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Parkinson Disease: HELP
Articles by Diego E. Rincon-Limas
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Diego E. Rincon-Limas wrote the following article about Parkinson Disease.
+ Citations + Abstracts
1 Review Drosophila models of proteinopathies: the little fly that could. 2012

Rincon-Limas, Diego E / Jensen, Kurt / Fernandez-Funez, Pedro. ·Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0236, USA. diego.rincon@neurology.ufl.edu ·Curr Pharm Des · Pubmed #22288402.

ABSTRACT: Alzheimer's, Parkinson's, and Huntington's disease are complex neurodegenerative conditions with high prevalence characterized by protein misfolding and deposition in the brain. Considerable progress has been made in the last two decades in identifying the genes and proteins responsible for several human 'proteinopathies'. A wide variety of wild type and mutant proteins associated with neurodegenerative conditions are structurally unstable, misfolded, and acquire conformations rich in ß-sheets (ß-state). These conformers form highly toxic self-assemblies that kill the neurons in stereotypical patterns. Unfortunately, the detailed understanding of the molecular and cellular perturbations caused by these proteins has not produced a single disease-modifying therapy. More than a decade ago, several groups demonstrated that human proteinopathies reproduce critical features of the disease in transgenic flies, including protein mis-folding, aggregation, and neurotoxicity. These initial reports led to an explosion of research that has contributed to a better understanding of the molecular mechanisms regulating conformational dynamics and neurotoxic cascades. To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications.