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Parkinson Disease: HELP
Articles by London C. Butterfield
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, London C. Butterfield wrote the following 3 articles about Parkinson Disease.
+ Citations + Abstracts
1 Article The Parkinson's Active Living (PAL) Program. 2017

Butterfield, London C / Cimino, Cynthia R / Salazar, Robert / Sanchez-Ramos, Juan / Bowers, Dawn / Okun, Michael S. ·1 Department of Psychology, College of Arts and Sciences, University of South Florida, Tampa, FL, USA. · 2 Department of Clinical and Health Psychology, College of Public Health & Health Professions, University of Florida, Gainesville, FL, USA. · 3 Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. · 4 Department of Neurology, College of Medicine, University of South Florida, Tampa, FL, USA. · 5 Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA. · 6 Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, FL, USA. · 7 Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA. ·J Geriatr Psychiatry Neurol · Pubmed #28248557.

ABSTRACT: BACKGROUND: Apathy, one of the most common neuropsychiatric symptoms in Parkinson's disease (PD), has been associated with reduced daily functioning, cognition, treatment compliance, quality of life, and increased caregiver burden and distress, among other outcomes. OBJECTIVES: The purpose of the present study was to develop and gather pilot data on the feasibility, acceptability, and efficacy of the Parkinson's Active Living (PAL) program, to our knowledge, the first behavioral treatment specifically designed to target apathy in patients with PD. The Parkinson's Active Living is a primarily telephone-based, 6-week activity scheduling and monitoring intervention that incorporates external cueing to target disease-related self-generational deficits to reduce levels of apathy in nondemented, highly apathetic patients with PD. METHODS: Participants aged 44 to 86 years (mean = 66, SD [standard deviation] = 10.7) ranging in disease duration from <1 to 23 years with elevated apathy (Apathy Evaluation Scale >35) were enrolled in a 1-arm trial and tested at 3 time points (baseline, posttest, and 1-month follow-up). RESULTS: Feasibility aspects (ie, acceptability, demand, implementation, practicality, adaptation, integration, and expansion) and efficacy of PAL program are reported. Matched pairs t tests showed a medium to large effect of treatment on patient apathy (52% showing ≥1 SD improvement), depression (33% showing ≥1 SD improvement), and quality of life at posttest, with improvements in apathy and depression maintained at follow-up. CONCLUSIONS: The program may hold promise as an effective nonpharmacological intervention for apathy in PD. Implications and future directions are discussed. Randomized controlled trials are needed.

2 Article Anxiety and Depression Are Better Correlates of Parkinson's Disease Quality of Life Than Apathy. 2015

Jones, Jacob D / Butterfield, London C / Song, Woojin / Lafo, Jacob / Mangal, Paul / Okun, Michael S / Bowers, Dawn. ·From the Dept. of Clinical and Health Psychology (JDJ, LCB, JL, PM, DB), Dept. of Neurology (MSO, DB), and Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL · and Dept. of Psychiatry, University of Michigan, Ann Arbor, MI (WS). ·J Neuropsychiatry Clin Neurosci · Pubmed #25162776.

ABSTRACT: Due to controversy regarding the influence of apathy on quality of life (QoL), the authors examined the independent influence of apathy, depression, and trait anxiety in a nondemented sample of patients with Parkinson disease (PD). Participants (N=107) completed standard self-report measures of QoL and mood/motivation. Analyses investigated the contribution of these measures and empirically derived factor scores on QoL. QoL was predicted by trait anxiety, dysphoria, and decreased interest, with no independent contribution of apathy. Different patterns emerged with respect to domain-specific QoL, with trait anxiety being the strongest predictor across most domains. Anxiety was most widely related to QoL in PD, with minimal contribution of apathy. Future studies should examine different roles of PD mood/motivation symptoms on caregiver QoL.

3 Article The independent influence of apathy and depression on cognitive functioning in Parkinson's disease. 2010

Butterfield, London C / Cimino, Cynthia R / Oelke, Lynn E / Hauser, Robert A / Sanchez-Ramos, Juan. ·Department of Psychology, University of South Florida, 4202 East Fowler Avenue, PCD 4118G, Tampa, FL 33620-7200, USA. londonbutterfield@gmail.com ·Neuropsychology · Pubmed #20853956.

ABSTRACT: OBJECTIVE: The purpose of the present study was to examine the independent influence of symptoms of depression and apathy, two of the most common neuropsychiatric symptoms in Parkinson's disease (PD), on executive functioning and memory in PD patients using measures designed to discriminate between these symptoms. METHOD: Participants included 68 nondemented, idiopathic PD patients, ages 56-82 years. The Apathy Evaluation Scale-Self-Rating and select items of the Beck Depression Inventory II were used to assess symptoms of apathy and depression, respectively. Cognitive function was assessed using the Wisconsin Card Sorting Test and Hopkins Verbal Learning Test-Revised. Correlations and hierarchical regressions were conducted to investigate the relationships between apathy, depression, and cognitive function. Hierarchical regression analyses were conducted to evaluate the degree of influence of depression and apathy on cognitive function. RESULTS: Results revealed that symptoms of apathy, but not depression, were significantly and negatively associated with executive functioning. Immediate memory was significantly and negatively associated with both apathy and depression. However, apathy accounted for additional variance in memory performance after controlling for depression at a level approaching significance. CONCLUSIONS: Apathy is not only associated with cognitive impairment, but also with impaired daily functioning, caregiver burden and distress, medication noncompliance, and increased mortality. Differentiating apathy and depression, understanding their unique effects, and appropriately identifying apathy symptoms in patients have robust implications for the development of neuropsychological models of these effects in PD as well as practical implications in guiding improvements to patient care and enhancing quality of life in patients and caregivers.