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Osteoporosis: HELP
Articles by Matthias Epple
Based on 2 articles published since 2008
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Between 2008 and 2019, M. Epple wrote the following 2 articles about Osteoporosis.
 
+ Citations + Abstracts
1 Review The relevance of biomaterials to the prevention and treatment of osteoporosis. 2014

Arcos, D / Boccaccini, A R / Bohner, M / Díez-Pérez, A / Epple, M / Gómez-Barrena, E / Herrera, A / Planell, J A / Rodríguez-Mañas, L / Vallet-Regí, M. ·Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Dpto. Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Erlangen-Nuremberg, Institute of Biomaterials, 91058 Erlangen, Germany. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; RMS Fundation, CH-2544 Bettlach, Switzerland. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Hospital del Mar-IMIM, Department Internal Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), D-45117 Essen, Germany. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Servicio Cirugia Ortopedica & Traumatologia, Hospital La Paz, IdiPAZ, Universidad Autonoma Madrid, Madrid 28046, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Zaragoza, Department of Surgery, E-50009 Zaragoza, Spain; Miguel Servet University Hospital, Department of Orthopaedic Surgery & Traumatology, Zaragoza 50009, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Institute of Bioengineering of Catalonia IBEC, BaldiriReixac 15-20, Barcelona 08028, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University Hospital Getafe, Division Geriatric Medicine, Madrid, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Dpto. Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain. Electronic address: vallet@farm.ucm.es. ·Acta Biomater · Pubmed #24418434.

ABSTRACT: Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often lead to patient disability or even death. A number of commercial biomaterials are currently used to treat osteoporotic bone fractures, but most of these have not been specifically designed for that purpose. Many drug- or cell-loaded biomaterials have been proposed in research laboratories, but very few have received approval for commercial use. In order to analyze this scenario and propose alternatives to overcome it, the Spanish and European Network of Excellence for the Prevention and Treatment of Osteoporotic Fractures, "Ageing", was created. This network integrates three communities, e.g. clinicians, materials scientists and industrial advisors, tackling the same problem from three different points of view. Keeping in mind the premise "living longer, living better", this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network.

2 Article Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. 2018

Weske, Sarah / Vaidya, Mithila / Reese, Alina / von Wnuck Lipinski, Karin / Keul, Petra / Bayer, Julia K / Fischer, Jens W / Flögel, Ulrich / Nelsen, Jens / Epple, Matthias / Scatena, Marta / Schwedhelm, Edzard / Dörr, Marcus / Völzke, Henry / Moritz, Eileen / Hannemann, Anke / Rauch, Bernhard H / Gräler, Markus H / Heusch, Gerd / Levkau, Bodo. ·Institute for Pathophysiology, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. · Institute of Pharmacology and Clinical Pharmacology, University of Düsseldorf, Düsseldorf, Germany. · Institute of Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany. · Institute of Inorganic Chemistry, University of Duisburg-Essen, Essen, Germany. · Department of Bioengineering, University of Washington, Seattle, WA, USA. · Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. · German Centre for Cardiovascular Research (DZHK), partner site Hamburg, Hamburg, Germany. · DZHK, partner site Greifswald, Greifswald, Germany. · Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. · Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. · Institute of Pharmacology, Department of General Pharmacology, University Medicine Greifswald, Greifswald, Germany. · Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. · Department of Anesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care, and Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany. · Institute for Pathophysiology, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. bodo.levkau@uni-due.de. ·Nat Med · Pubmed #29662200.

ABSTRACT: Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show that raising S1P levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P, markedly increased bone formation, mass and strength and substantially decreased white adipose tissue. S1P signaling through S1P