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Parkinson Disease: HELP
Articles by Ke Chen
Based on 22 articles published since 2010
(Why 22 articles?)
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Between 2010 and 2020, Ke Chen wrote the following 22 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Article Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation. 2019

Chen, Ke / Vincis, Roberto / Fontanini, Alfredo. ·Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, USA. · Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY, USA. · Department of Biological Science, Florida State University, Tallahassee, FL, USA. · Graduate Program in Neuroscience, Florida State University, Tallahassee, FL, USA. ·Cereb Cortex · Pubmed #30721984.

ABSTRACT: Dysfunction of motor cortices is thought to contribute to motor disorders such as Parkinson's disease (PD). However, little is known on the link between cortical dopaminergic loss, abnormalities in motor cortex neural activity and motor deficits. We address the role of dopamine in modulating motor cortical activity by focusing on the anterior lateral motor cortex (ALM) of mice performing a cued-licking task. We first demonstrate licking deficits and concurrent alterations of spiking activity in ALM of head-fixed mice with unilateral depletion of dopaminergic neurons (i.e., mice injected with 6-OHDA into the medial forebrain bundle). Hemilesioned mice displayed delayed licking initiation, shorter duration of licking bouts, and lateral deviation of tongue protrusions. In parallel with these motor deficits, we observed a reduction in the prevalence of cue responsive neurons and altered preparatory activity. Acute and local blockade of D1 receptors in ALM recapitulated some of the key behavioral and neural deficits observed in hemilesioned mice. Altogether, our data show a direct relationship between cortical D1 receptor modulation, cue-evoked, and preparatory activity in ALM, and licking initiation.

2 Article No association of GPNMB rs156429 polymorphism with Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in Chinese population. 2016

Xu, YaQian / Chen, YongPing / Ou, RuWei / Wei, Qian-Qian / Cao, Bei / Chen, Ke / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. · Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: hfshang2002@126.com. ·Neurosci Lett · Pubmed #27132081.

ABSTRACT: BACKGROUND: The rs156429 polymorphism in the glycoprotein nonmetastatic melanoma protein B (GPNMB) gene was found to be associated with the risk for Parkinson disease (PD) in Caucasian population by genome-wide association studies (GWAS). Recently, encoded protein, GPNMB, was identified as a novel neuro-protective factor in amyotrophic lateral sclerosis (ALS). The overlapping of clinical manifestations and pathologic characteristics among PD, ALS, and multiple system atrophy (MSA) are observed. OBJECT: This study aimed at investigating the possible associations of the polymorphism and the three neurodegenerative diseases: PD, ALS and MSA in a Chinese population. METHODS: All of the subjects, including PD (n=1096), sporadic ALS (SALS) (n=876) and MSA (n=356) patients, and 829 health controls (HCs) were included. All subjects were genotyped for this polymorphism using Sequenom iPLEX Assay technology. RESULTS: No differences were found in the genotype distributions and minor allele frequency of GPNMB rs156429 between PD patients and HCs, between SALS patients and HCs, between MSA patients and HCs, and between subgroups of PD, ALS and MSA patients with regard to clinical features such as sex, age of onset, presence or absence of cognitive abnormality, depression and anxiety. CONCLUSION: Lack of association identified in our study suggests that it may be premature to conclude associations between GPNMB rs156429 and SALS, PD and MSA. More studies on such an association involving a larger number of participants are needed to confirm the present findings.

3 Article Progression of non-motor symptoms in Parkinson's disease among different age populations: A two-year follow-up study. 2016

Ou, Ruwei / Yang, Jing / Cao, Bei / Wei, Qianqian / Chen, Ke / Chen, Xueping / Zhao, Bi / Wu, Ying / Song, Wei / Shang, Huifang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. · Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@126.com. ·J Neurol Sci · Pubmed #26723977.

ABSTRACT: BACKGROUND: Non-motor symptoms (NMS) are gaining increasing relevance in the management of Parkinson's disease (PD), but little is known about their progression, especially among patients with different ages. METHODS: A total of 117 PD patients who were divided into four age groups (<50, 50-60, 60-70, and >70years old) were included to assess NMS at baseline and follow-up visit (21.6±5.6months). The frequency and severity of NMS were assessed using the Non-Motor Symptom Scale (NMSS). RESULTS: After adjusting for confounding factors, patients at the last visit had significantly higher frequency of "Difficulty falling asleep" item (p=0.034) and "Urinary" domain (p=0.017), and higher total NMSS score (p=0.011) as well as scores for "Sleep/fatigue" (p=0.013) and "Sexual dysfunction" (p=0.014) domains and scores for "Fatigue" (p=0.004), "Lack of motivation" (p=0.033), "Interest in sex" (p=0.014) and "Problems having sex" (p=0.031) items than patients at baseline. The frequency changes of each NMS among four age groups exhibited an anfractuous result, while the annual severity changes of each NMS were not significant different among four age groups. Multinomial logistic regression model indicated that age had no correlation with the changes of NMS frequency and severity. CONCLUSIONS: The severity of NMS in PD tends to become progressively worse with the course of the disease. Age is not related to the progression of NMS in PD.

4 Article Impact of Frontal Lobe Function and Behavioral Changes on Health-Related Quality of Life in Patients with Parkinson's Disease: A Cross-Sectional Study from Southwest China. 2015

Guo, Xiaoyan / Song, Wei / Chen, Ke / Chen, Xueping / Zheng, Zhenzhen / Cao, Bei / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. ·Eur Neurol · Pubmed #26417992.

ABSTRACT: BACKGROUND: Cognitive impairment may negatively impact the health-related quality of life (HRQoL) in patients with Parkinson's disease (PD). However, information on the effects of frontal lobe function and behavior changes on the HRQoL of the Chinese PD population is limited. Studies on the associations among frontal lobe function, behavioral changes and the HRQoL may help optimize the treatment and improve the HRQoL of PD patients. METHODS: A total of 309 PD patients were evaluated using the Frontal Assessment Battery, the Frontal Behavioral Inventory (FBI) and the PD Questionnaire 39-item version (PDQ-39). RESULTS: Patients with worse frontal lobe function were older (p < 0.001), had longer disease durations (p = 0.002), higher Unified Parkinson's Disease Rating Scale part III (UPDRS-III) scores (p < 0.001) and higher Hoehn and Yahr (H-Y) stages (p = 0.001), and exhibited significantly higher PDQ-39 summary index (SI; p = 0.001) compared with those who had better frontal lobe function. In addition, the disease duration (p = 0.008), UPDRS-III scores (p < 0.001), H-Y stage (p < 0.001), PDQ-39 SI and scores for each domain of the PDQ-39 (p < 0.001) were higher as the severity of frontal behavioral changes increased. The total FBI score (p < 0.001) was positively correlated with the PDQ-39 SI. CONCLUSIONS: Frontal behavioral changes were closely associated with poor HRQoL in Chinese PD patients.

5 Article Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population. 2015

Chen, YongPing / Wei, Qian-Qian / Ou, RuWei / Cao, Bei / Chen, XuePing / Zhao, Bi / Guo, XiaoYan / Yang, Yuan / Chen, Ke / Wu, Ying / Song, Wei / Shang, Hui-Fang. ·Department of Neurology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. · Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ·PLoS One · Pubmed #26208350.

ABSTRACT: BACKGROUND: The polymorphisms of α-synuclein (SNCA), rs3775444, rs3822086 and rs11931074 that are strongly associated with Parkinson's disease (PD) in Caucasian populations, were examined in this study to elucidate the role of polymorphisms in different ethnic backgrounds. The possible associations of these three polymorphisms were also investigated in PD, amyotrophic lateral sclerosis (ALS), and multiple system atrophy (MSA) in a Chinese population based on the overlapping of clinical manifestations and pathological characteristics of these three neurodegenerative diseases. METHODS: A total of 1276 PD, 885 sporadic ALS (SALS), 364 MSA patients, and 846 healthy controls (HCs) were included. All subjects were genotyped for the three polymorphisms using Sequenom iPLEX Assay technology. RESULTS: Significant differences in the genotype distributions (p = 5.99E-06 and p = 4.98E-06, respectively) and the minor allele frequency (MAF) (p = 2.16E-06 and p = 2.15E-06, respectively) of SNCA rs3822086 (C) and rs11931074 (G) were observed between PD and HCs. However, no differences were found in the genotype distributions and MAF of SNCA rs3775444 (T) between PD and HCs. Haplotype that incorporated the three SNPs further strengthened the association with PD (best haplotype, p = 9.62E-005). No significant differences in the genotype distributions and MAF of the SNPs were found between SALS and HCs, MSA and HCs, and subgroups of PD and SALS. However, the MAF of SNCA rs3775444 (T) was significantly higher in MSA patients with frontal lobe dysfunction than MSA patients without dysfunction (p = 0.0002, OR 2.53, 95%CI: 1.55-4.15). CONCLUSION: Our results suggest that the rs3822086 (C) allele and rs11931074 (G) allele in SNCA decrease the risk for PD, and SNCA rs11931074 may affect frontal lobe dysfunction of MSA in the Chinese population. However, these SNCA polymorphisms are not likely a common cause of SALS or MSA.

6 Article Diurnal drooling in Chinese patients with Parkinson's disease. 2015

Ou, Ruwei / Guo, Xiaoyan / Wei, Qianqian / Cao, Bei / Yang, Jing / Song, Wei / Chen, Ke / Zhao, Bi / Chen, Xueping / Shang, Huifang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. · Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@126.com. ·J Neurol Sci · Pubmed #25896289.

ABSTRACT: OBJECTIVE: The aim of this study is to explore the prevalence and clinical correlates of diurnal drooling in Chinese patients with Parkinson's disease (PD). METHODS: A cross-sectional analysis of 518 Chinese patients with PD was conducted. Each subject was categorized as a diurnal "drooler" or a "non-drooler" using the Non-Motor Symptoms Scale (NMSS). RESULTS: One hundred and twenty-one (23.4%) patients exhibited diurnal drooling. Diurnal drooling was reported more frequently in male and late-onset PD patients (p<0.05). The levodopa equivalent daily doses, mean age and disease duration, the percentages of PD family history and levodopa or entacapone use, the incidences of dysarthria, dysphagia and fluctuation, and the Unified PD Rating Scale (UPDRS) part III, NMSS, Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and PD Questionnaire 39 (PDQ-39) scores in droolers were significantly greater than in non-droolers (p<0.05). The percentage of benzhexol use in non-droolers was significantly higher than in droolers (p<0.05). The Frontal assessment battery (FAB) and Montreal Cognitive Assessment (MoCA) scores were not different between the droolers and non-droolers. The forward binary logistic regression model indicated that dysarthria, male sex, age, UPDRS part III, sexual dysfunction and a family history of PD were associated with diurnal drooling. CONCLUSIONS: Diurnal drooling is a relatively common debilitating symptom in Chinese PD patients. It is not only related to male sex, age, dysarthria and PD family history, but also correlates with motor and non-motor severity especially sexual dysfunction of PD. However, it is not related to cognition.

7 Article Associations between neuropsychiatric symptoms and cognition in Chinese idiopathic Parkinson's disease patients. 2015

Guo, Xiaoyan / Song, Wei / Chen, Ke / Chen, XuePing / Zheng, Zhenzhen / Cao, Bei / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, 610041 ChengDu, SiChuan, China. · Department of Neurology, West China Hospital, SiChuan University, 610041 ChengDu, SiChuan, China. Electronic address: hfshang2002@126.com. ·J Clin Neurosci · Pubmed #25582976.

ABSTRACT: The associations between neuropsychiatric symptoms and cognition, frontal lobe function and frontal behavioral changes in the Chinese idiopathic Parkinson's disease (PD) population are largely unknown. This study included 348 idiopathic PD patients from southwest China. Neuropsychiatric symptoms were investigated using the Neuropsychiatric Inventory Questionnaire (NPI), and cognition was assessed using Addenbrooke's Cognitive Examination-Revised (ACE-R). The Frontal Assessment Battery (FAB) was used to evaluate frontal function and the Frontal Behavior Inventory (FBI) was used to assess frontal behavioral changes. The mean (± standard deviation) age of the PD patients was 60.24 ± 12.07 years, and the mean disease duration was 3.88 ± 3.34 years. The mean NPI score was 3.49 ± 4.00. The mean score of ACE-R was 76.82 ± 16.73. The mean score of FAB was 15.27 ± 2.90, and the mean score of FBI was 3.18 ± 5.17. Weak negative correlations between the NPI and ACE-R scores as well as FAB score were found in the total sample, the male patient subgroup, the early onset PD subgroup and the late onset PD subgroup. Strong positive correlations were found between the NPI and FBI scores in the total sample (r=0.661, p<0.001), the male patient subgroup (r=0.789, p<0.001) and the late onset PD subgroup (r=0.749, p<0.001). Moderate positive correlations were found between the NPI and FBI scores in the female patient subgroup (r=0.536, p<0.001) and the early onset PD subgroup (r=0.462, p<0.001). Neuropsychiatric symptoms were closely associated with frontal behavioral changes but were not closely related with worse cognition and frontal lobe function in the Chinese idiopathic PD population.

8 Article The serum lipid profile of Parkinson's disease patients: a study from China. 2015

Guo, Xiaoyan / Song, Wei / Chen, Ke / Chen, XuePing / Zheng, Zhenzhen / Cao, Bei / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China. ·Int J Neurosci · Pubmed #25340257.

ABSTRACT: BACKGROUND: The association between the fasting levels of serum lipids and Parkinson's disease (PD) in Chinese populations remains largely unknown. METHODS: This study enrolled 555 sporadic PD patients and 555 age-, gender- and body mass index (BMI)-matched controls. The fasting serum lipid concentrations of all subjects, including total cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and triglycerides (TG), were measured. RESULTS: Total cholesterol, LDL-C, HDL-C and TG were significantly lower in PD patients than in controls. The prevalence of PD is significantly lower in subjects with the second, third and fourth quartiles of total cholesterol than in those with the first quartile of total cholesterol, regardless of gender. The prevalence of PD is significantly lower in subjects with the third and fourth quartiles of LDL-C than in those with the first quartile of LDL-C, regardless of gender. Negative correlations were found between UPDRS part III score and level of total cholesterol/LDL-C. CONCLUSIONS: PD patients are with lower levels of total cholesterol, LDL-C, HDL-C and TG than controls. Lipids may be a marker of PD severity.

9 Article Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China. 2014

Wu, Ying / Guo, Xiao Yan / Wei, Qian Qian / Song, Wei / Chen, Ke / Cao, Bei / Ou, Ru Wei / Zhao, Bi / Shang, Hui Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. · Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: hfshang2002@163.com. ·J Neurol Sci · Pubmed #24679837.

ABSTRACT: BACKGROUND: The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown. METHODS: A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL. RESULTS: NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively. CONCLUSION: Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients.

10 Article Survey on general knowledge on Parkinson's disease in patients with Parkinson's disease and current clinical practice for Parkinson's disease among general neurologists from Southwest China. 2014

Li, Jianpeng / Chen, Dezhi / Song, Wei / Chen, Ke / Cao, Bei / Huang, Rui / Yang, Rong / Shang, Huifang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, China. · Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, China. Electronic address: Hxyangrong2004@126.com. · Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@126.com. ·Clin Neurol Neurosurg · Pubmed #24529223.

ABSTRACT: OBJECTIVE: To evaluate general knowledge on Parkinson's disease (PD) among patients with PD and current status and choices regarding diagnosis and treatment of PD among general neurologists from grassroots hospitals of Sichuan Province, China. METHODS: Cross-sectional questionnaire-based surveys were conducted among 344 PD patients and 368 general neurologists from grassroots hospitals in Sichuan Province, China from October 2010 to October 2012. One questionnaire was developed and distributed for the patient survey on general knowledge on PD, and another one for the neurologist survey on diagnosis and treatment of PD. RESULTS: PD patients lacked information about some aspects of PD, such as etiology, side effects of antiparkinsonian drugs, use of levodopa, and surgical treatment. Patients obtained information about PD mainly from their treating clinician. Neurologists from grassroots hospitals did not have sufficient awareness and knowledge of certain aspects of PD, including non-motor symptoms, differential diagnosis, therapeutic strategy, or appropriate indications of surgical treatment, although they were familiar with the motor symptoms of the disease. CONCLUSIONS: Both PD patients and neurologists from grassroots hospitals had minimal knowledge about the disease. Improved knowledge about PD may contribute to maintaining patients' quality of life.

11 Article Camptocormia in Chinese patients with Parkinson's disease. 2014

Song, Wei / Guo, Xiaoyan / Chen, Ke / Huang, Rui / Zhao, Bi / Cao, Bei / Chen, Yongping / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. · Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@126.com. ·J Neurol Sci · Pubmed #24360186.

ABSTRACT: To investigate the frequency and clinical characteristics of camptocormia in Chinese PD patients, we included 705 patients with PD and studied the clinical features and prevalence of camptocormia. Forty-six (6.5%) patients presented with camptocormia at the time of evaluation. The mean disease duration of PD patients with camptocormia was significantly longer than that without camptocormia (P < 0.01). After adjusted for age and disease duration, compared with patients without camptocormia, PD patients with camptocormia presented with higher score of UPDRS part III (P < 0.01), higher H&Y stage (P < 0.01), higher score of Non-Motor Symptoms Scale (P < 0.01) and lower score of Mini-Mental Status Examination (P < 0.01). Binary logistic regression models indicated that camptocormia is associated with higher H&Y stage and UPDRS part III score. Camptocormia is not rare (6.5%) with the disease progression of PD in Chinese PD population and is associated with more advanced PD.

12 Article Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depression. 2014

Luo, Chunyan / Chen, Qin / Song, Wei / Chen, Ke / Guo, Xiaoyan / Yang, Jing / Huang, Xiaoqi / Gong, Qiyong / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, , Chengdu, Sichuan, China. ·J Neurol Neurosurg Psychiatry · Pubmed #24227759.

ABSTRACT: OBJECTIVE: This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson's disease (PD) with and without depression. METHOD: We recruited 29 patients with PD with depression (PD-Dep), 30 patients with PD without depression (PD-NDep), and 30 normal controls. All participants underwent resting-state fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterise regional cerebral function. Functional integration of the brain network was evaluated by seed-based correlation approach. RESULTS: The PD-Dep group showed significantly higher ALFF value in the left orbitofrontal area compared with both the PD-NDep and control groups (p<0.05 corrected by FWE). In patients with PD, the Hamilton Depression Rating Scale score was positively correlated with the ALFF value in the left orbitofrontal cortex (p<0.005 uncorrected). Brain network connectivity analysis revealed reduced functional connectivity of putamen in both PD subgroups. However, the PD-Dep group showed more distributed reduced connectivity in the prefrontal-limbic network than the PD-NDep group did (p<0.05 corrected by FWE). CONCLUSIONS: Our study demonstrates that PD-Dep patients are characterised by increased regional spontaneous neural activity in the orbitofrontal area and decreased functional integration within the prefrontal-limbic network. These findings may be helpful for facilitating further understanding of the potential mechanisms underlying depression in PD.

13 Article The impact of non-motor symptoms on the Health-Related Quality of Life of Parkinson's disease patients from Southwest China. 2014

Song, Wei / Guo, Xiaoyan / Chen, Ke / Chen, Xueping / Cao, Bei / Wei, Qianqian / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu 610041, Sichuan, China. · Department of Neurology, West China Hospital, SiChuan University, Chengdu 610041, Sichuan, China. Electronic address: hfshang2002@163.com. ·Parkinsonism Relat Disord · Pubmed #24161377.

ABSTRACT: BACKGROUND: The impact of non-motor symptoms (NMS) on the Health-Related Quality of Life (HRQoL) of patients with Parkinson's disease (PD) in the Chinese population are largely unknown. OBJECTIVES: To study the impact of NMS on the HRQoL in Chinese PD patients. METHODS: A total of 693 PD patients from Southwest China were included in the study. NMS of patients were evaluated by non-motor symptoms scale (NMSS) and Parkinson's disease questionnaire-39 item version (PDQ-39) was used to evaluate the HRQoL of PD. RESULTS: The mean total score of NMSS was 37.2 ± 33.0 and the most prevalent NMS domain was sleep/fatigue (79.8%). There was a significant strong positive correlation between total NMSS score (rs = 0.71, P < 0.01), sleep/fatigue domain (rs = 0.60, P < 0.01) and PDQ-39 SI. Mood/apathy (rs = 0.55, P < 0.01), attention/memory (rs = 0.42, P < 0.01), gastrointestinal (rs = 0.44, P < 0.01) and Miscellany domains (rs = 0.46, P < 0.01) moderately correlated with PDQ-39 SI. A strong correlation was found between PDQ-39 SI (rs = 0.71, P < 0.01), emotional well-being (rs = 0.62, P < 0.01), cognitions (rs = 0.62, P < 0.01), and the total score of NMSS. Moderate correlation was found between mobility (rs = 0.45, P < 0.01), activities of daily living (rs = 0.43, P < 0.01), stigma (rs = 0.42, P < 0.01), communication (rs = 0.47, P < 0.01), bodily discomfort (rs = 0.46, P < 0.01) and the total score of NMSS. Female, H-Y stage, UPDRS-III and NMSS total score were the potential determinants of worse HRQoL of PD patients. CONCLUSIONS: NMS have close association with various aspects of the HRQoL. Severe NMS may be related to dramatic decline of the HRQoL of PD patients.

14 Article Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study. 2014

Luo, ChunYan / Song, Wei / Chen, Qin / Zheng, ZhenZhen / Chen, Ke / Cao, Bei / Yang, Jing / Li, JianPeng / Huang, XiaoQi / Gong, QiYong / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu Sichuan, China. ·Neurobiol Aging · Pubmed #24074808.

ABSTRACT: Although cardinal motor symptoms in Parkinson's disease (PD) are attributed to dysfunction of corticostriatal loops, early clinical nonmotor features are more likely to be associated with other pathologic mechanisms. We enrolled 52 early-stage drug-naive PD patients and 52 age- and sex-matched healthy controls and used resting-state functional connectivity magnetic resonance imaging to evaluate alteration of the functional brain network in PD, focusing in particular on the functional connectivity of the striatum subregions. Relative to healthy controls, the PD patient group showed reduced functional connectivity in mesolimbic-striatal and corticostriatal loops. Although the deceased functional connectivity within cortical sensorimotor areas was only evident in the most affected putamen subregion, reduced functional connectivity with mesolimbic regions was prevalent throughout the striatum. No increased functional connectivity was found in this cohort. By studying a cohort of early-stage drug-naive PD patients, we ruled out the potential confounding effect of prolonged antiparkinson medication use on the functional integration of neural networks. We demonstrate decreased functional integration across neural networks involving striatum, mesolimbic cortex, and sensorimotor regions in these patients and postulate that the prevalent disconnection in mesolimbic-striatal loops is associated with some early clinical nonmotor features in PD. This study offers additional insight into the early functional integration of neural networks in PD.

15 Article Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China. 2013

Guo, Xiaoyan / Song, Wei / Chen, Ke / Chen, Xueping / Zheng, Zhenzhen / Cao, Bei / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan 610041, China. ·Parkinsonism Relat Disord · Pubmed #23849500.

ABSTRACT: BACKGROUND: Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS: A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor Symptom Scale (NMSS) and Unified PD Rating Scale (UPDRS). RESULTS: More NMS and significantly higher NMSS score were found in LOPD patients than in EOPD patients (9.3 ± 5.9 vs. 7.7 ± 5.6, P = 0.005; 37.4 ± 32.2 vs. 30.5 ± 28.9, P = 0.018), while no such differences were found between male and female patients. The NMS of gastrointestinal and urinary domains were more common in LOPD patients than in EOPD patients, whereas sexual dysfunction was more common in EOPD than in LOPD. The sleep/fatigue domain, the mood/apathy domain and "pain" symptoms were more prevalent and severe in female patients than in male patients while urinary symptoms were more common and severe in male patients. Significant positive correlations were observed between disease duration, Hoehn & Yahr stage, UPDRS Ⅲ, and NMSS score in the total sample, subgroups of both male and female patients as well as both EOPD and LOPD patients. CONCLUSIONS: NMS are common in the Chinese PD population. LOPD patients are likely to present with more and severe NMS than EOPD patients. Males are subjected to urinary symptoms and females are subjected to mood/apathy, sleep and pain symptoms.

16 Article GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population. 2013

Chen, Yong Ping / Song, Wei / Huang, Rui / Chen, Ke / Zhao, Bi / Li, Jianpeng / Yang, Yuan / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu Sichuan, China. ·J Clin Neurosci · Pubmed #23618683.

ABSTRACT: Numerous single-nucleotide polymorphisms (SNPs) such as GAK rs1564282 and DGKQ rs11248060 have been reported to be associated with the risk of Parkinson's disease (PD) in Caucasian populations. However, this association is yet to be proven in the Chinese population. This study included 376 unrelated Han Chinese PD patients from Southwest China and 277 unrelated Chinese healthy controls from the same region. Two SNPs, namely, rs1564282 and rs11248060, were genotyped using Sequenom's iPLEX assay. The allele frequencies and genotype distributions of the SNPs in the PD patients and controls were compared using Fisher's exact test. Significant differences were found in the genotype distributions and allele frequencies for DGKQ rs11248060 between PD patients and controls (p = 0.0425 and p = 0.0308, respectively). Significant differences were also observed in the allele frequencies for GAK rs1564282 between PD patients and controls. No significant differences were observed in the genotype frequencies, minor allele frequency, and minor allele carrier frequencies between early-onset PD (EOPD) and controls, between late-onset PD (LOPD) and controls, and between EOPD and LOPD after conservative Bonferroni adjustment. GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients. More related studies with a larger number of participants are needed to confirm these findings.

17 Article Disease duration-related differences in non-motor symptoms: a study of 616 Chinese Parkinson's disease patients. 2013

Guo, Xiaoyan / Song, Wei / Chen, Ke / Chen, XuePing / Zheng, Zhenzhen / Cao, Bei / Huang, Rui / Zhao, Bi / Wu, Ying / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, China. ·J Neurol Sci · Pubmed #23601697.

ABSTRACT: The differences in non-motor symptoms (NMS) along with the duration of Parkinson's disease (PD) in Chinese populations remain largely unknown. A total of 616 PD patients consisting of 189 patients with disease duration of less than 2years, 239 patients with duration between 2 and 5years, 122 patients with duration between 5 and 10years, and 66 patients with duration more than 10years from Southwest China were studied. Each patient was assessed using the non-motor symptoms scale (NMSS). The mean affected number of NMS was 8.8±5.8, and the mean total NMSS score was 36.3±33.2. The mean affected number of NMS and the mean total NMSS score increased with the disease progression. The following symptoms became more common and severe with the disease duration: falls due to fainting, fatigue, difficulty falling asleep, restless legs, perceptual problem/hallucination domain (i.e., "hallucinations," "delusions," and "double vision"), gastrointestinal domain (i.e., "dribbling saliva," "swallowing," and "constipation"), urinary domain (i.e., "urgency," "frequency," and "nocturia"), and miscellaneous domain (i.e., "excessive sweating"). However, some symptoms such as mood/apathy pleasure, sexual dysfunction, and others remained stable. NMS are prevalent in all disease duration of the Chinese PD patients. Although the mean affected number of NMS and NMMS score increased with the disease duration, NMS progression is symptom specific.

18 Article VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China. 2013

Chen, YongPing / Chen, Ke / Song, Wei / Chen, XuePing / Cao, Bei / Huang, Rui / Zhao, Bi / Guo, XiaoYan / Burgunder, JeanMarc / Li, JianPeng / Shang, Hui-Fang. ·Department of Neurology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, SiChuan University, Chengdu, Sichuan, China. ·Neurobiol Aging · Pubmed #23261770.

ABSTRACT: The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, the frequencies of these 2 mutations among Chinese PD patients are unknown. We examined these mutations in a large cohort consisting of 609 PD patients and 600 healthy control subjects from Southwest China. Our results suggest that the Asp620Asn mutation in VPS35 and the Arg1205His mutation in EIF4G1 do not play a role in PD in the Southwest China population. The novel Arg1205Cys mutation in EIF4G1 detected in the current study should be further studied among other Asian patients.

19 Article Association analysis of single-nucleotide polymorphisms of USP24 and USP40 with Parkinson's disease in the Han Chinese population. 2012

Zhao, Bi / Song, Wei / Chen, Yong Ping / Huang, Rui / Chen, Ke / Cao, Bei / Yang, Yuan / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. ·Eur Neurol · Pubmed #22923019.

ABSTRACT: BACKGROUND: The ubiquitin-proteasomal pathway has been found to be involved in the etiology of Parkinson's disease (PD). Numerous single-nucleotide polymorphisms (SNPs) in both USP24 and USP40 genes have been linked to increased risks of late-onset PD, but the association has not been confirmed in the residents of mainland China, especially the Han population. METHODS: We included 378 unrelated Han Chinese PD patients from south west China and 274 unrelated Han Chinese healthy controls from the same region. Multiple SNPs, including rs13312, rs1165226, rs487230, and rs287235 of USP24 and rs1048603 of USP40, were genotyped using Sequenom iPLEX Assay technology. RESULTS: No significant differences in the genotype frequencies and minor allele frequency of all SNPs were observed between the PD and control groups, between the early-onset PD and control groups, between the late-onset PD and control groups, and between the early-onset PD and late-onset PD groups. CONCLUSION: The present study is the first to report a lack of association between SNPs of USP24 and USP40 and PD in Han Chinese patients. Other association studies with larger numbers of participants are necessary to confirm the present findings.

20 Article Association analysis of LRP8 SNP rs3820198 and rs5174 with Parkinson's disease in Han Chinese population. 2012

Chen, Ke / Chen, Yong Ping / Song, Wei / Huang, Rui / Zhao, Bi / Cao, Bei / Yang, Yuan / Satake, Wataru / Toda, Tatsushi / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. ·Neurol Res · Pubmed #22889673.

ABSTRACT: OBJECTIVES: The single-nucleotide polymorphism (SNP) rs5174 of the low-density lipoprotein receptor-related protein 8 (LRP8) gene has been linked to decreased risk for Parkinson's disease (PD) on Caucasian populations. However, this association has not been proven in Han Chinese populations. METHODS: A total of 378 unrelated Han patients with PD from the Department of Neurology, West China Hospital of Sichuan University and 274 unrelated Han healthy controls (HCs) from the same region were included in this study. SNPs rs5174 and rs3820198 were genotyped using the Sequenom iPLEX Assay technology. RESULTS: No significant difference was found in the genotype and minor allele frequencies (MAFs) of SNPs rs5174 and rs3820198 between the PD and HC groups, the early-onset PD and HC groups, the late-onset PD and HC groups, as well as the early-onset PD and late-onset PD groups. CONCLUSION: This report is the first one on the lack of association of the LRP8 SNPs rs5174 and rs3820198 with PD in Han Chinese population. Together with a Japanese study, the results indicate that the variants within the LRP8 gene do not contribute to the risk of developing PD in Asian populations.

21 Article GLIS1 rs797906: an increased risk factor for late-onset Parkinson's disease in the Han Chinese population. 2012

Song, Wei / Chen, Yong Ping / Huang, Rui / Chen, Ke / Pan, Ping Lei / Li, Jianpeng / Yang, Yuan / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, Sichuan University, Chengdu, PR China. ·Eur Neurol · Pubmed #22759478.

ABSTRACT: BACKGROUND: Single nucleotide polymorphism (SNP) rs797906 of the GLIS family zinc finger 1 (GLIS1) gene has been linked to a risk of Parkinson's disease (PD) in genome-wide association studies of Caucasian populations. METHODS: A total of 380 unrelated Han patients with PD from the Department of Neurology, West China Hospital of Sichuan University, and 275 unrelated Han Chinese healthy controls (HC) from the same region were included. rs797906 SNP was genotyped using Sequenom iPLEX Assay technology. RESULTS: No significant differences were found in the genotype and allele frequencies for rs797906 between the PD and HC groups. There were no significant differences in genotype frequencies between early-onset PD and HC groups and between late-onset PD and HC groups. The frequency of allele 'A' for rs797906 in the late-onset PD group was significantly higher than that in the HC group (p = 0.046, OR 1.2726, 95% CI 1.0039-1.6132). Moreover, the frequency of allele 'A' in the late-onset PD group was significantly higher than that in the early-onset PD group (p = 0.001). CONCLUSION: We have found that allele 'A' of rs797906 SNP increases the risk for late-onset PD in the Han Chinese population. More associated studies with larger numbers of participants are needed to confirm the present findings.

22 Article Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population. 2012

Song, Wei / Chen, Yong Ping / Huang, Rui / Chen, Ke / Pan, Ping Lei / Li, Jianpeng / Yang, Yuan / Shang, Hui-Fang. ·Department of Neurology, West China Hospital, SiChuan University, Chengdu Sichuan, China. ·Neurol India · Pubmed #22406787.

ABSTRACT: Numerous Single-Nucleotide Polymorphisms (SNPs) of the Diacylglycerol Kinase Delta (DGKD) isoform 1 gene have been associated with Parkinson Disease (PD) in the genome-wide association studies of Caucasian population. This association has not been proven in the Han Chinese PD patients. This study included 376 unrelated Han Chinese PD patients from West China and 273 unrelated healthy controls from the same region. Five SNPs (rs2971859, rs1550532, rs2305539, rs2034762, and rs2242102) were genotyped using the Sequenom iPLEX Assay technology. No significant differences were observed in genotype frequencies and in the Minor Allele Frequency (MAF) in the five SNPs between PD patients and controls, early-onset PD and controls, late-onset PD and controls, and between early-onset and late-onset PD patients. The present study is the first to report on the lack of association of DGKD SNPs with PD in the Han Chinese population. More related studies involving larger numbers of participants are necessary to confirm the present finding.