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Osteoporosis: HELP
Articles by S. B. Kritchevsky
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, S. B. Kritchevsky wrote the following 2 articles about Osteoporosis.
 
+ Citations + Abstracts
1 Article Changes in bone mineral density over time by body mass index in the health ABC study. 2016

Lloyd, J T / Alley, D E / Hochberg, M C / Waldstein, S R / Harris, T B / Kritchevsky, S B / Schwartz, A V / Strotmeyer, E S / Womack, C / Orwig, D L / Anonymous5661022. ·Centers for Medicare and Medicaid Services, 7500 Security Blvd, WB-06-05, Baltimore, MD, 21244, USA. Jennifer.Lloyd@cms.hhs.gov. · Centers for Medicare and Medicaid Services, 7500 Security Blvd, WB-06-05, Baltimore, MD, 21244, USA. · Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, USA. · Doctoral Program in Gerontology, University of Maryland, Baltimore and Baltimore County, Baltimore, MD, USA. · Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD, USA. · Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA. · Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA. · Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. · Department of Epidemiology, Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA, USA. · University of Tennessee Health Science Center, Memphis, TN, USA. ·Osteoporos Int · Pubmed #26856584.

ABSTRACT: INTRODUCTION: Cross-sectional studies have found a positive association between body mass index (BMI) and bone mineral density (BMD), but little is known about the longitudinal relationship in US older adults. METHODS: We examined average annual rate of change in BMD by baseline BMI in the Health, Aging, and Body Composition Study. Repeated measurement of BMD was performed with dual-energy X-ray absorptiometry (DXA) at baseline and years 3, 5, 6, 8, and 10. Multivariate generalized estimating equations were used to predict mean BMD (femoral neck, total hip, and whole body) by baseline BMI (excluding underweight), adjusting for covariates. RESULTS: In the sample (n = 2570), 43 % were overweight and 24 % were obese with a mean baseline femoral neck BMD of 0.743 g/cm(2), hip BMD of 0.888 g/cm(2), and whole-body BMD of 1.09 g/cm(2). Change in total hip or whole-body BMD over time did not vary by BMI groups. However, obese older adults lost 0.003 g/cm(2) of femoral neck BMD per year more compared with normal weight older adults (p < 0.001). Femoral neck BMD change over time did not differ between the overweight and normal weight BMI groups (p = 0.74). In year 10, adjusted femoral neck BMD ranged from 0.696 g/cm(2) among obese, 0.709 g/cm(2) among normal weight, and 0.719 g/cm(2) among overweight older adults. CONCLUSIONS: Findings underscore the importance of looking at the longitudinal relationship between body composition and bone mineral density among older adults, indicating that high body mass may not be protective for bone loss over time.

2 Article Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women. 2015

Tabatabai, L S / Cummings, S R / Tylavsky, F A / Bauer, D C / Cauley, J A / Kritchevsky, S B / Newman, A / Simonsick, E M / Harris, T B / Sebastian, A / Sellmeyer, D E / Anonymous3591108. ·Division of Endocrinology (L.S.T., D.E.S.), Johns Hopkins Hospital, Johns Hopkins School of Medicine, Baltimore, Maryland 21224 · California Pacific Medical Center Research Institute (S.R.C.), San Francisco, California 94118 · Department of Preventive Medicine (F.A.T.), University of Tennessee Health Science Center, Memphis, Tennessee 38163 · Department of Medicine (D.C.B., A.S.), School of Medicine, University of California, San Francisco, San Francisco, California 94143 · Department of Epidemiology (J.A.C., A.N.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 · Department of Internal Medicine (S.B.K.), Wake Forest School of Medicine, Winston-Salem, North Carolina 27157 · Translational Gerontology Branch (E.M.S.), National Institute on Aging, Baltimore, Maryland 21224 · and Laboratory of Epidemiology and Population Science (T.B.H.), National Institute on Aging, Bethesda, Maryland 20892. ·J Clin Endocrinol Metab · Pubmed #25642590.

ABSTRACT: CONTEXT: Higher dietary net acid loads have been associated with increased bone resorption, reduced bone mineral density (BMD), and increased fracture risk. OBJECTIVE: The objective was to compare bicarbonate (HCO3) measured in arterialized venous blood samples to skeletal outcomes. DESIGN: Arterialized venous samples collected from participants in the Health, Aging and Body Composition (Health ABC) Study were compared to BMD and rate of bone loss. SETTING: The setting was a community-based observational cohort. PARTICIPANTS: A total of 2287 men and women age 74 ± 3 years participated. INTERVENTION: Arterialized venous blood was obtained at the year 3 study visit and analyzed for pH and pCO2. HCO3 was determined using the Henderson-Hasselbalch equation. MAIN OUTCOME MEASURE: BMD was measured at the hip by dual-energy x-ray absorptiometry at the year 1 (baseline) and year 3 study visits. RESULTS: Plasma HCO3 was positively associated with BMD at both year 1 (P = .001) and year 3 (P = .001) in models adjusted for age, race, sex, clinic site, smoking, weight, and estimated glomerular filtration rate. Plasma HCO3 was inversely associated with rate of bone loss at the total hip over the 2.1 ± 0.3 (mean ± SD) years between the two bone density measurements (P < .001). Across quartiles of plasma HCO3, the rate of change in BMD over the 2.1 years ranged from a loss of 0.72%/y in the lowest quartile to a gain of 0.15%/y in the highest quartile of HCO3. CONCLUSIONS: Arterialized plasma HCO3 was associated positively with cross-sectional BMD and inversely with the rate of bone loss, implying that systemic acid-base status is an important determinant of skeletal health during aging. Ongoing bone loss was linearly related to arterialized HCO3, even after adjustment for age and renal function. Further research in this area may have major public health implications because reducing dietary net acid load is possible through dietary intervention or through supplementation with alkaline potassium compounds.