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Parkinson Disease: HELP
Articles by Carmen C. Janvin
Based on 4 articles published since 2010
(Why 4 articles?)
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Between 2010 and 2020, C. Janvin wrote the following 4 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Article Mapping cortical atrophy in Parkinson's disease patients with dementia. 2013

Hwang, Kristy S / Beyer, Mona K / Green, Amity E / Chung, Christine / Thompson, Paul M / Janvin, Carmen / Larsen, Jan P / Aarsland, Dag / Apostolova, Liana G. ·Department of Neurology, University of California, Los Angeles, CA, USA. ·J Parkinsons Dis · Pubmed #23938313.

ABSTRACT: BACKGROUND: Cognitive impairment is very common in patients with Parkinson's disease (PD). Brain changes accompanying cognitive decline in PD are still not fully established. METHODS: We applied cortical pattern matching and cortical thickness analyses to the three-dimensional T1-weighted brain MRI scans of 14 age-matched cognitively normal elderly (NC), 12 cognitively normal PD (PDC), and 11 PD dementia (PDD) subjects. We used linear regression models to investigate the effect of diagnosis on cortical thickness. All maps were adjusted for multiple comparisons using permutation testing with a threshold p < 0.01. RESULTS: PDD showed significantly thinner bilateral sensorimotor, perisylvian, lateral parietal, as well as right posterior cingulate, parieto-occipital, inferior temporal and lateral frontal cortices relative to NC (left p(corrected) = 0.06, right p(corrected) = 0.009). PDD showed significantly thinner bilateral sensorimotor, right frontal and right parietal-occipital cortices relative to PDC (right p(corrected) = 0.05). The absolute difference in cortical thickness between PDD and the other diagnostic groups ranged from 3% to 19%. CONCLUSION: Our data shows that cognitive decline in PD is associated with cortical atrophy. PDD subjects have the most widespread gray matter atrophy suggesting more cortical involvement as PD patients progress to dementia.

2 Article The economic impact of cognitive impairment in Parkinson's disease. 2011

Vossius, Corinna / Larsen, Jan P / Janvin, Carmen / Aarsland, Dag. ·Department of Neurology, Stavanger University Hospital, Stavanger, Norway. c.vossius@hotmail.com ·Mov Disord · Pubmed #21538519.

ABSTRACT: BACKGROUND: We investigated to what extent cognitive impairment and dementia were related to the direct medical and nonmedical costs in Parkinson's disease. METHODS: Sixty-one patients with Parkinson's disease from a population-based cohort were assessed for motor and cognitive symptoms in 1993, 1997, and 2001. Data on use of health care and social services were collected. RESULTS: The costs of patients with dementia were 3.3 times higher (€34,980) than those of nondemented patients (€10,626) per year of survival. Institutional care was the largest cost factor, representing 67% of the costs. Cognitive functioning predicted direct costs by 29.4%. Cognitive decline was associated with increased costs, even in nondemented subjects. CONCLUSIONS: Our findings suggest that dementia has a substantial impact on direct costs in Parkinson's disease, mainly due to high costs for institutional care. In addition, there were indications that even patients with mild cognitive impairment have higher nonmedical costs.

3 Article Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. 2010

Aarsland, D / Bronnick, K / Williams-Gray, C / Weintraub, D / Marder, K / Kulisevsky, J / Burn, D / Barone, P / Pagonabarraga, J / Allcock, L / Santangelo, G / Foltynie, T / Janvin, C / Larsen, J P / Barker, R A / Emre, M. ·Stavanger University Hospital, Psychiatric Division, PO Box 8100, 4068 Stavanger, Norway. daarsland@gmail.com ·Neurology · Pubmed #20855849.

ABSTRACT: BACKGROUND: In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles of MCI, likely to be due to methodologic differences between the studies. OBJECTIVE: The objective of this study was to determine frequency and the profile of MCI in a large, multicenter cohort of well-defined patients with PD using a standardized analytic method and a common definition of MCI. METHODS: A total of 1,346 patients with PD from 8 different cohorts were included. Standardized analysis of verbal memory, visuospatial, and attentional/executive abilities was performed. Subjects were classified as having MCI if their age- and education-corrected z score on one or more cognitive domains was at least 1.5 standard deviations below the mean of either control subjects or normative data. RESULTS: A total of 25.8% of subjects (95% confidence interval [CI] 23.5-28.2) were classified as having MCI. Memory impairment was most common (13.3%; 11.6-15.3), followed by visuospatial (11.0%; 9.4-13.0) and attention/executive ability impairment (10.1%; 8.6-11.9). Regarding cognitive profiles, 11.3% (9.7-13.1) were classified as nonamnestic single-domain MCI, 8.9% (7.0-9.9) as amnestic single-domain, 4.8% (3.8-6.1) as amnestic multiple-domain, and 1.3% (0.9-2.1) as nonamnestic multiple-domain MCI. Having MCI was associated with older age at assessment and at disease onset, male gender, depression, more severe motor symptoms, and advanced disease stage. CONCLUSIONS: MCI is common in patients with PD without dementia, affecting a range of cognitive domains, including memory, visual-spatial, and attention/executive abilities. Future studies of patients with PD with MCI need to determine risk factors for ongoing cognitive decline and assess interventions at a predementia stage.

4 Article Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia. 2010

Apostolova, Liana G / Beyer, Mona / Green, Amity E / Hwang, Kristy S / Morra, Jonathan H / Chou, Yi-Yu / Avedissian, Christina / Aarsland, Dag / Janvin, Carmen C / Larsen, Jan P / Cummings, Jeffrey L / Thompson, Paul M. ·Department of Neurology, David Geffen School of Medicine, UCLA, California, USA. lapostolova@mednet.ucla.edu ·Mov Disord · Pubmed #20437538.

ABSTRACT: Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20-30% for caudate and 5-20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.