Belgrade, Dr Subotica 2, 11000 Belgrade, Serbia. ·Magnes Res · Pubmed #29637898.

ABSTRACT: Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (RCADS). PedMIDAS scores significantly decreased from baseline to end-point (F(df, df

10 Article Addenbrooke's cognitive examination test for brief cognitive assessment of adolescents suffering from migraine with aura. 2017

Petrusic, Igor / Pavlovski, Vera / Savkovic, Zorica / Vucinic, Dragana / Filipovic, Branislav / Jancic, Jasna. ·Faculty of Medicine, University of Belgrade, Belgrade, Serbia. ip7med@yahoo.com. · Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia. · Clinic of Neurology and Psychiatry for Children and Youth, Doktora Subotica 6a, 11000, Belgrade, Serbia. · Department of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · Department of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. ·Acta Neurol Belg · Pubmed #27255917.

ABSTRACT: The aim of this study was to assess the role of the Addenbrooke's cognitive examination test (ACE-R) in the evaluation of cognitive status in migraineurs interictally. A total of 44 adolescent patients and 44 healthy controls, matched by age and gender, have undergone ACE-R testing. Migraineurs were additionally questioned about migraine aura features and presence of higher cortical dysfunctions (HCD) during an aura. According to the questionnaire results, patients were subsequently divided into HCD and Non-HCD group. ACE-R scores of migraine patients were significantly lower than in healthy controls (93.68 ± 3.64 vs 96.91 ± 2.49; t = 4.852, p < 0.001). Also, subscores of memory and verbal fluency were significantly higher in the control population. There was no correlation of HCD occurrence with cognitive examination score, although Non-HCD subgroup achieved better score (93.13 ± 3.91 vs 94.29 ± 3.30; t = 1.053, p = 0.298). Findings have shown that migraineurs get lower ACE-R test scores, with a tendency to have a poorer outcome in more complex aura. Also, our study has revealed that the ACE-R test is an easily administered test for brief assessment of cognitive status in migraineurs. Future perspectives could be further evaluation of ACE-R test in larger sample size and the impact of migraine with aura on cognitive function in adolescents.

11 Article Pattern-Reversal Visual Evoked Potential Parameters and Migraine in the Teenage Population. 2016

Jancic, Jasna / Petrusic, Igor / Pavlovski, Vera / Savkovic, Zorica / Vucinic, Dragana / Martinovic, Zarko. ·Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · Faculty of Medicine, University of Belgrade, Belgrade, Serbia Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia ip7med@yahoo.com. · Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · Faculty of Special education and rehabilitation, University of Belgrade, Belgrade, Serbia. · Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia. ·J Child Neurol · Pubmed #26542983.

ABSTRACT: Although migraine represents one of the most common form of primary headache in the teenage population, most neurophysiologic studies are only on the adulthood. We investigated 38 teenage patients with migraine with aura, 17 male and 21 female, with a mean age of 16.2 years, comparing them with gender- and age-matched patients with migraine without aura and healthy subjects. Also, characteristics of aura were correlated with pattern-reversal visual evoked potential parameters. There was a significant difference in left and right eye N2 wave latencies between migraine with aura and migraine without aura patients or healthy controls. In migraine with aura and migraine without aura, 26.3% of patients had abnormal wave latency. Reported tunnel vision during the aura was correlated with lower N1P1 and/or P1N2 wave amplitudes. Also, higher amplitude in patients with migraine with aura correlated with younger age and earlier disease onset, whereas longer aura duration correlated with prolonged wave latency. Findings suggest that migraine subtypes may be differentiated on the basis of N2 wave latency prolongation.

12 Article Do interictal microembolic signals play a role in higher cortical dysfunction during migraine aura? 2016

Petrusic, I / Podgorac, A / Zidverc-Trajkovic, J / Radojicic, A / Jovanovic, Z / Sternic, N. ·Faculty of Medicine, University of Belgrade, Serbia Department of Physiology, Faculty of Pharmacy, University of Belgrade, Serbia. · Faculty of Medicine, University of Belgrade, Serbia Institute of Mental Health, Serbia. · Faculty of Medicine, University of Belgrade, Serbia Neurology Clinic, Clinical Center of Serbia, Serbia jzidverc@gmail.com. · Faculty of Medicine, University of Belgrade, Serbia Neurology Clinic, Clinical Center of Serbia, Serbia. ·Cephalalgia · Pubmed #26419790.

ABSTRACT: INTRODUCTION: The aim of this study was to evaluate the prevalence and clinical impact of interictal microembolic signals (MES) in patients suffering from migraine with higher cortical dysfunction (HCD), such as language and memory impairment, during an aura. PATIENTS AND METHODS: This study was carried out on 34 migraineurs with language and memory impairment during aura (HCD group), 31 migraineurs with only visual or visual and somatosensory symptoms during aura (Control group I), and 34 healthy controls (Control group II). We used a Doppler instrument to detect microemboli. Demographic data, disease features and the detection of MES between these groups, as well as the predictors of HCD during the aura, were analyzed. RESULTS: The duration of aura was longer and the frequency of aura was higher among patients with language and memory impairment during aura compared to Control group I. MES was detected in 29.4% patients from the HCD group, which was significantly higher compared to 3.2% in Control group I and 5.9% in Control group II. Regarding the absence or presence of MES, demographic and aura features were not different in the HCD subgroups. A longer duration of aura, the presence of somatosensory symptoms during the aura and the presence of interictal MES were independent predictors of HCD during the aura. CONCLUSION: The present findings indicate that HCD and MES are related in patients with migraine with aura. Further research is needed to better understand the exact pathophysiological mechanism.

13 Article CAPOS syndrome and hemiplegic migraine in a novel pedigree with the specific ATP1A3 mutation. 2015

Potic, Ana / Nmezi, Bruce / Padiath, Quasar S. ·Department of Neurology, Clinic for Child Neurology and Psychiatry, Medical Faculty University of Belgrade, 6A Dr. Subotica Street, Belgrade 11000, Serbia. Electronic address: a.potic@yahoo.com. · Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA. Electronic address: bcn6@pitt.edu. · Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA. Electronic address: qpadiath@pitt.edu. ·J Neurol Sci · Pubmed #26453127.

ABSTRACT: OBJECTIVE: Identification and characterization of a novel pedigree with ATP1A3 mutations presenting with CAPOS syndrome and hemiplegic migraine. METHODS: We have carried out clinical examinations of a three-generation pedigree with CAPOS syndrome and analyzed the ATP1A3 gene to identify causative mutations. The pedigree is of Slavic origin from Southeastern Europe. RESULTS: The clinical phenotype comprised cerebellar ataxia, areflexia, optic atrophy, and sensorineural hearing loss. Pes cavus was present in two of the four patients studied. The symptoms were triggered by fever and varied in severity in family members, exhibiting a chronic progressive course with or without relapses/remissions. The ATP1A3 c.2452G>A mutation was identified in the affected members of the family, while one of the mutation carriers exhibited both CAPOS and hemiplegic migraine. CONCLUSIONS: This study confirms that the specific c.2452G>A mutation in the ATP1A3 gene is associated with the CAPOS syndrome in pedigrees of different ethnic backgrounds. In patients with febrile episodes of ataxic encephalopathy or weakness, or both, genetic analysis of the ATP1A3 gene should be warranted. This is also the first report showing the co-occurrence of hemiplegic migraine and CAPOS syndrome in a patient with ATP1A3 mutations. Migraine has not been previously documented in ATP1A3 mutation carriers.

14 Article Features of migraine aura in teenagers. 2014

Petrusic, Igor / Pavlovski, Vera / Vucinic, Dragana / Jancic, Jasna. ·Faculty of Medicine, University of Belgrade, Doktora Subotica 8, 11000 Belgrade, Serbia. ip7med@yahoo.com. ·J Headache Pain · Pubmed #25496701.

ABSTRACT: BACKGROUND: Complex migraine aura in teenagers can be complicated to diagnose. The aim of this study was to present detailed features of migraine aura in teenage migraineurs. METHODS: This cross-sectional study was conducted in the period from 2008 till 2013. A total number of 40 teenage migraineurs (20 females and 20 males) met criteria for this study. The patients were interviewed using a specially designed questionnaire for collecting data about migraine aura features. Main outcome measures were frequency of visual, somatosensory and higher cortical dysfunction (HCD) symptoms in teenage migraineurs population during the aura, and also within each individual. RESULTS: Visual aura was reported in every attack, followed by somatosensory (60%) and dysphasic (36.4%) aura. Scintillating scotoma and blurry vision were mostly reported and predominant visual symptoms. The most common somatosensory symptom was numbness in hand. HCD were reported by 22 (55%) patients. Slowed speech was mostly reported symptom of HCD, followed by dyslexia, déjà vu phenomenon, color dysgnosia, and dyspraxia. In patients with HCD, aura frequency per year (6.18 ± 3.17 vs. 3.33 ± 2.03, p = 0.003) and prevalence of somatosensory symptoms (77.3% vs. 38.9%, p = 0.014) were significantly higher than in patients without HCD. CONCLUSIONS: Aura symptoms vary to a great extent in complexity in teenage migraineurs. Consequently, results obtained in this study provide useful information for clinicians when faced with unusual migraine aura.

15 Article De novo mutation in the NOTCH3 gene causing CADASIL. 2014

Stojanov, Dragan / Grozdanović, Danijela / Petrović, Sladjana / Benedeto-Stojanov, Daniela / Stefanović, Ivan / Stojanović, Nebojša / Ilić, Dušica N. ·Institute of Radiology, Faculty of Medicine, University of Niš, Bul. Dr. Zorana Djindjića 48, 18000 Niš, Serbia. · Health Center Jagodina, Karađorđeva 4, 35000 Jagodina, Serbia. · Department of Mathematics and Informatics, Faculty of Sciences, University of Niš, Višegradska 33, 18000 Niš, Serbia. ·Bosn J Basic Med Sci · Pubmed #24579972.

ABSTRACT: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common hereditary forms of stroke, and migraine with aura, mood disorders and dementia. CADASIL is caused by mutations of the NOTCH3 gene. This mutation is inherited as an autosomal dominant trait. Most individuals with CADASIL have a parent with the disorder. In extremely rare cases, CADASIL may occur due to a spontaneous genetic mutation that occurs for unknown reasons (de novo mutation). We report a new case of patient with de novo mutation of the NOTCH3 gene and a condition strongly suggestive of CADASIL (migraine, stroke, and white matter abnormalities), except that this patient did not have any first-degree relatives with similar symptoms.

16 Article A survey of female students with migraine: what is the influence of family history and lifestyle? 2014

Dzoljic, Eleonora / Vlajinac, Hristina / Sipetic, Sandra / Marinkovic, Jelena / Grbatinic, Ivan / Kostic, Vladimir. ·1Clinic of Neurology, Faculty of Medicine, University of Belgrade , Belgrade , Serbia. ·Int J Neurosci · Pubmed #23855457.

ABSTRACT: OBJECTIVES: To compare characteristics of migraine and some lifestyle habits in migraineurs with and without a positive family history for migraine. METHOD: The prevalence study was combined with a case-control study and comprised 245 female students with migraine. RESULTS: Out of 245 female students with migraine, 132 (53.9%) had a positive family history for migraine. In comparison with migraineurs who had not, those with a positive family history were younger at the onset of migraine and significantly more frequently reported menstrual migraine (p < 0.001), unilateral pain (p < 0.05) and pulsate pain (p < 0.05) as well as severe headache (p < 0.01). In comparison to migraineurs with a positive family history for migraine, those who did not report a significantly higher frequency of average number of meals per day of <3 (p < 0.001), missed meals (p < 0.05) and an average sleep duration of ≤ 6 h (p < 0.05). CONCLUSIONS: The results of the present study are in line with literature showing a high frequency of positive family history for migraine among migraineurs. They also suggest that subjects with a positive family history have a lower "migrainous threshold" for the development of migraine and that environmental factors are more important for the occurrence of migraine in subjects without a positive family history. Accordingly, the conclusions of this study are limited to reproductive aged women.

17 Article Isolated inflammatory arthritis of the atlantooccipital joint confused with migraine. 2013

Kozić, Duško / Bjelan, Mladen / Njagulj, Vesna / Lučić, Miloš / Semnic, Marija / Cupara, Snežana. ·Associate Professor, Oncology Institute of Vojvodina, Diagnostic Imaging Center, Sremska Kamenica; and University of Novi Sad, School of Medicine, Novi Sad, Serbia; ·J Rheumatol · Pubmed #24293620.

ABSTRACT: -- No abstract --

18 Article Migraine-like accompanying features in patients with cluster headache. How important are they? 2013

Zidverc-Trajkovic, Jasna / Podgorac, Ana / Radojicic, Aleksandra / Sternic, Nadezda. ·School of Medicine, University of Belgrade, Belgrade, Serbia; Headache Center, Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia. ·Headache · Pubmed #23534887.

ABSTRACT: BACKGROUND: According to the International Classification of Headache Disorders diagnostic criteria, the differences between migraine and cluster headache (CH) are clear. In addition to headache attack duration and pain characteristics, the symptoms accompanying headache represent the key features in a differential diagnosis of these 2 primary headache disorders. Just a few studies of patients with CH exist examining the presence of nausea, vomiting, photophobia, phonophobia, and aura, the features commonly accompanying migraine headache. The aim of this study was to determine the presence of migraine-like features (MF) in patients with CH and establish the significance of these phenomena related to other clinical features and response to treatment. METHODS: One hundred and fifty-five patients with CH were studied, and 24.5% of them experienced at least one of MF during every CH attack. Nausea and vomiting were the most frequently reported MF. The clinical presentation between CH patients with and without MF was not significantly different with the exception of aggravation of pain by effort (20.6% vs 4.1%) and facial sweating (13.2% vs 0.85%), both more frequent in CH patients with MF. CONCLUSION: Inferred from the results of our study, the presence of MF in CH patients had no important influence on the diagnosis and treatment of CH patients. The major differences of these 2 primary headache disorders, attack duration, lateralization, and the nature of associated symptoms, as delineated in the International Classification of Headache Disorders, are still useful tools for effective diagnosis.

19 Article Underestimated phenomena: higher cortical dysfunctions during migraine aura. 2013

Petrusic, Igor / Zidverc-Trajkovic, Jasna / Podgorac, Ana / Sternic, Nadezda. ·Clinic of Neurology, Clinical Center of Serbia, Serbia. ·Cephalalgia · Pubmed #23430982.

ABSTRACT: INTRODUCTION: Aura occurs in 20-30% of patients with migraine. Some descriptions of aura go far beyond the most frequent visual and sensory symptoms, suggesting the involvement of different cortical areas. The aim of this prospective study was to evaluate the frequency and types of disorders of higher cortical functions (HCF) that occur during visual and/or sensory aura. METHODS: We interviewed 60 patients with visual and/or sensory aura about HCF disorders of praxia, gnosia, memory, and speech, during aura. Patients were divided into two groups, with and without HCF disorders, and were compared in terms of demographic data and aura characteristics. RESULTS: From all 60 patients, 65% reported at least one HCF disorder during aura. The patients with HCF disorders had longer-lasting auras (28.51 ± 16.39 vs. 19.76 ± 11.23, P  = 0.016). The most common HCF disorders were motor dysphasia (82.05%) and dysnomia (30.74%). Motor dysphasia was more often reported by patients with visual as well as sensory aura ( P  = 0.002). The number of HCF disorders correlated with the aura duration ( P  = 0.003). CONCLUSION: According to our results, HCF disorders during aura occur more often than previously thought. The aura duration has some influence on the HCF disorders.

20 Article Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study. 2013

Stojanovich, Ljudmila / Kontic, Milica / Djokovic, Aleksandra / Marisavljevic, Dragomir / Ilijevski, Nenad / Stanisavljevic, Natasa / Mikovic, Zeljko / Petkovic, Milena / Kovcin, Vladimir. ·Bezanijska Kosa University Medical Centre, Belgrade, Serbia. ljudmila_stojanovich@yahoo.com ·Clin Exp Rheumatol · Pubmed #23306109.

ABSTRACT: OBJECTIVES: The aim of this study was to investigate the importance of aPL type and level for non-criteria-related events in APS patients. METHODS: Our study included 374 patients: 260 with PAPS and 114 with APS associated with systemic lupus erythematosus (SLE). RESULTS: We discovered significant connection between migraine and LA absence, livedo reticularis and aCL-IgG, skin ulcerations with aCL-IgG and anti-β2GPI-IgM, pseudovasculitis lesions with aCL-IgG, aCL-IgM and anti-β2GPI-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG and anti-β2GPI-IgG. Thrombocytopenia occurred more frequently in patients with more than one aPL. In PAPS, epilepsy correlated with ß2GPI-IgM, migraine with aCL-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG, anti ß2GPI-IgG and LA. Skin ulcerations occurred more frequently in IIc category patients and in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Livedo reticularis was more prominent in PAPS with high levels of aCL-IgG. Significantly higher prevalence of thrombocytopenia was observed in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Epilepsy was related to high levels of anti ß2GPI-IgM and thrombocytopenia in the SAPS was correlated with aCL-IgG. Skin ulcerations were more prevalent in aCL-IgM positive SAPS patients and epilepsy more frequently in SAPS patients with high levels of anti ß2GPI-IgG. CONCLUSIONS: Our study showed that certain aPL type with certain level correlated with non-criteria manifestations, suggesting their predictive role.

21 Article Risk of the recurrent headache and migraine appearance within the family. 2011

Knezevic-Pogancev, Marija / Filipović, Danka / Ivetić, Vesna / Mikov, Aleksandra / Katanić, Dragan. ·Department for Epileptology and Developmental Neurology, Child and Youth Health Care Institute of Vojvodina, Novi Sad, Serbia. godipo@eunet.rs ·Med Glas (Zenica) · Pubmed #21849942.

ABSTRACT: AIM: The aim of this research was to determine the risk for family appearance of the recurrent headache (non-migraine and migraine). METHODS: The research was conducted in Vojvodina, the Northern Province of Serbia. The population of Vojvodina is around 2 million people belonging to more than 20 different ethnic groups. During the 20-year period (1988-2008), 30,363 children aged 3 to 17 years were tested, independent of their place of birth. The presence of headaches similar to those tested was compared among all the members of the family within three generations. RESULTS: Positive family data of the recurrent headaches were detected among 98.6% children with migraine headaches, 64.7% children with non-migraine headaches, and 32.4% children without recurrent headaches. The relation among the members of the nuclear family (contingency quotient of 0.429) was significantly stronger than the relation to the members of wider family (contingency quotient of 0.338). CONCLUSIONS: The probability of a child having the migraine headache rather than the non-migraine one was very high for parents and high for father's mother, while it was not significant for mother's mother, mother's father and father's father, having similar recurrent headaches.

22 Article Comorbidities in cluster headache and migraine. 2011

Zidverc-Trajkovic, Jasna J / Pekmezovic, Tatjana D / Sundic, Ana L / Radojicic, Aleksandra P / Sternic, Nadezda M. ·Headache Center, Institute of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. jzidverc@gmail.com ·Acta Neurol Belg · Pubmed #21510234.

ABSTRACT: The aim of this study was to investigate the most frequent comorbid diseases occurring in patients with cluster headache (CH) and, for comparison, in migraine patients. Over a period of eight years 130 patients with CH and 982 patients with migraine were diagnosed according to ICHD-II criteria. In all patients the presence and type of different diseases were assessed from medical records and coded by the ICD, X revision. Odds ratios (OR) with corresponding 95% confidence intervals (95% CI) were calculated by logistic regression analyses. Comorbid disorders were present in 56.9% patients with CH and in 56.7% migraine patients. Chronic sinusitis (p = 0.001), malignancy (p = 0.012), diabetes mellitus (p = 0.021), glaucoma (p = 0.038), as well as another primary headache disorders were more frequently present in patients with cluster headache (p = 0.001), than in migraine patients. In the multivariate analysis, chronic sinusitis (OR = 7.6, p = 0.001) and diabetes mellitus (OR = 4.2, p = 0.035), adjusted by gender, age and duration of headache, are more frequently associated with CH than with migraine. Comorbid disorders in CH patients were frequent and similar to those noticed in migraine patients, except chronic sinusitis and diabetes mellitus.

23 Article Perimenstrual headache: migraine without aura or premenstrual syndrome symptom? 2010

Sundić, Ana / Zidverc-Trajković, Jasna / Vujović, Svetlana / Sternić, Nadezda. ·Clinical Center of Serbia, Institute for Neurology, Headache Center, Belgrade, Serbia. anasundic@yahoo.com ·Vojnosanit Pregl · Pubmed #21417101.

ABSTRACT: BACKGROUND/AIM: Definition of menstrual migraine as a specific clinical entity or, maybe, migraine headache with menstrually related occurring, still remains unresolved question. The aim of this study was to investigate if perimenstrual headache in our patients fulfills diagnostic the International Classification of Headache Disorders (ICHD) criteria for migraine without aura or represents a different type of headache which is the symptom of premenstrual syndrome (PMS). METHODS: The study included 50 women with headache in perimenstrual period in at least two out of three menstrual cycles, during the last year or longer. Two questionnaires, a questionnaire for headache and a questionnaire for PMS, were used. RESULTS: The majority of all the examined women, 29 of them, had migraine and PMS and 9 women had migraine without PMS. Headache in 38 (76.0%) patients fulfilled diagnostic criteria for menstrual migraine, (26 and 12 women had pure menstrual migraine and menstrually related migraine respectively). Intensity of PMS was not different in a groups of women with different types of headache (p = 0.184): a total number of PMS symptoms was 8.2 +/- 4.6 in the group with pure menstrual migraine, 10.8 +/- 3.9 in the group with menstrually related migraine and 10.8 +/- 6.3 in the group with non-migraine headache. CONCLUSION: This study shows that headache, occurring in perimenstrual period, is not always migraine, but could fulfill criteria for tension-type headache, as well. Specific characteristics of perimenstrual headache, which could distinguish it as a symptom of PMS, were not found. Expected relation in time of headache onset and menarche was not confirmed.

24 Article Migraine in children-migraine syndrome in children of Vojvodina. 2010

Knezevic-Pogancev, Marija / Jovic, N / Katanic, D / Mikov, A / Stojadinovic, ?. ·Institute of Child and Youth Health Care of Vojvodina, Department for Neurology and Epileptology, Hajduk Veljkova 10, 21000, Novi Sad, Serbia. godipo@eunet.rs ·Med Arh · Pubmed #21218753.

ABSTRACT: To assess the incidence of children with various types of migraine, an investigation was carried out from 1988 to 2008, on 30636 children (50.38% male, 49.62% female), in nine towns of the north province of Serbia. Migraine was reported in 8.63% children aged 3 to 17 (8.0% male, 9.6% female) as well as in 3.87% children aged 3-7 (4.2% boys, 3.57% girls). The proportion of children with either migraine or non-migraine headaches increased with their age, from 2.65% to 11.72% in boys, and from 2.71% to 15.86% in girls. Such increasing trend was also found for migraine with aura (from 1.8% to 32.7%). Children with migraine with aura showed their pick at the age of 9, while other migraine syndromes had the most frequent appearance at the age of 5 years. Migraine with aura accounted for 25.55%, migraine without aura for 67.21% and other migraine syndromes for 7.23% of investigated subjects with migraine. The average age of the migraine diagnosis was 5 years 1.8 months, while it was 4 years 11.4 months for migraine with aura, 5 years 7.2 months for migraine without aura and 3 years 7.2 months for other migraine syndromes. Migraine is much more frequent in second born children and in these from incomplete families. Migraine with aura appeared mostly in children coming from family with median socioeconomic welfare, while poor family welfare was predominant in children with migraine without aura. The length of breast-feeding influenced the appearance of the migraine in general, showing reciprocal influence of the length of breast-feeding on the appearance of migraine. Migraine was more often found (39.4%) among children who earlier joined nursery schools on a whole-day stay basis. Children with migraine have been diagnosed and treated by neuropaediatricians or neurologists in 55.4% cases (70.0% migraine with aura, 42.7% migraine without aura and 92.4% children with other migraine syndromes).

25 Minor Authors' Response to the Comments on "Pattern-Reversal Visual Evoked Potential Parameters and Migraine in the Teenage Population". 2017

Jancic, Jasna / Petrusic, Igor / Pavlovski, Vera / Savkovic, Zorica / Vucinic, Dragana / Martinovic, Zarko. ·1 Clinic of Neurology and Psychiatry for Children and Youth, Belgrade, Serbia. · 2 Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · 3 Faculty of Pharmacy, Department of Physiology, University of Belgrade, Belgrade, Serbia. · 4 Faculty of Special education and rehabilitation, University of Belgrade, Belgrade, Serbia. ·J Child Neurol · Pubmed #27885105.

ABSTRACT: -- No abstract --

Next