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Parkinson Disease: HELP
Articles by Rebecca Banerjee
Based on 5 articles published since 2010
(Why 5 articles?)

Between 2010 and 2020, Rebecca Banerjee wrote the following 5 articles about Parkinson Disease.
+ Citations + Abstracts
1 Review Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations. 2017

Sauerbier, Anna / Jitkritsadakul, Onanong / Titova, Nataliya / Klingelhoefer, Lisa / Tsuboi, Yoshio / Carr, Harry / Kumar, Hrishikesh / Banerjee, Rebecca / Erro, Roberto / Bhidayasiri, Roongroj / Schrag, Anette / Zis, Panagiotis / Lim, Shen-Yang / Al-Hashel, J Y / Kamel, Walaa A / Martinez-Martin, Pablo / Ray Chaudhuri, K. ·Neurology, King's College Hospital, London, UK. ·Neuroepidemiology · Pubmed #28803229.

ABSTRACT: BACKGROUND: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. SUMMARY: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS). In total, 24 articles were included: 12 using the NMS Quest and 12 using the NMSS. Symptoms of constipation, memory impairment, and nocturia were the most frequently self-reported symptoms (NMS Quest) in selected Asian populations, while symptoms within the domains sleep/fatigue, attention/memory, and mood/apathy were most prevalent when applying the health-professional completed NMSS. Key Messages: NMS are generally prevalent and highly burdensome within selected Asian PD populations living in countries included in this review. Our review suggests that NMS-driven phenotypic heterogeneity is present in Asian patients, and compared to Western PD populations there might be variations in assessed NMS.

2 Article Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study. 2020

Chatterjee, Koustav / Roy, Akash / Banerjee, Rebecca / Choudhury, Supriyo / Mondal, Banashree / Halder, Saptak / Basu, Purba / Shubham, Shantanu / Dey, Sanjit / Kumar, Hrishikesh. ·Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. · Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India. · Department of Physiology, University of Calcutta, Kolkata, India; Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, Kolkata, India. · Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. Electronic address: rishi_medicine@yahoo.com. ·J Neuroimmunol · Pubmed #31704453.

ABSTRACT: BACKGROUND: Alpha-synuclein and inflammatory pathology are evident in Parkinson's disease (PD) but, their link to disease pathogenesis needs further elucidation. OBJECTIVES: To explore α-synuclein-mediated inflammation in the serum of PD patients and its link with disease severity. METHODS: Serum levels of IL-1β, NLRP3, total and phosphorylated α-synuclein were compared. RESULTS: IL-1β, NLRP3 levels were significantly increased in PD. We also observed a linear correlation of NLRP3 with α-synuclein. Phosphorylated α-synuclein levels were significantly elevated in later stages of PD. CONCLUSIONS: The α-synuclein-NLRP3 mediated inflammation may underline the pathophysiology of PD and might serve as a novel therapeutic target in PD.

3 Article Mirror movements in Parkinson's disease: An under-appreciated clinical sign. 2016

Chatterjee, Payel / Banerjee, Rebecca / Choudhury, Supriyo / Mondal, Banashree / Kulsum, Marium Umme / Chatterjee, Koustav / Kumar, Hrishikesh. ·Department of Neurology and RGC Research Centre, Institute of Neurosciences, Kolkata, India. · Department of Pharmacology, College of Medicine and Sagor Dutta Hospital, Kolkata, India. · Department of Neurology and RGC Research Centre, Institute of Neurosciences, Kolkata, India. Electronic address: rishi_medicine@yahoo.com. ·J Neurol Sci · Pubmed #27288800.

ABSTRACT: INTRODUCTION: Mirror movements (MM) have been previously reported in patients with Parkinson's disease (PD). Despite being potentially relevant in PD, MM as a neurological sign have remained less recognized. In this study we critically evaluated the characteristic features of MM and their attributes among a cohort of PD patients from a tertiary care center of eastern part of India. METHODS: In this analytical cross-sectional study, 70 patients with PD were evaluated using Unified Parkinson's Disease Rating Scale (UPDRS) and a previously used scale to score MM in the OFF and ON phases of l-Dopa therapy. MM was video-recorded for 4 motor tasks (finger- tapping, hand-movement, pronation-supination, rapid ankle-flexion-extension) and scored for the MM attributes i.e. amplitude, distribution and proportion. RESULTS: A vast majority of PD patients (95.7%) exhibited MM and there was a trend of higher MM score with lesser severity of disease affection. Marked differences in amplitude, distribution and proportion of MM in the upper and lower limbs were evident in response to l-Dopa therapy in certain motor tasks. In addition, less involved limbs exhibited higher MM and the MM scores were higher for lower limb tasks in the ON phase. CONCLUSIONS: The high prevalence of MM in PD patients and its correlation to disease severity echoed previous studies across the globe. In addition, this study provides evidence for a differential response of MM attributes to l-Dopa. To our knowledge, this is the first study that characterized MM in a cohort of PD patients from India. Our findings suggest the significance of MM as a clinical neurological sign in PD.

4 Article Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. 2013

Kaidery, Navneet Ammal / Banerjee, Rebecca / Yang, Lichuan / Smirnova, Natalya A / Hushpulian, Dmitry M / Liby, Karen T / Williams, Charlotte R / Yamamoto, Masayuki / Kensler, Thomas W / Ratan, Rajiv R / Sporn, Michael B / Beal, M Flint / Gazaryan, Irina G / Thomas, Bobby. ·Department of Pharmacology & Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA. ·Antioxid Redox Signal · Pubmed #22746536.

ABSTRACT: AIMS: We evaluated whether the strategy of activation of Nrf2 and its downstream network of cytoprotective genes with small molecule synthetic triterpenoids (TP) attenuate MPTP-induced PD in mice. RESULTS: We show that synthetic TP are thus far the most potent and direct activators of the Nrf2 pathway using a novel Neh2-luciferase reporter. They upregulate several cytoprotective genes, including those involved in glutathione biosynthesis in vitro. Oral administration of TP that were structurally modified to penetrate the brain-induced messenger RNA and protein levels for a battery of Nrf2-dependent cytoprotective genes reduced MPTP-induced oxidative stress and inflammation, and ameliorated dopaminergic neurotoxicity in mice. The neuroprotective effect of these TP against MPTP neurotoxicity was dependent on Nrf2, since treatment with TP in Nrf2 knockout mice failed to block against MPTP neurotoxicity and induce Nrf2-dependent cytoprotective genes. INNOVATION: Extremely potent synthetic TP that are direct activators of the Nrf2 pathway block dopaminergic neurodegeneration in the MPTP mouse model of PD. CONCLUSION: Our results indicate that activation of Nrf2/antioxidant response element (ARE) signaling by synthetic TP is directly associated with their neuroprotective effects against MPTP neurotoxicity and suggest that targeting the Nrf2/ARE pathway is a promising approach for therapeutic intervention in PD.

5 Minor Transcranial direct current stimulation in Parkinson's disease dementia: A randomised double-blind crossover trial. 2017

Elder, Greg J / Ashcroft, James / da Silva Morgan, Katrina / Umme Kulsum, Marium / Banerjee, Rebecca / Chatterjee, Payel / Firbank, Michael J / McKeith, Ian G / Kumar, Hrishikesh / Taylor, John-Paul. ·Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. Electronic address: greg.elder@ncl.ac.uk. · Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. · Institute of Neurosciences Kolkata, AJC Bose Road, Kolkata 700017, West Bengal, India. ·Brain Stimul · Pubmed #28802804.

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