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Parkinson Disease: HELP
Articles by Joseph J. Carroll
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Joseph Carroll wrote the following 2 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Article Assessing Retinal Structure in Patients with Parkinson's Disease. 2019

Young, Jonathon B / Godara, Pooja / Williams, Vesper / Summerfelt, Phyllis / Connor, Thomas B / Tarima, Sergey / Visotcky, Alexis / Cooper, Robert F / Blindauer, Karen / Carroll, Joseph. ·Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, USA. · Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, USA. · Department of Biomedical Engineering, Marquette University, Milwaukee, USA. · Department of Neurology, Medical College of Wisconsin, USA. · Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, USA. ·J Neurol Neurophysiol · Pubmed #31057987.

ABSTRACT: Objective: The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinson's disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of dopaminergic cells affects retinal anatomy could be relevant for monitoring disease progression. Here, our objective is to evaluate retinal structure (foveal pit morphology and thickness) in patients with PD. Methods: Thirty-three Caucasian subjects diagnosed with PD and 40 age-matched Caucasian control subjects underwent retinal imaging with spectral-domain optical coherence tomography (SD-OCT). Axial length measurements were used to correct the lateral scale of each macular volume scan. From these corrected volumes, foveal morphology was quantified with previously described algorithms, and Early Treatment Diabetic Retinopathy Study (ETDRS) grids of retinal thickness were generated and incorporated into a logistic regression model to predict PD. Results: Interocular foveal morphology measurements were highly symmetrical in PD patients and control subjects. There were no significant differences in foveal pit morphology between PD patients and control subjects. Using a model incorporating sex and axial length corrected ETDRS regions, we generated a receiver operating characteristic curve with a C-statistic of 0.80. Conclusion: Our study, which to our knowledge is the first to properly scale OCT measurements when quantifying retinal thickness, demonstrates that PD patients retain foveal symmetry between eyes. When constructing a model to predict PD, sex, along with the center 1 mm and temporal outer ETDRS regions, were significant predictors of PD. In addition to proper scaling of OCT measures, gender and racial differences in retinal anatomy should be considered in building future predictive PD models when using OCT.

2 Article Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. 2016

Brilliant, Murray H / Vaziri, Kamyar / Connor, Thomas B / Schwartz, Stephen G / Carroll, Joseph J / McCarty, Catherine A / Schrodi, Steven J / Hebbring, Scott J / Kishor, Krishna S / Flynn, Harry W / Moshfeghi, Andrew A / Moshfeghi, Darius M / Fini, M Elizabeth / McKay, Brian S. ·Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wis. · Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Palm Beach Gardens, Fla. · Department of Ophthalmology, Medical College of Wisconsin, Milwaukee. · Department of Ophthalmology, Medical College of Wisconsin, Milwaukee; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee. · Essentia Institute of Rural Health, Duluth, Minn. · Department of Ophthalmology, USC Eye Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles. · Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, Calif. · USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles; Department of Cell & Neurobiology, Keck School of Medicine of USC, University of Southern California, Los Angeles; Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, Los Angeles. · Department of Ophthalmology and Vision Science, University of Arizona, Tucson; Department of Cellular and Molecular Medicine, University of Arizona, Tucson. Electronic address: bsmckay@eyes.arizona.edu. ·Am J Med · Pubmed #26524704.

ABSTRACT: BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. A key cell type involved in AMD, the retinal pigment epithelium, expresses a G protein-coupled receptor that, in response to its ligand, L-DOPA, up-regulates pigment epithelia-derived factor, while down-regulating vascular endothelial growth factor. In this study we investigated the potential relationship between L-DOPA and AMD. METHODS: We used retrospective analysis to compare the incidence of AMD between patients taking vs not taking L-DOPA. We analyzed 2 separate cohorts of patients with extensive medical records from the Marshfield Clinic (approximately 17,000 and approximately 20,000) and the Truven MarketScan outpatient and databases (approximately 87 million) patients. We used International Classification of Diseases, 9th Revision codes to identify AMD diagnoses and L-DOPA prescriptions to determine the relative risk of developing AMD and age of onset with or without an L-DOPA prescription. RESULTS: In the retrospective analysis of patients without an L-DOPA prescription, AMD age of onset was 71.2, 71.3, and 71.3 in 3 independent retrospective cohorts. Age-related macular degeneration occurred significantly later in patients with an L-DOPA prescription, 79.4 in all cohorts. The odds ratio of developing AMD was also significantly negatively correlated by L-DOPA (odds ratio 0.78; confidence interval, 0.76-0.80; P <.001). Similar results were observed for neovascular AMD (P <.001). CONCLUSIONS: Exogenous L-DOPA was protective against AMD. L-DOPA is normally produced in pigmented tissues, such as the retinal pigment epithelium, as a byproduct of melanin synthesis by tyrosinase. GPR143 is the only known L-DOPA receptor; it is therefore plausible that GPR143 may be a fruitful target to combat this devastating disease.