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Parkinson Disease: HELP
Articles by Akshay A. Gupte
Based on 5 articles published since 2010
(Why 5 articles?)

Between 2010 and 2020, Akshay Gupte wrote the following 5 articles about Parkinson Disease.
+ Citations + Abstracts
1 Review MRI-related heating near deep brain stimulation electrodes: more data are needed. 2011

Gupte, Akshay A / Shrivastava, Devashish / Spaniol, Maggie A / Abosch, Aviva. ·Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA. ·Stereotact Funct Neurosurg · Pubmed #21494064.

ABSTRACT: Magnetic resonance imaging (MRI) of patients with implanted deep brain stimulation (DBS) devices poses a challenge for healthcare providers. As a consequence of safety concerns about magnetic field interactions with the device, induced electrical currents and thermal damage due to radiofrequency heating, a number of stringent guidelines have been proposed by the device manufacturer. Very few detailed investigations of these safety issues have been published to date, and the stringent manufacturer guidelines have gone unchallenged, leading some hospitals and imaging centers around the world to ban or restrict the use of MRI in DBS patients. The purpose of this review is to stimulate research towards defining appropriate guidelines for the use of MRI in patients with DBS. Additionally, this review is intended to help healthcare providers and researchers make sound clinical judgments about the use of MRI in the setting of implanted DBS devices.

2 Clinical Trial Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease. 2018

Telkes, Ilknur / Viswanathan, Ashwin / Jimenez-Shahed, Joohi / Abosch, Aviva / Ozturk, Musa / Gupte, Akshay / Jankovic, Joseph / Ince, Nuri F. ·Department of Biomedical Engineering, University of Houston, Houston, TX 77204-5060. · Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030. · Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030. · Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO 80045. · Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455. · Department of Biomedical Engineering, University of Houston, Houston, TX 77204-5060; nfince@uh.edu. ·Proc Natl Acad Sci U S A · Pubmed #30131429.

ABSTRACT: Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and postural instability and gait difficulty (PIGD), have been defined based on symptoms since the mid-1990s, no underlying neural correlates of these clinical subtypes have yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD. Here, we show that activity in subbands of local field potentials (LFPs) recorded with multiple microelectrodes from subterritories of STN provide distinguishing neurophysiological information about the motor subtypes of PD. We studied 24 patients with PD and found distinct patterns between TD (

3 Article Impulsive behavior and associated clinical variables in Parkinson's disease. 2011

Abosch, Aviva / Gupte, Akshay / Eberly, Lynn E / Tuite, Paul J / Nance, Martha / Grant, Jon E. ·Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA. aabosch@umn.edu ·Psychosomatics · Pubmed #21300194.

ABSTRACT: BACKGROUND: Parkinson's disease (PD) is a degenerative brain disorder accompanied by the loss of dopaminergic neurons and the presence of motor and non-motor symptoms. OBJECTIVE: We performed a cross-sectional, questionnaire-based analysis of impulsive behavior in our PD clinic population to assess prevalence and associated characteristics. RESULTS: We found a higher prevalence of impulsive behavior (29.7%) than previously reported, and found multiple, concurrent impulsive behaviors in 26% of subjects reporting impulsive behavior. CONCLUSIONS: Our findings contribute to the growing awareness of impulsive behavior in PD, and support the need for longitudinal studies to assess changes in impulsive behaviors in Parkinson's patients.

4 Article Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's disease. 2010

Ince, Nuri Firat / Gupte, Akshay / Wichmann, Thomas / Ashe, James / Henry, Thomas / Bebler, Margaret / Eberly, Lynn / Abosch, Aviva. ·Departments of Neurosurgery and Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA. ·Neurosurgery · Pubmed #20644424.

ABSTRACT: BACKGROUND: In the United States, the most commonly used surgical treatment for patients with Parkinson's disease is the implantation of deep brain stimulation (DBS) electrodes within the subthalamic nucleus. However, DBS device programming remains difficult and is a possible source of decreased efficacy. OBJECTIVE: We investigated the relationship between local field potential (LFP) activities in the subthalamic nucleus and the therapeutic response to programming. METHODS: We recorded LFPs with macroelectrodes placed unilaterally for DBS in 4 PD patients, 3 weeks after implantation, before the start of log-term DBS. Power-frequency spectra were calculated for each of 7 possible electrode contacts or contact pairs, over multiple 5- to 10-minute quiet waking epochs and over 30-second epochs during hand movements. Subsequently, DBS devices were programmed, with testing to determine which electrode contacts or contact pairs demonstrated optimal therapeutic efficacy. RESULTS: For each patient, the contact pair found to provide optimal efficacy was associated with the highest energy in the beta (13-32 Hz) and gamma (48-220 Hz) bands during postoperative LFP recordings at rest and during hand movements. Activities in other frequency bands did not show significant correlations between LFP power and optimal electrode contacts. CONCLUSION: Postoperative subband analysis of LFP recordings in beta and gamma frequency ranges may be used to select optimal electrode contacts. These results indicate that LFP recordings from implanted DBS electrodes can provide important clues to guide the optimization of DBS therapy in individual patients.

5 Article Bowstringing as a complication of deep brain stimulation: case report. 2010

Janson, Christopher / Maxwell, Robert / Gupte, Akshay A / Abosch, Aviva. ·Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. janson@memorymatters.org ·Neurosurgery · Pubmed #20495391.

ABSTRACT: OBJECTIVE: This retrospective case series describes bowstringing as a complication of deep brain stimulator implantation for Parkinson's disease, defined as abnormal tethering of leads between the pulse generator and stimulating electrode, associated with contracture of the patient's neck over the extension cable. There are no previous reports of this specific complication, which presumably has been more broadly classified under hardware-related complications. CLINICAL PRESENTATION: Bowstringing may result in discomfort, restriction of movements, and/or equipment malfunction. Patients were identified by postoperative surveillance in clinic and by review of our database of Parkinson's disease patients who had undergone subthalamic nucleus deep brain stimulator placement. The incidence of this complication was 2.6% (6/228) in our overall clinic population, composed of 0% (0/181) of patients who received a Soletra pulse generator and 12.7% (6/47) of patients who received a Kinetra pulse generator. INTERVENTION: The proportion of patients with bowstringing requiring operative revision was 83% (5/6), with 60% (3/5) patients undergoing conversion to single-channel pulse generators and 40% (2/5) undergoing revision of the original dual-channel pulse generator. CONCLUSION: Factors associated with bowstringing include the use of dual-channel pulse generators and scar lysis complicated by seroma or infection. The mean time from implantation to bowstringing was 8.6 months with a range of 0.5 to 22 months. Bowstringing is a rare but potentially serious complication, and further study is needed to accurately predict and avoid this problem.