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Parkinson Disease: HELP
Articles by Kamila Osypiuk
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, K. Osypiuk wrote the following 2 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Review The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson's disease: A systematic review and meta-analysis. 2017

Song, R / Grabowska, W / Park, M / Osypiuk, K / Vergara-Diaz, G P / Bonato, P / Hausdorff, J M / Fox, M / Sudarsky, L R / Macklin, E / Wayne, P M. ·College of Nursing, Chungnam National University, South Korea. Electronic address: songry@cnu.ac.kr. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: wgrabowska@coa.edu. · Department of Nursing, Woosong College, South Korea. Electronic address: mkpark@wsi.ac.kr. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: kosypiuk@partners.org. · Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, USA. Electronic address: gvergaradiaz@partners.org. · Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, USA. Electronic address: pbonato@partners.org. · Sackler Faculty of Medicine, Tel Aviv University, Center for the Study of Movement, Cognition, and Mobility at Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel. Electronic address: Jeff.hausdorff@gmail.com. · Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA. Electronic address: Mfox3@bidmc.harvard.edu. · Department of Neurology, Harvard Medical School, Brigham and Women's Hospital, USA. Electronic address: lsudarsky@partners.org. · Harvard Medical School, Massachusetts General Hospital, USA. Electronic address: emacklin@mgh.harvard.org. · Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, USA. Electronic address: pwayne@partners.org. ·Parkinsonism Relat Disord · Pubmed #28602515.

ABSTRACT: PURPOSE: To systematically evaluate and quantify the effects of Tai Chi/Qigong (TCQ) on motor (UPDRS III, balance, falls, Timed-Up-and-Go, and 6-Minute Walk) and non-motor (depression and cognition) function, and quality of life (QOL) in patients with Parkinson's disease (PD). METHODS: A systematic search in 7 electronic databases targeted clinical studies evaluating TCQ for individuals with PD published through August 2016. Meta-analysis was used to estimate effect sizes (Hedges's g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed by two raters. RESULTS: Our search identified 21 studies, 15 of which were RCTs with a total of 735 subjects. For RCTs, comparison groups included no treatment (n = 7, 47%) and active interventions (n = 8, 53%). Duration of TCQ ranged from 2 to 6 months. Methodological bias was low in 6 studies, moderate in 7, and high in 2. Fixed-effect models showed that TCQ was associated with significant improvement on most motor outcomes (UPDRS III [ES = -0.444, p < 0.001], balance [ES = 0.544, p < 0.001], Timed-Up-and-Go [ES = -0.341, p = 0.005], 6 MW [ES = -0.293, p = 0.06], falls [ES = -0.403, p = 0.004], as well as depression [ES = -0.457, p = 0.008] and QOL [ES = -0.393, p < 0.001], but not cognition [ES = -0.225, p = 0.477]). I CONCLUSION: Evidence to date supports a potential benefit of TCQ for improving motor function, depression and QOL for individuals with PD, and validates the need for additional large-scale trials.

2 Article Tai Chi for Reducing Dual-task Gait Variability, a Potential Mediator of Fall Risk in Parkinson's Disease: A Pilot Randomized Controlled Trial. 2018

Vergara-Diaz, Gloria / Osypiuk, Kamila / Hausdorff, Jeffrey M / Bonato, Paolo / Gow, Brian J / Miranda, Jose Gv / Sudarsky, Lewis R / Tarsy, Daniel / Fox, Michael D / Gardiner, Paula / Thomas, Cathi A / Macklin, Eric A / Wayne, Peter M. ·Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts. · Osher Center for Integrative Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts. · Center for the Study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel. · Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel. · Sagol School of Neuroscience, Tel Aviv University, Tel Aviv-Yafo, Israel. · Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois. · Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois. · Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts. · Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. · Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. · Department of Family Medicine. Boston University School of Medicine, Boston, MA. · Department of Neurology, Boston University Medical Campus, Boston, MA. ·Glob Adv Health Med · Pubmed #29796338.

ABSTRACT: Objectives: To assess the feasibility and inform design features of a fully powered randomized controlled trial (RCT) evaluating the effects of Tai Chi (TC) in Parkinson's disease (PD) and to select outcomes most responsive to TC assessed during off-medication states. Design: Two-arm, wait-list controlled RCT. Settings: Tertiary care hospital. Subjects: Thirty-two subjects aged 40-75 diagnosed with idiopathic PD within 10 years. Interventions: Six-month TC intervention added to usual care (UC) versus UC alone. Outcome Measures: Primary outcomes were feasibility-related (recruitment rate, adherence, and compliance). Change in dual-task (DT) gait stride-time variability (STV) from baseline to 6 months was defined, a priori, as the clinical outcome measure of primary interest. Other outcomes included: PD motor symptom progression (Unified Parkinson's Disease Rating Scale [UPDRS]), PD-related quality of life (PDQ-39), executive function (Trail Making Test), balance confidence (Activity-Specific Balance Confidence Scale, ABC), and Timed Up and Go test (TUG). All clinical assessments were made in the off-state for PD medications. Results: Thirty-two subjects were enrolled into 3 sequential cohorts over 417 days at an average rate of 0.08 subjects per day. Seventy-five percent (12/16) in the TC group vs 94% (15/16) in the UC group completed the primary 6-month follow-up assessment. Mean TC exposure hours overall: 52. No AEs occurred during or as a direct result of TC exercise. Statistically nonsignificant improvements were observed in the TC group at 6 months in DT gait STV (TC [20.1%] vs UC [-0.1%] group [effect size 0.49; Conclusions: Conducting an RCT of TC for PD is feasible, though measures to improve recruitment and adherence rates are needed. DT gait STV is a sensitive and logical outcome for evaluating the combined cognitive-motor effects of TC in PD.