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Parkinson Disease: HELP
Articles by Hidehiko Okazawa
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Hidehiko Okazawa wrote the following 2 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Clinical Trial Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET. 2011

Ikawa, Masamichi / Okazawa, Hidehiko / Kudo, Takashi / Kuriyama, Masaru / Fujibayashi, Yasuhisa / Yoneda, Makoto. ·Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui 910-1193, Japan. ·Nucl Med Biol · Pubmed #21982566.

ABSTRACT: INTRODUCTION: To clarify the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD) in living patients, positron emission tomography (PET) with [(62)Cu]diacetyl-bis(N(4)-methylthiosemicarbazone) ([(62)Cu]ATSM) was applied to functional imaging of oxidative stress mainly due to mitochondrial dysfunction in the striata of patients with PD. METHODS: Fifteen PD patients who presented with lateral dominant symptoms at onset and six healthy controls underwent [(62)Cu]ATSM PET. Dynamic PET data acquisition was performed, and standardized uptake values (SUVs) were obtained from the delayed phase of dynamic data by means of region of interest analysis. The striatum-to-cerebellum SUV ratio (S/C ratio) was calculated from the SUV in all subjects of the striatum and the cerebellar cortex. RESULTS: The mean S/C ratio of the bilateral striata of the patients (1.15±0.10) was significantly increased compared with that of the controls (1.08±0.02) (P<.05). In the patients, the S/C ratio of the bilateral striata showed a positive correlation with the Unified Parkinson's Disease Rating Scale (UPDRS) rating (r=0.52, P<.05), and the S/C ratio of the striatum contralateral to the initially affected body side showed a strong positive correlation with the UPDRS rating (r=0.62, P<.05). CONCLUSIONS: [(62)Cu]ATSM PET imaging demonstrated that striatal oxidative stress was enhanced in PD patients compared with the controls and increased with the progression of disease severity, particularly in the contralateral striatum. These findings indicated that oxidative stress associates with striatal neurodegeneration in PD.

2 Article Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in Patients with Parkinson's Disease: A Study with 62Cu-ATSM PET and 123I-FP-CIT SPECT. 2017

Neishi, Hiroyuki / Ikawa, Masamichi / Okazawa, Hidehiko / Tsujikawa, Tetsuya / Arishima, Hidetaka / Kikuta, Ken-Ichiro / Yoneda, Makoto. ·Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. · Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Fukui, Japan. · Biomedical Imaging Research Center, University of Fukui, Fukui, Japan. · Faculty of Nursing and Social Welfare Science/Department of Nursing Graduate School of Nursing and Social Welfare Sciences, Fukui Prefectural University, Fukui, Japan. ·Eur Neurol · Pubmed #28848099.

ABSTRACT: BACKGROUND: This study sought to precisely evaluate striatal oxidative stress and its relationship with the disease severity in Parkinson's disease (PD) using double brain imaging, 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM) PET and 123I-FP-CIT SPECT. METHODS: Nine PD patients were studied with brain 62Cu-ATSM PET for oxidative stress and 123I-FP-CIT SPECT for the density of striatal dopamine transporter. Standardized uptake values (SUVs) were obtained from the delayed phase of dynamic 62Cu-ATSM PET, and striatum-to-cerebellum SUV ratio (SUVR) was calculated. To correct the effect of neuronal loss in the striatum, 62Cu-ATSM SUVR was corrected for striatal specific binding ratio (SBR) values of 123I-FP-CIT (SUVR/SBR). RESULTS: 62Cu-ATSM SUVR without correction was not significantly correlated with disease severity estimated by the Unified Parkinson's Disease Rating Scale (UPDRS) scores or 123I-FP-CIT SBR. In contrast, the SUVR/SBR showed significant correlations with the UPDRS total and motor scores, and 123I-FP-CIT SBR. CONCLUSION: Oxidative stress in the remaining striatal dopaminergic neurons estimated by SUVR/SBR was increased with disease severity in PD patients, suggesting that oxidative stress based on mitochondrial dysfunction contributes to promoting dopaminergic neuronal degeneration in PD. 62Cu-ATSM PET with 123I-FP-CIT SPECT correction would be a promising tool to evaluate dopaminergic neuronal oxidative stress in PD.