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Parkinson Disease: HELP
Articles by Alain Delgado
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, A. Delgado wrote the following 3 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Clinical Trial Selection of deep brain stimulation candidates in private neurology practices: referral may be simpler than a computerized triage system. 2012

Oyama, Genko / Rodriguez, Ramon L / Jones, Jacob D / Swartz, Camille / Merritt, Stacy / Unger, Richard / Hubmann, Monica / Delgado, Alain / Simon, Ely / Doniger, Glen M / Bowers, Dawn / Foote, Kelly D / Fernandez, Hubert H / Okun, Michael S. ·Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, FL 32610, USA. ·Neuromodulation · Pubmed #22376158.

ABSTRACT: OBJECTIVE: The objective of this study is to compare a computerized deep brain stimulation (DBS) screening module (Comparing Private Practice vs. Academic Centers in Selection of DBS Candidates [COMPRESS], NeuroTrax Corp., Bellaire, TX, USA) with traditional triage by a movement disorders specialized neurologist as the gold standard. METHODS: The COMPRESS consists of a combination of the Florida Surgical Questionnaire for Parkinson disease (FLASQ-PD), a cognitive assessment battery provided by MindStreams® (NeuroTrax Corp.), and the Geriatric Depression Scale and the Zung Anxiety Self-Assessment Scale. COMPRESS resulted in the classification of patients into three categories: "optimal candidate,""probable candidate," and "not a good candidate." Similar categorical ratings made by a referring private practice neurologist and by a trained movement disorders specialist were compared with the ratings generated by COMPRESS. RESULTS: A total of 19 subjects with Parkinson's disease were enrolled from five private neurological practices. The clinical impressions of the private practice neurologist vs. those of the movement disorders specialist were in agreement approximately half the time (10/19 cases). The movement disorders specialist and COMPRESS agreed on 15/19 cases. A further comparison between outcomes from the entire COMPRESS module and the FLASQ-PD questionnaire by itself resulted in high agreement (18/19 cases in agreement). CONCLUSIONS: The COMPRESS agreed with an in-person evaluation by a movement disorders neurologist approximately 80% of the time. The computerized COMPRESS did not provide any screening advantage over the short FLASQ-PD paper questionnaire. Larger studies will be needed to assess the utility and cost effectiveness of this computerized triage method for DBS.

2 Article Effects of local activation and blockade of dopamine D4 receptors in the spiking activity of the reticular thalamic nucleus in normal and in ipsilateral dopamine-depleted rats. 2019

Barrientos, R / Alatorre, A / Martínez-Escudero, J / García-Ramírez, M / Oviedo-Chávez, A / Delgado, A / Querejeta, E. ·Academia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, CdMx 11340, Mexico; Sección de Investigación y Posgrado de la Escuela Superior de Medicina del IPN, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, CdMx 11340, Mexico. · Academia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, CdMx 11340, Mexico. · Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Wilfrido Massieu SN, Unidad profesional Adolfo López Mateos, Col. Planetario Zacatenco, CdMx 07738, Mexico. · Departamento de Fisiología Experimental, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito Universitario Campus II, Chihuahua, Chih 31127, Mexico. · Academia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, CdMx 11340, Mexico; Sección de Investigación y Posgrado de la Escuela Superior de Medicina del IPN, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, CdMx 11340, Mexico. Electronic address: equerejeta@ipn.mx. ·Brain Res · Pubmed #30716288.

ABSTRACT: The reticular thalamic nucleus (RTn) controls the overall activity of thalamo-cortical neurons information processing. GABAergic RTn neurons have one of the highest densities of D4-type dopamine receptors in subcortical structures. The unitary electrical activity of RTn neurons was recorded in vivo in Wistar rats in order to study the effects of local activation and blockade of D4 receptors under both conditions, normal and ipsilateral lesion of the dopaminergic pathways. Our data suggest that: i) there is a tonic dopaminergic input to the RTn; ii) local activation of D4 receptors increases the basal firing rate of RTn neurons in normal and lesioned rats, and iii) local blockade of D4 receptors diminishes the firing rate in normal but not in lesioned rats. Altogether, our findings support that dopamine contributes to the spontaneous basal firing of the RTn neurons through D4-type dopamine receptors.

3 Article Differential functioning of mini-mental test items according to disease. 2011

Prieto, G / Delgado, A R / Perea, M V / Ladera, V. ·Departamento de Psicología Básica, Psicobiología y Metodología, Universidad de Salamanca, Salamanca, Spain. ·Neurologia · Pubmed #21414692.

ABSTRACT: INTRODUCTION: Comparing the height of males and females would be impossible if the measuring device did not have the same properties for both populations. In a similar way, the cognitive level of diverse groups of patients should not be compared if the test has different measurement properties for these groups. Lack of Differential Item Functioning (DIF) is a condition for measurement invariance between populations. MATERIAL AND METHODS: The most internationally used screening test for dementia, the MMSE (or Mini-mental State Examination), has been analysed using an advanced psychometric technique, the Rasch Model. The objective was to determine the invariance of mini-mental measurements from diverse groups: Parkinson's disease patients, Alzheimer's type dementia and normal subjects. The hypothesis was that the scores would not show DIF against any of these groups. The total sample was composed of 400 subjects. RESULTS: Significant differences between groups were found. However, the quantitative comparison only makes sense if no evidence against measurement invariance was found: given the kind of items showing DIF against Parkinson's disease patients, the MMSE seems to underestimate the cognitive level of these patients. CONCLUSIONS: Despite the extended use of this test, 11 items out of 30 show DIF and consequently score comparisons between groups are not justified.