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Parkinson Disease: HELP
Articles by Jacob A. Lafo
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, Jacob Lafo wrote the following 5 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Clinical Trial The cognition and emotional well-being indices of the Parkinson's disease questionnaire-39: what do they really measure? 2014

Jones, Jacob D / Hass, Chris / Mangal, Paul / Lafo, Jacob / Okun, Michael S / Bowers, Dawn. ·Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. · Department of Applied Physiology and Kinesiology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. · Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. · Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Electronic address: dawnbowers@phhp.ufl.edu. ·Parkinsonism Relat Disord · Pubmed #25260967.

ABSTRACT: INTRODUCTION: The Parkinson's disease questionnaire-39 (PDQ-39) is a common measure of health related quality of life (HRQoL) that is widely used with Parkinson disease (PD) patients. Previous evidence suggests that the PDQ-39 reflects at least 8 dimensions (i.e., Emotion, Cognitions, Mobility, etc). To date, little research has examined the external/convergent validity of the Cognitions and Emotional Well-being domains of the PDQ-39. METHODS: A convenience sample of 303 PD patients underwent a comprehensive multi-domain neuropsychological evaluation, including tests of execution function, episodic verbal memory, processing speed, language and working memory, as well as completing measures of depression, apathy, state and trait anxiety and HRQoL (PDQ-39). Hierarchical regressions were conducted in order to examine the relationship between scores on neuropsychological tests and the Cognitions index, as well as mood measures and the Emotional Well-being index of the PDQ-39. RESULTS: Neuropsychological test performance did not account for a significant amount of variance in the PDQ-39 Cognitions index scores. Instead, it was depression that significantly contributed to the Cognitions index, above and beyond neuropsychological performance. The PDQ-39 Emotional Well-being index was also related to mood measures, primarily depression and trait anxiety. CONCLUSIONS: The PDQ-39 Cognition index may be more related to mood functioning, as opposed to cognitive functioning, and should not be considered a "proxy" for cognitive functioning. Future studies are needed to better explain the construct of this index.

2 Article Mood Differences Among Parkinson's Disease Patients With Mild Cognitive Impairment. 2016

Jones, Jacob D / Mangal, Paul / Lafo, Jacob / Okun, Michael S / Bowers, Dawn. ·From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville. ·J Neuropsychiatry Clin Neurosci · Pubmed #26792098.

ABSTRACT: Studies with healthy elderly adults suggest that apathy, depression, and anxiety are more common among individuals with mild cognitive impairment (MCI). This study examined differences in mood/amotivational symptoms among patients with Parkinson's disease (PD) with and without MCI. Patients with PD (N=214) underwent neurocognitive evaluations including assessment of apathy (Apathy Scale), depression (Beck Depression Inventory-II), and trait anxiety (State-Trait Anxiety Inventory trait scale). Trait anxiety and depression were more severe in patients with PD with MCI. Delineation of MCI into amnestic and nonamnestic subtypes revealed greater depression, apathy, and anxiety among patients with PD with amnestic MCI relative to cognitively intact patients with PD. Patients with PD and MCI report greater mood symptoms compared to patients with PD who are cognitively intact.

3 Article Memory Similarities Between Essential Tremor and Parkinson's Disease: A Final Common Pathway? 2015

Lafo, Jacob A / Jones, Jacob D / Okun, Michael S / Bauer, Russell M / Price, Catherine C / Bowers, Dawn. ·a Department of Clinical and Health Psychology, College of Public Health & Health Professions , University of Florida , Gainesville , FL , USA. · c Center for Movement Disorders and Neurorestoration , University of Florida College of Medicine, University of Florida , Gainesville , FL , USA. · b Department of Neurology , University of Florida College of Medicine, University of Florida , Gainesville , FL , USA. ·Clin Neuropsychol · Pubmed #26689342.

ABSTRACT: OBJECTIVE: A growing body of literature supports the view that essential tremor (ET) involves alteration of cerebellar-thalamo-cortical networks which can result in working memory and executive deficits. In this study, we tested the hypothesis that individuals with ET would exhibit worse performance on memory tasks requiring more intrinsic organization and structuring (i.e., word lists) relative to those with fewer 'executive' demands (i.e., stories), similar to that previously observed in individuals with Parkinson's disease (PD). METHOD: Participants included a convenience sample of 68 ET patients and 68 idiopathic PD patients, retrospectively matched based on age, education, and sex. All patients underwent routine neuropsychological evaluation assessing recent memory, auditory attention/working memory, language, and executive function. Memory measures included the Hopkins Verbal Learning Test-R and WMS-III Logical Memory. RESULTS: Both ET and PD patients performed significantly worse on word list than story memory recall tasks. The magnitude of the difference between these two memory tasks was similar for ET and PD patients. In both patient groups, performance on measures of executive function and auditory attention/working memory was not distinctly correlated with word list vs. story recall. CONCLUSIONS: These findings suggest that frontal-executive dysfunction in both ET and PD may negatively influence performance on memory tests that are not inherently organized. Although the pathophysiology of these two 'movement disorders' are quite distinct, both have downstream effects on thalamo-frontal circuitry which may provide a common pathway for a similar memory phenotype. Findings are discussed in terms of neuroimaging evidence, conceptual models, and best practice.

4 Article Anxiety and Depression Are Better Correlates of Parkinson's Disease Quality of Life Than Apathy. 2015

Jones, Jacob D / Butterfield, London C / Song, Woojin / Lafo, Jacob / Mangal, Paul / Okun, Michael S / Bowers, Dawn. ·From the Dept. of Clinical and Health Psychology (JDJ, LCB, JL, PM, DB), Dept. of Neurology (MSO, DB), and Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL · and Dept. of Psychiatry, University of Michigan, Ann Arbor, MI (WS). ·J Neuropsychiatry Clin Neurosci · Pubmed #25162776.

ABSTRACT: Due to controversy regarding the influence of apathy on quality of life (QoL), the authors examined the independent influence of apathy, depression, and trait anxiety in a nondemented sample of patients with Parkinson disease (PD). Participants (N=107) completed standard self-report measures of QoL and mood/motivation. Analyses investigated the contribution of these measures and empirically derived factor scores on QoL. QoL was predicted by trait anxiety, dysphoria, and decreased interest, with no independent contribution of apathy. Different patterns emerged with respect to domain-specific QoL, with trait anxiety being the strongest predictor across most domains. Anxiety was most widely related to QoL in PD, with minimal contribution of apathy. Future studies should examine different roles of PD mood/motivation symptoms on caregiver QoL.

5 Article α-Synuclein in cutaneous autonomic nerves. 2013

Wang, Ningshan / Gibbons, Christopher H / Lafo, Jacob / Freeman, Roy. ·From the Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. ·Neurology · Pubmed #24089386.

ABSTRACT: OBJECTIVE: To develop a cutaneous biomarker for Parkinson disease (PD). METHODS: Twenty patients with PD and 14 age- and sex-matched control subjects underwent examinations, autonomic testing, and skin biopsies at the distal leg, distal thigh, and proximal thigh. α-Synuclein deposition and the density of intraepidermal, sudomotor, and pilomotor nerve fibers were measured. α-Synuclein deposition was normalized to nerve fiber density (the α-synuclein ratio). Results were compared with examination scores and autonomic function testing. RESULTS: Patients with PD had a distal sensory and autonomic neuropathy characterized by loss of intraepidermal and pilomotor fibers (p < 0.05 vs controls, all sites) and morphologic changes to sudomotor nerve fibers. Patients with PD had greater α-synuclein deposition and higher α-synuclein ratios compared with controls within pilomotor nerves and sudomotor nerves (p < 0.01, all sites) but not sensory nerves. Higher α-synuclein ratios correlated with Hoehn and Yahr scores (r = 0.58-0.71, p < 0.01), with sympathetic adrenergic function (r = -0.40 to -0.66, p < 0.01), and with parasympathetic function (r = -0.66 to -0.77, p > 0.01). CONCLUSIONS: We conclude that α-synuclein deposition is increased in cutaneous sympathetic adrenergic and sympathetic cholinergic fibers but not sensory fibers of patients with PD. Higher α-synuclein deposition is associated with greater autonomic dysfunction and more advanced PD. These data suggest that measures of α-synuclein deposition in cutaneous autonomic nerves may be a useful biomarker in patients with PD.