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Parkinson Disease: HELP
Articles by M. Elizabeth Fini
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, M. Fini wrote the following 3 articles about Parkinson Disease.
+ Citations + Abstracts
1 Article Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. 2016

Brilliant, Murray H / Vaziri, Kamyar / Connor, Thomas B / Schwartz, Stephen G / Carroll, Joseph J / McCarty, Catherine A / Schrodi, Steven J / Hebbring, Scott J / Kishor, Krishna S / Flynn, Harry W / Moshfeghi, Andrew A / Moshfeghi, Darius M / Fini, M Elizabeth / McKay, Brian S. ·Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wis. · Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Palm Beach Gardens, Fla. · Department of Ophthalmology, Medical College of Wisconsin, Milwaukee. · Department of Ophthalmology, Medical College of Wisconsin, Milwaukee; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee. · Essentia Institute of Rural Health, Duluth, Minn. · Department of Ophthalmology, USC Eye Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles. · Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, Calif. · USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles; Department of Cell & Neurobiology, Keck School of Medicine of USC, University of Southern California, Los Angeles; Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, Los Angeles. · Department of Ophthalmology and Vision Science, University of Arizona, Tucson; Department of Cellular and Molecular Medicine, University of Arizona, Tucson. Electronic address: bsmckay@eyes.arizona.edu. ·Am J Med · Pubmed #26524704.

ABSTRACT: BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. A key cell type involved in AMD, the retinal pigment epithelium, expresses a G protein-coupled receptor that, in response to its ligand, L-DOPA, up-regulates pigment epithelia-derived factor, while down-regulating vascular endothelial growth factor. In this study we investigated the potential relationship between L-DOPA and AMD. METHODS: We used retrospective analysis to compare the incidence of AMD between patients taking vs not taking L-DOPA. We analyzed 2 separate cohorts of patients with extensive medical records from the Marshfield Clinic (approximately 17,000 and approximately 20,000) and the Truven MarketScan outpatient and databases (approximately 87 million) patients. We used International Classification of Diseases, 9th Revision codes to identify AMD diagnoses and L-DOPA prescriptions to determine the relative risk of developing AMD and age of onset with or without an L-DOPA prescription. RESULTS: In the retrospective analysis of patients without an L-DOPA prescription, AMD age of onset was 71.2, 71.3, and 71.3 in 3 independent retrospective cohorts. Age-related macular degeneration occurred significantly later in patients with an L-DOPA prescription, 79.4 in all cohorts. The odds ratio of developing AMD was also significantly negatively correlated by L-DOPA (odds ratio 0.78; confidence interval, 0.76-0.80; P <.001). Similar results were observed for neovascular AMD (P <.001). CONCLUSIONS: Exogenous L-DOPA was protective against AMD. L-DOPA is normally produced in pigmented tissues, such as the retinal pigment epithelium, as a byproduct of melanin synthesis by tyrosinase. GPR143 is the only known L-DOPA receptor; it is therefore plausible that GPR143 may be a fruitful target to combat this devastating disease.

2 Article Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus in idiopathic Parkinson's disease: effects on gait initiation and performance. 2014

Mazzone, P / Paoloni, M / Mangone, M / Santilli, V / Insola, A / Fini, M / Scarnati, E. ·Stereotactic and Functional Neurosurgery, CTO Hospital, ASL RMC, Rome, Italy. Electronic address: stereomaz@libero.it. · Biomechanics and Movement Analysis Laboratory, Physical Medicine and Rehabilitation, University of Rome La Sapienza, Italy. · Clinical Neurophysiology, CTO Hospital, ASL RMC, Rome, Italy. · IRCCS San Raffaele Pisana, Rome, Italy. · Department of Biotechnological and Applied Clinical Sciences (DISCAB),University of L'Aquila, L'Aquila, Italy. ·Gait Posture · Pubmed #24908195.

ABSTRACT: The pedunculopontine tegmental nucleus (PPTg) is a component of the locomotor mesencephalic area. In recent years it has been considered a new surgical site for deep brain stimulation (DBS) in movement disorders. Here, using objective kinematic and spatio-temporal gait analysis, we report the impact of low frequency (40 Hz) unilateral PPTg DBS in ten patients suffering from idiopathic Parkinson's disease with drug-resistant gait and axial disabilities. Patients were studied for gait initiation (GI) and steady-state level walking (LW) under residual drug therapy. In the LW study, a straight walking task was employed. Patients were compared with healthy age-matched controls. The analysis revealed that GI, cadence, stride length and left pelvic tilt range of motion (ROM) improved under stimulation. The duration of the S1 and S2 sub-phases of the anticipatory postural adjustment phase of GI was not affected by stimulation, however a significant improvement was observed in the S1 sub-phase in both the backward shift of centre of pressure and peak velocity. Speed during the swing phase, step width, stance duration, right pelvic tilt ROM phase, right and left hip flexion-extension ROM, and right and left knee ROM were not modified. Overall, the results show that unilateral PPTg DBS may affect GI and specific spatio-temporal and kinematic parameters during unconstrained walking on a straight trajectory, thus providing further support to the importance of the PPTg in the modulation of gait in neurodegenerative disorders.

3 Article The relation between Parkinson's disease and ageing. Comparison of the gait patterns of young Parkinson's disease subjects with healthy elderly subjects. 2013

Sale, P / De Pandis, M F / Vimercati, S L / Sova, I / Foti, C / Tenore, N / Fini, M / Stocchi, F / Albertini, G / Franceschini, M / Galli, M. ·IRCCS San Raffaele, Rome, Italy. patrizio.sale@gmail.com ·Eur J Phys Rehabil Med · Pubmed #22569487.

ABSTRACT: BACKGROUND: The gait of healthy elderly and of subjects with Parkinson's disease (PD) displays some common features, suggesting that PD may be a model of ageing. AIM: The aim of the study was to quantify highlight the differences and similarities between the gait patterns of young PD and healthy elderly, to uncover if PD could be assumed as a model of ageing. DESIGN: An optoelectronic system was used for 3D gait analysis evaluation. POPULATION AND METHODS: We compared the gait parameters of 15 young PD (YPD) with the gait of 32 healthy elderly subjects (ES) and 21 healthy subjects age-matched with the PD subjects. RESULTS. Common features between YPD and ES were majorly found in the parameters that reflect the presence of an unstable, uncertain gait, and of corrective strategies employed to reduce instability. On the other side, typical features were present in the gait patterns of PD subjects. CONCLUSION. Our study helped identifying some typical characteristics of the onset disease, and to unravel the symptoms of ageing from those of PD by comparing young PD subjects to elderly healthy subjects. CLINICAL REHABILITATION IMPACT: This allows a deeper understanding of the mechanisms underlying the gait in ageing and PD.