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Parkinson Disease: HELP
Articles by Sona Babakchanian
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Sona Babakchanian wrote the following 2 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Article Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease. 2013

Beyer, Mona K / Alves, Guido / Hwang, Kristy S / Babakchanian, Sona / Bronnick, Kolbjorn S / Chou, Yi-Yu / Dalaker, Turi O / Kurz, Martin W / Larsen, Jan P / Somme, Johanne H / Thompson, Paul M / Tysnes, Ole-Bjørn / Apostolova, Liana G. ·The Norwegian Center for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. mona.beyer@lyse.net ·Mov Disord · Pubmed #23408705.

ABSTRACT: ParkWest is a large Norwegian multicenter study of newly diagnosed drug-naïve subjects with Parkinson's disease (PD). Cognitively normal PD subjects (PDCN) and PD subjects with mild cognitive impairment (PDMCI) from this cohort have significant hippocampal atrophy and ventricular enlargement, compared to normal controls. Here, we aimed to investigate whether the same structural changes are associated with cerebrospinal fluid (CSF) levels of amyloid beta (Aβ)38 , Aβ40 , Aβ42 , total tau (t-tau), and phosphorylated tau (p-tau). We performed three-dimensional radial distance analyses of the hippocampi and lateral ventricles using the MRI data from ParkWest subjects who provided CSF at baseline. Our sample consisted of 73 PDCN and 18 PDMCI subjects. We found significant associations between levels of all three CSF Aβ analytes and t-tau and lateral ventricular enlargement in the pooled sample. In the PDCN sample, all three amyloid analytes showed significant associations with the radial distance of the occipital and frontal horns of the lateral ventricles. CSF Aβ38 and Aβ42 showed negative associations, with enlargement in occipital and frontal horns of the lateral ventricles in the pooled sample, and a negative association with the occipital horns in PDMCI. CSF Aβ levels in early PD correlate with ventricular enlargement, previously associated with PD dementia. Therefore, CSF and MRI markers may help identify PD patients at high risk for developing cognitive decline and dementia in the course of their illness. Contrary to Alzheimer's disease, we found no associations between CSF t-tau and p-tau and hippocampal atrophy.

2 Article Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment. 2012

Apostolova, Liana / Alves, Guido / Hwang, Kristy S / Babakchanian, Sona / Bronnick, Kolbjorn S / Larsen, Jan Petter / Thompson, Paul M / Chou, Yi-Yu / Tysnes, Ole B / Vefring, Hege K / Beyer, Mona K. ·Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. lapostolova@mednet.ucla.edu ·Neurobiol Aging · Pubmed #21813212.

ABSTRACT: We analyzed T1-weighted brain magnetic resonance imaging data of 100 cognitively normal elderly controls (NC), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment (PDMCI) subjects from the Norwegian ParkWest study. Using automated segmentation methods, followed by the radial distance technique and multiple linear regression we studied the effect of clinical diagnosis on hippocampal and ventricular radial distance while adjusting for age, education, and scanning site. PDCN subjects had significantly smaller bilateral hippocampal radial distance relative to NC. Nonamnestic PDMCI subjects showed smaller right hippocampal radial distance relative to NC. PDMCI subjects showed significant enlargement of all portions of the lateral ventricles relative to NC and significantly larger bilateral temporal and occipital and left frontal lateral ventricular expansion relative to PDCN subjects. Nonamnestic PDMCI subjects showed significant ventricular enlargement spanning all parts of the lateral ventricle while those with amnestic PDMCI showed changes localized to the left occipital horn. Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD.