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Migraine Disorders: HELP
Articles from Madrid
Based on 127 articles published since 2009
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These are the 127 published articles about Migraine Disorders that originated from Madrid during 2009-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6
1 Review [«Apuntes en Neurologia» (Notes in Neurology): a synthesis of the evidence on common paroxysmal neurological disorders and on neurodegenerative disorders]. 2018

Toledo, M / Carnero-Pardo, C / Carreno-Martinez, M / Escudero-Torrella, J / Gaig, C / Garcia-Ribas, G / Gil-Nagel, A / Grandas, F J / Kulisevsky, J / Lainez-Andres, J M / Pareja, J A / Porta-Etessam, J / Poza-Aldea, J J / Rodriguez-Oroz, M C / Serratosa, J M / Villanueva, V. ·Hospitals Vall d'Hebron, 08035 Barcelona, Espana. · Hospital Universitario Virgen de las Nieves, 18013 Granada, Espana. · Hospital Clinic de Barcelona, 08036 Barcelona, Espana. · Hospital General Universitario de Valencia, 46014 Valencia, Espana. · Hospital Universitario Ramon y Cajal, 28034 Madrid, Espana. · Hospital Ruber Internacional, 28034 Madrid, Espana. · Hospital General Universitario Gregorio Maranon, Madrid, Espana. · Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Espana. · Hospital Clinico Universitario de Valencia, 46010 Valencia, Espana. · Hospital Universitario Fundacion Alcorcon, 28922 Alcorcon, Espana. · Hospital Clinico San Carlos, 28040 Madrid, Espana. · Hospital de Donostia, San Sebastian, Espana. · Clinica Universidad de Navarra, Pamplona, Espana. · CIBERNED. Centro de Investigacion Biomedica en Red Enfermedades Neurodegenerativas, Madrid, Espana. · Ikerbasque, Fundacion Vasca para la Ciencia, Bilbao, Espana. · Centro Vasco de Cognicion, Cerebro y Lenguaje, San Sebastian, Espana. · Fundacion Jimenez Diaz, 28040 Madrid, Espana. · Hospital La Fe, 46009 Valencia, Espana. ·Rev Neurol · Pubmed #30484273.

ABSTRACT: «Apuntes en Neurologia» is an initiative in which prominent national and international leaders, with broad academic recognition, came together to synthesise the most outstanding clinical aspects within their area of interest and to discuss the latest developments in a more accessible language. Understanding the factors that affect the onset and progression of any neurological disease through a review is important to be able to develop strategies to reduce the burden of these diseases. Moreover, knowledge of the clinical aspects is essential to solve the problems of daily clinical practice. The data collected here reflect the weight of evidence and some of them anticipate a promising future in the treatment of these diseases. This first edition focuses on common paroxysmal neurological disorders such as migraine, epilepsy and sleep disorders, as well as neurodegenerative disorders such as Parkinson's disease and cognitive impairment. These are clearly different pathologies, although some of them such as migraine and epilepsy, may share clinical symptoms. Sleep disorders, however, are important manifestations of neurodegenerative diseases that are sometimes clinically apparent long before the onset of other neurological symptoms. After recalling pathophysiology and diagnosis, the current review focuses on bringing together the main advances in five of the major neurological diseases.

2 Review Sleep disturbances in tension-type headache and migraine. 2018

Fernández-de-Las-Peñas, César / Fernández-Muñoz, Juan J / Palacios-Ceña, María / Parás-Bravo, Paula / Cigarán-Méndez, Margarita / Navarro-Pardo, Esperanza. ·Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas s/n, 28922 Alcorcón, Madrid, Spain. · Department of Psychology, Universidad Rey Juan Carlos, Alcorcón, Spain. · Department of Physical Therapy, Occupational Therapy, Rehabilitation, and Physical Medicine, University Rey Juan Carlos, Alcorcón, Spain. · Department of Nursing, Universidad de Cantabria, Santander, Spain. · Department of Psicología Evolutiva y de la Educación, Universitat Valencia, Spain. ·Ther Adv Neurol Disord · Pubmed #29399051.

ABSTRACT: Current research into the pathogenesis of tension-type headache (TTH) and migraine is focused on altered nociceptive pain processing. Among the potential factors that influence sensitization mechanisms, emotional stress, depression, or sleep disorders all have an essential role: they increase the excitability of nociceptive firing and trigger hyperalgesic responses. Sleep disturbances and headache disorders share common brain structures and pathogenic mechanisms and TTH, migraine, and sleep disturbances often occur together; for example, 50% of individuals who have either TTH or migraine have insomnia. Moreover, insomnia and poor sleep quality have been associated with a higher frequency and intensity of headache attacks, supporting the notion that severity and prevalence of sleep problems correlate with headache burden. It should be noted that the association between headaches and sleep problems is bidirectional: headache can promote sleep disturbances, and sleep disturbances can also precede or trigger a headache attack. Therefore, a better understanding of the factors that affect sleep quality in TTH and migraine can assist clinicians in determining better and adequate therapeutic programs. In this review, the role of sleep disturbances in headaches, and the association with depression, emotional stress, and pain sensitivity in individuals with TTH or migraine are discussed.

3 Review Fragile X syndrome: An overview and update of the FMR1 gene. 2018

Mila, M / Alvarez-Mora, M I / Madrigal, I / Rodriguez-Revenga, L. ·Biochemistry and Molecular Genetics Department, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. · Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. ·Clin Genet · Pubmed #28617938.

ABSTRACT: Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability and the leading form of the monogenic cause of autism. Fragile X mental retardation type 1 (FMR1) gene premutation is the first single-gene cause of primary ovarian failure (Fragile X-associated primary ovarian insufficiency [FXPOI]) and one of the most common causes of ataxia (fragile X-associated tremor/ataxia syndrome [FXTAS]), multiple additional phenotypes such as fibromyalgia, hypothyroidism, migraine headaches, sleep disturbances, sleep apnea, restless legs syndrome, central pain syndrome, neuropathy and neuropsychiatric alterations has been described. Clinical involvement in men and women carrying the FMR1 premutation currently constitutes a real health problem in the society that should be taken into account. It is important to highlight that while in FXS there is a loss-of-function of the FMR1 gene, in premutation associated disorders there is a gain of FMR1 mRNA function. To date, the tremendous progress achieved in the understanding of the pathophysiology of FXS, has led to the development of several targeted therapies aimed at preventing or improving the neurological manifestations of the disease. This review is an update of the diseases associated with the FMR1 gene.

4 Review Consensus recommendations for anaesthetic peripheral nerve block. 2017

Santos Lasaosa, S / Cuadrado Pérez, M L / Guerrero Peral, A L / Huerta Villanueva, M / Porta-Etessam, J / Pozo-Rosich, P / Pareja, J A. ·Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address: ssantos@salud.aragon.es. · Servicio de Neurología, Hospital Clínico San Carlos, Departamento de Medicina, Universidad Complutense de Madrid, Madrid, España. · Servicio de Neurología, Hospital Clínico Universitario de Valladolid, Valladolid, España. · Sección de Neurología, Hospital de Viladecans, Viladecans, Barcelona, España. · Unidad de Cefalea, Servicio de Neurología, Hospital Universitari Vall d'Hebron, Barcelona. Grupo de Investigación en Cefalea, VHIR, Universitat Autònoma de Barcelona, Barcelona, España. · Servicio de Neurología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España. ·Neurologia · Pubmed #27342391.

ABSTRACT: INTRODUCTION: Anaesthetic block, alone or in combination with other treatments, represents a therapeutic resource for treating different types of headaches. However, there is significant heterogeneity in patterns of use among different professionals. DEVELOPMENT: This consensus document has been drafted after a thorough review and analysis of the existing literature and our own clinical experience. The aim of this document is to serve as guidelines for professionals applying anaesthetic blocks. Recommendations are based on the levels of evidence of published studies on migraine, trigeminal autonomic cephalalgias, cervicogenic headache, and pericranial neuralgias. We describe the main technical and formal considerations of the different procedures, the potential adverse reactions, and the recommended approach. CONCLUSION: Anaesthetic block in patients with headache should always be individualised and based on a thorough medical history, a complete neurological examination, and expert technical execution.

5 Review Histamine and Immune Biomarkers in CNS Disorders. 2016

Cacabelos, Ramón / Torrellas, Clara / Fernández-Novoa, Lucía / López-Muñoz, Francisco. ·Chair of Genomic Medicine, Camilo José Cela University, C/Castillo de Alarcón 49, Villanueva de la Cañada, 28692 Madrid, Spain; EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine, Santa Marta de Babio, Bergondo, 15165 Corunna, Spain. · EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine, Santa Marta de Babio, Bergondo, 15165 Corunna, Spain. · Chair of Genomic Medicine, Camilo José Cela University, C/Castillo de Alarcón 49, Villanueva de la Cañada, 28692 Madrid, Spain; Neuropsychopharmacology Unit, Hospital 12 de Octubre Research Institute (i+12), Avenida de Córdoba, s/n, 28041 Madrid, Spain. ·Mediators Inflamm · Pubmed #27190492.

ABSTRACT: Neuroimmune dysregulation is a common phenomenon in different forms of central nervous system (CNS) disorders. Cross-links between central and peripheral immune mechanisms appear to be disrupted as reflected by a series of immune markers (CD3, CD4, CD7, HLA-DR, CD25, CD28, and CD56) which show variability in brain disorders such as anxiety, depression, psychosis, stroke, Alzheimer's disease, Parkinson's disease, attention-deficit hyperactivity disorder, migraine, epilepsy, vascular dementia, mental retardation, cerebrovascular encephalopathy, multiple sclerosis, brain tumors, cranial nerve neuropathies, mental retardation, and posttraumatic brain injury. Histamine (HA) is a pleiotropic monoamine involved in several neurophysiological functions, neuroimmune regulation, and CNS pathogenesis. Changes in brain HA show an age- and sex-related pattern, and alterations in brain HA levels are present in different CNS regions of patients with Alzheimer's disease (AD). Brain HA in neuronal and nonneuronal compartments plays a dual role (neurotrophic versus neurotoxic) in a tissue-specific manner. Pathogenic mechanisms associated with neuroimmune dysregulation in AD involve HA, interleukin-1β, and TNF-α, whose aberrant expression contributes to neuroinflammation as an aggravating factor for neurodegeneration and premature neuronal death.

6 Review Physical therapy for headaches. 2016

Fernández-de-Las-Peñas, César / Cuadrado, María L. ·1 Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain. · 2 Grupo Excelencia Investigadora URJC-Banco Santander referencia N° 30VCPIGI03: Investigación traslacional en el proceso de salud - enfermedad (ITPSE). · 3 Cátedra de Investigación y Docencia en Fisioterapia: Terapia Manual y Punción Seca, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain. · 4 Headache Unit, Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain. · 5 Department of Medicine, Universidad Complutense, Madrid, Spain. ·Cephalalgia · Pubmed #26660851.

ABSTRACT: Background Headache is the medical problem most commonly observed by neurologists. Non-pharmacological treatments are commonly demanded by individuals with headaches, but their evidence of effectiveness is conflicting. Aim The current review provides an updated discussion on what is supported by current scientific evidence about physical therapies for tension-type headache (TTH), migraine, and cervicogenic headache (CeH), and which gaps there still may be in our understanding of the interventions. Methods PubMed, MEDLINE, EMBASE, AMED, CINAHL, EBSCO, Cochrane Database of Systematic Reviews, Cochrane Collaboration Trials Register, PEDro, and SCOPUS were searched from their inception through March 2015. Results/Discussion Several physical therapies including spinal joint manipulation/mobilization, soft tissue interventions, therapeutic exercises and needling therapies are proposed to be effective for the management of headaches. Current evidence has shown that the effectiveness of these interventions will depend on proper clinical reasoning since not all interventions are equally effective for all headache pain conditions. For instance, evidence of physical therapy in migraine is more controversial than in TTH, since migraine pathogenesis involves activation of sub-cortical structures and the trigemino-vascular system, whereas pathogenesis of TTH is more associated with musculoskeletal disorders, e.g. muscle pain. It seems that multimodal approaches including different interventions are more effective for patients with TTH, migraine and CeH.

7 Review Understanding the Impact of Brain Disorders: Towards a 'Horizontal Epidemiology' of Psychosocial Difficulties and Their Determinants. 2015

Cieza, Alarcos / Anczewska, Marta / Ayuso-Mateos, Jose Luis / Baker, Mary / Bickenbach, Jerome / Chatterji, Somnath / Hartley, Sally / Leonardi, Matilde / Pitkänen, Tuuli / Anonymous600842. ·Faculty of Social and Human Sciences, School of Psychology, University of Southampton, Southampton, United Kingdom; Department of Medical Informatics, Biometry and Epidemiology (IBE), Chair for Public Health and Health Services Research, Research Unit for Biopsychosocial Health, Ludwig-Maximilians-University (LMU), Munich, Germany; Swiss Paraplegic Research, Nottwil, Switzerland. · Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland. · Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Psychiatry, Universidad Autónoma de Madrid, Psychiatry Service, Instituto de Investigación del Hospital Universitario de La Princesa (IIS-IP), Madrid, Spain. · European Brain Council, Brussels, Belgium. · Swiss Paraplegic Research, Nottwil, Switzerland. · Multi-Country Studies, Department of Measurement and Health Information Systems, World Health Organization, Geneva, Switzerland. · Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom; Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia; The London School of Hygiene and Tropical Medicine, London, United Kingdom. · Neurology, Public Health and Disability Unit, Scientific Directorate, Neurological Institute Carlo Besta IRCCS Foundation, Milan, Italy. · A-Clinic Foundation, Helsinki, Finland. ·PLoS One · Pubmed #26352911.

ABSTRACT: OBJECTIVE: To test the hypothesis of 'horizontal epidemiology', i.e. that psychosocial difficulties (PSDs), such as sleep disturbances, emotional instability and difficulties in personal interactions, and their environmental determinants are experienced in common across neurological and psychiatric disorders, together called brain disorders. STUDY DESIGN: A multi-method study involving systematic literature reviews, content analysis of patient-reported outcomes and outcome instruments, clinical input and a qualitative study was carried out to generate a pool of PSD and environmental determinants relevant for nine different brain disorders, namely epilepsy, migraine, multiple sclerosis, Parkinson's disease, stroke, dementia, depression, schizophrenia and substance dependency. Information from these sources was harmonized and compiled, and after feedback from external experts, a data collection protocol including PSD and determinants common across these nine disorders was developed. This protocol was implemented as an interview in a cross-sectional study including a convenience sample of persons with one of the nine brain disorders. PSDs endorsed by at least 25% of patients with a brain disorder were considered associated with the disorder. PSD were considered common across disorders if associated to 5 out of the 9 brain disorders and if among the 5 both neurological and psychiatric conditions were represented. SETTING: The data collection protocol with 64 PSDs and 20 determinants was used to collect data from a convenience sample of 722 persons in four specialized health care facilities in Europe. RESULTS: 57 of the PSDs and 16 of the determinants included in the protocol were found to be experienced across brain disorders. CONCLUSION: This is the first evidence that supports the hypothesis of horizontal epidemiology in brain disorders. This result challenges the brain disorder-specific or vertical approach in which clinical and epidemiological research about psychosocial difficulties experienced in daily life is commonly carried in neurology and psychiatry and the way in which the corresponding health care delivery is practiced in many countries of the world.

8 Review Effectiveness of therapeutic patient education for adults with migraine. A systematic review and meta-analysis of randomized controlled trials. 2014

Kindelan-Calvo, Paula / Gil-Martínez, Alfonso / Paris-Alemany, Alba / Pardo-Montero, Joaquín / Muñoz-García, Daniel / Angulo-Díaz-Parreño, Santiago / La Touche, Roy. ·Department of Physiotherapy, Faculty of Health Science, The Center for Advanced Studies University La Salle, Universidad Autónoma de Madrid, Madrid, Spain; Research Group on Movement and Behavioral Science and Study of Pain, The Center for Advanced Studies University La Salle, Universidad Autónoma de Madrid, Madrid, Spain. ·Pain Med · Pubmed #25159212.

ABSTRACT: OBJECTIVE: Our aim was to systematically review and meta-analyze the effectiveness of therapeutic patient education for migraine. METHODS: A literature search of multiple electronic databases (MEDLINE, EMBASE, PEDro, CINAHL, and PsychINFO) was conducted to identify randomized control trials (RCTs) published in the English and Spanish languages up to and including May 2013. Two reviewers independently selected the studies, conducted the quality assessment (Delphi list), and extracted the results. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method was used throughout the systematic review and meta-analysis. Standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated for relevant outcome measures (headache frequency, headache disability, self-efficacy, depressive symptoms, and quality of life) and pooled in a meta-analysis using the random effects model. RESULTS: Fourteen RCTs were included in the systematic review. Only nine studies were included in the meta-analysis. The median quality score was 6.14 ± 1.29 (range: 5-9). There was strong-moderate evidence for intermediate-term effectiveness of therapeutic patient education on headache frequency (five studies: N = 940, SMD = -0.24, 95% CI of -0.48 to -0.01, P = 0.03), headache disability (four studies: N = 799, SMD = -1.02, 95% CI of -1.95 to -0.08, P = 0.03), and quality of life (three studies: N = 674, SMD = 0.36, 95% CI of 0.05-0.67, P = 0.02). There was no evidence for either short-term or intermediate-term effectiveness of therapeutic patient education on self-efficacy or depressive symptoms. CONCLUSION: This systematic review revealed strong-moderate evidence for intermediate-term effectiveness of therapeutic patient education for migraine. Further high-quality RCTs are required for conclusive determination of its effectiveness.

9 Review Cortical spreading depression in traumatic brain injuries: is there a role for astrocytes? 2014

Torrente, Daniel / Cabezas, Ricardo / Avila, Marco Fidel / García-Segura, Luis Miguel / Barreto, George E / Guedes, Rubem Carlos Araújo. ·Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia. · Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain. · Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address: guedes.rca@gmail.com. ·Neurosci Lett · Pubmed #24394907.

ABSTRACT: Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.

10 Review [Migraine: ignition of the brain]. 2013

Sánchez-del-Río González, Margarita. ·Hospital Ruber Internacional, 28034 Madrid, Espana. ·Rev Neurol · Pubmed #24265145.

ABSTRACT: Although our knowledge of which systems are activated during migraine is reasonably complete, why the system is activated remains unknown. Incorporating the findings obtained in studies on pain in general has allowed a more integrated model to be generated. According to this new model, there is an anatomical substrate consisting in a complex framework of pain that is made up not only of the trigeminovascular system (end pathway) but of a number of networks that are in turn connected to one another, like the neurolimbic, the ascending and descending modulatory system. This complex network is responsible for modulating and conveying nociceptive signals. In patients with migraine, hyperexcitability of this framework is conditioned by genetic and epigenetic alterations. Epigenetic changes are chemical modifications affecting chromatin, which modulates the activity of genes without modifying the DNA sequence, and which are capable of modulating the expression of genes involved in a number of different aspects, such as plasticity, system excitability, memory of pain or moods. In turn, the presence of external factors (such as environmental changes or alcohol) and internal factors (such as hormones or sleep disorders) contribute to activate this loaded anatomical substrate, resulting in the attack of migraine.

11 Review [Therapeutic exercise as treatment for migraine and tension-type headaches: a systematic review of randomised clinical trials]. 2013

Gil-Martínez, Alfonso / Kindelan-Calvo, Paula / Agudo-Carmona, Diego / Muñoz-Plata, Rosa / López-de-Uralde-Villanueva, Ibai / La Touche, Roy. ·Centro Superior de Estudios Universitarios La Salle. Universidad Autonoma de Madrid, Madrid, Espana. ·Rev Neurol · Pubmed #24203665.

ABSTRACT: AIM. To analyse the effectiveness of therapeutic exercise on migraines and tension-type headaches (TTH). MATERIALS AND METHODS. Electronic databases were used to search the literature for relevant articles. Eligibility criteria were: controlled randomised clinical trials (RCT), conducted on patients with migraine or TTH, in which the therapeutic intervention was based on therapeutic exercise, and the papers had been published in English and Spanish. Two independent reviewers performed the analysis of the methodological quality using the Delphi scale. RESULTS. Ten RCT were selected, seven of which offered good methodological quality. According to all the studies analysed, the intensity and frequency of pain diminished in comparison to the situation prior to establishing therapeutic exercise, and in five studies the effect was higher than in the control group. The qualitative analysis showed strong evidence of the absence of adverse events following the application of therapeutic exercise. Furthermore, strong evidence was also found of the effect of physiotherapeutic treatment, including therapeutic exercise, in lowering the intensity, frequency and duration of pain in patients with TTH. Limited evidence was also found of the effectiveness of aerobic exercise in patients with migraine, although it was not better than the effects derived from other forms of treatment. CONCLUSIONS. Results show that therapeutic exercise is a safe treatment that provides beneficial effects on migraines or TTH. Further RCT are required in the future with appropriate methodological designs to confirm these results.

12 Review [Chronic migraine and work: occupational risks and prevention]. 2013

Vicente-Herrero, M T / Ramírez Iñiguez de la Torre, M V / Capdevila García, L M / López-González, Á A / Terradillos García, M J. ·Medicina del Trabajo, Grupo Correos-Valencia y Castellón, Albacete, España; Grupo de Investigación en Medicina del Trabajo (GIMT), Grupo de Neurología, Asociación Española de Especialistas en Medicina del Trabajo (AEEMT), Madrid, España. Electronic address: MTVH@ono.com. ·Semergen · Pubmed #24034760.

ABSTRACT: Chronic migraine is a clinically difficult to manage primary headache which affects the quality of life of the patients. This impact is important in the occupational world, where along with the clinical aspects of the disease, the therapies used for the control of the symptoms or preventive aspects, must be assessed. The side effects of the drugs and the limitations associated with their symptoms are aspects to highlight in occupational health, especially in individual workplaces, where there is a high risk of work-related injuries. The medical officer must assess the occupational risks of particular importance in the progression of this disease, as well as preventive actions, within the ambit of the current Spanish legislation, that may be favorable for both the company and the worker. The coordinated medical intervention and knowledge of these occupational aspects can provide clinically relevant tools, andoccupational and social optimization in the use of available resources.

13 Review Palinopsia induced by topiramate and zonisamide in a patient with migraine. 2013

Sierra-Hidalgo, Fernando / de Pablo-Fernández, Eduardo. ·Neurology Department, Hospital Universitario 12 de Octubre, Madrid, Spain. fsierra.hdoc@salud.madrid.org ·Clin Neuropharmacol · Pubmed #23503550.

ABSTRACT: Palinopsia is an illusory visual phenomenon consisting in the persistence or recurrence of visual images after the exciting stimulus object has been removed. It has been reported in association with parietal and occipital lobe lesions, migraine auras, and related to the use of several drugs and illicit drugs. Here, we report the case of a 23-year-old woman with a 4-year history of episodic migraine with aura who developed palinopsia during sequential prophylactic therapies with topiramate and zonisamide. Although the exact physiopathology of this phenomenon remains unknown, topiramate- and zonisamide-induced palinopsia support an increase on serotonergic activity as a possible mechanism for this visual disorder.

14 Review [Chronic migraine: pathophysiology]. 2012

Sánchez del Río-González, Margarita. ·Programa de Cefaleas, Servicio de Neurología, Hospital Ruber Internacional, Madrid, España. msanchezdelrio@ruberinternacional.es ·Rev Neurol · Pubmed #22532238.

ABSTRACT: Chronic migraine is considered a complication of episodic migraine. Several risk factors, which may be modifiable or non-modifiable, make varying contributions to the progression towards chronification. Every year 2.5% of patients with episodic migraine go on to suffer chronic migraine. Experimental studies point to a dysfunction in the descending pain modulatory system that would facilitate nociceptive afferents, in the absence of damage to tissues, and so chronic migraine would share a pathogenesis that is similar to that of fibromyalgia, irritable bowel syndrome or chronic tension-type headache (conditions that frequently coexist). This paper reviews the risk factors and the scientific evidence of the possible pathogenic mechanisms involved in the progression towards chronification.

15 Review [Migraine associated with conversion symptoms (Babinski's migraine): evaluation of a series of 43 cases]. 2012

García-Albea, E. ·Unidad de Cefaleas, Servicio de Neurología, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España. egarciaalbea.Hupa@Salud.Madrid.Org ·Neurologia · Pubmed #21889233.

ABSTRACT: BACKGROUND: In 1890 four cases of headache associated with visual symptoms and hysterical disorder were described by the French neurologist Babinski as migraine ophthalmique hystérique, or hysterical ophthalmic migraine. Since that time this association has seldom been described, and the possibly high frequency previously reported still remains to be established. This paper has reused Babinski's description and it tries to rehabilitate the syndrome described by the French semiologist across the relatively frequent experience of this type of patients in a public hospital. Also it analyzes the reason of the oblivion of his description. METHOD: This study presents a series of 43 cases of headache of the migraine type associated with other symptoms, most consistent with basilar-type migraine according to IHS criteria. Diagnosis of conversion disorder (hysteria) was grounded in the criteria set forth in the DSM-IV. RESULTS: All patients exhibited one or more manifestations of hysteria (conversion symptoms) during migraine attacks, and some did in the intervals between attacks as well. Details of the headaches, associated symptoms, and hysterical manifestations are discussed. Most patients improved with antimigraine medication. Altered consciousness may have contributed to the onset of hysterical symptoms. CONCLUSIONS: The basilar type migraine associated with conversion symptoms described of systematized form by Babinski, it is not a rare entity. Similar pictures have been described along the history of the medicine. The later silence possibly is due to the historical difficulty in defining accurately the conversión disorders. The Babinskís migraine is a certain well entity and must be recovered for the clinic.

16 Review Ethinylestradiol/Chlormadinone acetate: dermatological benefits. 2011

Guerra-Tapia, Aurora / Sancho Pérez, Blanca. ·Department of Dermatology, University Hospital October 12, Complutense University, Madrid, Spain. aurora@auroraguerra.com ·Am J Clin Dermatol · Pubmed #21895044.

ABSTRACT: Acne vulgaris, hirsutism, seborrhea and female pattern hair loss (FPHL) are common disorders of the pilosebaceous unit (PSU). In some women with hyperandrogenemia, an excess of androgens at the PSU can lead to the development of these dermatological manifestations. These manifestations can cause many psychiatric and psychological implications, such as social fears and anxiety, and can adversely affect quality of life. High androgen levels at the PSU as a possible underlying cause of acne vulgaris, hirsutism, seborrhea and FPHL supports the rationale for using combined oral contraceptives for the management of these conditions in women. The purpose of this review is to describe these dermatological manifestations of the PSU and the management of these conditions through the use of the oral contraceptive ethinylestradiol/chlormadinone acetate (EE/CMA). EE/CMA 0.03/2 mg is a combined monophasic contraceptive pill with anti-androgenic properties. It is approved in Europe for contraception and has been investigated in phase III trials for the treatment of acne. EE/CMA was better than placebo and similar to another low-dose oral contraceptive (ethinylestradiol/levonorgestrel) in improving symptoms of acne in two phase III randomized controlled trials in patients with mild to moderate papulopustular acne. In addition, in trials investigating the contraceptive efficacy of EE/CMA, limited data suggest that there were also improvements in hirsutism, FPHL and seborrhea in small subgroups of patients. EE/CMA has a good safety profile. The most commonly reported adverse events are breast tenderness/pain, headache/migraine and nausea. Evidence in the literature indicates that the use of EE/CMA for the treatment of dermatological disorders under the control of androgens may be a valid treatment option. Further investigation is warranted.

17 Review Neuromodulators and therapeutic targets in neuropathic pain: from molecules to man. 2009

Bermejo, P E / Anciones, B. ·Sanatorio Nuestra Señora del Rosario, Hospital Sanitas La Zarzuela, Servicio de Neurología, Madrid, Spain. pedro_bermejo@hotmail.com ·CNS Neurol Disord Drug Targets · Pubmed #19601815.

ABSTRACT: Neuropathic pain is a phenomenon characterized by a high population prevalence by possessing several etiologies. In contrast to nociceptive pain, painful signals in neuropathic pain are originated in the nervous system, present poor responses to conventional treatments and may worsen the quality of life. Antiepileptic drugs are increasingly used for different purposes including migraine, neuropathic pain, tremor or psychiatric disorders and they have started to be called neuromodulators. These drugs may act on very different targets such as sodium, potassium or calcium channels, purinergic, GABAergic, glutamatergic or vanilloid receptors and different cytokines including IL-6 or TNF, each if which may be important in managing some aspects of neuropathic pain. Antiepileptic drugs have demonstrated effectiveness in the treatment of this pathology, and owing to the important development of these drugs in the last years, they may become a very effective tool. On the other hand, the increasing knowledge of the pathophysiology of nociception is leading to new channels and receptors as potential targets for treatment. In this paper we try to review the different potential therapeutic targets and role of antiepileptic drugs in the treatment of this pathology.

18 Review Chronic tension-type headache: what is new? 2009

Fernández-de-las-Peñas, César / Schoenen, Jean. ·Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain. cesar.fernandez@urjc.es ·Curr Opin Neurol · Pubmed #19300250.

ABSTRACT: PURPOSE OF REVIEW: This review discusses current data on nosological boundaries related to diagnosis, pathophysiology and therapeutic strategies in chronic tension-type headache (CTTH). RECENT FINDINGS: Diagnostic criteria of CTTH should be adapted to improve its sensitivity against migraine. It seems that mechanical pain sensitivity is a consequence and not a causative factor of CTTH. Recent evidence is modifying previous knowledge about relationships between muscle tissues and CTTH, suggesting a potential role of muscle trigger points in the genesis of pain. An updated pain model suggests that headache perception can be explained by referred pain from trigger points in the craniocervical muscles, mediated through the spinal cord and the trigeminal nucleus caudalis rather than only tenderness of the muscles themselves. Different therapeutic strategies, pharmacological, physical therapy, psychological and acupuncture, are generally used. The therapeutic efficacy of nonsteroidal anti-inflammatory drugs remains incomplete. The tricyclic antidepressants are the most used first-line therapeutic agents for CTTH. Surprisingly, few controlled studies have been performed and not all of them have found an efficacy superior to placebo. Further, there is insufficient evidence to support/refute the efficacy of physical therapy in CTTH. SUMMARY: Although there is an increasing scientific interest in CTTH, future studies incorporating subgroups of patients who will likely to benefit from a specific treatment (clinical prediction rules) should be conducted.

19 Clinical Trial Greater occipital nerve block for the acute treatment of prolonged or persistent migraine aura. 2017

Cuadrado, María L / Aledo-Serrano, Ángel / López-Ruiz, Pedro / Gutiérrez-Viedma, Álvaro / Fernández, Cristina / Orviz, Aida / Arias, José A. ·1 Department of Neurology, Instituto de Investigación Sanitaria San Carlos, Hospital Clínico San Carlos, Madrid, Spain. · 2 Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain. · 3 Department of Preventive Medicine, Instituto de Investigación Sanitaria San Carlos, Hospital Clínico San Carlos, Madrid, Spain. · 4 School of Medicine, Universidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, Spain. ·Cephalalgia · Pubmed #27288355.

ABSTRACT: Background Presently, there is no evidence to guide the acute treatment of migraine aura. We aimed to describe the effect of greater occipital nerve (GON) anaesthetic block as a symptomatic treatment for long-lasting (prolonged or persistent) migraine aura. Methods Patients who presented with migraine aura lasting > 2 hours were consecutively recruited during one year at the Headache Unit and the Emergency Department of a tertiary hospital. All patients underwent a bilateral GON block with bupivacaine 0.5%. Patients were followed up for 24 hours. Results A total of 22 auras were treated in 18 patients. Auras consisted of visual ( n = 13), visual and sensory ( n = 4) or sensory symptoms alone ( n = 5). Eleven episodes met diagnostic criteria for persistent aura (>1 week) without infarction. The response was complete without early recurrence in 11 cases (50%), complete with recurrence in < 24 hours in two cases (9.1%), and partial with ≥ 50% improvement in six cases (27.3%). Complete responses without recurrence were more common in cases with prolonged auras lasting < 1 week than in those with persistent auras (72.7% vs. 27.3%; p = 0.033). Conclusions GON block could be an effective symptomatic treatment for prolonged or persistent migraine aura. Randomised controlled trials are still required to confirm these results.

20 Clinical Trial Variation in almotriptan effectiveness according to different prophylactic treatments. 2009

Bermejo, Pedro Emilio / Dorado, Rodolfo / Gomez-Arguelles, Jose Maria. ·Puerta de Hierro University Hospital - Neurology, Madrid, Spain. ·Headache · Pubmed #19788470.

ABSTRACT: OBJECTIVE: To evaluate the effect of different migraine prophylaxis medications on subject responsiveness to almotriptan. BACKGROUND: There is evidence supporting an increase of responsiveness of symptomatic medications for migraine attacks by some prophylactic treatments although this has not been probed. METHODS: A total of 345 patients (230 women, mean age 37.3) with episodic or chronic migraine were classified according to the prophylaxis they were taking in the following groups: (1) no prophylactic medication; (2) propranolol; (3) topiramate; (4) flunarizine. Decrease in Analogical Visual Scale and pain-free at 2 hours after almotriptan intake was assessed at 2 months. Side effects and discontinuation or treatment were also assessed. RESULTS: Headache severity was reduced 4.2 in control group, 5.3 in propranolol group, 4.1 in topiramate group, and 4.0 in flunarizine group, whereas pain-free status was achieved in 37.3%, 48.7%, 36.1%, and 38.1% respectively. These two parameters were statistically significative between propranolol and control groups. Side effects were similar in all groups. CONCLUSIONS: Our results displayed a higher efficacy of almotriptan in propranolol group and we hypothesized it may be due to a common mechanism of action at serotoninergic receptors.

21 Article Extensor/flexor ratio of neck muscle strength and electromyographic activity of individuals with migraine: a cross-sectional study. 2019

Benatto, Mariana Tedeschi / Florencio, Lidiane Lima / Bragatto, Marcela Mendes / Lodovichi, Samuel Straceri / Dach, Fabíola / Bevilaqua-Grossi, Débora. ·Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue - Monte Alegre, Ribeirão Preto, SP, 390014049-900, Brazil. mariana.benatto@gmail.com. · Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Spain. · Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue - Monte Alegre, Ribeirão Preto, SP, 390014049-900, Brazil. · Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. ·Eur Spine J · Pubmed #31399847.

ABSTRACT: PURPOSE: Neck pain is considered a common characteristic of migraine attacks. The relationship between neck pain and migraine can be explained by central sensitization of the trigeminocervical complex, where superior cervical afferents and the trigeminal nerve converge. However, few studies have evaluated motor control of cervical muscles in individuals with migraine. Thus, the purpose of the present study was to determine the extensor/flexor ratio of neck muscle strength and electromyographic activity during a test of maximal voluntary isometric contraction and craniocervical flexion in individuals with migraine and individuals without history of migraine or other headaches. METHODS: Fifty-two women with the disease and 52 women with neither a history of migraine nor neck pain, between 18 and 55 years old, were included in the study. The electromyographic activities of the sternocleidomastoid, anterior scalene, splenius capitis, and upper trapezius muscles were evaluated during a test of maximal voluntary isometric contraction and craniocervical flexion. RESULTS: The migraine group presented lower flexor muscle strength and a higher extensor/flexor muscle strength ratio than the control group. In addition, the migraine group showed a reduced electromyographic extensor/flexor muscle ratio during maximal voluntary isometric contraction in flexion. The results demonstrated worse performance in the craniocervical flexion test of the migraine group and a lower electromyographic ratio of extensor/flexor neck muscles in the last stage of the test. CONCLUSION: Altogether, the migraine group presented an imbalance in cervical muscles verified not only during force production, but also during muscle activity. These slides can be retrieved under Electronic Supplementary Material.

22 Article Is the presence of neck pain associated with more severe clinical presentation in patients with migraine? A cross-sectional study. 2019

Bragatto, Marcela Mendes / Bevilaqua-Grossi, Débora / Benatto, Mariana Tedeschi / Lodovichi, Samuel Straceri / Pinheiro, Carina Ferreira / Carvalho, Gabriela Ferreira / Dach, Fabiola / Fernández-de-Las-Peñas, César / Florencio, Lidiane Lima. ·Department of Health of Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil. · Department of Neurosciences and Behavioral Sciences - Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil. · Department of Physiotherapy, Occupational Therapy, Physiscal Medicine and Rehabilitation, King Juan Carlos University, Madrid, Spain. ·Cephalalgia · Pubmed #31132869.

ABSTRACT: OBJECTIVE: To investigate the association between the presence of self-reported neck pain in patients with migraine and clinical features, upper cervical mobility, and neck muscle performance. METHODS: A total of 142 patients with migraine were recruited and stratified by the presence (n = 99) or absence of self-reported neck pain (n = 43). The clinical examination included the Migraine Disability Assessment, the 12-item Allodynia Symptom Checklist, a flexion rotation test, and the Craniocervical Flexion Test. RESULTS: Migraine-related disability was reported by more than 80% in both groups ( CONCLUSIONS: The presence of self-reported neck pain in patients with migraine was associated with a poor clinical presentation regarding cutaneous allodynia, neck mobility, and muscle function. However, there were no differences in migraine-related disability.

23 Article Self-reported periodontitis and migraine: results from a multicenter, cross-sectional survey in Spain. 2019

Leira, Yago / Pozo-Rosich, Patricia / Torres-Ferrús, Marta / Orlandi, Marco / Láinez, José Miguel / Álvaro, Luis Carlos / Monzón, María José / Guerrero, Ángel / García-Azorín, David / Belvís, Roberto / González-Oria, Carmen / Gago-Veiga, Ana Beatriz / Latorre, Germán / Santos, Sonia / Cuadrado, María Luz / Blanco, Juan / Leira, Rogelio / D'Aiuto, Francesco. ·Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, 256 Gray's Inn Road, London, WC1X 8LD, UK. y.leira@ucl.ac.uk. · Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. y.leira@ucl.ac.uk. · Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain. · Headache Research Group, Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain. · Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, 256 Gray's Inn Road, London, WC1X 8LD, UK. · Department of Neurology, Hospital Clínico Universitario, Universidad Católica de Valencia, Valencia, Spain. · Hospital Universitario Basurto, Universidad del País Vasco/Euskal Herriko Unibertsitatea EHU/UPV, Bilbao, Spain. · Hospital Universitario Miguel Servet, Zaragoza, Spain. · Hospital Clínico Universitario de Valladolid, Valladolid, Spain. · Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. · Hospital Universitario Virgen del Rocío, Sevilla, Spain. · Hospital Universitario La Princesa, Madrid, Spain. · Hospital Universitario de Fuenlabrada, Madrid, Spain. · Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. · Department of Neurology, Headache Unit, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Complutense University of Madrid, Madrid, Spain. · Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. · Department of Neurology, Headache Unit, Hospital Clínico Universitario, University of Santiago de Compostela, Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. ·Odontology · Pubmed #31030294.

ABSTRACT: The aim of this study was to evaluate self-reported periodontitis (PD) prevalence in migraineurs as well as to investigate the association between both diseases. A cross-sectional survey was carried out including patients diagnosed with migraine attending 12 Spanish Headache Units. We determined diagnosis of PD administering a validated self-reported questionnaire. Socio-demographic, clinical and medical information, comorbidities, daily habits, migraine characteristics and medication were collected using a questionnaire. Of the 651 consecutive migraineurs included in the study, 393 suffered from chronic migraine (CM). Self-reported PD was detected in 327 patients with migraine (50.2%). Migraineurs with self-reported PD were significantly older and had a previous history of fibromyalgia, stress, anxiety, depression, and allodynia (all P < 0.001). Additionally, this group of patients consumed more topiramate (P = 0.008) and simple analgesics (P < 0.001) than patients with migraine and without self-reported PD. Also, they were less active physically and belonged to a low education level (both P < 0.001). Prevalence of self-reported PD was significantly higher in chronic migraineurs compared to those diagnosed with episodic migraine (EM) (53.9% vs. 44.6%, P = 0.019). Logistic regression analyses showed that self-reported PD was associated with CM (OR 1.456; 95% CI 1.062-1.997, P = 0.020). However, after adjusting for significant confounders, the association was attenuated (OR 1.100; 95% CI 0.784-1.543, P = 0.581). We concluded that self-reported PD was significantly more frequent in CM compared to EM. Self-reported PD was associated with the presence of CM, although some comorbidities shared by both diseases could have an effect on this association.

24 Article CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA. 2019

Moreno-Mayordomo, R / Ruiz, M / Pascual, J / Gallego de la Sacristana, M / Vidriales, I / Sobrado, M / Cernuda-Morollon, E / Gago-Veiga, A B / Garcia-Azorin, D / Telleria, J J / Guerrero, A L. ·Clinical Analysis Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. · Headache Unit, Neurology Department, Hospital Clínico Universitario de Valladolid, Avda. Ramón y Cajal 3, 47005, Valladolid, Spain. · Neurosciences Department, Hospital Universitario Central de Asturias, Oviedo, Spain. · Hospital Universitario Marqués de Valdecilla, Santander, Spain. · Neurology Department. Hospital Universitario de La Princesa, Madrid, Spain. · Headache Unit, Neurology Department, Hospital Clínico Universitario de Valladolid, Avda. Ramón y Cajal 3, 47005, Valladolid, Spain. davilink@hotmail.com. · Instituto de Biología y Genética Molecular, University of Valladolid, Valladolid, Spain. · Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain. ·J Headache Pain · Pubmed #31014225.

ABSTRACT: BACKGROUND: Some variables have been proposed as predictors of efficacy of OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence of single nucleotide polymorphisms in the response to OnabotulinumtoxinA. METHODS: We included 156 female patients treated with OnabotulinumtoxinA accordingly to PREEMPT paradigm in three headache units. OnabotulinumtoxinA was offered to patients that had not responded to topiramate and at least one other preventative. Age at first procedure was 43.7 ± 11.8 years (16-74). Patients with a reduction of at least 50% in the number of migraine days after two OnabotulinumtoxinA procedures were considered as responders. We analysed 25 polymorphisms selected for their relevance regarding migraine pathophysiology and their association with migraine according to previously published genome-wide association studies. Genotyping was performed using KASP probes and a LightCycler-480 (Roche-Diagnostics). Allelic, genotypic frequencies and dominance/recesivity hypothesis of the allelic variants were compared between responders and non-responders by Fisher's exact test. RESULTS: Response to treatment with OnabotulinumtoxinA was achieved in 120 patients (76,9%). Two polymorphisms showed differences: CALCA rs3781719, where allele C represents 26.9% in responders and 40.9% in non-responders (p = 0.007, OR = 3.11 (1.33-7.26)); and TRPV1 rs222749, where allele A represents 4.17% in responders and 12.5% in non-responders (p = 0.013, OR = 3.29 (1.28-8.43)). No significant differences in rest of polymorphisms or clinical or demographic variables were found. CONCLUSIONS: Polymorphic variations of CALCA and TRPV1 genes might play a role as prognostic markers of efficacy of OnabotulinumtoxinA in chronic migraine female patients in our population.

25 Article Predictive factors of sleep quality in patients with chronic migraine. 2019

Garrigós-Pedrón, M / Segura-Ortí, E / Gracia-Naya, M / La Touche, R. ·Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Motion in Brains Research Group, Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España. Electronic address: miriamgarrigos@hotmail.com. · Department of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, España. · Departamento de Neurología, Hospital Universitario Miguel Servet, Zaragoza, España. · Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Motion in Brains Research Group, Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Instituto de Neurociencia y Dolor Craneofacial (INDCRAN), Madrid, España; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, España. ·Neurologia · Pubmed #30857790.

ABSTRACT: INTRODUCTION: One of the factors contributing to transformation of migraine are sleep disorders, which can act as a trigger and/or perpetuating factor in these patients. This study's primary objective was to identify predictive factors related to sleep quality in patients with chronic migraine (CM); the secondary objective was to identify any differences in psychological variables and disability between patients with CM with better or poorer sleep quality. METHODS: A total of 50 patients with CM were included in an observational, cross-sectional study. We recorded data on demographic, psychological, and disability variables using self-administered questionnaires. RESULTS: A direct, moderate-to-strong correlation was observed between the different disability and psychological variables analysed (P<.05). Regression analysis identified depressive symptoms, headache-related disability, and pain catastrophising as predictors of sleep quality; together, these factors explain 33% of the variance. Statistically significant differences were found between patients with better and poorer sleep quality for depressive symptoms (P=.016) and pain catastrophising (P=.036). CONCLUSIONS: The predictive factors for sleep quality in patients with CM were depressive symptoms, headache-related disability, and pain catastrophising. Patients with poorer sleep quality had higher levels of pain catastrophising and depressive symptoms.

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