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Parkinson Disease: HELP
Articles by M. Fox
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, M. Fox wrote the following 2 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Review The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson's disease: A systematic review and meta-analysis. 2017

Song, R / Grabowska, W / Park, M / Osypiuk, K / Vergara-Diaz, G P / Bonato, P / Hausdorff, J M / Fox, M / Sudarsky, L R / Macklin, E / Wayne, P M. ·College of Nursing, Chungnam National University, South Korea. Electronic address: songry@cnu.ac.kr. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: wgrabowska@coa.edu. · Department of Nursing, Woosong College, South Korea. Electronic address: mkpark@wsi.ac.kr. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: kosypiuk@partners.org. · Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, USA. Electronic address: gvergaradiaz@partners.org. · Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, USA. Electronic address: pbonato@partners.org. · Sackler Faculty of Medicine, Tel Aviv University, Center for the Study of Movement, Cognition, and Mobility at Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel. Electronic address: Jeff.hausdorff@gmail.com. · Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA. Electronic address: Mfox3@bidmc.harvard.edu. · Department of Neurology, Harvard Medical School, Brigham and Women's Hospital, USA. Electronic address: lsudarsky@partners.org. · Harvard Medical School, Massachusetts General Hospital, USA. Electronic address: emacklin@mgh.harvard.org. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: pwayne@partners.org. ·Parkinsonism Relat Disord · Pubmed #28602515.

ABSTRACT: PURPOSE: To systematically evaluate and quantify the effects of Tai Chi/Qigong (TCQ) on motor (UPDRS III, balance, falls, Timed-Up-and-Go, and 6-Minute Walk) and non-motor (depression and cognition) function, and quality of life (QOL) in patients with Parkinson's disease (PD). METHODS: A systematic search in 7 electronic databases targeted clinical studies evaluating TCQ for individuals with PD published through August 2016. Meta-analysis was used to estimate effect sizes (Hedges's g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed by two raters. RESULTS: Our search identified 21 studies, 15 of which were RCTs with a total of 735 subjects. For RCTs, comparison groups included no treatment (n = 7, 47%) and active interventions (n = 8, 53%). Duration of TCQ ranged from 2 to 6 months. Methodological bias was low in 6 studies, moderate in 7, and high in 2. Fixed-effect models showed that TCQ was associated with significant improvement on most motor outcomes (UPDRS III [ES = -0.444, p < 0.001], balance [ES = 0.544, p < 0.001], Timed-Up-and-Go [ES = -0.341, p = 0.005], 6 MW [ES = -0.293, p = 0.06], falls [ES = -0.403, p = 0.004], as well as depression [ES = -0.457, p = 0.008] and QOL [ES = -0.393, p < 0.001], but not cognition [ES = -0.225, p = 0.477]). I CONCLUSION: Evidence to date supports a potential benefit of TCQ for improving motor function, depression and QOL for individuals with PD, and validates the need for additional large-scale trials.

2 Article Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy. 2018

Yu, F / Barron, D S / Tantiwongkosi, B / Fox, M / Fox, P. ·Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA. Electronic address: frankfy21@gmail.com. · Department of Psychiatry, Yale School of Medicine, 333 Cedar St., New Haven, CT 06510, USA. · Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7800, San Antonio, TX 78229, USA. · Research Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229, USA. ·Clin Radiol · Pubmed #29269038.

ABSTRACT: AIM: To characterise the meta-analytical functional connectivity patterns in progressive supranuclear palsy (PSP) and compare them to idiopathic Parkinson's disease (IPD). MATERIALS AND METHODS: It was previously reported that PSP and IPD showed distinct regions of brain atrophy based on voxel-based morphometry (VBM) meta-analysis. Using these regions as seeds, healthy control data were referenced to create and statistically compare meta-analytical functional connectivity maps of PSP and IPD. RESULTS: Some overlap was noted between the two diseases, including within the thalamus, striatum, and prefrontal cortex; however, the PSP seeds demonstrated more extensive functional co-activity throughout the brain, particularly within the midbrain, precentral gyrus, parietal cortex, basal ganglia, and cerebellum. CONCLUSION: These findings may help guide future longitudinal studies in the development of new functional imaging biomarkers for diagnosis and assessing treatment response.