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Osteoporosis: HELP
Articles by Nourhène Zammel
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Nourhène Zammel wrote the following 2 articles about Osteoporosis.
 
+ Citations + Abstracts
1 Article Proficiencies of Zingiber officinale against spine curve and vertebral damage induced by corticosteroid therapy associated with gonadal hormone deficiency in a rat model of osteoporosis. 2018

Zammel, Nourhène / Amri, Nahed / Chaabane, Rim / Rebai, Tarek / Badraoui, Riadh. ·Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax University, 3029, Sfax, Tunisia. · Laboratory of Biochemistry, CHU Hédi Chaker of Sfax, 3029, Sfax, Tunisia. · Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax University, 3029, Sfax, Tunisia; Laboratory of Histology - Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, 1007, La Rabta-Tunis, Tunisia. Electronic address: riadh.badraoui@fmt.utm.tn. ·Biomed Pharmacother · Pubmed #29864927.

ABSTRACT: This study was assessed to examine whether Zingiber officinale (ZO) can prevent spine disorder and trabecular microarchitecture disruption in osteoporotic murin model. Three groups of male rats were selected: Controls (CTRL), combined model of osteoporosis (CMO), in which rats were orchidectomized and treated with cortisol, and CMO treated with ZO (CMO + ZO). One month after the surgical procedures, the rats were sacrificed. Lumbar curve of the spine has been evaluated using the kyphotic method. The spines were submitted to histological and histomorphometric analysis and mineral (calcium and phosphorus) metabolism assessment. Compared to CTRL, the mean kyphotic angle (KA) was significantly higher in CMO rats. The spinal deconditioning associated decreased bone trabecular volume and a disrupted microarchitecture. A disorder was observed in the serum and bone levels of calcium and phosphorus in the combined severe osteopenia model. An increase in the level of TRAcP associated with an increase in osteoclast number and activity has been reported. These disturbances were reduced following the use of ZO in the CMO + ZO group. Finally, ginger might be an alternative therapeutic candidate for the treatment of severe osteopenia induced vertebral damage and spine curve disruption.

2 Article Corticosteroid treatment exacerbates bone osteopenia in mice with gonadal hormone deficiency-induced osteoporosis. 2017

Badraoui, Riadh / Amri, Nahed / Zammel, Nourhène / Chaabane, Rim / Rebai, Tarek. ·Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty, Sfax University, 3029 Sfax, Tunisia; Laboratory of Histology - Cytology, Medicine Faculty, University of Tunis El-Manar, 1007 La Rabta-, Tunis, Tunisia. Electronic address: badraouir@yahoo.fr. · Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty, Sfax University, 3029 Sfax, Tunisia. · Laboratory of Biochemistry, CHU Hédi Chaker of Sfax, 3029 Sfax, Tunisia. ·Eur J Pharm Sci · Pubmed #28473228.

ABSTRACT: Gonadic deficiency and corticotherapy are important risk factors in the pathogenesis of osteoporosis. This study was outlined to assess the effects of combined orchidectomy (ORX) and corticosteroid (cortisol; CS) administration on bone remodeling and metabolism. Twenty-week-old male Swiss mice were randomized into four groups: either sham operated (sham), ORX, CS injected (CS), or ORX and CS injected (ORX+CS). After 28days, mice were euthanized. Both ORX and CS resulted in reduced trabecular volume, and mineral apposition rate and increased osteoclast number and activity. TRAcP levels were increased in ORX and CS mice, but reached highest values in ORX+CS. Bone and serum mineral content (calcium and phosphorus) were disrupted in ORX and CS groups when compared to Sham, and were more affected in ORX+CS group. Urinary calcium measures were increased in ORX, CS, and ORX+CS during the time course of the study. Increases were more prominent in ORX+CS. The differences between groups were generally more accentuated at ORX+CS group. Biochemical data showed a parallel extent to the histologic and histomorphometric changes. This study provides a valid pre-clinical model for severe and rapid osteopenia by ORX associated corticotherapy in which bone loss was significantly higher than either ORX or CS alones.