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Osteoporosis: HELP
Articles by Leocadio Rodríguez-Mañas
Based on 5 articles published since 2008
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Between 2008 and 2019, L. Rodríguez-Mañas wrote the following 5 articles about Osteoporosis.
 
+ Citations + Abstracts
1 Review Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty. 2016

Viña, Jose / Rodriguez-Mañas, Leocadio / Salvador-Pascual, Andrea / Tarazona-Santabalbina, Francisco José / Gomez-Cabrera, Mari Carmen. ·Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Spain. · Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Instituto de Salud Carlos III, Servicio de Geriatría, Hospital Universitario de Getafe, Ministerio de Sanidad y Consumo, Madrid, España. · Hospital Universitario de la Ribera, Catholic University of Valencia, Valencia, Spain. ·J Physiol · Pubmed #26872560.

ABSTRACT: The beneficial effects of exercise have been well recognized for over half a century. Dr Jeremy Morris's pioneering studies in the fifties showed a striking difference in cardiovascular disease between the drivers and conductors on the double-decker buses in London. These studies sparked off a vast amount of research on the effects of exercise in health, and the general consensus is that exercise contributes to improved outcomes and treatment for several diseases including osteoporosis, diabetes, depression and atherosclerosis. Evidence of the beneficial effects of exercise is reviewed here. One way of highlighting the impact of exercise on disease is to consider it from the perspective of good practice. However, the intensity, duration, frequency (dosage) and counter indications of the exercise should be taken into consideration to individually tailor the exercise programme. An important case of the beneficial effect of exercise is that of ageing. Ageing is characterized by a loss of homeostatic mechanisms, on many occasions leading to the development of frailty, and hence frailty is one of the major geriatric syndromes and exercise is very useful to mitigate, or at least delay, it. Since exercise is so effective in reducing frailty, we would like to propose that exercise be considered as a supplement to other treatments. People all over the world have been taking nutritional supplements in the hopes of improving their health. We would like to think of exercise as a physiological supplement not only for treating diseases, but also for improving healthy ageing.

2 Review The relevance of biomaterials to the prevention and treatment of osteoporosis. 2014

Arcos, D / Boccaccini, A R / Bohner, M / Díez-Pérez, A / Epple, M / Gómez-Barrena, E / Herrera, A / Planell, J A / Rodríguez-Mañas, L / Vallet-Regí, M. ·Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Dpto. Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Erlangen-Nuremberg, Institute of Biomaterials, 91058 Erlangen, Germany. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; RMS Fundation, CH-2544 Bettlach, Switzerland. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Hospital del Mar-IMIM, Department Internal Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), D-45117 Essen, Germany. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Servicio Cirugia Ortopedica & Traumatologia, Hospital La Paz, IdiPAZ, Universidad Autonoma Madrid, Madrid 28046, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University of Zaragoza, Department of Surgery, E-50009 Zaragoza, Spain; Miguel Servet University Hospital, Department of Orthopaedic Surgery & Traumatology, Zaragoza 50009, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Institute of Bioengineering of Catalonia IBEC, BaldiriReixac 15-20, Barcelona 08028, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; University Hospital Getafe, Division Geriatric Medicine, Madrid, Spain. · Envejecimiento: red de excelencia española y europea para la prevención y tratamiento local de fracturas osteoporóticas, MINECO, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; Dpto. Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain. Electronic address: vallet@farm.ucm.es. ·Acta Biomater · Pubmed #24418434.

ABSTRACT: Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often lead to patient disability or even death. A number of commercial biomaterials are currently used to treat osteoporotic bone fractures, but most of these have not been specifically designed for that purpose. Many drug- or cell-loaded biomaterials have been proposed in research laboratories, but very few have received approval for commercial use. In order to analyze this scenario and propose alternatives to overcome it, the Spanish and European Network of Excellence for the Prevention and Treatment of Osteoporotic Fractures, "Ageing", was created. This network integrates three communities, e.g. clinicians, materials scientists and industrial advisors, tackling the same problem from three different points of view. Keeping in mind the premise "living longer, living better", this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network.

3 Review Low calcium intake and inadequate vitamin D status in postmenopausal osteoporotic women. 2013

Quesada-Gómez, José Manuel / Diaz-Curiel, Manuel / Sosa-Henriquez, Manuel / Malouf-Sierra, Jorge / Nogues-Solan, Xavier / Gomez-Alonso, Carlos / Rodriguez-Mañas, Leocadio / Neyro-Bilbao, Jose Luis / Cortes, Xavier / Delgadillo, Joaquín. ·Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Córdoba, Spain. jmquesada@uco.es ·J Steroid Biochem Mol Biol · Pubmed #23142144.

ABSTRACT: RESULTS: vitamin D serum levels were lower in the untreated group as compared with the treated group (58±27 vs. 67±27nmol/l; p=0.006). Prevalence of vitamin D deficiency (cut-off point set at <50nmol/l) was higher in the non-treated group (43.8% vs. 29.5%; p=0.009). Nearly all PMOW, whether treated or not for osteoporosis had a total calcium intake of less than 1200mg. Sunlight exposure did not influence the vitamin D status. CONCLUSIONS: vitamin D deficiency and an insufficient calcium intake are highly prevalent in both treated and untreated Spanish PMOW older than 65 years. This can be related to low therapeutic adherence and/or insufficient prescription. Therefore physician's and patient's knowledge regarding the optimization of vitamin D status and calcium intake should be improved and implemented. This article is part of a Special Issue entitled 'Vitamin D workshop'.

4 Article Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging. 2018

Álvarez-Sánchez, Nuria / Álvarez-Ríos, Ana Isabel / Guerrero, Juan Miguel / García-García, Francisco José / Rodríguez-Mañas, Leocadio / Cruz-Chamorro, Ivan / Lardone, Patricia Judith / Carrillo-Vico, Antonio. ·Instituto de Biomedicina de Sevilla, IBIS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Sevilla, Spain. · Department of Clinical Biochemistry, Virgen del Rocío University Hospital, Seville, Spain. · Instituto de Biomedicina de Sevilla, IBIS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Sevilla, Spain; Department of Clinical Biochemistry, Virgen del Rocío University Hospital, Seville, Spain; Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Spain. · Division of Geriatric Medicine, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain. · Servicio de Geriatría y Fundación para la Investigación Biomédica, Hospital Universitario de Getafe Madrid, Spain. · Instituto de Biomedicina de Sevilla, IBIS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Sevilla, Spain; Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Spain. · Instituto de Biomedicina de Sevilla, IBIS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Sevilla, Spain; Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Spain. Electronic address: vico@us.es. ·Exp Gerontol · Pubmed #29704640.

ABSTRACT: BACKGROUND: Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral density is associated with altered bone metabolism in women. However, no previous works have studied the relationship among frailty, Hcy levels and bone turnover. METHODS: We studied the association among Hcy, osteoporosis and N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (β-CTX), parathyroid hormone (PTH), calcium and 25-hydroxyvitamin D (25(OH)D) in 631 Spanish women between the ages of 65-78 from the Toledo Study for Healthy Aging (TSHA) cohort, who were classified as highly functional (robust subjects) or non-robust (pre-frail or frail subjects) according to Fried's criteria. RESULTS: Hcy was independently associated with β-CTX in the entire population (B = 0.22; 95% CI, 0.09-0.34; p = 0.001) and in the non-robust group (B = 0.24; 95% CI, 0.09-0.39; p = 0.002). Hcy was also associated with PINP in the entire and non-robust populations, but the association was lost after including the levels of β-CTX, but not the other bone biomarkers, in the multivariate analysis. This suggests that the controversial relationship between Hcy and bone formation might be explained, at least to a certain extent, by the confounding effects of β-CTX. CONCLUSIONS: This work highlights the important implication of frailty status in the association between Hcy and increased bone turnover in older women.

5 Article High Serum Retinol as a Relevant Contributor to Low Bone Mineral Density in Postmenopausal Osteoporotic Women. 2018

Navarro-Valverde, Cristina / Caballero-Villarraso, Javier / Mata-Granados, José M / Casado-Díaz, Antonio / Sosa-Henríquez, Manuel / Malouf-Sierra, Jorge / Nogués-Solán, Xavier / Rodríguez-Mañas, Leocadio / Cortés-Gil, Xavier / Delgadillo-Duarte, Joaquín / Quesada-Gómez, José Manuel. ·UGC Cardiología, Hospital Universitario Virgen de Valme, Seville, Spain. · IMIBIC (Instituto Maimónides de Investigación Biomédica de Córdoba)/Hospital Universitario Reina Sofía/ Universidad de Córdoba & RETICEF, CIBERFES (ISCIII), Córdoba, Spain. bc2cavij@uco.es. · IMIBIC (Instituto Maimónides de Investigación Biomédica de Córdoba)/Hospital Universitario Reina Sofía/ Universidad de Córdoba & RETICEF, CIBERFES (ISCIII), Córdoba, Spain. · Unidad Metabólica Ósea, Hospital Universitario Insular & RETICEF, Las Palmas, Spain. · Servicio de Medicina Interna, Hospital de la Santa Creu i Sant Pau & RETICEF (ISCIII), Barcelona, Spain. · Servicio de Medicina Interna (Hospital del Mar Medical Research Institute), Universitat Autònoma de Barcelona & RETICEF, CIBERFES (ISCIII), Barcelona, Spain. · Fundación para la Investigación Biomédica, Servicio de Geriatría, Hospital Universitario de Getafe & RETICEF, CIBERFES (ISCIII), Madrid, Spain. · Laboratorios Almirall, Barcelona, Spain. · Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Barcelona, Spain. ·Calcif Tissue Int · Pubmed #29294148.

ABSTRACT: There is controversial information about the impact of vitamin A on bone. Some epidemiological studies show that excessive intake of vitamin A, or an excess of serum vitamin A, has related with adverse impact on bone mass; however, other studies did not find these links, and some authors have proposed that this vitamin might promote a better bone health. The present work aims to contribute to clarify the real role of vitamin A in bone tissue. For this purpose, a cross-sectional study of 154 osteoporotic non-treated postmenopausal women (> 65 years old) was carried out. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. We assessed concentrations of serum retinol, osteocalcin, parathyroid hormone, alkaline phosphatase, calcium, and phosphorus. We also studied demographic and anthropometric parameters. Spearman's correlations between retinol levels and other variables found negative correlations with BMD in both lumbar spine (R = - 0.162, P < 0.01) and femoral neck (R = - 0.182, P < 0.01), as well as alkaline phosphatase (R = - 0.110; P < 0.05) and phosphorus (R = - 0.110; P < 0.05). A positive correlation between retinol and fertile window was observed (R = 0.158; P < 0.01). After multivariable adjustment, we still found a negative correlation between serum retinol and BMD, both at the lumbar spine (R = - 0.210; P < 0.01) and at the femoral neck (R = - 0.324, P < 0.001). It is concluded that elevated serum-retinol levels are associated with an increased risk of low bone mass and thus with osteoporotic fractures. Therefore, osteoporosis-risk assessment should include quantification of serum metabolite of vitamin A.