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Osteoporosis: HELP
Articles by Mark McEvoy
Based on 3 articles published since 2008
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Between 2008 and 2019, Mark McEvoy wrote the following 3 articles about Osteoporosis.
 
+ Citations + Abstracts
1 Article A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults. 2018

Potter, Michael D E / Walker, Marjorie M / Hancock, Stephen / Holliday, Elizabeth / Brogan, Gregory / Jones, Michael / McEvoy, Mark / Boyle, Michael / Talley, Nicholas J / Attia, John. ·Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. michael.potter@newcastle.edu.au. · Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. michael.potter@newcastle.edu.au. · Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. michael.potter@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. marjorie.walker@newcastle.edu.au. · Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. marjorie.walker@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Stephen.hancock@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. liz.holliday@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. gregory.brogan@hnehealth.nsw.gov.au. · Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. gregory.brogan@hnehealth.nsw.gov.au. · Department of Psychology, Macquarie University, Sydney 2109, Australia. mike.jones@mq.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Mark.McEvoy@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Michael.boyle@hnehealth.nsw.gov.au. · Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. Michael.boyle@hnehealth.nsw.gov.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. nicholas.talley@newcastle.edu.au. · Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. nicholas.talley@newcastle.edu.au. · Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. nicholas.talley@newcastle.edu.au. · Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. john.attia@newcastle.edu.au. · Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. john.attia@newcastle.edu.au. ·Nutrients · Pubmed #29966287.

ABSTRACT: Previously thought to be mainly a disorder of childhood and early adult life, coeliac disease (CeD) is increasingly diagnosed in older adults. This may be important given the association between CeD and osteoporosis. The primary aim of this study was to determine the seroprevalence of undiagnosed CeD (‘at-risk serology’) in an older Australian community and relate this to a diagnosis of osteoporosis and fractures during a follow-up period of 12 years. We included participants from the Hunter Community Study (2004⁻2007) aged 55⁻85, who had anti-tissue transglutaminase (tTG) titres, human leukocyte antigen (HLA) genotypes, and bone mineral density measurements at baseline. Follow-up data included subsequent diagnosis of CeD and fractures using hospital information. ‘At-risk’ serology was defined as both tTG and HLA positivity. Complete results were obtained from 2122 patients. The prevalence of ‘at-risk’ serology was 5%. At baseline, 3.4% fulfilled criteria for a diagnosis of osteoporosis. During a mean of 9.7 years of follow-up, 7.4% of the cohort suffered at least one fracture and 0.7% were subsequently diagnosed with CeD. At-risk serology was significantly associated with osteoporosis in a multivariate model (odds ratio 2.83, 95% confidence interval 1.29⁻6.22); there was insufficient power to look at the outcome of fractures. The results of this study demonstrate that at-risk CeD serology was significantly associated with concurrent osteoporosis but not future fractures. Most individuals with a serological diagnosis of CeD were not diagnosed with CeD during the follow-up period according to medical records. Coeliac disease likely remains under-diagnosed.

2 Article A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease. 2018

Iseme, Rosebella A / McEvoy, Mark / Kelly, Brian / Agnew, Linda / Walker, Frederick R / Boyle, Michael / Attia, John. ·Department of Population and Reproductive Health, School of Public Health, Kenyatta University, P.O. Box 43844, Nairobi 00100, Kenya. · School of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia. · Hunter Medical Research Institute, Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia. · Centre for Brain and Mental Health Research, The University of Newcastle, Callaghan, NSW, Australia. · Brain Behaviour Research Group, School of Science and Technology, University of New England, Armidale, NSW 2351, Australia. · Laboratory of Affective Neuroscience, The University of Newcastle, Callaghan, NSW, Australia. · University of Newcastle, Medical Sciences MS413, University Drive, Callaghan, NSW 2308, Australia. · Department of General Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia. ·J Immunol Res · Pubmed #29854851.

ABSTRACT: Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers. We attempted to examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical autoimmune disease. Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, anti-neutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated peptide). Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus. The relationship between each autoantibody and bone mass was determined using linear regression models. Anti-nuclear autoantibodies were the most prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample. They were also the only autoantibody observed to be significantly associated with QUS index in the univariate analysis (

3 Article Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. 2014

Moayyeri, Alireza / Hsu, Yi-Hsiang / Karasik, David / Estrada, Karol / Xiao, Su-Mei / Nielson, Carrie / Srikanth, Priya / Giroux, Sylvie / Wilson, Scott G / Zheng, Hou-Feng / Smith, Albert V / Pye, Stephen R / Leo, Paul J / Teumer, Alexander / Hwang, Joo-Yeon / Ohlsson, Claes / McGuigan, Fiona / Minster, Ryan L / Hayward, Caroline / Olmos, José M / Lyytikäinen, Leo-Pekka / Lewis, Joshua R / Swart, Karin M A / Masi, Laura / Oldmeadow, Chris / Holliday, Elizabeth G / Cheng, Sulin / van Schoor, Natasja M / Harvey, Nicholas C / Kruk, Marcin / del Greco M, Fabiola / Igl, Wilmar / Trummer, Olivia / Grigoriou, Efi / Luben, Robert / Liu, Ching-Ti / Zhou, Yanhua / Oei, Ling / Medina-Gomez, Carolina / Zmuda, Joseph / Tranah, Greg / Brown, Suzanne J / Williams, Frances M / Soranzo, Nicole / Jakobsdottir, Johanna / Siggeirsdottir, Kristin / Holliday, Kate L / Hannemann, Anke / Go, Min Jin / Garcia, Melissa / Polasek, Ozren / Laaksonen, Marika / Zhu, Kun / Enneman, Anke W / McEvoy, Mark / Peel, Roseanne / Sham, Pak Chung / Jaworski, Maciej / Johansson, Åsa / Hicks, Andrew A / Pludowski, Pawel / Scott, Rodney / Dhonukshe-Rutten, Rosalie A M / van der Velde, Nathalie / Kähönen, Mika / Viikari, Jorma S / Sievänen, Harri / Raitakari, Olli T / González-Macías, Jesús / Hernández, Jose L / Mellström, Dan / Ljunggren, Osten / Cho, Yoon Shin / Völker, Uwe / Nauck, Matthias / Homuth, Georg / Völzke, Henry / Haring, Robin / Brown, Matthew A / McCloskey, Eugene / Nicholson, Geoffrey C / Eastell, Richard / Eisman, John A / Jones, Graeme / Reid, Ian R / Dennison, Elaine M / Wark, John / Boonen, Steven / Vanderschueren, Dirk / Wu, Frederick C W / Aspelund, Thor / Richards, J Brent / Bauer, Doug / Hofman, Albert / Khaw, Kay-Tee / Dedoussis, George / Obermayer-Pietsch, Barbara / Gyllensten, Ulf / Pramstaller, Peter P / Lorenc, Roman S / Cooper, Cyrus / Kung, Annie Wai Chee / Lips, Paul / Alen, Markku / Attia, John / Brandi, Maria Luisa / de Groot, Lisette C P G M / Lehtimäki, Terho / Riancho, José A / Campbell, Harry / Liu, Yongmei / Harris, Tamara B / Akesson, Kristina / Karlsson, Magnus / Lee, Jong-Young / Wallaschofski, Henri / Duncan, Emma L / O'Neill, Terence W / Gudnason, Vilmundur / Spector, Timothy D / Rousseau, François / Orwoll, Eric / Cummings, Steven R / Wareham, Nick J / Rivadeneira, Fernando / Uitterlinden, Andre G / Prince, Richard L / Kiel, Douglas P / Reeve, Jonathan / Kaptoge, Stephen K. ·Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ·Hum Mol Genet · Pubmed #24430505.

ABSTRACT: Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.